Polycythemia history and symptoms: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Polycythemia}} | {{Polycythemia}} | ||
{{CMG}}; {{AE}} {{Debduti}} {{ZO}} | |||
==Overview== | ==Overview== | ||
The | The hallmark symptoms of [[polycythemia vera]] are [[Headache|headaches]], [[dizziness]], [[erythromelalgia]], [[Abdomen|abdominal]] fullness due to [[splenomegaly]], etc. | ||
==History and Symptoms== | |||
*Clinical course is insidious, more commonly it is noticed as an incidental finding on a routine [[blood test]]. Patients may present with nonspecific findings like [[fatigue]], [[headache]], [[dizziness]], [[Itch|itchiness]], especially after a warm shower. Bloating or "fullness" is also sometimes reported due to marked [[splenomegaly]]. | |||
*If adequately managed, the natural course of the disease tends to be long. The cause of death remains unknown in a large majority of cases. Other causes of death include acute [[leukemia]], [[malignancies]] secondary to the disease, [[Thrombosis|thrombotic]] complications, [[Sudden cardiac death|cardiac]] failure, and natural progression of the disease. <ref name="pmid30114348">{{cite journal |vauthors=Büyükaşik Y, Alİ R, Ar C, Turgut M, Yavuz S, Saydam G |title=Polycythemia vera: diagnosis, clinical course, and current management |journal=Turk J Med Sci |volume=48 |issue=4 |pages=698–710 |date=August 2018 |pmid=30114348 |doi=10.3906/sag-1806-43 |url=}}</ref> | |||
*The majority of | |||
=== | |||
=== | ===Symptoms=== | ||
Common symptoms of | Common symptoms of PV include:<ref name="pmid29437189">{{cite journal| author=Lelonek E, Matusiak Ł, Wróbel T, Szepietowski JC| title=Aquagenic Pruritus in Polycythemia Vera: Clinical Characteristics. | journal=Acta Derm Venereol | year= 2018 | volume= 98 | issue= 5 | pages= 496-500 | pmid=29437189 | doi=10.2340/00015555-2906 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29437189 }}</ref><ref name="pmid20597963">{{cite journal| author=Saini KS, Patnaik MM, Tefferi A| title=Polycythemia vera-associated pruritus and its management. | journal=Eur J Clin Invest | year= 2010 | volume= 40 | issue= 9 | pages= 828-34 | pmid=20597963 | doi=10.1111/j.1365-2362.2010.02334.x | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=20597963 }}</ref><ref name="pmid1587207">{{cite journal| author=Murphy S| title=Polycythemia vera. | journal=Dis Mon | year= 1992 | volume= 38 | issue= 3 | pages= 153-212 | pmid=1587207 | doi=10.1016/0011-5029(92)90002-7 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=1587207 }}</ref><ref name="pmid9387203">{{cite journal| author=Michiels JJ| title=Erythromelalgia and vascular complications in polycythemia vera. | journal=Semin Thromb Hemost | year= 1997 | volume= 23 | issue= 5 | pages= 441-54 | pmid=9387203 | doi=10.1055/s-2007-996121 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=9387203 }}</ref><ref name="pmid23855810">{{cite journal| author=Sekhar M, McVinnie K, Burroughs AK| title=Splanchnic vein thrombosis in myeloproliferative neoplasms. | journal=Br J Haematol | year= 2013 | volume= 162 | issue= 6 | pages= 730-47 | pmid=23855810 | doi=10.1111/bjh.12461 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=23855810 }}</ref> | ||
*[[Dizziness]] or [[vertigo]] | |||
*Headaches | |||
*[ | *[[Diaphoresis]] | ||
*[ | *Itchiness | ||
*[ | *[[Tinnitus]] | ||
*[[Blurred vision]] | |||
*[[Fatigue]] | |||
*Reddish or purplish skin on the palms, earlobes, and nose | |||
*Bleeding or bruising | |||
*Burning sensation in the feet | |||
*Abdominal fullness | |||
*[[Epistaxis]] | |||
*Bleeding gums | |||
*[[Gout]] | |||
*[[Budd-Chiari syndrome]] | |||
*Atypical [[chest pain]] | |||
==References== | ==References== | ||
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{{WS}} | {{WS}} | ||
[[Category:Hematology]] | [[Category:Hematology]] | ||
[[Category:Emergency medicine]] | [[Category: Emergency medicine]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Up-To-Date]] | [[Category: Blood disorders]] | ||
[[Category: Up-To-Date]] | |||
Latest revision as of 15:07, 4 March 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2] Zaida Obeidat, M.D.
Overview
The hallmark symptoms of polycythemia vera are headaches, dizziness, erythromelalgia, abdominal fullness due to splenomegaly, etc.
History and Symptoms
- Clinical course is insidious, more commonly it is noticed as an incidental finding on a routine blood test. Patients may present with nonspecific findings like fatigue, headache, dizziness, itchiness, especially after a warm shower. Bloating or "fullness" is also sometimes reported due to marked splenomegaly.
- If adequately managed, the natural course of the disease tends to be long. The cause of death remains unknown in a large majority of cases. Other causes of death include acute leukemia, malignancies secondary to the disease, thrombotic complications, cardiac failure, and natural progression of the disease. [1]
Symptoms
Common symptoms of PV include:[2][3][4][5][6]
- Dizziness or vertigo
- Headaches
- Diaphoresis
- Itchiness
- Tinnitus
- Blurred vision
- Fatigue
- Reddish or purplish skin on the palms, earlobes, and nose
- Bleeding or bruising
- Burning sensation in the feet
- Abdominal fullness
- Epistaxis
- Bleeding gums
- Gout
- Budd-Chiari syndrome
- Atypical chest pain
References
- ↑ Büyükaşik Y, Alİ R, Ar C, Turgut M, Yavuz S, Saydam G (August 2018). "Polycythemia vera: diagnosis, clinical course, and current management". Turk J Med Sci. 48 (4): 698–710. doi:10.3906/sag-1806-43. PMID 30114348.
- ↑ Lelonek E, Matusiak Ł, Wróbel T, Szepietowski JC (2018). "Aquagenic Pruritus in Polycythemia Vera: Clinical Characteristics". Acta Derm Venereol. 98 (5): 496–500. doi:10.2340/00015555-2906. PMID 29437189.
- ↑ Saini KS, Patnaik MM, Tefferi A (2010). "Polycythemia vera-associated pruritus and its management". Eur J Clin Invest. 40 (9): 828–34. doi:10.1111/j.1365-2362.2010.02334.x. PMID 20597963.
- ↑ Murphy S (1992). "Polycythemia vera". Dis Mon. 38 (3): 153–212. doi:10.1016/0011-5029(92)90002-7. PMID 1587207.
- ↑ Michiels JJ (1997). "Erythromelalgia and vascular complications in polycythemia vera". Semin Thromb Hemost. 23 (5): 441–54. doi:10.1055/s-2007-996121. PMID 9387203.
- ↑ Sekhar M, McVinnie K, Burroughs AK (2013). "Splanchnic vein thrombosis in myeloproliferative neoplasms". Br J Haematol. 162 (6): 730–47. doi:10.1111/bjh.12461. PMID 23855810.