Heart transplantation risk factors: Difference between revisions

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==Overview==
==Overview==
There are no established risk factors that lead to cardiac transplantation. Cardiac transplant is the end result of heart failure and the common risk factors in the development of heart failure include hypertension, diabetes, coronary disease, and obesity.
There are no established risk factors that lead to cardiac transplantation. The prognosis of the patient post-transplantation depends on various donor and recipient factors.


==Risk Factors==
==Risk Factors==
There are no established risk factors for [disease name].


OR
Risk factors for poor outcome post-transplantation can be due to donor-specific characteristics, recipient-specific characteristics, and risk factors due to interactions between the donor and recipient.


The most potent risk factor in the development of [disease name] is [risk factor 1]. Other risk factors include [risk factor 2], [risk factor 3], and [risk factor 4].
===Common risk factors===


OR
==== Donor factors====
Both the following factors are associated with an increased one-year mortality rate in the recipient.
*Advanced donor age <ref name="PotapovLoebe1999">{{cite journal|last1=Potapov|first1=Evgenij V.|last2=Loebe|first2=Matthias|last3=H??bler|first3=Michael|last4=Musci|first4=Michele|last5=Hummel|first5=Manfred|last6=Weng|first6=Yu-guo|last7=Hetzer|first7=Roland|title=MEDIUM-TERM RESULTS OF HEART TRANSPLANTATION USING DONORS OVER 63 YEARS OF AGE1|journal=Transplantation|volume=68|issue=12|year=1999|pages=1834–1838|issn=0041-1337|doi=10.1097/00007890-199912270-00002}}</ref>
*Prolonged [[ischemia]] time
====Recipient factors====
* Use of total artificial heart as a bridge to transplant or a need for end-organ support in the form of [[mechanical ventilation]] or [[dialysis]]- associated with the greatest one-year mortality
* Best prognosis is seen if the indication for transplant is [[ischemic]] and [[nonischemic cardiomyopathy]] <ref name="KhushCherikh2018">{{cite journal|last1=Khush|first1=Kiran K.|last2=Cherikh|first2=Wida S.|last3=Chambers|first3=Daniel C.|last4=Goldfarb|first4=Samuel|last5=Hayes|first5=Don|last6=Kucheryavaya|first6=Anna Y.|last7=Levvey|first7=Bronwyn J.|last8=Meiser|first8=Bruno|last9=Rossano|first9=Joseph W.|last10=Stehlik|first10=Josef|title=The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-fifth Adult Heart Transplantation Report—2018; Focus Theme: Multiorgan Transplantation|journal=The Journal of Heart and Lung Transplantation|volume=37|issue=10|year=2018|pages=1155–1168|issn=10532498|doi=10.1016/j.healun.2018.07.022}}</ref>


Common risk factors in the development of [disease name] include [risk factor 1], [risk factor 2], [risk factor 3], and [risk factor 4].
* Patients with a history of [[congenital heart disease]], [[restrictive cardiomyopathy]], and those undergoing retransplantation have a worse prognosis.
===Common Risk Factors===
* Younger recipients (below age 55) have an advantage
*Common risk factors in the development of [disease name] may be occupational, environmental, genetic, and viral.
* Pre-transplant serum [[creatinine]] and total [[bilirubin]] are linearly related to survival.
*Common risk factors in the development of [disease name] include:
**[Risk factor 1]
**[Risk factor 2]
**[Risk factor 3]


===Less Common Risk Factors===
===Less common risk factors===
*Less common risk factors in the development of [disease name] include:
 
**[Risk factor 1]
* Use of [[Amiodarone]] pretransplantation <ref name="pmid27520780">{{cite journal| author=Cooper LB, Mentz RJ, Edwards LB, Wilk AR, Rogers JG, Patel CB | display-authors=etal| title=Amiodarone use in patients listed for heart transplant is associated with increased 1-year post-transplant mortality. | journal=J Heart Lung Transplant | year= 2017 | volume= 36 | issue= 2 | pages= 202-210 | pmid=27520780 | doi=10.1016/j.healun.2016.07.009 | pmc=5241253 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=27520780  }} </ref>
**[Risk factor 2]
*[[Hypertension]]
**[Risk factor 3]
*[[Hypercholesterolemia]] <ref name="pmid22308287">{{cite journal| author=Singh TP, Almond CS, Semigran MJ, Piercey G, Gauvreau K| title=Risk prediction for early in-hospital mortality following heart transplantation in the United States. | journal=Circ Heart Fail | year= 2012 | volume= 5 | issue= 2 | pages= 259-66 | pmid=22308287 | doi=10.1161/CIRCHEARTFAILURE.111.965996 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=22308287  }} </ref> <ref name="pmid2361019">{{cite journal| author=Radovancevic B, Poindexter S, Birovljev S, Velebit V, McAllister HA, Duncan JM | display-authors=etal| title=Risk factors for development of accelerated coronary artery disease in cardiac transplant recipients. | journal=Eur J Cardiothorac Surg | year= 1990 | volume= 4 | issue= 6 | pages= 309-12; discussion 313 | pmid=2361019 | doi=10.1016/1010-7940(90)90207-g | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=2361019  }} </ref>
*[[Diabetes]]
*[[Renal insufficiency]]
* Use of specific [[Immunosuppression|immunosuppressive]] regimen
* Elevated [[body mass index]]
*[[Tobacco]] use
*[[Obesity]]
* Early post-transplant complications
* Prior [[cardiac surgery]]
*[[Transplantation]] of a female heart into a male or female recipient <ref name="pmid9456101">{{cite journal| author=Prendergast TW, Furukawa S, Beyer AJ, Browne BJ, Eisen HJ, Jeevanandam V| title=The role of gender in heart transplantation. | journal=Ann Thorac Surg | year= 1998 | volume= 65 | issue= 1 | pages= 88-94 | pmid=9456101 | doi=10.1016/s0003-4975(97)01105-3 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9456101  }} </ref>


==References==
==References==

Latest revision as of 20:08, 15 July 2020

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:

Overview

There are no established risk factors that lead to cardiac transplantation. The prognosis of the patient post-transplantation depends on various donor and recipient factors.

Risk Factors

Risk factors for poor outcome post-transplantation can be due to donor-specific characteristics, recipient-specific characteristics, and risk factors due to interactions between the donor and recipient.

Common risk factors

Donor factors

Both the following factors are associated with an increased one-year mortality rate in the recipient.

Recipient factors

Less common risk factors

References

  1. ↑ Potapov, Evgenij V.; Loebe, Matthias; H??bler, Michael; Musci, Michele; Hummel, Manfred; Weng, Yu-guo; Hetzer, Roland (1999). "MEDIUM-TERM RESULTS OF HEART TRANSPLANTATION USING DONORS OVER 63 YEARS OF AGE1". Transplantation. 68 (12): 1834–1838. doi:10.1097/00007890-199912270-00002. ISSN 0041-1337.
  2. ↑ Khush, Kiran K.; Cherikh, Wida S.; Chambers, Daniel C.; Goldfarb, Samuel; Hayes, Don; Kucheryavaya, Anna Y.; Levvey, Bronwyn J.; Meiser, Bruno; Rossano, Joseph W.; Stehlik, Josef (2018). "The International Thoracic Organ Transplant Registry of the International Society for Heart and Lung Transplantation: Thirty-fifth Adult Heart Transplantation Report—2018; Focus Theme: Multiorgan Transplantation". The Journal of Heart and Lung Transplantation. 37 (10): 1155–1168. doi:10.1016/j.healun.2018.07.022. ISSN 1053-2498.
  3. ↑ Cooper LB, Mentz RJ, Edwards LB, Wilk AR, Rogers JG, Patel CB; et al. (2017). "Amiodarone use in patients listed for heart transplant is associated with increased 1-year post-transplant mortality". J Heart Lung Transplant. 36 (2): 202–210. doi:10.1016/j.healun.2016.07.009. PMC 5241253. PMID 27520780.
  4. ↑ Singh TP, Almond CS, Semigran MJ, Piercey G, Gauvreau K (2012). "Risk prediction for early in-hospital mortality following heart transplantation in the United States". Circ Heart Fail. 5 (2): 259–66. doi:10.1161/CIRCHEARTFAILURE.111.965996. PMID 22308287.
  5. ↑ Radovancevic B, Poindexter S, Birovljev S, Velebit V, McAllister HA, Duncan JM; et al. (1990). "Risk factors for development of accelerated coronary artery disease in cardiac transplant recipients". Eur J Cardiothorac Surg. 4 (6): 309–12, discussion 313. doi:10.1016/1010-7940(90)90207-g. PMID 2361019.
  6. ↑ Prendergast TW, Furukawa S, Beyer AJ, Browne BJ, Eisen HJ, Jeevanandam V (1998). "The role of gender in heart transplantation". Ann Thorac Surg. 65 (1): 88–94. doi:10.1016/s0003-4975(97)01105-3. PMID 9456101.

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