C4 glomerulopathy causes: Difference between revisions
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==Overview== | ==Overview== | ||
C4 glomerulopathy may be caused by mutation of complement factor,anti-factor H, anti-factor B, or C4 nephritic factor. | |||
==Causes== | ==Causes== | ||
Common causes of is not yet known but C4 glomerulopathy is analogous to C3 glomerulopathy and the causes may include<ref name="pmid15163532">{{cite journal |vauthors=Rodríguez de Córdoba S, Esparza-Gordillo J, Goicoechea de Jorge E, Lopez-Trascasa M, Sánchez-Corral P |title=The human complement factor H: functional roles, genetic variations and disease associations |journal=Mol. Immunol. |volume=41 |issue=4 |pages=355–67 |date=June 2004 |pmid=15163532 |doi=10.1016/j.molimm.2004.02.005 |url=}}</ref><ref name="pmid29948306">{{cite journal |vauthors=Noris M, Donadelli R, Remuzzi G |title=Autoimmune abnormalities of the alternative complement pathway in membranoproliferative glomerulonephritis and C3 glomerulopathy |journal=Pediatr. Nephrol. |volume= |issue= |pages= |date=June 2018 |pmid=29948306 |doi=10.1007/s00467-018-3989-0 |url=}}</ref><ref name="pmid28096309">{{cite journal| author=Marinozzi MC, Roumenina LT, Chauvet S, Hertig A, Bertrand D, Olagne J | display-authors=etal| title=Anti-Factor B and Anti-C3b Autoantibodies in C3 Glomerulopathy and Ig-Associated Membranoproliferative GN. | journal=J Am Soc Nephrol | year= 2017 | volume= 28 | issue= 5 | pages= 1603-1613 | pmid=28096309 | doi=10.1681/ASN.2016030343 | pmc=5407719 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28096309 }} </ref><ref name="pmid28838767">{{cite journal| author=Zhang Y, Meyer NC, Fervenza FC, Lau W, Keenan A, Cara-Fuentes G | display-authors=etal| title=C4 Nephritic Factors in C3 Glomerulopathy: A Case Series. | journal=Am J Kidney Dis | year= 2017 | volume= 70 | issue= 6 | pages= 834-843 | pmid=28838767 | doi=10.1053/j.ajkd.2017.07.004 | pmc=5701858 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28838767 }} </ref><ref name="pmid25917093">{{cite journal| author=Blanc C, Togarsimalemath SK, Chauvet S, Le Quintrec M, Moulin B, Buchler M | display-authors=etal| title=Anti-factor H autoantibodies in C3 glomerulopathies and in atypical hemolytic uremic syndrome: one target, two diseases. | journal=J Immunol | year= 2015 | volume= 194 | issue= 11 | pages= 5129-38 | pmid=25917093 | doi=10.4049/jimmunol.1402770 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25917093 }} </ref>: | Common causes of is not yet known but C4 glomerulopathy is analogous to C3 glomerulopathy and the causes may include<ref name="pmid15163532">{{cite journal |vauthors=Rodríguez de Córdoba S, Esparza-Gordillo J, Goicoechea de Jorge E, Lopez-Trascasa M, Sánchez-Corral P |title=The human complement factor H: functional roles, genetic variations and disease associations |journal=Mol. Immunol. |volume=41 |issue=4 |pages=355–67 |date=June 2004 |pmid=15163532 |doi=10.1016/j.molimm.2004.02.005 |url=}}</ref><ref name="pmid29948306">{{cite journal |vauthors=Noris M, Donadelli R, Remuzzi G |title=Autoimmune abnormalities of the alternative complement pathway in membranoproliferative glomerulonephritis and C3 glomerulopathy |journal=Pediatr. Nephrol. |volume= |issue= |pages= |date=June 2018 |pmid=29948306 |doi=10.1007/s00467-018-3989-0 |url=}}</ref><ref name="pmid28096309">{{cite journal| author=Marinozzi MC, Roumenina LT, Chauvet S, Hertig A, Bertrand D, Olagne J | display-authors=etal| title=Anti-Factor B and Anti-C3b Autoantibodies in C3 Glomerulopathy and Ig-Associated Membranoproliferative GN. | journal=J Am Soc Nephrol | year= 2017 | volume= 28 | issue= 5 | pages= 1603-1613 | pmid=28096309 | doi=10.1681/ASN.2016030343 | pmc=5407719 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28096309 }} </ref><ref name="pmid28838767">{{cite journal| author=Zhang Y, Meyer NC, Fervenza FC, Lau W, Keenan A, Cara-Fuentes G | display-authors=etal| title=C4 Nephritic Factors in C3 Glomerulopathy: A Case Series. | journal=Am J Kidney Dis | year= 2017 | volume= 70 | issue= 6 | pages= 834-843 | pmid=28838767 | doi=10.1053/j.ajkd.2017.07.004 | pmc=5701858 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=28838767 }} </ref><ref name="pmid25917093">{{cite journal| author=Blanc C, Togarsimalemath SK, Chauvet S, Le Quintrec M, Moulin B, Buchler M | display-authors=etal| title=Anti-factor H autoantibodies in C3 glomerulopathies and in atypical hemolytic uremic syndrome: one target, two diseases. | journal=J Immunol | year= 2015 | volume= 194 | issue= 11 | pages= 5129-38 | pmid=25917093 | doi=10.4049/jimmunol.1402770 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=25917093 }} </ref>: | ||
* C4 | * C4 nephritic factor-an autoantibody against C4 can cause complement dysregulation against immune complex-myeloproliferative glomerulonephritic patients. | ||
*[[Mutation]] of complement factor H (CFH). | *[[Mutation]] of complement factor H (CFH). | ||
** CFH is a small glycoprotein that is produced in the [[liver]] and circulates freely in the [[blood plasma]]. | ** CFH is a small glycoprotein that is produced in the [[liver]] and circulates freely in the [[blood plasma]]. | ||
Latest revision as of 03:51, 8 August 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Ali Poyan Mehr, M.D. [2]; Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3]
Overview
C4 glomerulopathy may be caused by mutation of complement factor,anti-factor H, anti-factor B, or C4 nephritic factor.
Causes
Common causes of is not yet known but C4 glomerulopathy is analogous to C3 glomerulopathy and the causes may include[1][2][3][4][5]:
- C4 nephritic factor-an autoantibody against C4 can cause complement dysregulation against immune complex-myeloproliferative glomerulonephritic patients.
- Mutation of complement factor H (CFH).
- CFH is a small glycoprotein that is produced in the liver and circulates freely in the blood plasma.
- Autoantibodies against CFH.
- Anti-Factor H, anti-Factor B, and C3- or C4 nephritic factors are frequently seen in patients with complement-mediated renal disorders.
- Mutation of membrane cofactor protein (MCP).
References
- ↑ Rodríguez de Córdoba S, Esparza-Gordillo J, Goicoechea de Jorge E, Lopez-Trascasa M, Sánchez-Corral P (June 2004). "The human complement factor H: functional roles, genetic variations and disease associations". Mol. Immunol. 41 (4): 355–67. doi:10.1016/j.molimm.2004.02.005. PMID 15163532.
- ↑ Noris M, Donadelli R, Remuzzi G (June 2018). "Autoimmune abnormalities of the alternative complement pathway in membranoproliferative glomerulonephritis and C3 glomerulopathy". Pediatr. Nephrol. doi:10.1007/s00467-018-3989-0. PMID 29948306.
- ↑ Marinozzi MC, Roumenina LT, Chauvet S, Hertig A, Bertrand D, Olagne J; et al. (2017). "Anti-Factor B and Anti-C3b Autoantibodies in C3 Glomerulopathy and Ig-Associated Membranoproliferative GN". J Am Soc Nephrol. 28 (5): 1603–1613. doi:10.1681/ASN.2016030343. PMC 5407719. PMID 28096309.
- ↑ Zhang Y, Meyer NC, Fervenza FC, Lau W, Keenan A, Cara-Fuentes G; et al. (2017). "C4 Nephritic Factors in C3 Glomerulopathy: A Case Series". Am J Kidney Dis. 70 (6): 834–843. doi:10.1053/j.ajkd.2017.07.004. PMC 5701858. PMID 28838767.
- ↑ Blanc C, Togarsimalemath SK, Chauvet S, Le Quintrec M, Moulin B, Buchler M; et al. (2015). "Anti-factor H autoantibodies in C3 glomerulopathies and in atypical hemolytic uremic syndrome: one target, two diseases". J Immunol. 194 (11): 5129–38. doi:10.4049/jimmunol.1402770. PMID 25917093.