Mepyramine: Difference between revisions

Jump to navigation Jump to search
VisualWikitext
WikiBot (talk | contribs)
Bots, Bureaucrats, bureaucrats, interwiki, nocaptcha, Administrators
57,550 edits
m Protected "Mepyramine": Protecting pages from unwanted edits ([edit=sysop] (indefinite) [move=sysop] (indefinite))
 
Kiran Singh (talk | contribs)
nocaptcha, Administrators
24,170 edits
No edit summary
 
(2 intermediate revisions by the same user not shown)
Line 1: Line 1:
{{Drugbox
{{Drugbox
| IUPAC_name = N1-(4-methoxybenzyl)- N2,N2-dimethyl- N1-(pyridin-2-yl)ethane- 1,2-diamine
| Verifiedfields = changed
| verifiedrevid = 408591350
| IUPAC_name = ''N''-(4-methoxybenzyl)-''N<nowiki>'</nowiki>'',''N<nowiki>'</nowiki>''-dimethyl-''N''-pyridin-2-ylethane-1,2-diamine
| image = Mepyramine.png
| image = Mepyramine.png
<!--Clinical data-->
| tradename = 
| Drugs.com = {{drugs.com|international|mepyramine}}
| MedlinePlus = a606008
| pregnancy_category = 
| legal_status = 
| routes_of_administration = 
<!--Pharmacokinetic data-->
| bioavailability = 
| protein_bound = 
| metabolism = 
| elimination_half-life = 
| excretion = 
<!--Identifiers-->
| CASNo_Ref = {{cascite|correct|CAS}}
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 91-84-9
| CAS_number = 91-84-9
| ATC_prefix       = R06
| CAS_supplemental = <br/>{{CAS|59-33-6}} (maleate)
| ATC_suffix       = AC01
| ATC_prefix = R06
| ATC_supplemental  = {{ATC|D04|AA02}}
| ATC_suffix = AC01
| PubChem           =  
| ATC_supplemental = {{ATC|D04|AA02}}
| DrugBank         =  
| PubChem = 4992
| C=17 | H=23 | N=3 | O=1
| IUPHAR_ligand = 1220
| DrugBank_Ref = {{drugbankcite|changed|drugbank}}
| DrugBank = DB06691
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 4818
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = HPE317O9TL
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D08183
| ChEBI_Ref = {{ebicite|changed|EBI}}
| ChEBI = 6762
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 511
 
<!--Chemical data-->
| C=17 | H=23 | N=3 | O=1  
| molecular_weight = 285.38 g/mol
| molecular_weight = 285.38 g/mol
| bioavailability  =  
| smiles = O(c1ccc(cc1)CN(c2ncccc2)CCN(C)C)C
| protein_bound    =  
| InChI = 1/C17H23N3O/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15/h4-11H,12-14H2,1-3H3
| metabolism        =  
| InChIKey = YECBIJXISLIIDS-UHFFFAOYAS
| elimination_half-life =  
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| excretion        =
| StdInChI = 1S/C17H23N3O/c1-19(2)12-13-20(17-6-4-5-11-18-17)14-15-7-9-16(21-3)10-8-15/h4-11H,12-14H2,1-3H3
| pregnancy_AU      = <!-- A / B1 / B2 / B3 / C / D / X -->
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| pregnancy_US      =  <!-- A / B            / C / D / X -->
| StdInChIKey = YECBIJXISLIIDS-UHFFFAOYSA-N
| pregnancy_category= 
| synonyms = <small>''N''-[2-(dimethylamino)ethyl]-''N''-[(4-methoxyphenyl)methyl]pyridin-2-amine</small>
| legal_AU          =  <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA          =  <!--             / Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK          = <!-- GSL        / P      / POM / CD / Class A, B, C -->
| legal_US          = <!-- OTC                  / Rx-only  / Schedule I, II, III, IV, V -->
| legal_status      =
| routes_of_administration =
}}
}}
'''Mepyramine''' (INN, also known as pyrilamine) <ref>{{cite journal | author = Parsons, M. E. and Ganellin, C. R. | title = Histamine and its receptors | journal = British Journal of Pharmacology | volume = 147 | pages = S127–S135 | year = 2006 | | id = PMID 16402096}}</ref> is a [[Antihistamine#First-generation H1-receptor antagonists|first generation antihistamine]], targeting the [[histamine H1 receptor|H<sub>1</sub> receptor]]. However, it rapidly permeates the brain and so often causes [[drowsiness]] as a side effect.
__Notoc__
 
{{SI}}
It is used in over-the-counter combination products for colds and menstrual symptoms.<ref>http://www.uspharmacist.com/oldformat.asp?url=newlook/files/Cons/sep00cyp.cfm</ref>
{{CMG}}
 
==Overview==
Side effects may include [[sedation]]/drowsiness, muscle weakness, and insomnia.<ref>http://www.drugs.com/pdr/pyrilamine_maleate.html</ref>
'''Mepyramine''', also known as '''pyrilamine''', is a [[Antihistamine#H1-receptor antagonists|first generation antihistamine]], targeting the [[Histamine H1 receptor|H<sub>1</sub> receptor]].<ref>{{cite journal | last1 = Parsons | first1 = Mike E. | last2 = Ganellin |first2 = C. Robin | title = Histamine and its receptors | journal = British Journal of Pharmacology | volume = 147 | pages = S127–S135 |date=January 2006 | pmid = 16402096 | doi = 10.1038/sj.bjp.0706440 | pmc = 1760721 | issue = S1}}</ref> However, it rapidly permeates the brain often causing [[drowsiness]]. It also has [[anticholinergic]] properties. It is used in over-the-counter combination products to treat the common cold and menstrual symptoms.<ref>[http://midol.com/menstrual_complete_caps.html#q1 Active Ingredients for Midol Complete]</ref> It is also the active ingredient of the topical antihistamine creams ''Anthisan'' and ''Neoantergan'', sold for the treatment of insect bites, stings, and nettle rash.
 
==Synthesis==
==References==
[[File:Pyrilamine synthesis.png |thumb|center|700px|Pyrilamine synthesis:<ref>R.J. Horclois, {{US Patent|2502151}} (1950).</ref><ref>{{Cite doi|10.1021/ja01214a037}}</ref><ref>D. Bovet, R. Horclois, F. Walthert, C.R. Soc. Biol., 138, 99 (1944).</ref>]]
<div class="references-small">
  <references/>
</div>
 
==External links==
*[http://www.oaep.on.ca/MedsSheets/Pyrilamine%20Maleate.htm Mepyramine use in horses]


==See also==
*[[Chloropyramine]] (chloro instead of methoxy)
== References ==
{{Reflist|2}}


{{Antipruritics}}
{{Antipruritics}}
{{Antihistamines}}
{{Antihistamines}}
{{Cholinergics}}
{{Hallucinogens}}
{{Histaminergics}}


[[Category:Antihistamines]]
[[Category:Drug]]
[[Category:Amines]]
[[Category:Aromatic amines]]
[[Category:H1 receptor antagonists]]
[[Category:Phenol ethers]]
[[Category:Pyridines]]
[[Category:Pyridines]]




{{pharma-stub}}
{{respiratory-system-drug-stub}}
{{WikiDoc Sources}}
{{dermatologic-drug-stub}}

Latest revision as of 12:46, 9 April 2015

Mepyramine
Clinical data
SynonymsN-[2-(dimethylamino)ethyl]-N-[(4-methoxyphenyl)methyl]pyridin-2-amine
AHFS/Drugs.comInternational Drug Names
MedlinePlusa606008
ATC code
Identifiers
CAS Number
PubChem CID
IUPHAR/BPS
DrugBank
ChemSpider
UNII
KEGG
ChEBI
ChEMBL
E number{{#property:P628}}
ECHA InfoCard{{#property:P2566}}Lua error in Module:EditAtWikidata at line 36: attempt to index field 'wikibase' (a nil value).
Chemical and physical data
FormulaC17H23N3O
Molar mass285.38 g/mol
3D model (JSmol)
 ☒N☑Y (what is this?)  (verify)

WikiDoc Resources for Mepyramine

Articles

Most recent articles on Mepyramine

Most cited articles on Mepyramine

Review articles on Mepyramine

Articles on Mepyramine in N Eng J Med, Lancet, BMJ

Media

Powerpoint slides on Mepyramine

Images of Mepyramine

Photos of Mepyramine

Podcasts & MP3s on Mepyramine

Videos on Mepyramine

Evidence Based Medicine

Cochrane Collaboration on Mepyramine

Bandolier on Mepyramine

TRIP on Mepyramine

Clinical Trials

Ongoing Trials on Mepyramine at Clinical Trials.gov

Trial results on Mepyramine

Clinical Trials on Mepyramine at Google

Guidelines / Policies / Govt

US National Guidelines Clearinghouse on Mepyramine

NICE Guidance on Mepyramine

NHS PRODIGY Guidance

FDA on Mepyramine

CDC on Mepyramine

Books

Books on Mepyramine

News

Mepyramine in the news

Be alerted to news on Mepyramine

News trends on Mepyramine

Commentary

Blogs on Mepyramine

Definitions

Definitions of Mepyramine

Patient Resources / Community

Patient resources on Mepyramine

Discussion groups on Mepyramine

Patient Handouts on Mepyramine

Directions to Hospitals Treating Mepyramine

Risk calculators and risk factors for Mepyramine

Healthcare Provider Resources

Symptoms of Mepyramine

Causes & Risk Factors for Mepyramine

Diagnostic studies for Mepyramine

Treatment of Mepyramine

Continuing Medical Education (CME)

CME Programs on Mepyramine

International

Mepyramine en Espanol

Mepyramine en Francais

Business

Mepyramine in the Marketplace

Patents on Mepyramine

Experimental / Informatics

List of terms related to Mepyramine

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]

Overview

Mepyramine, also known as pyrilamine, is a first generation antihistamine, targeting the H1 receptor.[1] However, it rapidly permeates the brain often causing drowsiness. It also has anticholinergic properties. It is used in over-the-counter combination products to treat the common cold and menstrual symptoms.[2] It is also the active ingredient of the topical antihistamine creams Anthisan and Neoantergan, sold for the treatment of insect bites, stings, and nettle rash.

Synthesis

Pyrilamine synthesis:[3][4][5]

See also

References

  1. ↑ Parsons, Mike E.; Ganellin, C. Robin (January 2006). "Histamine and its receptors". British Journal of Pharmacology. 147 (S1): S127–S135. doi:10.1038/sj.bjp.0706440. PMC 1760721. PMID 16402096.
  2. ↑ Active Ingredients for Midol Complete
  3. ↑ R.J. Horclois, Template:US Patent (1950).
  4. ↑ Template:Cite doi
  5. ↑ D. Bovet, R. Horclois, F. Walthert, C.R. Soc. Biol., 138, 99 (1944).

Template:Antipruritics


Template:Respiratory-system-drug-stub Template:Dermatologic-drug-stub

Retrieved from "https://www.wikidoc.org/index.php?title=Mepyramine&oldid=1085110"