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__NOTOC__
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''


{{Infobox_Disease |
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  Image          = |
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  DiseasesDB    = 33713 |
  ICD10          = |
  ICD9          = |
  ICDO          = 9560/0 |
  OMIM          = |
  MedlinePlus    = |
  eMedicineSubj  = |
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{{Schwannoma}}
{{Schwannoma}}


{{CMG}}
{{CMG}}; {{AE}} {{SC}}
 
{{SK}} Neurilemmoma, Neurinoma, Neurolemmoma, Schwann cell tumor, Schwannomatosis
 
==[[Schwannoma overview|Overview]]==
 
==[[Schwannoma historical perspective|Historical Perspective]]==


'''''Synonyms and keywords:''''' Acoustic neuroma, acoustic neurinoma, or acoustic neurilemoma, neurilemmoma, neurinoma, neurolemmoma, Schwann cell tumor
==[[Schwannoma classification|Classification]]==


==Overview==
==[[Schwannoma pathophysiology|Pathophysiology]]==
A '''schwannoma''' is a kind of [[tumor]] originating from the [[Schwann cell]]s.
The insulating [[myelin sheath]] which covers peripheral nerves is produced by the Schwann cells. Hence, one kind of tumor originating from the Schwann cells is called a schwannoma.


Schwannomas are very homogenous tumors consisting only of Schwann cells. The tumor cells always stay on the outside of the nerve, but the tumor itself may either push the nerve aside and/or up against a bony structure (thereby possibly causing damage). Schwannomas are relatively slow growing. For reasons not yet understood, schwannomas are mostly [[benign]] and less than 1% become malignant degenerating into a form of [[cancer]] known as [[neurofibrosarcoma]].
==[[ Schwannoma causes|Causes]]==


Schwannomas can arise from a genetic disorder called [[neurofibromatosis]].  They are universally [[S-100 protein|S-100]] positive.
==[[ Schwannoma differential diagnosis|Differentiating Schwannoma from other Diseases]]==


Schwannomas can arise from a genetic disorder called [[schwannomatosis]].
==[[Schwannoma epidemiology and demographics|Epidemiology and Demographics]]==


==Pathophysiology==
==[[Schwannoma risk factors|Risk Factors]]==


===Microscopic Pathology===
==[[Schwannoma screening|Screening]]==


<gallery>
==[[Schwannoma natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
Image:Peripheral schwannoma Antoni type A (2).JPG
Image:Subcutaneous schwannoma (1) Antoni B.jpg|Subcutaneous schwannoma
Image:Subcutaneous schwannoma (2) Antoni B.jpg
Image:Subcutaneous schwannoma (3) Antoni B.jpg
Image:Subcutaneous schwannoma (4) S-100 immunostain.jpg
</gallery>


==Diagnosis==
==Diagnosis==
===Symptoms===
[[Schwannoma diagnostic study of choice|Diagnostic study of choice]] | [[Schwannoma history and symptoms|History and Symptoms]] | [[Schwannoma physical examination|Physical Examination]] | [[Schwannoma laboratory findings|Laboratory Findings]] | [[Schwannoma electrocardiogram|Electrocardiogram]] | [[Schwannoma x ray|X-Ray Findings]] | [[Schwannoma echocardiography and ultrasound|Echocardiography and Ultrasound]] | [[ Schwannoma CT scan|CT-Scan Findings]] | [[Schwannoma MRI|MRI Findings]] | [[Schwannoma other imaging findings|Other Imaging Findings]] | [[Schwannoma other diagnostic studies|Other Diagnostic Studies]]
Unilateral/asymmetric hearing loss and/or [[tinnitus]] and loss of balance/[[dizziness]] are early signs of a vestibular schwannoma. Unfortunately, early detection of the tumor is sometimes difficult because the symptoms may be subtle and may not appear in the beginning stages of growth. Also, [[hearing loss]], [[dizziness]], and [[tinnitus]] are common symptoms of many middle and inner ear problems (the important point here is that unilateral or asymmetric symptoms are the worrisome ones).
 
==Treatment==
[[Schwannoma medical therapy|Medical Therapy]] | [Schwannoma interventions|Interventions]] | [[ Schwannoma surgery|Surgery]] | [[Schwannoma primary prevention|Primary Prevention]] | [[Schwannoma secondary prevention|Secondary Prevention]] | [[Schwannoma cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[ Schwannomafuture or investigational therapies|Future or Investigational Therapies]]
 
==Case Studies==
[[ case study one|Case #1]]
 
[[Category: (name of the system)]]


===Audiogram===
Once the symptoms appear, a thorough ear examination and hearing test ([[audiogram]]) are essential for proper diagnosis.


===Imaging Studies===
Computerized tomography (CT) scans, enhanced with intravenous dye (contrast), and magnetic resonance imaging (MRI) are critical in the early detection of a vestibular schwannoma and are helpful in determining the location and size of a tumor and in planning its microsurgical removal.


==Treatment==
Schwannomas can be removed surgically, but they can then recur.


== References ==
==Case Studies==
{{Reflist|2}}
[[Schwannoma case study one|Case #1]]


==See also==
==Related Chapters==
*[[Neurofibroma]]
*[[Neurofibroma]]
*[[Vestibular schwannoma]] (Acoustic neuroma)
*[[Vestibular schwannoma]] (Acoustic neuroma)
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{{Nervous tissue tumors}}
{{Nervous tissue tumors}}


[[Category:PNS neoplasia]]
[[Category:Dermal and subcutaneous growths]]
[[Category:Dermal and subcutaneous growths]]
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[[Category:Neurology]]
[[Category:Neurology]]
[[cs:Neurinom]]
[[de:Schwannom]]
[[es:Schwannoma]]
[[fa:شوانوما]]
[[it:Schwannoma]]
[[pl:Nerwiakowłókniak]]
[[fr:Schwannome]]
[[it:Schwannoma]]


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Latest revision as of 15:45, 15 October 2019


For patient information click here

Schwannoma Microchapters

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Overview

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Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Staging

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Laboratory Findings

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shanshan Cen, M.D. [2]

Synonyms and keywords: Neurilemmoma, Neurinoma, Neurolemmoma, Schwann cell tumor, Schwannomatosis

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Schwannoma from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

Diagnostic study of choice | History and Symptoms | Physical Examination | Laboratory Findings | Electrocardiogram | X-Ray Findings | Echocardiography and Ultrasound | CT-Scan Findings | MRI Findings | Other Imaging Findings | Other Diagnostic Studies

Treatment

Medical Therapy | [Schwannoma interventions|Interventions]] | Surgery | Primary Prevention | Secondary Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1



Case Studies

Case #1

Related Chapters

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