Eczema causes: Difference between revisions
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{{Eczema}} | {{Eczema}} | ||
{{CMG}}, {{AE}} | {{CMG}}, {{AE}} {{EdzelCo}} | ||
==Overview== | ==Overview== | ||
[[ | The [[etiology]] of [[eczema]] is multifactorial and complex. This involves aberrations in [[genetic]] components, [[adverse effect]]s of certain [[medication]]s, and some environmental factors. | ||
== | ==Etiology of Eczema== | ||
* | ===Genetic problem=== | ||
*Damage from the [[Enzyme|enzymatic]] activity of [[allergens]] is usually prevented by the body's own [[protease inhibitor]]s, such as ''[[LEKTI]]'', produced from the gene ''[[SPINK5]]''. | |||
*Lack of [[filaggrin]] [[gene]] causes [[dry skin]]. <ref name="pmid16550169">{{cite journal| author=Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP | display-authors=etal| title=Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis. | journal=Nat Genet | year= 2006 | volume= 38 | issue= 4 | pages= 441-6 | pmid=16550169 | doi=10.1038/ng1767 | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16550169 }} </ref> | |||
===Eczema as an Adverse Drug Reaction=== | |||
*[[Eczema]] can also be brought about by some adverse effects of [[medications]]. | |||
*Below is a list of commonly prescribed medications with [[eczema]] as the common [[adverse drug effect]] '''(Table 1)'''. | *Below is a list of commonly prescribed medications with [[eczema]] as the common [[adverse drug effect]] '''(Table 1)'''. | ||
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|+<big>''' Table 1. | |+<big>''' Table 1. List of [[medications]] with [[eczema]] as its [[adverse effect]].''' | ||
! align="center" style="background: #00CED1; width: 500px;" |{{fontcolor|#FFF|[[Medication]]}} | ! align="center" style="background: #00CED1; width: 500px;" |{{fontcolor|#FFF|[[Medication]]}} | ||
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==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
[[category:Up to Date]] | |||
Latest revision as of 07:43, 13 November 2023
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1], Associate Editor(s)-in-Chief: Edzel Lorraine Co, DMD, MD[2]
Overview
The etiology of eczema is multifactorial and complex. This involves aberrations in genetic components, adverse effects of certain medications, and some environmental factors.
Etiology of Eczema
Genetic problem
- Damage from the enzymatic activity of allergens is usually prevented by the body's own protease inhibitors, such as LEKTI, produced from the gene SPINK5.
- Lack of filaggrin gene causes dry skin. [1]
Eczema as an Adverse Drug Reaction
- Eczema can also be brought about by some adverse effects of medications.
- Below is a list of commonly prescribed medications with eczema as the common adverse drug effect (Table 1).
| Medication |
|---|
| Cidofovir |
| Flurbiprofen |
| Olaparib |
| Siltuximab |
| Sorafenib |
| Tiagabine |
References
- ↑ Palmer CN, Irvine AD, Terron-Kwiatkowski A, Zhao Y, Liao H, Lee SP; et al. (2006). "Common loss-of-function variants of the epidermal barrier protein filaggrin are a major predisposing factor for atopic dermatitis". Nat Genet. 38 (4): 441–6. doi:10.1038/ng1767. PMID 16550169.