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| Image = Q fever.jpg| | | Image = Q fever.jpg| |
| Caption =Organism Responsible for Q fever, ''Rocky Mountain Laboratories, NIAID, NIH''| | | Caption =Organism Responsible for Q fever, ''Rocky Mountain Laboratories, NIAID, NIH''| |
| ICD10 = {{ICD10|A|78||a|75}} |
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| ICD9 = {{ICD9|083.0}} |
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| MeshID = D011778 |
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| {{Search infobox}} | | __NOTOC__ |
| {{CMG}} | | {{About1|Coxiella burnetii}} |
| | '''For patient information click [[{{PAGENAME}} (patient information)|here]]''' |
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| ==Overview==
| | {{Q fever}} |
| '''Q fever''' is caused by infection with ''[[Coxiella burnetii]]''. This organism is uncommon but may be found in cattle, sheep, goats and other domestic mammals, including cats and dogs. The infection results from [[inhalation]] of contaminated particles in the air, and from contact with the vaginal mucus, milk, feces, urine or semen of infected animals. The incubation time is 9-40 days. It is considered possibly the most infectious disease in the world, as a human being can be infected by a single bacterium <ref>http://www.cdc.gov/ncidod/dvrd/qfever/</ref>.
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| '''''Related Key Words and Synonyms:'''''
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| Coxiella burnetii Infection | | {{SK}} Query fever; ''Coxiella burnetii'' infection; Abattoir fever; Balkan grippe; Balkan influenza; Infection due to Coxiella burnetii. |
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| == Epidemiology and Demographics == | | ==[[Q fever overview|Overview]]== |
| In 1999, Q fever became a notifiable disease in the United States but reporting is not required in many other countries. Because the disease is underreported, scientists cannot reliably assess how many cases of Q fever have actually occurred worldwide. Many human infections are inapparent.
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| Cattle, sheep, and goats are the primary reservoirs of C. burnetii. Infection has been noted in a wide variety of other animals, including other species of livestock and in domesticated pets. Coxiella burnetii does not usually cause clinical disease in these animals, although abortion in goats and sheep has been linked to C. burnetii infection. Organisms are excreted in milk, urine, and feces of infected animals. Most importantly, during birthing the organisms are shed in high numbers within the amniotic fluids and the placenta. The organisms are resistant to heat, drying, and many common disinfectants. These features enable the bacteria to survive for long periods in the environment. Infection of humans usually occurs by inhalation of these organisms from air that contains airborne barnyard dust contaminated by dried placental material, birth fluids, and excreta of infected herd animals. Humans are often very susceptible to the disease, and very few organisms may be required to cause infection.
| | ==[[Q fever historical perspective|Historical Perspective]]== |
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| [[Image:Coxiella burnetii.JPG|thumb|left|C. burnetii, the Q fever causing agent]] | | ==[[Q fever classification|Classification]]== |
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| The pathogenic agent is to be found everywhere except Antarctica and New Zealand.
| | ==[[Q fever pathophysiology|Pathophysiology]]== |
| In Europe it appears as hepatitis rather than pneumonia as in the United States. The bacterium is extremely sustainable and infectious: a single organism is able to cause an infection. The common way of infection is inhalation of contaminated dust, contact with contaminated milk, meat, wool and particularly birthing products. Ticks can transfer the pathogenic agent to other animals. Transfer between humans seems extremely rare and has so far been described in very few cases.
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| Men are slightly more often affected than women, which most likely is attributed to different employment rates in typical professions.
| | ==[[Q fever causes|Causes]]== |
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| "At risk" occupations include, but are not limited to:
| | ==[[Q fever epidemiology and demographics|Epidemiology and Demographics]]== |
| * veterinary personnel
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| * stockyard workers
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| * farmers
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| * shearers
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| * animal transporters
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| * laboratory workers handling potentially infected veterinary samples or visiting abattoirs
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| * people who cull and process kangaroos
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| * hide (tannery) workers.
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| == Pathophysiology & Etiology== | | ==[[Q fever risk factors|Risk Factors]]== |
| Q fever is a rickettsial infection caused by Coxiella burnetii (COX-ee-ELL-uh burn-ETT-eye).
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| Ingestion of contaminated milk, followed by regurgitation and inspiration of the contaminated food, is a less common mode of transmission. Other modes of transmission to humans, including tick bites and human to human transmission, are rare.
| | ==[[Q fever screening|Screening]]== |
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| ''Can animals transmit Q fever to me?''
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| Yes, some animals can pass Q fever to people. Cattle, sheep, and goats are most likely to carry C. burnetii, but other kinds of animals can also have this disease. Most infected animals do not show signs of Q fever, but the organism can be in barnyard dust that contains manure, urine or dried fluids from the births of calves or lambs. People usually get Q fever by breathing in this contaminated barnyard dust. Occasionally, people can get Q fever from drinking contaminated milk or from tick bites.
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| == Manifestations == | |
| Incubation period is usually 2 to 3 weeks.
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| The most common manifestation is flu-like symptoms with abrupt onset of [[fever]], [[malaise]], profuse perspiration, severe [[headache]], [[myalgia]] (muscle pain), joint pain, loss of appetite, upper respiratory problems, dry cough, pleuritic pain, chills, confusion and gastro-intestinal [[symptoms]] such as [[nausea]], vomiting and [[diarrhea]]. The fever lasts approximately 7-14 days.
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| During the course, the disease can progress to an atypical [[pneumonia]], which can result in a life threatening [[acute respiratory distress syndrome]] (ARDS), whereby such symptoms usually occur during the first 4-5 days of infection.
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| Less often the Q fever causes (granulomatous) [[hepatitis]] which becomes symptomatic with malaise, fever, liver enlargement (hepatomegaly), pain in the right upper quadrant of the [[abdomen]] and [[jaundice]] (icterus).
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| The chronic form of the Q fever is virtually identical with the [[inflammation]] of the inner lining of the heart ([[endocarditis]]), which can occur after months or decades following the infection. It is usually deadly if untreated. However, with appropriate treatment this lethality is around 10%
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| | ==[[Q fever natural history, complications, and prognosis|Natural History, Complications, and Prognosis]]== |
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| == Diagnosis == | | == Diagnosis == |
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| Because the signs and symptoms of Q fever are not specific to this disease, it is difficult to make an accurate diagnosis without appropriate laboratory testing. Results from some types of routine laboratory tests in the appropriate clinical and epidemiologic settings may suggest a diagnosis of Q fever. For example, a platelet count may be suggestive because persons with Q fever may show a transient [[thrombocytopenia]]. Confirming a diagnosis of Q fever requires serologic testing to detect the presence of [[antibodies]] to Coxiella burnetii antigens. In most laboratories, the indirect immunofluorescence assay (IFA) is the most dependable and widely used method. Coxiella burnetii may also be identified in infected tissues by using [[immunohistochemical]] staining and DNA detection methods.
| | [[Q fever history and symptoms|History and Symptoms]] | [[Q fever physical examination|Physical Examination]] | [[Q fever laboratory tests|Laboratory Findings]] | [[Q fever chest x ray|Chest X Ray]]| [[Q fever CT|CT]] | [[Q fever MRI|MRI]] | [[Q fever other imaging findings|Other Imaging Findings]] | [[Q fever other diagnostic studies|Other Diagnostic Studies]] |
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| ''Coxiella burnetii'' exists in two antigenic phases called phase I and phase II. This antigenic difference is important in diagnosis. In acute cases of Q fever, the antibody level to phase II is usually higher than that to phase I, often by several orders of magnitude, and generally is first detected during the second week of illness. In chronic Q fever, the reverse situation is true. Antibodies to phase I antigens of C. burnetii generally require longer to appear and indicate continued exposure to the bacteria. Thus, high levels of antibody to phase I in later specimens in combination with constant or falling levels of phase II antibodies and other signs of inflammatory disease suggest chronic Q fever. Antibodies to phase I and II antigens have been known to persist for months or years after initial infection.
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| Recent studies have shown that greater accuracy in the diagnosis of Q fever can be achieved by looking at specific levels of classes of antibodies other than [[IgG]], namely [[IgA]] and [[IgM]]. Combined detection of IgM and IgA in addition to IgG improves the specificity of the assays and provides better accuracy in diagnosis. IgM levels are helpful in the determination of a recent infection. In acute Q fever, patients will have IgG antibodies to phase II and IgM antibodies to phases I and II. Increased IgG and IgA antibodies to phase I are often indicative of Q fever [[endocarditis]].
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| === History and Symptoms ===
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| Only about one-half of all people infected with C. burnetii show signs of clinical illness. Most acute cases of Q fever begin with sudden onset of one or more of the following: high [[fever]]s (up to 104-105° F), severe [[headache]], general malaise, [[myalgia]], [[confusion]], sore throat, chills, sweats, non-productive [[cough]], [[nausea]], [[vomiting]], [[diarrhea]], [[abdominal pain]], and [[chest pain]]. Fever usually lasts for 1 to 2 weeks. [[Weight loss]] can occur and persist for some time. Thirty to fifty percent of patients with a symptomatic infection will develop [[pneumonia]]. Additionally, a majority of patients have abnormal results on liver function tests and some will develop [[hepatitis]]. In general, most patients will recover to good health within several months without any treatment. Only 1%-2% of people with acute Q fever die of the disease.
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| Chronic Q fever, characterized by infection that persists for more than 6 months is uncommon but is a much more serious disease. Patients who have had acute Q fever may develop the chronic form as soon as 1 year or as long as 20 years after initial infectioQ-fever can cause [[endocarditis]] (infection of the heart valves) which may require [[Echocardiography#Transesophageal_echocardiogram|transoesophageal echocardiography]] to diagnose. Most patients who develop chronic Q fever have pre-existing valvular heart disease or have a history of vascular graft. Transplant recipients, patients with [[cancer]], and those with chronic kidney disease are also at risk of developing chronic Q fever. As many as 65% of persons with chronic Q fever may die of the disease. Q-fever [[hepatitis]] manifests as an elevation of [[Alanine transaminase|ALT]] and [[Aspartate transaminase|AST]], but a definitive diagnosis is only possible on liver biopsy which shows the characteristic [[fibrin ring granuloma]]s.<ref>{{cite journal | title=Patient with fever and diarrea | author=van de Veerdonk FL, Schneeberger PM. | journal=Clin Infect Dis | year=2006 | volume=42 | pages=1051–2 }}</ref>
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| The incubation period for Q fever varies depending on the number of organisms that initially infect the patient. Infection with greater numbers of organisms will result in shorter incubation periods. Most patients become ill within 2-3 weeks after exposure. Those who recover fully from infection may possess lifelong immunity against re-infection.
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| == Risk Stratification and Prognosis==
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| ''Coxiella burnetii'' is a highly infectious agent that is rather resistant to heat and drying. It can become airborne and inhaled by humans. A single ''C. burnetii'' organism may cause disease in a susceptible person. This agent could be developed for use in biological warfare and is considered a potential terrorist threat.
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| == Treatment == | | == Treatment == |
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| ==== Acute Pharmacotherapies ====
| | [[Q fever medical therapy|Medical Therapy]] | [[Q fever surgery|Surgery]] | [[Q fever primary prevention|Prevention]] | [[Q fever cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Q fever future or investigational therapies|Future or Investigational Therapies]] |
| [[Doxycycline]] is the treatment of choice for acute Q fever. Antibiotic treatment is most effective when initiated within the first 3 days of illness. A dose of 100 mg of doxycycline taken orally twice daily for 15-21 days is a frequently prescribed therapy. [[Quinolone]] antibiotics have demonstrated good in vitro activity against ''C. burnetii'' and may be considered by the physician. Therapy should be started again if the disease relapses. | |
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| | ==Case Studies== |
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| Q fever in pregnancy is especially difficult to treat because doxycycline and [[ciprofloxacin]] are contraindicated in pregnancy. The preferred treatment is five weeks of [[co-trimoxazole]].<ref>{{cite journal|journal=Clin Infect Dis|year=2007|volume=45|pages=548–555|title=Managing Q fever during pregnancy: The benefits of long-term Cctrimoxazole therapy|author=Carcopino X, Raoult D, Bretelle F, Boubli L, Stein A|url=http://www.journals.uchicago.edu/CID/journal/issues/v45n5/51070/51070.html}}</ref>
| | [[Q fever case study one|Case #1]] |
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| ==== Chronic Pharmacotherapies ==== | | ==External Links== |
| Chronic Q fever endocarditis is much more difficult to treat effectively and often requires the use of multiple drugs. Two different treatment protocols have been evaluated: 1) doxycycline in combination with quinolones for at least 4 years and 2) doxycycline in combination with [[hydroxychloroquine]] for 1.5 to 3 years. The second therapy leads to fewer relapses, but requires routine eye exams to detect accumulation of [[chloroquine]]. Surgery to remove damaged valves may be required for some cases of ''C. burnetii'' [[endocarditis]].
| | http://www.cdc.gov/ncidod/diseases/submenus/sub_q_fever.htm<br> |
| | http://www.cdc.gov/ncidod/dvrd/qfever/index.htm<br> |
| | http://www.cdc.gov/healthypets/diseases/qfever.htm<br> |
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| == Prevention ==
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| [[Image:Lambs2.jpg|right|Sheep with lambs]]
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| In the United States, Q fever outbreaks have resulted mainly from occupational exposure involving veterinarians, meat processing plant workers, sheep and dairy workers, livestock farmers, and researchers at facilities housing sheep. Prevention and control efforts should be directed primarily toward these groups and environments.
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| The following measures should be used in the prevention and control of Q fever:
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| *Educate the public on sources of infection.
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| *Appropriately dispose of placenta, birth products, fetal membranes, and aborted fetuses at facilities housing sheep and goats.
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| *Restrict access to barns and laboratories used in housing potentially infected animals.
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| *Use only pasteurized milk and milk products.
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| *Use appropriate procedures for bagging, autoclaving, and washing of laboratory clothing.
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| *Vaccinate (where possible) individuals engaged in research with pregnant sheep or live ''C. burnetii''.
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| *Quarantine imported animals.
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| *Ensure that holding facilities for sheep should be located away from populated areas. Animals should be routinely tested for antibodies to ''C. burnetii'', and measures should be implemented to prevent airflow to other occupied areas.
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| *Counsel persons at highest risk for developing chronic Q fever, especially persons with pre-existing cardiac valvular disease or individuals with vascular grafts.
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| A vaccine for Q fever has been developed and has successfully protected humans in occupational settings in Australia. However, this vaccine is not commercially available in the United States. Persons wishing to be vaccinated should first have a skin and blood test to determine a history of previous exposure. Individuals who have previously been exposed to ''C. burnetii'' should not receive the vaccine because severe reactions, localized to the area of the injected vaccine, may occur. After a single dose of vaccine, protective immunity lasts for many years and revaccination is not generally required. Annual screening is typically recommended.[http://cdp.ucsf.edu/fileUpload/UCSF_CDP_Q_Fever_Surveillance_Policy_Q_Neg_Wethers.pdf]
| | [[Category:Emergency mdicine]] |
| A vaccine for use in animals has also been developed, but it is not available in the United States.
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| Q fever is effectively prevented by intradermal vaccination using a vaccine composed of killed ''Coxiella burnetii'' organisms. A skin and blood test, prior to vaccination must be undertaken in order to establish whether there is pre-existing immunity, as vaccination of immune subjects can result in a severe local reaction.
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| In 2001, Australia introduced a national Q fever vaccination program for people working in "at risk" occupations.
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| == Other ==
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| Because of its route of infection it can be used as [[biological warfare]] agent. See also bioterrorism.Q-fever is category "B" agent. It is highly contagious and very stable in aerosols in a wide range of temperatures. Just 1-2 particles are enough to infect an individual. Q-fever microorganisms may survive on surfaces up to 60 days (like sporulating bacteria) and C. burnetii is known to reproduce and grow well in chicken egg embryos reaching very high concentrations. Protection against disease is offered by Q-Vax, a whole cell inactivated vaccine developed by a leading Australian vaccine manufacturing company CSL.
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| (http://www.csl.com.au/QFever.asp)
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| == History ==
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| [[Image:Pneumonia_x-ray.jpg|right|thumb|''Image A'': A normal [[chest X-ray]]. ''Image B'': [[Q fever]] pneumonia.]]
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| It was first described by Edward Holbrook Derrick in abattoir workers in Brisbane, Queensland, Australia. The "Q" stands for “query” and was applied historically at a time when the causative agent was unknown.
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| In 1937 the bacterium was isolated by Frank Macfarlane Burnet and Mavis Freeman from one of Derrick’s patients for the first time and identified as ''[[Rickettsia]]''-species. H.R. Cox and Davis isolated the [[pathogen]] from [[tick]]s in Montana, USA in 1938, called it ''Rickettsia diasporica'', it was considered nonpathogenic until laboratory investigators were infected; it was officially named ''[[Coxiella burnetii]]'' the same year. It is a zoonotic disease and most common animal reservoirs are cattle, sheep and goats. ''Coxiella burnetii'' is no longer regarded as closely related to [[Rickettsia]]e.
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| == Acknowledgements ==
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| '''List of contributors:'''
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| Pilar Almonacid
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| ==References==
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| http://www.cdc.gov/ncidod/diseases/submenus/sub_q_fever.htm
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| http://www.cdc.gov/ncidod/dvrd/qfever/index.htm
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| http://www.cdc.gov/healthypets/diseases/qfever.htm
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| <references/>
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| * {{cite journal |author=Maurin M, Raoult D |title=Q fever |journal=Clin. Microbiol. Rev. |volume=12 |issue=4 |pages=518-53 |year=1999 |pmid=10515901 |doi=}}
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| {{Bacterial diseases}}
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| [[cs:Q-horečka]]
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| [[de:Q-Fieber]] | |
| [[es:Fiebre Q]]
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| [[fr:Fièvre Q]]
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| [[hr:Q groznica]]
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| [[it:Febbre Q]]
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| [[he:קדחת Q]]
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| [[nl:Q-koorts]]
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| [[ja:Q熱]]
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| [[fi:Q-kuume]]
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| {{Reflist}}
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| http://www.csl.com.au/QFever.asp
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| [[Category:Overview complete]]
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| [[Category:Infectious disease]] | | [[Category:Infectious disease]] |
| [[Category:Bacterial diseases]] | | [[Category:Gastroenterology]] |
| | | [[Category:Hepatology]] |
| [[pl:Gorączka Q]] | | [[Category:Pulmonology]] |
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