Testicular cancer pathophysiology: Difference between revisions

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{{CMG}}; {{AE}} {{G.D.}}, {{SC}}
{{CMG}}; {{AE}} {{G.D.}}, {{SC}}
==Overview==
==Overview==
The [[pathophysiology]] of testicular cancer depends on the [[histological]] cell subtypes and findings. Most testicular cancers derived from the lack of differentiation of [[Primordial germ cells|primordial]] [[germ cell]] into [[spermatogonia]]. [[Germ cells]] testicular tumor have some [[genetic]] component while most sex [[Stromal|cord stromal]] testicular cancer have are [[hormonal]] dependent. Most gross [[pathology]] of testicular tumors look similar on the physical appearance. On [[microscopic]] [[histopathological]] analysis of testicular cancer, fried-egg appearance is the characteristic finding of [[seminoma]]; marked [[nuclear]] [[atypia]] is the characteristic finding of [[embryonal carcinoma]]; hyaline-type globules, and Schiller-Duval bodies are characteristic findings of [[yolk sac tumor ]] ; syncytiotrophoblasts and [[cytotrophoblast]] cells are the characteristic findings of [[choriocarcinoma]], [[Polymorphism]] with"spirene" [[chromatin]] for spermatocytic.
The [[pathophysiology]] of testicular cancer depends on the [[histological]] cell subtypes and findings. Most testicular cancers derived from the lack of differentiation of [[Primordial germ cells|primordial]] [[germ cell]] into [[spermatogonia]]. [[Germ cells]] testicular tumor have some [[genetic]] component while most sex [[Stromal|cord stromal]] testicular cancer are [[hormonal]] dependent. Most gross [[pathology]] of testicular tumors look similar on the physical appearance. On [[microscopic]] [[histopathological]] analysis of testicular cancer, fried-egg appearance is the characteristic finding of [[seminoma]]; marked [[nuclear]] [[atypia]] is the characteristic finding of [[embryonal carcinoma]]; hyaline-type globules, and Schiller-Duval bodies are characteristic findings of [[yolk sac tumor ]] ; syncytiotrophoblasts and [[cytotrophoblast]] cells are the characteristic findings of [[choriocarcinoma]], [[Polymorphism]] with"spirene" [[chromatin]] for spermatocytic.


==Pathogenesis==
==Pathogenesis==
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[[Epidermoid cyst|Epidermoid]] [[cyst]]
[[Epidermoid cyst|Epidermoid]] [[cyst]]
|
|
* Solid and firm mass  
* [[Solid]] and firm [[mass]]
|
|
* Lack of cytologic [[atypia]]
* Lack of cytologic [[atypia]]
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|-
|-
!Leydig cells tumor
![[Leydig cells|Leydig cells tumor]]
|
|
* Homogeneous and well circumscribed mass
* [[Homogeneous]] and well circumscribed [[mass]]


* Solitary and unilateral mass
* [[Solitary]] and unilateral [[mass]]
* White to brown to yellow on cut surface
* White to [[brown]] to yellow on cut surface
|
|
* Cells are arranged in nest, sheets polygonal fahsion
* [[Cells]] are arranged in nest, sheets polygonal fahsion
* [[Cytoplasm]] is [[eosinophilic]] with round [[nuclei]] and prominent nucleoli
* [[Cytoplasm]] is [[eosinophilic]] with round [[nuclei]] and prominent [[nucleoli]]
* Presence of [[lipofuscin]] pigment and reinke crystal intracytoplasmic  
* Presence of [[lipofuscin]] [[pigment]] and reinke [[crystal]] [[Intracytoplasmic sperm injection|intracytoplasmic]]
|[[File:Leydig cell tumour1.jpg|thumb|none|300px|Contributed by Nephron in wikimedia.commons]]  
|[[File:Leydig cell tumour1.jpg|thumb|none|300px|Contributed by Nephron in wikimedia.commons]]  


|-
|-
!Sertoli tumor
![[Sertoli cell|Sertoli tumor]]
|
|
* Homogeneous and well circumscribed mass
* [[Homogeneous]] and well circumscribed [[mass]]


* White to grey on cut surface
* White to grey on cut surface
*  
*  
|
|
* Cells are arranged in cords, nests and lobulated tubules  
* [[Cells]] are arranged in [[Cord|cords]], nests and lobulated [[tubules]]
* Fibrous [[stroma]] ans septa with lymphocytes  
* [[Fibrous]] [[stroma]] ans septa with [[lymphocytes]]
* Elongated spaces and microscysts  
* Elongated spaces and microscysts  
* Pale lipid- rich cytoplasm
* Pale lipid- rich [[cytoplasm]]
* No prominent nucleoli
* No prominent [[nucleoli]]
|[[File:Sertoli cell tumour high mag.jpg|thumb|none|300px|Contributed by Nephron in wikimedia.commons]]
|[[File:Sertoli cell tumour high mag.jpg|thumb|none|300px|Contributed by Nephron in wikimedia.commons]]
|-
|-


!Granulosa tumor
![[Granulosa|Granulosa tumor]]
|
|
Adult type  
Adult type  
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* No distint feature
* No distint feature
Juvenile type
Juvenile type
* Solid, [[nodule]] yellow-orange and cystic mass
* [[Solid]], [[nodule]] yellow-orange and [[cystic]] [[mass]]
*  
*  
|
|
Adult type
Adult type
* Cells are arranged in elongated, microfollicular "call-Exner bodies"
* [[Cells]] are arranged in elongated, microfollicular "call-Exner bodies"
Juvenile type  
Juvenile type  
*Cells are presented in solid sheets and nodules and form the estatic space
*[[Cells]] are presented in [[solid]] sheets and [[nodules]] and form the estatic space
*[[Eosinophilic]] [[cytoplasm]]  
*[[Eosinophilic]] [[cytoplasm]]  
*Hyperchromatic, round to oval [[nuclei]]  
*Hyperchromatic, round to oval [[nuclei]]  
*High [[mitotic]] activities
*High [[mitotic]] activities
*Follicles are located on the periphery  
*[[Follicle|Follicles]] are located on the periphery  
|[[File:Granulosa cell tumour2.jpg|thumb|none|300px|Contributed by Nephron in wikimedia.commons]]  
|[[File:Granulosa cell tumour2.jpg|thumb|none|300px|Contributed by Nephron in wikimedia.commons]]  


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*
*
==Genetics==
==Genetics==
These are genes involved in the pathogenesis of testicular cancer:<ref name="pmid8527395">{{cite journal |vauthors=van Echten J, Oosterhuis JW, Looijenga LH, van de Pol M, Wiersema J, te Meerman GJ, Schaffordt Koops H, Sleijfer DT, de Jong B |title=No recurrent structural abnormalities apart from i(12p) in primary germ cell tumors of the adult testis |journal=Genes Chromosomes Cancer |volume=14 |issue=2 |pages=133–44 |date=October 1995 |pmid=8527395 |doi= |url=}}</ref><ref name="pmid9227931">{{cite journal |vauthors=Bosl GJ, Motzer RJ |title=Testicular germ-cell cancer |journal=N. Engl. J. Med. |volume=337 |issue=4 |pages=242–53 |date=July 1997 |pmid=9227931 |doi=10.1056/NEJM199707243370406 |url=}}</ref>
These are [[genes]] involved in the pathogenesis of testicular cancer:<ref name="pmid8527395">{{cite journal |vauthors=van Echten J, Oosterhuis JW, Looijenga LH, van de Pol M, Wiersema J, te Meerman GJ, Schaffordt Koops H, Sleijfer DT, de Jong B |title=No recurrent structural abnormalities apart from i(12p) in primary germ cell tumors of the adult testis |journal=Genes Chromosomes Cancer |volume=14 |issue=2 |pages=133–44 |date=October 1995 |pmid=8527395 |doi= |url=}}</ref><ref name="pmid9227931">{{cite journal |vauthors=Bosl GJ, Motzer RJ |title=Testicular germ-cell cancer |journal=N. Engl. J. Med. |volume=337 |issue=4 |pages=242–53 |date=July 1997 |pmid=9227931 |doi=10.1056/NEJM199707243370406 |url=}}</ref>
*Chromosome 12p
*[[Chromosome]] 12p
*12q22.2
*12q22.2


==Immunohistochemical Markers==
==Immunohistochemical Markers==
*Germ cell Neoplastic in situ:
*[[Germ]] [[cell]] [[neoplastic]] [[in situ]]:
**+PLAP (Placenta like-alkaline phosphatase)<ref name="pmid6209917">{{cite journal |vauthors=Jacobsen GK, Nørgaard-Pedersen B |title=Placental alkaline phosphatase in testicular germ cell tumours and in carcinoma-in-situ of the testis. An immunohistochemical study |journal=Acta Pathol Microbiol Immunol Scand A |volume=92 |issue=5 |pages=323–9 |date=September 1984 |pmid=6209917 |doi= |url=}}</ref>
**+PLAP (Placenta like-alkaline phosphatase)<ref name="pmid6209917">{{cite journal |vauthors=Jacobsen GK, Nørgaard-Pedersen B |title=Placental alkaline phosphatase in testicular germ cell tumours and in carcinoma-in-situ of the testis. An immunohistochemical study |journal=Acta Pathol Microbiol Immunol Scand A |volume=92 |issue=5 |pages=323–9 |date=September 1984 |pmid=6209917 |doi= |url=}}</ref>
*[[Seminoma]]<nowiki/>s:<ref name="pmid29262668">{{cite journal |vauthors=Boccellino M, Vanacore D, Zappavigna S, Cavaliere C, Rossetti S, D'Aniello C, Chieffi P, Amler E, Buonerba C, Di Lorenzo G, Di Franco R, Izzo A, Piscitelli R, Iovane G, Muto P, Botti G, Perdonà S, Caraglia M, Facchini G |title=Testicular cancer from diagnosis to epigenetic factors |journal=Oncotarget |volume=8 |issue=61 |pages=104654–104663 |date=November 2017 |pmid=29262668 |pmc=5732834 |doi=10.18632/oncotarget.20992 |url=}}</ref><ref name="pmid17527070">{{cite journal |vauthors=Santagata S, Ligon KL, Hornick JL |title=Embryonic stem cell transcription factor signatures in the diagnosis of primary and metastatic germ cell tumors |journal=Am. J. Surg. Pathol. |volume=31 |issue=6 |pages=836–45 |date=June 2007 |pmid=17527070 |doi=10.1097/PAS.0b013e31802e708a |url=}}</ref><ref name="pmid17117392">{{cite journal |vauthors=Cheng L, Sung MT, Cossu-Rocca P, Jones TD, MacLennan GT, De Jong J, Lopez-Beltran A, Montironi R, Looijenga LH |title=OCT4: biological functions and clinical applications as a marker of germ cell neoplasia |journal=J. Pathol. |volume=211 |issue=1 |pages=1–9 |date=January 2007 |pmid=17117392 |doi=10.1002/path.2105 |url=}}</ref>
*[[Seminoma]]<nowiki/>s:<ref name="pmid29262668">{{cite journal |vauthors=Boccellino M, Vanacore D, Zappavigna S, Cavaliere C, Rossetti S, D'Aniello C, Chieffi P, Amler E, Buonerba C, Di Lorenzo G, Di Franco R, Izzo A, Piscitelli R, Iovane G, Muto P, Botti G, Perdonà S, Caraglia M, Facchini G |title=Testicular cancer from diagnosis to epigenetic factors |journal=Oncotarget |volume=8 |issue=61 |pages=104654–104663 |date=November 2017 |pmid=29262668 |pmc=5732834 |doi=10.18632/oncotarget.20992 |url=}}</ref><ref name="pmid17527070">{{cite journal |vauthors=Santagata S, Ligon KL, Hornick JL |title=Embryonic stem cell transcription factor signatures in the diagnosis of primary and metastatic germ cell tumors |journal=Am. J. Surg. Pathol. |volume=31 |issue=6 |pages=836–45 |date=June 2007 |pmid=17527070 |doi=10.1097/PAS.0b013e31802e708a |url=}}</ref><ref name="pmid17117392">{{cite journal |vauthors=Cheng L, Sung MT, Cossu-Rocca P, Jones TD, MacLennan GT, De Jong J, Lopez-Beltran A, Montironi R, Looijenga LH |title=OCT4: biological functions and clinical applications as a marker of germ cell neoplasia |journal=J. Pathol. |volume=211 |issue=1 |pages=1–9 |date=January 2007 |pmid=17117392 |doi=10.1002/path.2105 |url=}}</ref>
**OCT3/4 transcription factors<ref name="pmid15818593">{{cite journal |vauthors=de Jong J, Stoop H, Dohle GR, Bangma CH, Kliffen M, van Esser JW, van den Bent M, Kros JM, Oosterhuis JW, Looijenga LH |title=Diagnostic value of OCT3/4 for pre-invasive and invasive testicular germ cell tumours |journal=J. Pathol. |volume=206 |issue=2 |pages=242–9 |date=June 2005 |pmid=15818593 |doi=10.1002/path.1766 |url=}}</ref>
**OCT3/4 [[transcription]] factors<ref name="pmid15818593">{{cite journal |vauthors=de Jong J, Stoop H, Dohle GR, Bangma CH, Kliffen M, van Esser JW, van den Bent M, Kros JM, Oosterhuis JW, Looijenga LH |title=Diagnostic value of OCT3/4 for pre-invasive and invasive testicular germ cell tumours |journal=J. Pathol. |volume=206 |issue=2 |pages=242–9 |date=June 2005 |pmid=15818593 |doi=10.1002/path.1766 |url=}}</ref>
**C-kit
**[[C-kit]]
**[[CD30]]
**[[CD30]]
**D2-40 monoclonal antibody
**D2-40 [[monoclonal antibody]]
**PLAP
**PLAP
**NANOG transcription factor
**NANOG [[transcription factor]]


*[[Embryonal carcinoma]]:<ref name="pmid17527070">{{cite journal |vauthors=Santagata S, Ligon KL, Hornick JL |title=Embryonic stem cell transcription factor signatures in the diagnosis of primary and metastatic germ cell tumors |journal=Am. J. Surg. Pathol. |volume=31 |issue=6 |pages=836–45 |date=June 2007 |pmid=17527070 |doi=10.1097/PAS.0b013e31802e708a |url=}}</ref><ref name="pmid17117392">{{cite journal |vauthors=Cheng L, Sung MT, Cossu-Rocca P, Jones TD, MacLennan GT, De Jong J, Lopez-Beltran A, Montironi R, Looijenga LH |title=OCT4: biological functions and clinical applications as a marker of germ cell neoplasia |journal=J. Pathol. |volume=211 |issue=1 |pages=1–9 |date=January 2007 |pmid=17117392 |doi=10.1002/path.2105 |url=}}</ref>
*[[Embryonal carcinoma]]:<ref name="pmid17527070">{{cite journal |vauthors=Santagata S, Ligon KL, Hornick JL |title=Embryonic stem cell transcription factor signatures in the diagnosis of primary and metastatic germ cell tumors |journal=Am. J. Surg. Pathol. |volume=31 |issue=6 |pages=836–45 |date=June 2007 |pmid=17527070 |doi=10.1097/PAS.0b013e31802e708a |url=}}</ref><ref name="pmid17117392">{{cite journal |vauthors=Cheng L, Sung MT, Cossu-Rocca P, Jones TD, MacLennan GT, De Jong J, Lopez-Beltran A, Montironi R, Looijenga LH |title=OCT4: biological functions and clinical applications as a marker of germ cell neoplasia |journal=J. Pathol. |volume=211 |issue=1 |pages=1–9 |date=January 2007 |pmid=17117392 |doi=10.1002/path.2105 |url=}}</ref>
Line 263: Line 263:


*[[Yolk sac tumor]]:<ref name="pmid26612222">{{cite journal |vauthors=Howitt BE, Berney DM |title=Tumors of the Testis: Morphologic Features and Molecular Alterations |journal=Surg Pathol Clin |volume=8 |issue=4 |pages=687–716 |date=December 2015 |pmid=26612222 |doi=10.1016/j.path.2015.07.007 |url=}}</ref><ref name="pmid19365862">{{cite journal |vauthors=Cao D, Humphrey PA, Allan RW |title=SALL4 is a novel sensitive and specific marker for metastatic germ cell tumors, with particular utility in detection of metastatic yolk sac tumors |journal=Cancer |volume=115 |issue=12 |pages=2640–51 |date=June 2009 |pmid=19365862 |doi=10.1002/cncr.24308 |url=}}</ref>
*[[Yolk sac tumor]]:<ref name="pmid26612222">{{cite journal |vauthors=Howitt BE, Berney DM |title=Tumors of the Testis: Morphologic Features and Molecular Alterations |journal=Surg Pathol Clin |volume=8 |issue=4 |pages=687–716 |date=December 2015 |pmid=26612222 |doi=10.1016/j.path.2015.07.007 |url=}}</ref><ref name="pmid19365862">{{cite journal |vauthors=Cao D, Humphrey PA, Allan RW |title=SALL4 is a novel sensitive and specific marker for metastatic germ cell tumors, with particular utility in detection of metastatic yolk sac tumors |journal=Cancer |volume=115 |issue=12 |pages=2640–51 |date=June 2009 |pmid=19365862 |doi=10.1002/cncr.24308 |url=}}</ref>
**+SALL4
**+[[SALL4]]
**+AFP
**+AFP
**+[[GATA3]]
**+[[GATA3]]
**+Glypican3
**+Glypican3
**+[[Keratin]]
**+[[Keratin]]
**+/-C-kit
**+/-[[C-kit]]


*[[Choriocarcinoma]]:<ref name="pmid26612222">{{cite journal |vauthors=Howitt BE, Berney DM |title=Tumors of the Testis: Morphologic Features and Molecular Alterations |journal=Surg Pathol Clin |volume=8 |issue=4 |pages=687–716 |date=December 2015 |pmid=26612222 |doi=10.1016/j.path.2015.07.007 |url=}}</ref>
*[[Choriocarcinoma]]:<ref name="pmid26612222">{{cite journal |vauthors=Howitt BE, Berney DM |title=Tumors of the Testis: Morphologic Features and Molecular Alterations |journal=Surg Pathol Clin |volume=8 |issue=4 |pages=687–716 |date=December 2015 |pmid=26612222 |doi=10.1016/j.path.2015.07.007 |url=}}</ref>
**+Ck7
**+Ck7
**+[[GATA3]]
**+[[GATA3]]
**+HCG
**+[[HCG]]
**+/-Sall4
**+/-[[SALL4]]


*Spermatocytic tumor:<ref name="pmid26612222">{{cite journal |vauthors=Howitt BE, Berney DM |title=Tumors of the Testis: Morphologic Features and Molecular Alterations |journal=Surg Pathol Clin |volume=8 |issue=4 |pages=687–716 |date=December 2015 |pmid=26612222 |doi=10.1016/j.path.2015.07.007 |url=}}</ref>
*Spermatocytic [[tumor]]:<ref name="pmid26612222">{{cite journal |vauthors=Howitt BE, Berney DM |title=Tumors of the Testis: Morphologic Features and Molecular Alterations |journal=Surg Pathol Clin |volume=8 |issue=4 |pages=687–716 |date=December 2015 |pmid=26612222 |doi=10.1016/j.path.2015.07.007 |url=}}</ref>
**+Sall4
**+[[SALL4]]
**+/-C-kit
**+/-[[C-kit]]


*[[Teratoma]]:<ref name="pmid8583612">{{cite journal |vauthors=Simmonds PD, Lee AH, Theaker JM, Tung K, Smart CJ, Mead GM |title=Primary pure teratoma of the testis |journal=J. Urol. |volume=155 |issue=3 |pages=939–42 |date=March 1996 |pmid=8583612 |doi= |url=}}</ref><ref name="pmid377749">{{cite journal |vauthors=Brosman SA |title=Testicular tumors in prepubertal children |journal=Urology |volume=13 |issue=6 |pages=581–8 |date=June 1979 |pmid=377749 |doi= |url=}}</ref><ref name="pmid26612222">{{cite journal |vauthors=Howitt BE, Berney DM |title=Tumors of the Testis: Morphologic Features and Molecular Alterations |journal=Surg Pathol Clin |volume=8 |issue=4 |pages=687–716 |date=December 2015 |pmid=26612222 |doi=10.1016/j.path.2015.07.007 |url=}}</ref>
*[[Teratoma]]:<ref name="pmid8583612">{{cite journal |vauthors=Simmonds PD, Lee AH, Theaker JM, Tung K, Smart CJ, Mead GM |title=Primary pure teratoma of the testis |journal=J. Urol. |volume=155 |issue=3 |pages=939–42 |date=March 1996 |pmid=8583612 |doi= |url=}}</ref><ref name="pmid377749">{{cite journal |vauthors=Brosman SA |title=Testicular tumors in prepubertal children |journal=Urology |volume=13 |issue=6 |pages=581–8 |date=June 1979 |pmid=377749 |doi= |url=}}</ref><ref name="pmid26612222">{{cite journal |vauthors=Howitt BE, Berney DM |title=Tumors of the Testis: Morphologic Features and Molecular Alterations |journal=Surg Pathol Clin |volume=8 |issue=4 |pages=687–716 |date=December 2015 |pmid=26612222 |doi=10.1016/j.path.2015.07.007 |url=}}</ref>
**+Sall4
**+[[SALL4]]
**+[[Cytokeratin]]
**+[[Cytokeratin]]
**+[[HCG]]
**+[[HCG]]
**+/-GATA3,SOX2,OCT4
**+/-[[GATA3]],[[SOX2]],[[OCT4]]


*Testicular lymphoma:<ref name="pmid26612222">{{cite journal |vauthors=Howitt BE, Berney DM |title=Tumors of the Testis: Morphologic Features and Molecular Alterations |journal=Surg Pathol Clin |volume=8 |issue=4 |pages=687–716 |date=December 2015 |pmid=26612222 |doi=10.1016/j.path.2015.07.007 |url=}}</ref>
*[[Testicular]] [[lymphoma]]:<ref name="pmid26612222">{{cite journal |vauthors=Howitt BE, Berney DM |title=Tumors of the Testis: Morphologic Features and Molecular Alterations |journal=Surg Pathol Clin |volume=8 |issue=4 |pages=687–716 |date=December 2015 |pmid=26612222 |doi=10.1016/j.path.2015.07.007 |url=}}</ref>
**+[[CD3]]
**+[[CD3]]
**+[[CD20]]
**+[[CD20]]
Line 301: Line 301:
**+[[Vimentin]]
**+[[Vimentin]]
**+EMA (epithelial menbrane antigen)
**+EMA (epithelial menbrane antigen)
**+/-Cytokeratin
**+/-[[Cytokeratin]]


*[[Granulosa cell tumor]]:<ref name="pmid17628299">{{cite journal |vauthors=Ditonno P, Lucarelli G, Battaglia M, Mancini V, Palazzo S, Trabucco S, Bettocchi C, Paolo Selvaggi F |title=Testicular granulosa cell tumor of adult type: a new case and a review of the literature |journal=Urol. Oncol. |volume=25 |issue=4 |pages=322–5 |date=2007 |pmid=17628299 |doi=10.1016/j.urolonc.2006.08.019 |url=}}</ref><ref name="pmid15502809">{{cite journal |vauthors=Young RH |title=Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems |journal=Mod. Pathol. |volume=18 Suppl 2 |issue= |pages=S81–98 |date=February 2005 |pmid=15502809 |doi=10.1038/modpathol.3800311 |url=}}</ref><ref name="pmid9591732">{{cite journal |vauthors=McCluggage WG, Shanks JH, Whiteside C, Maxwell P, Banerjee SS, Biggart JD |title=Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody |journal=Am. J. Surg. Pathol. |volume=22 |issue=5 |pages=615–9 |date=May 1998 |pmid=9591732 |doi= |url=}}</ref>
*[[Granulosa cell tumor]]:<ref name="pmid17628299">{{cite journal |vauthors=Ditonno P, Lucarelli G, Battaglia M, Mancini V, Palazzo S, Trabucco S, Bettocchi C, Paolo Selvaggi F |title=Testicular granulosa cell tumor of adult type: a new case and a review of the literature |journal=Urol. Oncol. |volume=25 |issue=4 |pages=322–5 |date=2007 |pmid=17628299 |doi=10.1016/j.urolonc.2006.08.019 |url=}}</ref><ref name="pmid15502809">{{cite journal |vauthors=Young RH |title=Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems |journal=Mod. Pathol. |volume=18 Suppl 2 |issue= |pages=S81–98 |date=February 2005 |pmid=15502809 |doi=10.1038/modpathol.3800311 |url=}}</ref><ref name="pmid9591732">{{cite journal |vauthors=McCluggage WG, Shanks JH, Whiteside C, Maxwell P, Banerjee SS, Biggart JD |title=Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody |journal=Am. J. Surg. Pathol. |volume=22 |issue=5 |pages=615–9 |date=May 1998 |pmid=9591732 |doi= |url=}}</ref>

Latest revision as of 09:25, 29 May 2019

Testicular cancer Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Gertrude Djouka, M.D.[2], Shanshan Cen, M.D. [3]

Overview

The pathophysiology of testicular cancer depends on the histological cell subtypes and findings. Most testicular cancers derived from the lack of differentiation of primordial germ cell into spermatogonia. Germ cells testicular tumor have some genetic component while most sex cord stromal testicular cancer are hormonal dependent. Most gross pathology of testicular tumors look similar on the physical appearance. On microscopic histopathological analysis of testicular cancer, fried-egg appearance is the characteristic finding of seminoma; marked nuclear atypia is the characteristic finding of embryonal carcinoma; hyaline-type globules, and Schiller-Duval bodies are characteristic findings of yolk sac tumor  ; syncytiotrophoblasts and cytotrophoblast cells are the characteristic findings of choriocarcinoma, Polymorphism with"spirene" chromatin for spermatocytic.

Pathogenesis

Normal process of testicular germ cells

Normal process of testicular sex cord stromal

Leydig cells

Germ cells tumors

Germ cell tumors derived from germ cell neoplasia in situ

Germ cell tumors unrelated to germ cell neoplasia in situ

Testicular sex cord stromal tumors

Leydig cells tumor

Sertoli cell tumor

Granulosa cell tumor

Gross and Microscopic Pathology

The gross and microscopic features of the most common tumors are described below:[16][17][18][19][20][21][22][19][23][24][25][26][27][3][28][29][15]

Types Gross pathology Microscopic pathology Images
Germ cell neoplasia in situ
Contributed by Nephron in wikimedia.commons
Seminoma
  • Solid, firm without cross section
Contributed by Nephron in wikimedia.commons
Embryonal carcinoma
Contributed by Nephron in wikimedia.commons
Yolk sac tumor
Contributed by EDDAOUALLINE Hanane in wikimedia.commons
Choriocarcinoma
Contributed by Nephron in wikimedia.commons
Teratoma, postpubertal-type
Contributed by Nephron in wikimedia.commons
Mixed germ cell tumors
Contributed by Nephron in wikimedia.commons
Spermatocytic tumor
  • Soft, gray, and gelatinous mass
  • Well circumscribed with small hemorrhagic and necrotic foci.
Contributed by Nephron in wikimedia.commons
Teratoma, prepubertal-type,

Desmoid cyst

Epidermoid cyst

Contributed by Nephron in wikimedia.commons
Testicular lymphoma
  • Soft, gray, and gelatinous mass
  • Well circumscribed with small hemorrhagic and necrotic foci.
Contributed by Nephron in wikimedia.commons
Leydig cells tumor
Contributed by Nephron in wikimedia.commons
Sertoli tumor
  • White to grey on cut surface
Contributed by Nephron in wikimedia.commons
Granulosa tumor

Adult type

  • No distint feature

Juvenile type

Adult type

  • Cells are arranged in elongated, microfollicular "call-Exner bodies"

Juvenile type

Contributed by Nephron in wikimedia.commons

Genetics

These are genes involved in the pathogenesis of testicular cancer:[30][31]

Immunohistochemical Markers

References

  1. ↑ Miyai, Kosuke; Ito, Keiichi; Nakanishi, Kuniaki; Tsuda, Hitoshi (2019). "Seminoma component of mixed testicular germ cell tumor shows a higher incidence of loss of heterozygosity than pure-type seminoma". Human Pathology. 84: 71–80. doi:10.1016/j.humpath.2018.09.007. ISSN 0046-8177.
  2. ↑ 2.0 2.1 Kraggerud SM, Hoei-Hansen CE, Alagaratnam S, Skotheim RI, Abeler VM, Rajpert-De Meyts E, Lothe RA (June 2013). "Molecular characteristics of malignant ovarian germ cell tumors and comparison with testicular counterparts: implications for pathogenesis". Endocr. Rev. 34 (3): 339–76. doi:10.1210/er.2012-1045. PMC 3787935. PMID 23575763.
  3. ↑ 3.0 3.1 3.2 3.3 3.4 Al-Agha OM, Axiotis CA (February 2007). "An in-depth look at Leydig cell tumor of the testis". Arch. Pathol. Lab. Med. 131 (2): 311–7. doi:10.1043/1543-2165(2007)131[311:AILALC]2.0.CO;2. PMID 17284120.
  4. ↑ Neaves WB (May 1975). "Leydig cells". Contraception. 11 (5): 571–606. PMID 1095296.
  5. ↑ Bray F, Richiardi L, Ekbom A, Forman D, Pukkala E, Cuninkova M, Møller H (April 2006). "Do testicular seminoma and nonseminoma share the same etiology? Evidence from an age-period-cohort analysis of incidence trends in eight European countries". Cancer Epidemiol. Biomarkers Prev. 15 (4): 652–8. doi:10.1158/1055-9965.EPI-05-0565. PMID 16614105.
  6. ↑ Linke J, Loy V, Dieckmann KP (May 2005). "Prevalence of testicular intraepithelial neoplasia in healthy males". J. Urol. 173 (5): 1577–9. doi:10.1097/01.ju.0000154348.68575.95. PMID 15821489.
  7. ↑ Rosenberg C, Van Gurp RJ, Geelen E, Oosterhuis JW, Looijenga LH (November 2000). "Overrepresentation of the short arm of chromosome 12 is related to invasive growth of human testicular seminomas and nonseminomas". Oncogene. 19 (51): 5858–62. PMID 11127816.
  8. ↑ 8.0 8.1 Powles T, Bower M, Daugaard G, Shamash J, De Ruiter A, Johnson M, Fisher M, Anderson J, Mandalia S, Stebbing J, Nelson M, Gazzard B, Oliver T (May 2003). "Multicenter study of human immunodeficiency virus-related germ cell tumors". J. Clin. Oncol. 21 (10): 1922–7. doi:10.1200/JCO.2003.09.107. PMID 12743144.
  9. ↑ Rapley, Elizabeth A.; Crockford, Gillian P.; Teare, Dawn; Biggs, Patrick; Seal, Sheila; Barfoot, Rita; Edwards, Sandra; Hamoudi, Rifat; Heimdal, Ketil; Fosså, Sophie D.; Tucker, Kathy; Donald, Jenny; Collins, Felicity; Friedlander, Michael; Hogg, David; Goss, Paul; Heidenreich, Axel; Ormiston, Wilma; Daly, Peter A.; Forman, David; Oliver, Timothy D.; Leahy, Michael; Huddart, Robert; Cooper, Colin S.; Bodmer, Julia G.; Easton, Douglas F.; Stratton, Michael R.; Bishop, D. Timothy (2000). "Localization to Xq27 of a susceptibility gene for testicular germ-cell tumours". Nature Genetics. 24 (2): 197–200. doi:10.1038/72877. ISSN 1061-4036.
  10. ↑ Hoei-Hansen CE, Rajpert-De Meyts E, Daugaard G, Skakkebaek NE (June 2005). "Carcinoma in situ testis, the progenitor of testicular germ cell tumours: a clinical review". Ann. Oncol. 16 (6): 863–8. doi:10.1093/annonc/mdi175. PMID 15821122.
  11. ↑ Looijenga LH (August 2011). "Spermatocytic seminoma: toward further understanding of pathogenesis". J. Pathol. 224 (4): 431–3. doi:10.1002/path.2939. PMID 21725972.
  12. ↑ 12.0 12.1 12.2 12.3 12.4 12.5 Howitt BE, Berney DM (December 2015). "Tumors of the Testis: Morphologic Features and Molecular Alterations". Surg Pathol Clin. 8 (4): 687–716. doi:10.1016/j.path.2015.07.007. PMID 26612222.
  13. ↑ Conkey DS, Howard GC, Grigor KM, McLaren DB, Kerr GR (August 2005). "Testicular sex cord-stromal tumours: the Edinburgh experience 1988-2002, and a review of the literature". Clin Oncol (R Coll Radiol). 17 (5): 322–7. PMID 16097561.
  14. ↑ Dilworth, J. Patrick; Farrow, George M.; Oesterling, Joseph E. (1991). "Non-germ cell tumors of testis". Urology. 37 (5): 399–417. doi:10.1016/0090-4295(91)80100-L. ISSN 0090-4295.
  15. ↑ 15.0 15.1 Jimenez-Quintero LP, Ro JY, Zavala-Pompa A, Amin MB, Tetu B, Ordoñez NG, Ayala AG (October 1993). "Granulosa cell tumor of the adult testis: a clinicopathologic study of seven cases and a review of the literature". Hum. Pathol. 24 (10): 1120–5. PMID 8406422.
  16. ↑ Boccellino M, Vanacore D, Zappavigna S, Cavaliere C, Rossetti S, D'Aniello C, Chieffi P, Amler E, Buonerba C, Di Lorenzo G, Di Franco R, Izzo A, Piscitelli R, Iovane G, Muto P, Botti G, Perdonà S, Caraglia M, Facchini G (November 2017). "Testicular cancer from diagnosis to epigenetic factors". Oncotarget. 8 (61): 104654–104663. doi:10.18632/oncotarget.20992. PMC 5732834. PMID 29262668.
  17. ↑ Howitt BE, Berney DM (December 2015). "Tumors of the Testis: Morphologic Features and Molecular Alterations". Surg Pathol Clin. 8 (4): 687–716. doi:10.1016/j.path.2015.07.007. PMID 26612222.
  18. ↑ Siegel RL, Miller KD, Jemal A (2016). "Cancer statistics, 2016". CA Cancer J Clin. 66 (1): 7–30. doi:10.3322/caac.21332. PMID 26742998.
  19. ↑ 19.0 19.1 Krag Jacobsen G, Barlebo H, Olsen J, Schultz HP, Starklint H, Søgaard H; et al. (1984). "Testicular germ cell tumours in Denmark 1976-1980. Pathology of 1058 consecutive cases". Acta Radiol Oncol. 23 (4): 239–47. PMID 6093440.
  20. ↑ Emerson RE, Cheng L (April 2013). "Premalignancy of the testis and paratestis". Pathology. 45 (3): 264–72. doi:10.1097/PAT.0b013e32835f3e1a. PMID 23478232.
  21. ↑ 21.0 21.1 Boccellino M, Vanacore D, Zappavigna S, Cavaliere C, Rossetti S, D'Aniello C, Chieffi P, Amler E, Buonerba C, Di Lorenzo G, Di Franco R, Izzo A, Piscitelli R, Iovane G, Muto P, Botti G, Perdonà S, Caraglia M, Facchini G (November 2017). "Testicular cancer from diagnosis to epigenetic factors". Oncotarget. 8 (61): 104654–104663. doi:10.18632/oncotarget.20992. PMC 5732834. PMID 29262668.
  22. ↑ Talerman A, Haije WG, Baggerman L (1980). "Serum alphafetoprotein (AFP) in patients with germ cell tumors of the gonads and extragonadal sites: correlation between endodermal sinus (yolk sac) tumor and raised serum AFP". Cancer. 46 (2): 380–5. PMID 6155988.
  23. ↑ 23.0 23.1 Simmonds PD, Lee AH, Theaker JM, Tung K, Smart CJ, Mead GM (March 1996). "Primary pure teratoma of the testis". J. Urol. 155 (3): 939–42. PMID 8583612.
  24. ↑ Shahab N, Doll DC (June 1999). "Testicular lymphoma". Semin. Oncol. 26 (3): 259–69. PMID 10375083.
  25. ↑ Chuang KL, Liaw CC, Ueng SH, Liao SK, Pang ST, Chang YH, Chuang HC, Chuang CK (March 2010). "Mixed germ cell tumor metastatic to the skin: case report and literature review". World J Surg Oncol. 8: 21. doi:10.1186/1477-7819-8-21. PMC 2851696. PMID 20331874.
  26. ↑ Ramón y Cajal S, Piñango L, Barat A, Moldenhauer F, Oliva H (March 1987). "Metastatic pure choriocarcinoma of the testis in an elderly man". J. Urol. 137 (3): 516–9. PMID 3820391.
  27. ↑ Wei Y, Wu S, Lin T, He D, Li X, Liu J, Liu X, Hua Y, Lu P, Wei G (December 2014). "Testicular yolk sac tumors in children: a review of 61 patients over 19 years". World J Surg Oncol. 12: 400. doi:10.1186/1477-7819-12-400. PMC 4326497. PMID 25547829.
  28. ↑ Cheville JC, Sebo TJ, Lager DJ, Bostwick DG, Farrow GM (November 1998). "Leydig cell tumor of the testis: a clinicopathologic, DNA content, and MIB-1 comparison of nonmetastasizing and metastasizing tumors". Am. J. Surg. Pathol. 22 (11): 1361–7. PMID 9808128.
  29. ↑ 29.0 29.1 29.2 Young RH (February 2005). "Sex cord-stromal tumors of the ovary and testis: their similarities and differences with consideration of selected problems". Mod. Pathol. 18 Suppl 2: S81–98. doi:10.1038/modpathol.3800311. PMID 15502809.
  30. ↑ van Echten J, Oosterhuis JW, Looijenga LH, van de Pol M, Wiersema J, te Meerman GJ, Schaffordt Koops H, Sleijfer DT, de Jong B (October 1995). "No recurrent structural abnormalities apart from i(12p) in primary germ cell tumors of the adult testis". Genes Chromosomes Cancer. 14 (2): 133–44. PMID 8527395.
  31. ↑ Bosl GJ, Motzer RJ (July 1997). "Testicular germ-cell cancer". N. Engl. J. Med. 337 (4): 242–53. doi:10.1056/NEJM199707243370406. PMID 9227931.
  32. ↑ Jacobsen GK, Nørgaard-Pedersen B (September 1984). "Placental alkaline phosphatase in testicular germ cell tumours and in carcinoma-in-situ of the testis. An immunohistochemical study". Acta Pathol Microbiol Immunol Scand A. 92 (5): 323–9. PMID 6209917.
  33. ↑ 33.0 33.1 Santagata S, Ligon KL, Hornick JL (June 2007). "Embryonic stem cell transcription factor signatures in the diagnosis of primary and metastatic germ cell tumors". Am. J. Surg. Pathol. 31 (6): 836–45. doi:10.1097/PAS.0b013e31802e708a. PMID 17527070.
  34. ↑ 34.0 34.1 Cheng L, Sung MT, Cossu-Rocca P, Jones TD, MacLennan GT, De Jong J, Lopez-Beltran A, Montironi R, Looijenga LH (January 2007). "OCT4: biological functions and clinical applications as a marker of germ cell neoplasia". J. Pathol. 211 (1): 1–9. doi:10.1002/path.2105. PMID 17117392.
  35. ↑ 35.0 35.1 de Jong J, Stoop H, Dohle GR, Bangma CH, Kliffen M, van Esser JW, van den Bent M, Kros JM, Oosterhuis JW, Looijenga LH (June 2005). "Diagnostic value of OCT3/4 for pre-invasive and invasive testicular germ cell tumours". J. Pathol. 206 (2): 242–9. doi:10.1002/path.1766. PMID 15818593.
  36. ↑ Cao D, Humphrey PA, Allan RW (June 2009). "SALL4 is a novel sensitive and specific marker for metastatic germ cell tumors, with particular utility in detection of metastatic yolk sac tumors". Cancer. 115 (12): 2640–51. doi:10.1002/cncr.24308. PMID 19365862.
  37. ↑ Brosman SA (June 1979). "Testicular tumors in prepubertal children". Urology. 13 (6): 581–8. PMID 377749.
  38. ↑ 38.0 38.1 Iczkowski KA, Bostwick DG, Roche PC, Cheville JC (August 1998). "Inhibin A is a sensitive and specific marker for testicular sex cord-stromal tumors". Mod. Pathol. 11 (8): 774–9. PMID 9720507.
  39. ↑ Ditonno P, Lucarelli G, Battaglia M, Mancini V, Palazzo S, Trabucco S, Bettocchi C, Paolo Selvaggi F (2007). "Testicular granulosa cell tumor of adult type: a new case and a review of the literature". Urol. Oncol. 25 (4): 322–5. doi:10.1016/j.urolonc.2006.08.019. PMID 17628299.
  40. ↑ McCluggage WG, Shanks JH, Whiteside C, Maxwell P, Banerjee SS, Biggart JD (May 1998). "Immunohistochemical study of testicular sex cord-stromal tumors, including staining with anti-inhibin antibody". Am. J. Surg. Pathol. 22 (5): 615–9. PMID 9591732.


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