C4 glomerulopathy classification: Difference between revisions
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==Overview== | ==Overview== | ||
C4 glomerulopathy may be classified based on complement deposition into | C4 glomerulopathy may be classified based on complement deposition into dense deposit disease and C4 glomerulonephritis. | ||
==Classification== | ==Classification== | ||
*[[C4 (complement)|C4]] [[glomerulopathy]] is categorized as a variant of [[MPGN]]<ref name="pmid26704376">{{cite journal| author=Ali A, Schlanger L, Nasr SH, Sethi S, Gorbatkin SM| title=Proliferative C4 Dense Deposit Disease, Acute Thrombotic Microangiopathy, a Monoclonal Gammopathy, and Acute Kidney Failure. | journal=Am J Kidney Dis | year= 2016 | volume= 67 | issue= 3 | pages= 479-82 | pmid=26704376 | doi=10.1053/j.ajkd.2015.10.020 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26704376 }} </ref><ref name="pmid24552345">{{cite journal| author=Sethi S, Sullivan A, Smith RJ| title=C4 dense-deposit disease. | journal=N Engl J Med | year= 2014 | volume= 370 | issue= 8 | pages= 784-6 | pmid=24552345 | doi=10.1056/NEJMc1309449 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24552345 }} </ref>. | *[[C4 (complement)|C4]] [[glomerulopathy]] is categorized as a variant of [[MPGN]]<ref name="pmid26704376">{{cite journal| author=Ali A, Schlanger L, Nasr SH, Sethi S, Gorbatkin SM| title=Proliferative C4 Dense Deposit Disease, Acute Thrombotic Microangiopathy, a Monoclonal Gammopathy, and Acute Kidney Failure. | journal=Am J Kidney Dis | year= 2016 | volume= 67 | issue= 3 | pages= 479-82 | pmid=26704376 | doi=10.1053/j.ajkd.2015.10.020 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26704376 }} </ref><ref name="pmid24552345">{{cite journal| author=Sethi S, Sullivan A, Smith RJ| title=C4 dense-deposit disease. | journal=N Engl J Med | year= 2014 | volume= 370 | issue= 8 | pages= 784-6 | pmid=24552345 | doi=10.1056/NEJMc1309449 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24552345 }} </ref>. | ||
*Recently, Sethi et al. have defined a new term “C4d glomerulopathy” | *Recently, Sethi et al. have defined a new term “C4d glomerulopathy” | ||
*C4 Glomerulopathy may be classified into 2 main subtypes based on the appearance of complement deposition in the glomerular basement membrane on | *C4 Glomerulopathy may be classified into 2 main subtypes based on the appearance of complement deposition in the glomerular basement membrane on electron microscopy: | ||
**'''Dense deposit disease (DDD)''' | **'''Dense deposit disease (DDD)''' | ||
***Presence of C4 granular or osmiophilic deposition along the basement membrane on immunofluorescence or immunohistochemistry. | ***Presence of C4 granular or osmiophilic deposition along the basement membrane on immunofluorescence or immunohistochemistry. | ||
Latest revision as of 04:37, 8 August 2020
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C4 glomerulopathy Microchapters |
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C4 glomerulopathy classification On the Web |
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American Roentgen Ray Society Images of C4 glomerulopathy classification |
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Risk calculators and risk factors for C4 glomerulopathy classification |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Ali Poyan Mehr, M.D. [2]; Associate Editor(s)-in-Chief: Olufunmilola Olubukola M.D.[3]
Overview
C4 glomerulopathy may be classified based on complement deposition into dense deposit disease and C4 glomerulonephritis.
Classification
- C4 glomerulopathy is categorized as a variant of MPGN[1][2].
- Recently, Sethi et al. have defined a new term “C4d glomerulopathy”
- C4 Glomerulopathy may be classified into 2 main subtypes based on the appearance of complement deposition in the glomerular basement membrane on electron microscopy:
- Dense deposit disease (DDD)
- Presence of C4 granular or osmiophilic deposition along the basement membrane on immunofluorescence or immunohistochemistry.
- C4 Glomerulonephritis (C4GN)
- Isolated deposition of C4.
- Dense deposit disease (DDD)
References
- ↑ Ali A, Schlanger L, Nasr SH, Sethi S, Gorbatkin SM (2016). "Proliferative C4 Dense Deposit Disease, Acute Thrombotic Microangiopathy, a Monoclonal Gammopathy, and Acute Kidney Failure". Am J Kidney Dis. 67 (3): 479–82. doi:10.1053/j.ajkd.2015.10.020. PMID 26704376.
- ↑ Sethi S, Sullivan A, Smith RJ (2014). "C4 dense-deposit disease". N Engl J Med. 370 (8): 784–6. doi:10.1056/NEJMc1309449. PMID 24552345.