GLYCAM1: Difference between revisions
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'''Glycosylation-dependent [[cell adhesion molecule]]-1''' ('''GLYCAM1''') is a [[proteoglycan]] [[ligand]] expressed on cells of the [[high endothelial venule]]s in lymphoid tissues. It is the ligand for the receptor [[L-selectin]] allowing for naive lymphocytes to exit the bloodstream into lymphoid tissues.<ref name=":0">{{Cite book|url=http://linkinghub.elsevier.com/retrieve/pii/S0065277608606239|title=Leukocyte Migration and Adhesion|last=Imhof|first=Beat A.|last2=Dunon|first2=Dominique|pages=345–416|doi=10.1016/s0065-2776(08)60623-9}}</ref><ref>{{Cite journal|last=|first=|last2=|date=1 November 1992|title=Identification of a soluble form of a ligand for the lymphocyte homing receptor|pmc=2119429|journal=The Journal of Experimental Medicine|volume=176|issue=5|pages=1415–1419|pmid=1383387|via=}}</ref> | |||
GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin.{{citation needed|date=May 2016}} | |||
Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex.<ref>{{cite journal | vauthors = Dowbenko D, Kikuta A, Fennie C, Gillett N, Lasky LA | title = Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk | journal = The Journal of Clinical Investigation | volume = 92 | issue = 2 | pages = 952–60 | date = August 1993 | pmid = 8349827 | pmc = 294935 | doi = 10.1172/JCI116671 }}</ref> | |||
GlyCAM-1 is expressed exclusively on high endothelial venules. It is unclear how GlyCAM-1 is attached to the membrane as it lacks a transmembrane region.<ref name=":0" /> | |||
== External links == | |||
==External links== | |||
* {{MeshName|GlyCAM-1}} | * {{MeshName|GlyCAM-1}} | ||
== References == | == References == | ||
{{reflist}} | {{reflist}} | ||
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Latest revision as of 23:19, 29 November 2018
| glycosylation dependent cell adhesion molecule-1 | |
|---|---|
| Identifiers | |
| Symbol | GLYCAM1 |
| Entrez | 644076 |
| HUGO | 18023 |
| RefSeq | XM_927461 |
| UniProt | Q8IVK1 |
| Other data | |
| Locus | Chr. 12 q13.2 |
Glycosylation-dependent cell adhesion molecule-1 (GLYCAM1) is a proteoglycan ligand expressed on cells of the high endothelial venules in lymphoid tissues. It is the ligand for the receptor L-selectin allowing for naive lymphocytes to exit the bloodstream into lymphoid tissues.[1][2] GLYCAM1 binds to L-selectin by presenting one or more O-linked carbohydrates to the lectin domain of the leukocyte cell surface selectin.[citation needed] Data suggests that GLYCAM1 is a hormone-regulated milk protein that is part of the milk mucin complex.[3]
GlyCAM-1 is expressed exclusively on high endothelial venules. It is unclear how GlyCAM-1 is attached to the membrane as it lacks a transmembrane region.[1]
External links
- GlyCAM-1 at the US National Library of Medicine Medical Subject Headings (MeSH)
References
- ↑ 1.0 1.1 Imhof, Beat A.; Dunon, Dominique. Leukocyte Migration and Adhesion. pp. 345–416. doi:10.1016/s0065-2776(08)60623-9.
- ↑ "Identification of a soluble form of a ligand for the lymphocyte homing receptor". The Journal of Experimental Medicine. 176 (5): 1415–1419. 1 November 1992. PMC 2119429. PMID 1383387.
- ↑ Dowbenko D, Kikuta A, Fennie C, Gillett N, Lasky LA (August 1993). "Glycosylation-dependent cell adhesion molecule 1 (GlyCAM 1) mucin is expressed by lactating mammary gland epithelial cells and is present in milk". The Journal of Clinical Investigation. 92 (2): 952–60. doi:10.1172/JCI116671. PMC 294935. PMID 8349827.
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