Central pontine myelinolysis epidemiology and demographics: Difference between revisions

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{{CMG}}; {{AE}} {{MMJ}}
{{CMG}}; {{AE}} {{MMJ}}
==Overview==
==Overview==
The prevalence of central pontine myelinolysis is approximately 250–500 per 100,000 in the general population. Among hospitalized patients in the [[Intensive care unit|ICU]] the incidence of central pontine myelinolysis is approximately 2500 per 100,000 patients. Among patients undergoing [[liver transplantation]] the incidence of central pontine myelinolysis is approximately 10,000 per 100,000 patients. The case-[[mortality rate]] of central pontine myelinolysis is approximately 12%. Patients of all age groups may develop central pontine myelinolysis but the incidence of central pontine myelinolysis increases with age. There is no racial predilection to central pontine myelinolysis. Central pontine myelinolysis affects men and women equally. There is no regional predilection to central pontine myelinolysis.


==Epidemiology and Demographics==
==Epidemiology and Demographics==
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*Among patients undergoing [[liver transplantation]] the incidence of central pontine myelinolysis is approximately 10,000 per 100,000 patients.<ref name="pmid10460448">{{cite journal| author=Menger H, Jörg J| title=Outcome of central pontine and extrapontine myelinolysis (n = 44). | journal=J Neurol | year= 1999 | volume= 246 | issue= 8 | pages= 700-5 | pmid=10460448 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10460448  }} </ref><ref name="pmid11803185">{{cite journal| author=Lampl C, Yazdi K| title=Central pontine myelinolysis. | journal=Eur Neurol | year= 2002 | volume= 47 | issue= 1 | pages= 3-10 | pmid=11803185 | doi=10.1159/000047939 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11803185  }} </ref><ref name="pmid25810613">{{cite journal| author=Rao PB, Azim A, Singh N, Baronia AK, Kumar A, Poddar B| title=Osmotic demyelination syndrome in Intensive Care Unit. | journal=Indian J Crit Care Med | year= 2015 | volume= 19 | issue= 3 | pages= 166-9 | pmid=25810613 | doi=10.4103/0972-5229.152760 | pmc=4366916 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25810613  }} </ref>
*Among patients undergoing [[liver transplantation]] the incidence of central pontine myelinolysis is approximately 10,000 per 100,000 patients.<ref name="pmid10460448">{{cite journal| author=Menger H, Jörg J| title=Outcome of central pontine and extrapontine myelinolysis (n = 44). | journal=J Neurol | year= 1999 | volume= 246 | issue= 8 | pages= 700-5 | pmid=10460448 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=10460448  }} </ref><ref name="pmid11803185">{{cite journal| author=Lampl C, Yazdi K| title=Central pontine myelinolysis. | journal=Eur Neurol | year= 2002 | volume= 47 | issue= 1 | pages= 3-10 | pmid=11803185 | doi=10.1159/000047939 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=11803185  }} </ref><ref name="pmid25810613">{{cite journal| author=Rao PB, Azim A, Singh N, Baronia AK, Kumar A, Poddar B| title=Osmotic demyelination syndrome in Intensive Care Unit. | journal=Indian J Crit Care Med | year= 2015 | volume= 19 | issue= 3 | pages= 166-9 | pmid=25810613 | doi=10.4103/0972-5229.152760 | pmc=4366916 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25810613  }} </ref>


===Case-fatality rate/Mortality rate===
===Mortality rate===
*In [year], the incidence of [disease name] is approximately [number range] per 100,000 individuals with a case-fatality rate/mortality rate of [number range]%.
 
*The case-fatality rate/mortality rate of [disease name] is approximately [number range].
*The case-[[mortality rate]] of central pontine myelinolysis is approximately 12%.<ref name="pmid25810613" />


===Age===
===Age===
*Patients of all age groups may develop [disease name].
*Patients of all age groups may develop central pontine myelinolysis but the incidence of central pontine myelinolysis increases with age.
*The incidence of [disease name] increases with age; the median age at diagnosis is [#] years.
*[Disease name] commonly affects individuals younger than/older than [number of years] years of age.
*[Chronic disease name] is usually first diagnosed among [age group].
*[Acute disease name] commonly affects [age group].


===Race===
===Race===
*There is no racial predilection to [disease name].
*There is no racial predilection to central pontine myelinolysis.
*[Disease name] usually affects individuals of the [race 1] race. [Race 2] individuals are less likely to develop [disease name].
 
===Gender===
===Gender===
*[Disease name] affects men and women equally.
*Central pontine myelinolysis affects men and women equally.<ref name="pmid31128892">{{cite journal| author=Bansal LR, Zinkus T| title=Osmotic Demyelination Syndrome in Children. | journal=Pediatr Neurol | year= 2019 | volume= 97 | issue=  | pages= 12-17 | pmid=31128892 | doi=10.1016/j.pediatrneurol.2019.03.018 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=31128892  }} </ref>
*[Gender 1] are more commonly affected by [disease name] than [gender 2]. The [gender 1] to [gender 2] ratio is approximately [number > 1] to 1.


===Region===
===Region===
*The majority of [disease name] cases are reported in [geographical region].
*There is no regional predilection to central pontine myelinolysis.
 
*[Disease name] is a common/rare disease that tends to affect [patient population 1] and [patient population 2].
 
===Developed Countries===
 
===Developing Countries===


==References==
==References==

Latest revision as of 13:49, 9 August 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]

Overview

The prevalence of central pontine myelinolysis is approximately 250–500 per 100,000 in the general population. Among hospitalized patients in the ICU the incidence of central pontine myelinolysis is approximately 2500 per 100,000 patients. Among patients undergoing liver transplantation the incidence of central pontine myelinolysis is approximately 10,000 per 100,000 patients. The case-mortality rate of central pontine myelinolysis is approximately 12%. Patients of all age groups may develop central pontine myelinolysis but the incidence of central pontine myelinolysis increases with age. There is no racial predilection to central pontine myelinolysis. Central pontine myelinolysis affects men and women equally. There is no regional predilection to central pontine myelinolysis.

Epidemiology and Demographics

Incidence and prevalence

  • The prevalence of central pontine myelinolysis is approximately 250–500 per 100,000 in the general population.[1]
  • Among hospitalized patients in the ICU the incidence of central pontine myelinolysis is approximately 2500 per 100,000 patients.[2][1]
  • Among patients undergoing liver transplantation the incidence of central pontine myelinolysis is approximately 10,000 per 100,000 patients.[2][3][1]

Mortality rate

Age

  • Patients of all age groups may develop central pontine myelinolysis but the incidence of central pontine myelinolysis increases with age.

Race

  • There is no racial predilection to central pontine myelinolysis.

Gender

  • Central pontine myelinolysis affects men and women equally.[4]

Region

  • There is no regional predilection to central pontine myelinolysis.

References

  1. ↑ 1.0 1.1 1.2 1.3 Rao PB, Azim A, Singh N, Baronia AK, Kumar A, Poddar B (2015). "Osmotic demyelination syndrome in Intensive Care Unit". Indian J Crit Care Med. 19 (3): 166–9. doi:10.4103/0972-5229.152760. PMC 4366916. PMID 25810613.
  2. ↑ 2.0 2.1 Menger H, Jörg J (1999). "Outcome of central pontine and extrapontine myelinolysis (n = 44)". J Neurol. 246 (8): 700–5. PMID 10460448.
  3. ↑ Lampl C, Yazdi K (2002). "Central pontine myelinolysis". Eur Neurol. 47 (1): 3–10. doi:10.1159/000047939. PMID 11803185.
  4. ↑ Bansal LR, Zinkus T (2019). "Osmotic Demyelination Syndrome in Children". Pediatr Neurol. 97: 12–17. doi:10.1016/j.pediatrneurol.2019.03.018. PMID 31128892.

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