Uroguanylin: Difference between revisions

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{{infobox protein
| Name=guanylate cyclase activator 2B (uroguanylin)
| HGNCid=4683
| Symbol=GUCA2B
| AltSymbols=
| EntrezGene=2981
| OMIM=601271
| RefSeq=NM_007102
| UniProt=Q16661
| PDB=
| ECnumber=
| Chromosome=1
| Arm=p
| Band=34
| LocusSupplementaryData=-p33
}}
{{Chembox
| ImageFile = Uroguanylin.svg
| ImageFile_Ref = {{chemboximage|correct|??}}
| ImageName = Stereo, skeletal formula of uroguanylin
|Section1={{Chembox Identifiers
| CASNo = 152175-68-3
| CASNo_Ref = {{cascite|correct|??}}
| PubChem = 5488765
| ChemSpiderID = 4589972
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| MeSHName = uroguanylin
| SMILES = C[C@H]1C(=O)N[C@H]2CSSC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@@H](CSSC[C@H](NC(=O)CNC(=O)[C@@H](NC2=O)[C@@H](C)O)C(=O)N[C@@H](CC(C)C)C(=O)O)C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N1)C(C)C)CC(=O)N)C(C)C)CC(C)C)CCC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CC(=O)N)N
| StdInChI = 1S/C64H102N18O26S4/c1-24(2)13-32-53(96)79-40-23-112-109-20-37(57(100)76-36(64(107)108)14-25(3)4)70-43(86)19-68-61(104)49(29(10)83)82-60(103)39(77-50(93)28(9)69-62(105)47(26(5)6)80-56(99)33(16-42(67)85)75-63(106)48(27(7)8)81-59(40)102)22-111-110-21-38(58(101)71-31(52(95)73-32)11-12-44(87)88)78-55(98)35(18-46(91)92)74-54(97)34(17-45(89)90)72-51(94)30(65)15-41(66)84/h24-40,47-49,83H,11-23,65H2,1-10H3,(H2,66,84)(H2,67,85)(H,68,104)(H,69,105)(H,70,86)(H,71,101)(H,72,94)(H,73,95)(H,74,97)(H,75,106)(H,76,100)(H,77,93)(H,78,98)(H,79,96)(H,80,99)(H,81,102)(H,82,103)(H,87,88)(H,89,90)(H,91,92)(H,107,108)/t28-,29+,30-,31-,32-,33-,34-,35-,36-,37-,38-,39-,40-,47-,48-,49-/m0/s1
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = VQZRYOAXGUCZMI-HWMZBCIHSA-N
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
}}
|Section2={{Chembox Properties
| C=61 | H=101 | N=17 | O=25 | S=4
}}
|Section3={{Chembox Related
| OtherCompounds = [[PMDTA]]
}}
}}


'''Uroguanylin''' is a 16 [[amino acid]] [[peptide]] that is secreted by [[enterochromaffin cells]] in the [[duodenum]] and proximal [[small intestine]]. Guanylin acts as an [[agonist]] of the [[guanylyl cyclase]] receptor [[guanylate cyclase 2C]] (GC-C), and regulates [[electrolyte]] and [[water]] transport in [[intestinal]] and [[renal]] [[epithelia]]. Its sequence is H-Asn-Asp-Asp-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH.


==Overview==
In humans, the uroguanylin peptide is encoded by the ''GUCA2B'' [[gene]].<ref name="Miyazato-1996">{{cite journal | vauthors = Miyazato M, Nakazato M, Yamaguchi H, Date Y, Kojima M, Kangawa K, Matsuo H, Matsukura S | title = Cloning and characterization of a cDNA encoding a precursor for human uroguanylin | journal = Biochemical and Biophysical Research Communications | volume = 219 | issue = 2 | pages = 644–8 | date = February 1996 | pmid = 8605041 | doi = 10.1006/bbrc.1996.0287 }}</ref><ref name="Miyazato-1997">{{cite journal | vauthors = Miyazato M, Nakazato M, Matsukura S, Kangawa K, Matsuo H | title = Genomic structure and chromosomal localization of human uroguanylin | journal = Genomics | volume = 43 | issue = 3 | pages = 359–65 | date = August 1997 | pmid = 9268639 | doi = 10.1006/geno.1997.4808 }}</ref> Uroguanylin may be involved in appetite and perceptions of 'fullness' after eating meals, as suggested by a study into mice.<ref name="Rahbi-H-2012">{{cite journal | vauthors = Rahbi H, Narayan H, Jones DJ, Ng LL | title = The uroguanylin system and human disease | journal = Clinical Science | volume = 123 | issue = 12 | pages = 659–68 | date = December 2012 | pmid = 22877138 | doi = 10.1042/CS20120021 }}</ref>
{{protein
|Name=guanylate cyclase activator 2B (uroguanylin)
|caption=
|image=
|width=
|HGNCid=4683
|Symbol=GUCA2B
|AltSymbols=
|EntrezGene=2981
|OMIM=601271
|RefSeq=NM_007102
|UniProt=Q16661
|PDB=
|ECnumber=
|Chromosome=1
|Arm=p
|Band=34
|LocusSupplementaryData=-p33
}}
{{SI}}
'''Uroguanylin''' is a 16 [[amino acid]] [[peptide]] that is secreted by [[enterochromaffin cells]] in the [[duodenum]] and proximal [[small intestine]]. Guanylin acts as an [[agonist]] of the [[guanylyl cyclase]] receptor [[GC-C]] and regulates [[electrolyte]] and [[water]] transport in [[intestinal]] and [[renal]] [[epithelia]].


==See also==
== See also ==
* [[Natriuretic peptide]]
* [[Natriuretic peptide]]
* [[Plecanatide]] – a medication structurally related to uroguanylin
== References ==
{{Reflist}}


==External links==
== External links ==
* {{MeshName|uroguanylin}}
* {{MeshName|uroguanylin}}


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[[Category:Digestive system]]
[[Category:Digestive system]]


 
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Latest revision as of 17:34, 7 February 2018

guanylate cyclase activator 2B (uroguanylin)
Identifiers
SymbolGUCA2B
Entrez2981
HUGO4683
OMIM601271
RefSeqNM_007102
UniProtQ16661
Other data
LocusChr. 1 p34-p33
Template:Chembox E number
Uroguanylin
Stereo, skeletal formula of uroguanylin
Identifiers
3D model (JSmol)
ChemSpider
ECHA InfoCard Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value). Lua error in Module:Wikidata at line 879: attempt to index field 'wikibase' (a nil value).
MeSH uroguanylin
Properties
C61H101N17O25S4
Molar mass 1,600.81 g·mol−1
Related compounds
Related compounds
 PMDTA
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
Infobox references

Uroguanylin is a 16 amino acid peptide that is secreted by enterochromaffin cells in the duodenum and proximal small intestine. Guanylin acts as an agonist of the guanylyl cyclase receptor guanylate cyclase 2C (GC-C), and regulates electrolyte and water transport in intestinal and renal epithelia. Its sequence is H-Asn-Asp-Asp-Cys(1)-Glu-Leu-Cys(2)-Val-Asn-Val-Ala-Cys(1)-Thr-Gly-Cys(2)-Leu-OH.

In humans, the uroguanylin peptide is encoded by the GUCA2B gene.[1][2] Uroguanylin may be involved in appetite and perceptions of 'fullness' after eating meals, as suggested by a study into mice.[3]

See also

References

  1. ↑ Miyazato M, Nakazato M, Yamaguchi H, Date Y, Kojima M, Kangawa K, Matsuo H, Matsukura S (February 1996). "Cloning and characterization of a cDNA encoding a precursor for human uroguanylin". Biochemical and Biophysical Research Communications. 219 (2): 644–8. doi:10.1006/bbrc.1996.0287. PMID 8605041.
  2. ↑ Miyazato M, Nakazato M, Matsukura S, Kangawa K, Matsuo H (August 1997). "Genomic structure and chromosomal localization of human uroguanylin". Genomics. 43 (3): 359–65. doi:10.1006/geno.1997.4808. PMID 9268639.
  3. ↑ Rahbi H, Narayan H, Jones DJ, Ng LL (December 2012). "The uroguanylin system and human disease". Clinical Science. 123 (12): 659–68. doi:10.1042/CS20120021. PMID 22877138.

External links

Retrieved from "https://www.wikidoc.org/index.php?title=Uroguanylin&oldid=1530343"