Guillain-Barré syndrome: Difference between revisions

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Latest revision as of 05:05, 2 January 2019

For patient information click, here

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Fahimeh Shojaei, M.D.

Synonyms and keywords: Acute inflammatory demyelinating polyradiculoneuropathy

Overview

Historical Perspective

Classification

Pathophysiology

Causes

Differentiating Guillain-Barré Syndrome from other Diseases

Epidemiology and Demographics

Risk Factors

Natural history, Complications and Prognosis

Diagnosis

Treatment

Medical Therapy | Physical Therapy | Secondary Prevention

Case Study

Case #1

Related Chapters

Acute motor axonal neuropathy

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-{{Infobox_Disease |
+__NOTOC__
-  Name           = {{PAGENAME}} |
+'''For patient information click, [[{{PAGENAME}} (patient information)|here]]'''
-  Image          = |
-  Caption        = |
-  DiseasesDB     = 5465 |
-  ICD10          = {{ICD10|G|61|0|g|60}} |
-  ICD9           = {{ICD9|357.0}} |
-  ICDO           = |
-  OMIM           = |
-  MedlinePlus    = |
-  eMedicineSubj  = |
-  eMedicineTopic = |
-  MeshID         = D020275 |
-}}
 {{Guillain-Barré syndrome}}
-'''For patient information click [[{{PAGENAME}} (patient information)|here]]'''
+{{CMG}}; {{AE}} {{Fs}}
-{{CMG}}; '''Associate Editors-In-Chief:''' [[Priyamvada Singh|Priyamvada Singh, MBBS]] [mailto:psingh@perfuse.org]
+{{SK}} Acute inflammatory demyelinating polyradiculoneuropathy
-==[[Guillain-Barré syndrome overview|Overview]]==
+== [[Guillain-Barré syndrome overview|Overview]] ==
-==[[Guillain-Barré syndrome pathophysiology|Pathophysiology]]==
+== [[Guillain-Barré syndrome historical perspective|Historical Perspective]] ==
-All forms of Guillain-Barré syndrome are due to an immune response to foreign antigens (such as infectious agents or vaccines) but mistargeted to host nerve tissues instead (a form of [[antigenic mimicry]]). The targets of such immune attack are thought to be [[gangliosides]], which are complex glycosphingolipids present in large quantities on human nerve tissues, especially in the [[nodes of Ranvier]]. An example is the GM1 ganglioside, which can be affected in as many as 20-50% of cases, especially in those preceded by ''[[Campylobacter jejuni]]'' infections. Another example is the GQ1b ganglioside, which is the target in the Miller Fisher syndrome variant (see below).
+== [[Guillain-Barré syndrome classification|Classification]] ==
-The end result of such [[autoimmune]] attack on the peripheral nerves is inflammation of [[myelin]] and conduction block, leading to a muscle [[paralysis]] that may be accompanied by sensory or [[autonomic]] disturbances.
+== [[Guillain-Barré syndrome pathophysiology|Pathophysiology]] ==
-However, in mild cases, axonal function remains intact and recovery can be rapid if remyelination occurs. In severe cases, such as in the AMAN or AMSAN variants (see below), axonal degeneration occurs, and recovery depends on axonal regeneration. Recovery becomes much slower, and there is a greater degree of residual damage. Recent studies on the disease have demonstrated that approximately 80% of the patients have [[myelin]] loss, whereas, in the remaining 20%, the pathologic hallmark of the disease is indeed [[axon]] loss.
+== [[Guillain-Barré syndrome causes|Causes]] ==
-==[[Guillain-Barré syndrome history and symptoms|History & Symptoms]]==
+== [[Guillain-Barré syndrome differential diagnosis|Differentiating Guillain-Barré Syndrome from other Diseases]] ==
-==[[Guillain-Barré syndrome physical examination|Physical Examination]]==
+== [[Guillain-Barré syndrome epidemiology and demographics|Epidemiology and Demographics]] ==
-==[[Guillain-Barré syndrome classification|Classification]]==
+== [[Guillain-Barré syndrome risk factors|Risk Factors]] ==
-==Diagnosis==
+== [[Guillain-Barré syndrome natural history, complications, and prognosis|Natural history, Complications and Prognosis]] ==
-==[[Guillain-Barré syndrome other diagnostic studies|Other Diagnostic Studies]]==
-==[[Guillain-Barré syndrome differential diagnosis|Differentiating Guillain-Barré syndrome from other Diseases]]==
+== Diagnosis ==
-==Treatment==
+[[Guillain-Barré syndrome diagnostic criteria|Diagnostic Criteria]] | [[Guillain-Barré syndrome history and symptoms|History and Symptoms]] | [[Guillain-Barré syndrome physical examination|Physical Examination]] | [[Guillain-Barré syndrome laboratory tests|Laboratory Findings]] | [[Guillain-Barré syndrome electrocardiogram|Electrocardiogram]] | [[Guillain-Barré syndrome MRI|MRI]] | [[Guillain-Barré syndrome other diagnostic studies|Other Diagnostic Studies]]
-==[[Guillain-Barré syndrome medical therapy|Medical Therapy]]==
-==[[Guillain-Barré syndrome natural history, complications, and prognosis|Natural history, Complications, and Prognosis]]==
+== Treatment ==
-==[[Guillain-Barré syndrome historical perspective|Historical perspective]]==
+[[Guillain-Barré syndrome medical therapy|Medical Therapy]] | [[Guillain-Barré syndrome physical therapy|Physical Therapy]] | [[Guillain-Barré syndrome secondary prevention|Secondary Prevention]]
+== Case Study ==
-==References==
+[[Guillain-Barré syndrome case study one|Case #1]]
-{{reflist|2}}
-[[ca:Síndrome de Guillain-Barré]]
+==Related Chapters==
-[[de:Guillain-Barré-Syndrom]]
+*[[Acute motor axonal neuropathy]]
-[[es:Síndrome de Guillain-Barré]]
-[[fr:Syndrome de Guillain-Barré]]
-[[it:Sindrome di Guillain-Barré]]
-[[he:תסמונת גיאן-בארה]]
-[[lb:Guillain-Barré-Syndrom]]
-[[ms:Sindrom Guillain-Barré]]
-[[nl:Syndroom van Guillain-Barré]]
-[[ja:ギラン・バレー症候群]]
-[[pl:Zespół Guillaina-Barrégo]]
-[[pt:Síndrome de Guillain-Barré]]
-[[ru:Синдром Гийена-Барре]]
-[[fi:Guillain-Barrén oireyhtymä]]
-[[sv:Guillain-Barrés syndrom]]
-[[tr:Guillain-Barré sendromu]]
-[[zh:格林-巴利综合征]]
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 [[Category:Neurology]]
 [[Category:Immunology]]
-[[Category:Syndromes]]
-[[Category:Overview complete]]
 [[Category:Disease]]
 [[Category:Emergency medicine]]
-[[Category:Infectious disease]]