Pancreatic fistula epidemiology and demographics: Difference between revisions
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==Epidemiology and Demographics== | ==Epidemiology and Demographics== | ||
*[[Pancreatic]] [[fistula]] is a known complication following [[surgical resection]] of the [[pancreas]]. | ===Incidence=== | ||
*[[Pancreatic]] [[fistula]] is a known complication following [[surgical resection]] of the [[pancreas]]. | |||
*The [[incidence rate]] varies from as low as 5% in high volume centers to as high as 26%.<ref name="pmid24019766">{{cite journal| author=Reddymasu SC, Pakseresht K, Moloney B, Alsop B, Oropezia-Vail M, Olyaee M| title=Incidence of pancreatic fistula after distal pancreatectomy and efficacy of endoscopic therapy for its management: results from a tertiary care center. | journal=Case Rep Gastroenterol | year= 2013 | volume= 7 | issue= 2 | pages= 332-9 | pmid=24019766 | doi=10.1159/000354136 | pmc=3764947 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24019766 }} </ref> | *The [[incidence rate]] varies from as low as 5% in high volume centers to as high as 26%.<ref name="pmid24019766">{{cite journal| author=Reddymasu SC, Pakseresht K, Moloney B, Alsop B, Oropezia-Vail M, Olyaee M| title=Incidence of pancreatic fistula after distal pancreatectomy and efficacy of endoscopic therapy for its management: results from a tertiary care center. | journal=Case Rep Gastroenterol | year= 2013 | volume= 7 | issue= 2 | pages= 332-9 | pmid=24019766 | doi=10.1159/000354136 | pmc=3764947 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24019766 }} </ref> | ||
*The [[incidence]] of [[pancreatic]] [[fistula]] varies depending on the type of [[pancreatic]] [[resection]] as it can be as low as 3% following a [[pancreatic]] head [[resection]] to as high as 30% after [[distal]] [[pancreatectomy]].<ref name="pmid29588609">{{cite journal| author=Nahm CB, Connor SJ, Samra JS, Mittal A| title=Postoperative pancreatic fistula: a review of traditional and emerging concepts. | journal=Clin Exp Gastroenterol | year= 2018 | volume= 11 | issue= | pages= 105-118 | pmid=29588609 | doi=10.2147/CEG.S120217 | pmc=5858541 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29588609 }} </ref><ref name="pmid21672661">{{cite journal| author=Hackert T, Werner J, Büchler MW| title=Postoperative pancreatic fistula. | journal=Surgeon | year= 2011 | volume= 9 | issue= 4 | pages= 211-7 | pmid=21672661 | doi=10.1016/j.surge.2010.10.011 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=21672661 }} </ref> | |||
*[[Acute]] [[fluid]] collection is recorded in up to 40% patients with [[acute pancreatitis]], out of which some cases develops true [[pancreatic]] [[fistula]] depending upon the severity of the insult.<ref name="pmid24650171">{{cite journal| author=Larsen M, Kozarek R| title=Management of pancreatic ductal leaks and fistulae. | journal=J Gastroenterol Hepatol | year= 2014 | volume= 29 | issue= 7 | pages= 1360-70 | pmid=24650171 | doi=10.1111/jgh.12574 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24650171 }} </ref> | *[[Acute]] [[fluid]] collection is recorded in up to 40% patients with [[acute pancreatitis]], out of which some cases develops true [[pancreatic]] [[fistula]] depending upon the severity of the insult.<ref name="pmid24650171">{{cite journal| author=Larsen M, Kozarek R| title=Management of pancreatic ductal leaks and fistulae. | journal=J Gastroenterol Hepatol | year= 2014 | volume= 29 | issue= 7 | pages= 1360-70 | pmid=24650171 | doi=10.1111/jgh.12574 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=24650171 }} </ref> | ||
===Mortality rate=== | |||
*[[Pancreatic]] [[fistula]] can lead to certain severe [[complications]] if not addressed on time, as it carries a [[mortality]] risk of 25% in patients with grade C [[pancreatic]] [[fistula]]. | *[[Pancreatic]] [[fistula]] can lead to certain severe [[complications]] if not addressed on time, as it carries a [[mortality]] risk of 25% in patients with grade C [[pancreatic]] [[fistula]]. | ||
* | *Post-operative [[pancreatic]] [[Fistula|fistulae]] can affect 13% to 41% of patients after [[pancreatic]] [[resection]], making it a known source of [[morbidity]] and [[mortality]]. | ||
==References== | ==References== | ||
Latest revision as of 15:18, 26 March 2021
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief:
Overview
The incidence of pancreatic fistula following pancreatic resection surgery varies from 5% to 26%. The overall mortality risk due to pancreatic fistula is 1%, however patients with grade C pancreatic fistula carries a mortality risk of 25%.
Epidemiology and Demographics
Incidence
- Pancreatic fistula is a known complication following surgical resection of the pancreas.
- The incidence rate varies from as low as 5% in high volume centers to as high as 26%.[1]
- The incidence of pancreatic fistula varies depending on the type of pancreatic resection as it can be as low as 3% following a pancreatic head resection to as high as 30% after distal pancreatectomy.[2][3]
- Acute fluid collection is recorded in up to 40% patients with acute pancreatitis, out of which some cases develops true pancreatic fistula depending upon the severity of the insult.[4]
Mortality rate
- Pancreatic fistula can lead to certain severe complications if not addressed on time, as it carries a mortality risk of 25% in patients with grade C pancreatic fistula.
- Post-operative pancreatic fistulae can affect 13% to 41% of patients after pancreatic resection, making it a known source of morbidity and mortality.
References
- ↑ Reddymasu SC, Pakseresht K, Moloney B, Alsop B, Oropezia-Vail M, Olyaee M (2013). "Incidence of pancreatic fistula after distal pancreatectomy and efficacy of endoscopic therapy for its management: results from a tertiary care center". Case Rep Gastroenterol. 7 (2): 332–9. doi:10.1159/000354136. PMC 3764947. PMID 24019766.
- ↑ Nahm CB, Connor SJ, Samra JS, Mittal A (2018). "Postoperative pancreatic fistula: a review of traditional and emerging concepts". Clin Exp Gastroenterol. 11: 105–118. doi:10.2147/CEG.S120217. PMC 5858541. PMID 29588609.
- ↑ Hackert T, Werner J, Büchler MW (2011). "Postoperative pancreatic fistula". Surgeon. 9 (4): 211–7. doi:10.1016/j.surge.2010.10.011. PMID 21672661.
- ↑ Larsen M, Kozarek R (2014). "Management of pancreatic ductal leaks and fistulae". J Gastroenterol Hepatol. 29 (7): 1360–70. doi:10.1111/jgh.12574. PMID 24650171.