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==Risk factors==
*[[Human papillomavirus]] (HPV) infection: An examination of squamous cell carcinoma tumor tissues from patients in Denmark and Sweden showed a high proportion of anal cancers to be positive for the types of HPV that are also associated with high risk of cervical cancer (90% of the tumors from women, 100% of the tumors from homosexual men, and 58% of tumors from heterosexual men).<ref>Danish Medical Bulletin. 2002 Aug;49(3):194-209</ref> In another study done, high-risk types of HPV, notably HPV-16, were detected in 84 percent of anal cancer specimens examined.<ref>New England Journal of Medicine. 1997 Nov 6;337(19):1350-8</ref>


*Sexual activity: Having multiple sex partners or having [[anal sex]], due to the increased risk of exposure to the HPV virus.<ref name="ACS">American Cancer Society.[http://www.cancer.org/docroot/CRI/content/CRI_2_4_2X_What_are_the_risk_factors_for_Anal_Cancer_47.asp?sitearea "What Are the Risk Factors for Anal Cancer?"]</ref>  
==Overview==
 
The most potent risk factor in the development of anal cancer is [[Human Papillomavirus]] (HPV). Other risk factors include receptive anal intercourse with multiple sexual partners, smoking, and [[immunosuppression]].
 
==Common Risk Factors==
Common risk factors associated with anal cancer are:
*[[Human papillomavirus]] (HPV) infection, notably HPV-16.<ref>New England Journal of Medicine. 1997 Nov 6;337(19):1350-8</ref>
 
*Sexual activity: Having multiple sex partners or having anal sex, due to the increased risk of exposure to the HPV virus.<ref name="ACS">American Cancer Society.[http://www.cancer.org/docroot/CRI/content/CRI_2_4_2X_What_are_the_risk_factors_for_Anal_Cancer_47.asp?sitearea "What Are the Risk Factors for Anal Cancer?"]</ref>  


*[[Smoking]]: Current smokers are several times more likely to develop anal cancer compared with nonsmokers.<ref name="ACS">American Cancer Society. [http://www.cancer.org/docroot/CRI/content/CRI_2_4_2X_What_are_the_risk_factors_for_Anal_Cancer_47.asp?sitearea "What Are the Risk Factors for Anal Cancer?"]</ref>
*[[Smoking]]: Current smokers are several times more likely to develop anal cancer compared with nonsmokers.<ref name="ACS">American Cancer Society. [http://www.cancer.org/docroot/CRI/content/CRI_2_4_2X_What_are_the_risk_factors_for_Anal_Cancer_47.asp?sitearea "What Are the Risk Factors for Anal Cancer?"]</ref>
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*[[Immunosuppression]], which is often associated with [[HIV]] infection.<ref name="ACS">American Cancer Society.[http://www.cancer.org/docroot/CRI/content/CRI_2_4_2X_What_are_the_risk_factors_for_Anal_Cancer_47.asp?sitearea "What Are the Risk Factors for Anal Cancer?"]</ref>
*[[Immunosuppression]], which is often associated with [[HIV]] infection.<ref name="ACS">American Cancer Society.[http://www.cancer.org/docroot/CRI/content/CRI_2_4_2X_What_are_the_risk_factors_for_Anal_Cancer_47.asp?sitearea "What Are the Risk Factors for Anal Cancer?"]</ref>


==References==
*Being older than 50 years <ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/types/anal/patient/anal-treatment-pdq</ref>


{{reflist|2}}
*Frequent anal redness, swelling, and soreness <ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/types/anal/patient/anal-treatment-pdq</ref>


*Having anal fistulas (abnormal openings) <ref name="cancergov">National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/types/anal/patient/anal-treatment-pdq</ref>


==References==


[[fr:Cancer de l'anus]]
{{reflist|2}}
[[hu:Anális rák]]
[[fi:Peräaukon syöpä]]
 
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Mohamad Alkateb, MBBCh [2]

Overview

The most potent risk factor in the development of anal cancer is Human Papillomavirus (HPV). Other risk factors include receptive anal intercourse with multiple sexual partners, smoking, and immunosuppression.

Common Risk Factors

Common risk factors associated with anal cancer are:

  • Sexual activity: Having multiple sex partners or having anal sex, due to the increased risk of exposure to the HPV virus.[2]
  • Smoking: Current smokers are several times more likely to develop anal cancer compared with nonsmokers.[2]
  • Being older than 50 years [3]
  • Frequent anal redness, swelling, and soreness [3]
  • Having anal fistulas (abnormal openings) [3]

References

  1. New England Journal of Medicine. 1997 Nov 6;337(19):1350-8
  2. 2.0 2.1 2.2 American Cancer Society."What Are the Risk Factors for Anal Cancer?"
  3. 3.0 3.1 3.2 National Cancer Institute. Physician Data Query Database 2015. http://www.cancer.gov/types/anal/patient/anal-treatment-pdq

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