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{{Chronic obstructive pulmonary disease}} | {{Chronic obstructive pulmonary disease}} | ||
{{CMG}}; [[Philip Marcus, M.D., M.P.H.]] [mailto:pmarcus192@aol.com]; {{ | {{CMG}}; [[Philip Marcus, M.D., M.P.H.]] [mailto:pmarcus192@aol.com]; {{AE}} {{MJ}} | ||
==Overview== | ==Overview== | ||
COPD may be classified based on [[pathology]], into two types: chronic bronchitis type, and emphysema type. Emphysema may be classified further in to four sub-types such as panacinary, centroacinary, congenital lobar emphysema and paraseptal. | |||
==Classification== | |||
COPD may be classified based on [[pathology]], into two types: chronic bronchitis and emphysema. | |||
== | ===Chronic Bronchitis=== | ||
There is no classification system established for chronic bronchitis. | |||
===Emphysema=== | |||
Emphysema can be classified by location into four categories:<ref>{{cite book |author=Kumar V, Abbas AK |title=Robbins Pathologic Basis of Disease |year=2009 |page=684 }}</ref> | |||
==== '''1- Panacinary (panlobular):''' ==== | |||
* The entire [[respiratory]] [[acinus]], from [[respiratory bronchiole]] to [[Pulmonary alveolus|alveoli]], is expanded. Occurs more commonly in the lower lobes (especially basal segments) and in the anterior margins of the [[Lung|lungs]].<ref name="urlEmphysema">{{cite web |url=http://www.meddean.luc.edu/Lumen/MedEd/MEDICINE/PULMONAR/pathms/mpath6.htm |title=Emphysema |work= |accessdate=2008-11-20}}</ref> | |||
==== '''2- Centroacinary (panacinar and centriacinar):''' ==== | |||
* The [[respiration|respiratory bronchiole]] (proximal and central part of the [[acinus]]) is expanded. The distal [[acinus]] or [[Pulmonary alveolus|alveoli]] are unchanged. Occurs more commonly in the upper lobes.<ref name="urlEmphysema">{{cite web |url=http://www.meddean.luc.edu/Lumen/MedEd/MEDICINE/PULMONAR/pathms/mpath6.htm |title=Emphysema |work= |accessdate=2010-01-20}}</ref><ref name="pmid4784376">{{cite journal |author=Anderson AE, Foraker AG |title=Centrilobular emphysema and panlobular emphysema: two different diseases |journal=Thorax |volume=28 |issue=5 |pages=547–50 |year=1973 |month=September |pmid=4784376 |doi= 10.1136/thx.28.5.547|pmc=470076}}</ref> | |||
'''3- Congenital lobar emphysema (CLE)''': | |||
* CLE results in over-expansion of a [[Pulmonary|pulmonary lobe]], and resultant compression of the remaining lobes of the ipsi-lateral lung (and possibly also the contralateral [[lung]]). There is [[bronchus|bronchial]] narrowing because of weakened or absent bronchial [[cartilage]].<ref name="Wood">[http://emedicine.medscape.com/article/407635-overview eMedicine Specialties > Radiology > Pediatrics --> Congenital Lobar Emphysema] Author: Beverly P Wood, MD, MS, PhD, University of Southern California. Updated: December 1, 2008</ref> There may be [[congenital]] extrinsic compression, commonly by an abnormally large [[pulmonary artery]]. This causes malformation of [[bronchial]] [[cartilage]], making them soft and collapsible.<ref name="Wood" /> CLE is a potentially reversible (yet possibly life-threatening) cause of [[Acute respiratory distress syndrome|respiratory distress]] in the [[infant|neonate]].<ref name="Wood" /> | |||
'''4- Paraseptal emphysema''': | |||
* Para-septal emphysema is a type of emphysema which involves the alveolar ducts and sacs at the [[lung]] periphery. The emphysematous areas are sub-pleural in location and often surrounded by inter-lobular septa (hence the name). It may be an incidental finding in young adults, and may be associated with spontaneous [[pneumothorax]]. It may also be seen in older patients with centri-lobular emphysema. Both centri-lobular and para-septal emphysema may progress to bullous emphysema. A bulla is defined as being at least 1 cm in diameter, and with a wall less than 1 mm thick. Bullae are thought to arise by [[air trapping]] in emphysematous spaces, causing local expansion.<ref>Webb WR, Higgins CB. ''Thoracic Imaging''. Lippincott, Williams & Wilkins 2005.</ref> | |||
==References== | ==References== | ||
{{reflist|2}} | {{reflist|2}} | ||
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{{WikiDoc Sources}} | |||
[[Category:Pulmonology]] | [[Category:Pulmonology]] | ||
[[Category:Emergency medicine]] | [[Category:Emergency medicine]] | ||
Latest revision as of 20:58, 29 July 2020
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Differentiating Chronic obstructive pulmonary disease from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Philip Marcus, M.D., M.P.H. [2]; Associate Editor(s)-in-Chief: Mehrian Jafarizade, M.D [3]
Overview
COPD may be classified based on pathology, into two types: chronic bronchitis type, and emphysema type. Emphysema may be classified further in to four sub-types such as panacinary, centroacinary, congenital lobar emphysema and paraseptal.
Classification
COPD may be classified based on pathology, into two types: chronic bronchitis and emphysema.
Chronic Bronchitis
There is no classification system established for chronic bronchitis.
Emphysema
Emphysema can be classified by location into four categories:[1]
1- Panacinary (panlobular):
- The entire respiratory acinus, from respiratory bronchiole to alveoli, is expanded. Occurs more commonly in the lower lobes (especially basal segments) and in the anterior margins of the lungs.[2]
2- Centroacinary (panacinar and centriacinar):
- The respiratory bronchiole (proximal and central part of the acinus) is expanded. The distal acinus or alveoli are unchanged. Occurs more commonly in the upper lobes.[2][3]
3- Congenital lobar emphysema (CLE):
- CLE results in over-expansion of a pulmonary lobe, and resultant compression of the remaining lobes of the ipsi-lateral lung (and possibly also the contralateral lung). There is bronchial narrowing because of weakened or absent bronchial cartilage.[4] There may be congenital extrinsic compression, commonly by an abnormally large pulmonary artery. This causes malformation of bronchial cartilage, making them soft and collapsible.[4] CLE is a potentially reversible (yet possibly life-threatening) cause of respiratory distress in the neonate.[4]
4- Paraseptal emphysema:
- Para-septal emphysema is a type of emphysema which involves the alveolar ducts and sacs at the lung periphery. The emphysematous areas are sub-pleural in location and often surrounded by inter-lobular septa (hence the name). It may be an incidental finding in young adults, and may be associated with spontaneous pneumothorax. It may also be seen in older patients with centri-lobular emphysema. Both centri-lobular and para-septal emphysema may progress to bullous emphysema. A bulla is defined as being at least 1 cm in diameter, and with a wall less than 1 mm thick. Bullae are thought to arise by air trapping in emphysematous spaces, causing local expansion.[5]
References
- ↑ Kumar V, Abbas AK (2009). Robbins Pathologic Basis of Disease. p. 684.
- ↑ 2.0 2.1 "Emphysema". Retrieved 2008-11-20.
- ↑ Anderson AE, Foraker AG (1973). "Centrilobular emphysema and panlobular emphysema: two different diseases". Thorax. 28 (5): 547–50. doi:10.1136/thx.28.5.547. PMC 470076. PMID 4784376. Unknown parameter
|month=ignored (help) - ↑ 4.0 4.1 4.2 eMedicine Specialties > Radiology > Pediatrics --> Congenital Lobar Emphysema Author: Beverly P Wood, MD, MS, PhD, University of Southern California. Updated: December 1, 2008
- ↑ Webb WR, Higgins CB. Thoracic Imaging. Lippincott, Williams & Wilkins 2005.