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==Causes of Glioblastoma Multiforme==
==Overview==
Almost all cases of GBM are sporadic, without a familial predilection, although [[chromosome|chromosomal]] aberrations such as [[PTEN (gene)|PTEN]] mutation, and [[p53]] mutation are commonly seen in these tumors. Growth factor aberrant signaling associated with [[Epidermal_growth_factor_receptor|EGFR]], and [[PDGF]] are also seen.
Common causes of glioblastoma multiforme include genetic mutations.<ref name=ddd>Etiology of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref>


{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align=center
|valign=top|
|+
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Type of glioblastoma multiforme}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Genes}}
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
:Primary​
| style="padding: 5px 5px; background: #F5F5F5;" |
*''[[Mdm2]]''
*''[[PTEN]]''
*Gene on chromosome 10p
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Secondary
| style="padding: 5px 5px; background: #F5F5F5;" |
*''IDH1''
*''[[p53]]''
*Gene on chromosome 10q
*Gene on chromosome 17p
*Gene on chromosome 19q
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Classic
| style="padding: 5px 5px; background: #F5F5F5;" |
*''[[EGFR]]''
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Proneural
| style="padding: 5px 5px; background: #F5F5F5;" |
*''[[TP53]]''
*''PDGFRA''
*''IDH1''
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Mesenchymal
| style="padding: 5px 5px; background: #F5F5F5;" |
*''[[NF-1]]''
|}
==Causes==
Common causes of glioblastoma multiforme include genetic mutations.<ref name=ddd>Etiology of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma</ref>
{| style="border: 0px; font-size: 90%; margin: 3px; width: 600px" align=center
|valign=top|
|+
! style="background: #4479BA; width: 200px;" | {{fontcolor|#FFF|Type of glioblastoma multiforme}}
! style="background: #4479BA; width: 400px;" | {{fontcolor|#FFF|Genes}}
|-
| style="padding: 5px 5px; background: #DCDCDC; font-weight: bold" |
:Primary​
| style="padding: 5px 5px; background: #F5F5F5;" |
*''[[Mdm2]]''
*''[[PTEN]]''
*Gene on chromosome 10p
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Secondary
| style="padding: 5px 5px; background: #F5F5F5;" |
*''IDH1''
*''[[p53]]''
*Gene on chromosome 10q
*Gene on chromosome 17p
*Gene on chromosome 19q
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Classic
| style="padding: 5px 5px; background: #F5F5F5;" |
*''[[EGFR]]''
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Proneural
| style="padding: 5px 5px; background: #F5F5F5;" |
*''[[TP53]]''
*''PDGFRA''
*''IDH1''
|-
| style="padding: 5px 5px; background: #DCDCDC;font-weight: bold" |
:Mesenchymal
| style="padding: 5px 5px; background: #F5F5F5;" |
*''[[NF-1]]''
|}
==References==
==References==
{{reflist|2}}
{{reflist|2}}
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[[Category:Neurology]]
[[Category:Neurology]]
[[Category:Types of cancer]]
[[Category:Types of cancer]]
[[Category:Oncology]]


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Latest revision as of 14:59, 19 February 2019

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Marjan Khan M.B.B.S.[2]

Overview

Common causes of glioblastoma multiforme include genetic mutations.[1]

Type of glioblastoma multiforme Genes
Primary​
Secondary
  • IDH1
  • p53
  • Gene on chromosome 10q
  • Gene on chromosome 17p
  • Gene on chromosome 19q
Classic
Proneural
Mesenchymal

Causes

Common causes of glioblastoma multiforme include genetic mutations.[1]

Type of glioblastoma multiforme Genes
Primary​
Secondary
  • IDH1
  • p53
  • Gene on chromosome 10q
  • Gene on chromosome 17p
  • Gene on chromosome 19q
Classic
Proneural
Mesenchymal

References

  1. ↑ 1.0 1.1 Etiology of glioblastoma multiforme. Dr Dylan Kurda and Dr Frank Gaillard et al. Radiopaedia 2015. http://radiopaedia.org/articles/glioblastoma


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