Anasarca causes: Difference between revisions

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{{CMG}} {{AE}} {{LRO}}
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==Overview==
==Overview==
==Causes==
Common causes of anasarca include cardiovascular events, drug-induced side effects, gastroenterologic events, genetic factors, metabolic conditions, and ob/gyn conditions, such as pregnancy.


(In alphabetical order)
==Common Causes==
 
*[[Calcium channel blockers]]
*[[Acute renal failure]], especially oliguric renal failure with fluid retention
*[[Allergic reactions]], only systemic severe allergic reactions with associated capillary leak
*[[Angioedema]], rarely, when it is severe and generalized
*[[Burns]] (generalized severe burns can result in [[Hypoalbuminemia]] and capillary leak)
*[[Calcium channel blockers]] usually cause localized edma and not anasarca
*[[Capillary leak syndrome]]
*[[Cardiac tamponade ]] resulting in heart failure and generalized edema
*[[Chronic kidney disease]] (advanced stages with fluid retention)
*[[Constrictive pericarditis]] with associated heart failure
*[[Cor pulmonale]] resulting in right heart failure
*[[Diazoxide]] usually cause localized edma and not anasarca
*Corticosteriods
*[[Dilated cardiomyopathy]]
*[[Dilated cardiomyopathy]]
*[[Docetaxel]] usually cause localized edma and not anasarca
*[[Docetaxel]]
*[[Eclampsia]] (severe eclampsia)
*[[Eclampsia]]
*[[Effusive-constrictive pericarditis]] with associated heart failure
*[[Estrogens]]
*[[Fludrocortisone]]
*[[Fludrocortisone]]
*[[Glomerulonephritis]]
*[[Haemolytic disease of the newborn]]
*[[Haemolytic disease of the newborn]]
*[[Heart failure]]
*[[Heart failure]]
*Hepatic [[cirrhosis]]
**[[Alcoholic liver disease]]
**[[Alpha-1-antitrypsin deficiency]]
**[[Autoimmune hepatitis]]
**Chronic [[hepatitis B]]
**Chronic [[hepatitis C]]
**Hepatic venous obstruction
**[[Hereditary hemochromatosis]]
**[[Primary biliary cirrhosis]]
**[[Primary sclerosing cholangitis]]
**[[Non-alcoholic fatty liver disease|Nonalcoholic fatty liver disease]]
**[[Wilson's disease]]
*[[Hereditary angioedema]] in severe cases
*[[Hypertrophic cardiomyopathy]]
*[[Hypoalbuminemia]]
*[[Hypoproteinemia]]
*[[Hypothyroidism]] (advanced untreated hypothyroidism)
*Idiopathic [[edema]]
*[[Increased capillary permeability]]
*Increased interstitial oncotic pressure
*[[Interleukin-2]] therapy
*[[Kwashiorkor]]
*[[Kwashiorkor]]
*Lymphatic obstruction usually cause localized limb [[edema]] unless very proximal
*[[Malabsorption syndrome]]
*[[Malnutrition]]
*[[Minoxidil]]
*[[Malignant ascites]] is usually associated with lower extremities edema
*[[Minoxidil]] usually causes localized edema to the lower extremities
*[[Nephrotic syndrome]]
*[[Nephrotic syndrome]]
*[[Nonsteroidal antiinflammatory drug]] causes localized edma
*[[Ovarian hyperstimulation syndrome]]
*[[Ovarian hyperstimulation syndrome]]
*[[POEMS syndrome]]
*[[POEMS syndrome]]
*[[Portal thrombosis]] causes lower extremities edema
*[[Pramipexole]]
*[[Pramipexole]]
*[[Pregnancy]]
*[[Pregnancy]]
*Protein loss
*[[Sodium]] overload
*[[Protein-losing enteropathy]]
*Reduced [[albumin]] synthesis
*[[Refeeding]] edema
*[[Restrictive cardiomyopathy]]
*Severe inflammation or [[sepsis]]  
*Sodium overload
*[[Thiazolidinediones]]
*[[Trauma]] (severe trauma)
*[[Tricuspid stenosis]]
*[[Tropical sprue]]
*Venous obstruction usually causes localized edema in the limb
*[[Water overload]]
*[[Water overload]]
*[[Yellow nail syndrome]]
*[[Yellow nail syndrome]]
== '''Complete Differential Diagnosis of the Causes of Anasarca''': ==
 
(By organ system)
==Causes by Organ System==
{|style="width:75%; height:100px" border="1"
{| style="width:75%; height:100px" border="1"
|style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
| style="height:100px"; style="width:25%" border="1" bgcolor="LightSteelBlue" | '''Cardiovascular'''
|style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | [[Cardiac tamponade ]], [[Constrictive pericarditis]], [[Cor pulmonale]], [[Dilated cardiomyopathy]], [[Effusive-constrictive pericarditis]], [[Heart failure]], [[Hypertrophic cardiomyopathy]],[[Restrictive cardiomyopathy]], [[Tricuspid stenosis]]
| style="height:100px"; style="width:75%" border="1" bgcolor="Beige" | [[Cardiac tamponade ]], [[Constrictive pericarditis]], [[Cor pulmonale]], [[Dilated cardiomyopathy]], [[Effusive-constrictive pericarditis]], [[Heart failure]], [[Hypertrophic cardiomyopathy]],[[Restrictive cardiomyopathy]], [[Tricuspid stenosis]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Chemical / poisoning'''
| '''Chemical / poisoning'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Dermatologic'''
| '''Dermatologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Drug Side Effect'''
| '''Drug Side Effect'''
|bgcolor="Beige"| [[Calcium channel blockers]], [[Diazoxide]], [[Docetaxel]], [[Estrogens]]
| bgcolor="Beige"| [[Calcium channel blockers]], [[Diazoxide]], [[Docetaxel]], [[Estrogens]]
[[Fludrocortisone]], Interleukin-2 therapy, [[Minoxidil]], Nonsteroidal antiinflammatory drugs, Corticosteriods
[[Fludrocortisone]], Interleukin-2 therapy, [[Minoxidil]], Nonsteroidal antiinflammatory drugs, Corticosteriods
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Ear Nose Throat'''
| '''Ear Nose Throat'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige"| No underlying causes
|-  
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Endocrine'''
| '''Endocrine'''
|bgcolor="Beige"| Corticosteriods
| bgcolor="Beige"| Corticosteriods
|-  
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Environmental'''
| '''Environmental'''
|bgcolor="Beige"| [[Water intoxication]]
| bgcolor="Beige"| [[Water intoxication]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Gastroenterologic'''
| '''Gastroenterologic'''
|bgcolor="Beige"| [[Alcoholic liver disease ]], [[Autoimmune hepatitis]], [[Chronic hepatitis B]], [[Chronic hepatitis C]],[[Hepatic cirrhosis]], [[Hepatic venous obstruction]], [[Hereditary hemochromatosis]], [[Portal thrombosis]], [[Primary biliary cirrhosis]], [[Primary sclerosing cholangitis]], [[Wilson's disease]]
| bgcolor="Beige"| [[Alcoholic liver disease ]], [[Autoimmune hepatitis]], [[Chronic hepatitis B]], [[Chronic hepatitis C]],[[Hepatic cirrhosis]], [[Hepatic venous obstruction]], [[Hereditary hemochromatosis]], [[Portal thrombosis]], [[Primary biliary cirrhosis]], [[Primary sclerosing cholangitis]], [[Wilson's disease]]


|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Genetic'''
| '''Genetic'''
|bgcolor="Beige"| [[Angioedema]], [[Alpha-1-antitrypsin deficiency]], [[Hereditary angioedema]]
| bgcolor="Beige"| [[Angioedema]], [[Alpha-1-antitrypsin deficiency]], [[Hereditary angioedema]]
[[Hereditary hemochromatosis]], [[Hypertrophic cardiomyopathy]], [[Wilson's disease]], [[Yellow nail syndrome]]
[[Hereditary hemochromatosis]], [[Hypertrophic cardiomyopathy]], [[Wilson's disease]], [[Yellow nail syndrome]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Hematologic'''
| '''Hematologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Iatrogenic'''
| '''Iatrogenic'''
|bgcolor="Beige"| [[Water intoxication]], excess intravenous fluids
| bgcolor="Beige"| [[Water intoxication]], excess intravenous fluids
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Infectious Disease'''
| '''Infectious Disease'''
|bgcolor="Beige"| [[Tropical sprue]]
| bgcolor="Beige"| [[Tropical sprue]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Musculoskeletal / Ortho'''
| '''Musculoskeletal / Ortho'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Neurologic'''
| '''Neurologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Nutritional / Metabolic'''
| '''Nutritional / Metabolic'''
|bgcolor="Beige"| [[Hypoalbuminemia]], Hypoproteinemia, [[Kwashiorkor]], [[Malnutrition]]
| bgcolor="Beige"| [[Hypoalbuminemia]], Hypoproteinemia, [[Kwashiorkor]], [[Malnutrition]]
Protein loss, [[Protein-losing enteropathy]], Reduced albumin synthesis, Refeeding edema, Sodium overload, [[Tropical sprue]], Water overload
Protein loss, [[Protein-losing enteropathy]], Reduced albumin synthesis, Refeeding edema, Sodium overload, [[Tropical sprue]], Water overload
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Obstetric/Gynecologic'''
| '''Obstetric/Gynecologic'''
|bgcolor="Beige"|[[Eclampsia]], [[Estrogens]], [[Haemolytic disease of the newborn]], [[Ovarian hyperstimulation syndrome]],[[Pregnancy ]]
| bgcolor="Beige"|[[Eclampsia]], [[Estrogens]], [[Haemolytic disease of the newborn]], [[Ovarian hyperstimulation syndrome]],[[Pregnancy ]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Oncologic'''
| '''Oncologic'''
|bgcolor="Beige"| [[Malignant ascites]]
| bgcolor="Beige"| [[Malignant ascites]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Opthalmologic'''
| '''Opthalmologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Overdose / Toxicity'''
| '''Overdose / Toxicity'''
|bgcolor="Beige"| [[Water intoxication]]
| bgcolor="Beige"| [[Water intoxication]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Psychiatric'''
| '''Psychiatric'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Pulmonary'''
| '''Pulmonary'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Renal / Electrolyte'''
| '''Renal / Electrolyte'''
|bgcolor="Beige"| [[Nephrotic syndrome]]
| bgcolor="Beige"| [[Nephrotic syndrome]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Rheum / Immune / Allergy'''
| '''Rheum / Immune / Allergy'''
|bgcolor="Beige"| [[Haemolytic disease of the newborn]], [[Autoimmune hepatitis]]
| bgcolor="Beige"| [[Haemolytic disease of the newborn]], [[Autoimmune hepatitis]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Sexual'''
| '''Sexual'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Trauma'''
| '''Trauma'''
|bgcolor="Beige"| [[Trauma]]
| bgcolor="Beige"| [[Trauma]]
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Urologic'''
| '''Urologic'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige"| No underlying causes
|-
|-
|-bgcolor="LightSteelBlue"
|- bgcolor="LightSteelBlue"
| '''Miscellaneous'''
| '''Miscellaneous'''
|bgcolor="Beige"| No underlying causes
| bgcolor="Beige"| No underlying causes
|-
|-
|}
|}
<br>
<br>
==References==


==Causes in Alphabetical Order==
{{columns-list|
* [[Acute renal failure]]
* [[Allergic reactions]]
* [[Angioedema]]
* [[Burns]]
* [[Calcium channel blockers]]
* [[Capillary leak syndrome]]
* [[Cardiac tamponade ]]
* [[Chronic kidney disease]]
* [[Constrictive pericarditis]]
* [[Cor pulmonale]]
* [[Diazoxide]]
* Corticosteriods
* [[Dilated cardiomyopathy]]
* [[Docetaxel]]
* [[Eclampsia]]
* [[Effusive-constrictive pericarditis]]
* [[Estrogens]]
* [[Fludrocortisone]]
* [[Glomerulonephritis]]
* [[Haemolytic disease of the newborn]]
* [[Heart failure]]
* Hepatic [[cirrhosis]]
** [[Alcoholic liver disease]]
** [[Alpha-1-antitrypsin deficiency]]
** [[Autoimmune hepatitis]]
** Chronic [[hepatitis B]]
** Chronic [[hepatitis C]]
** Hepatic venous obstruction
** [[Hereditary hemochromatosis]]
** [[Primary biliary cirrhosis]]
** [[Primary sclerosing cholangitis]]
** [[Non-alcoholic fatty liver disease|Nonalcoholic fatty liver disease]]
** [[Wilson's disease]]
* [[Hereditary angioedema]]
* [[Hypertrophic cardiomyopathy]]
* [[Hypoalbuminemia]]
* [[Hypoproteinemia]]
* [[Hypothyroidism]]
* Idiopathic [[edema]]
* [[Increased capillary permeability]]
* Increased interstitial oncotic pressure
* [[Interleukin-2]] therapy
* [[Kwashiorkor]]
* Lymphatic obstruction
* [[Malnutrition]]
* [[Malignant ascites]]
* [[Minoxidil]]
* [[Nephrotic syndrome]]
* [[Nonsteroidal antiinflammatory drug]]
* [[Ovarian hyperstimulation syndrome]]
* [[POEMS syndrome]]
* [[Portal thrombosis]]
* [[Pramipexole]]
* [[Pregnancy]]
* Protein loss
* [[Protein-losing enteropathy]]
* Reduced [[albumin]]
* [[Refeeding]]
* [[Restrictive cardiomyopathy]]
* [[Rifaximin]]
* Severe inflammation or [[sepsis]]
* Sodium overload
* [[Thiazolidinediones]]
* [[Trauma]] (severe trauma)
* [[Tricuspid stenosis]]
* [[Tropical sprue]]
* Venous obstruction
* [[Water overload]]
* [[Yellow nail syndrome]]
}}
== References ==
{{reflist|2}}
{{reflist|2}}


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Latest revision as of 20:12, 10 January 2020

Anasarca Microchapters

Home

Patient Information

Overview

Classification

Causes

Differential Diagnosis

Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief: Luke Rusowicz-Orazem, B.S.

Overview

Common causes of anasarca include cardiovascular events, drug-induced side effects, gastroenterologic events, genetic factors, metabolic conditions, and ob/gyn conditions, such as pregnancy.

Common Causes

Causes by Organ System

Cardiovascular Cardiac tamponade , Constrictive pericarditis, Cor pulmonale, Dilated cardiomyopathy, Effusive-constrictive pericarditis, Heart failure, Hypertrophic cardiomyopathy,Restrictive cardiomyopathy, Tricuspid stenosis
Chemical / poisoning No underlying causes
Dermatologic No underlying causes
Drug Side Effect Calcium channel blockers, Diazoxide, Docetaxel, Estrogens

Fludrocortisone, Interleukin-2 therapy, Minoxidil, Nonsteroidal antiinflammatory drugs, Corticosteriods

Ear Nose Throat No underlying causes
Endocrine Corticosteriods
Environmental Water intoxication
Gastroenterologic Alcoholic liver disease , Autoimmune hepatitis, Chronic hepatitis B, Chronic hepatitis C,Hepatic cirrhosis, Hepatic venous obstruction, Hereditary hemochromatosis, Portal thrombosis, Primary biliary cirrhosis, Primary sclerosing cholangitis, Wilson's disease
Genetic Angioedema, Alpha-1-antitrypsin deficiency, Hereditary angioedema

Hereditary hemochromatosis, Hypertrophic cardiomyopathy, Wilson's disease, Yellow nail syndrome

Hematologic No underlying causes
Iatrogenic Water intoxication, excess intravenous fluids
Infectious Disease Tropical sprue
Musculoskeletal / Ortho No underlying causes
Neurologic No underlying causes
Nutritional / Metabolic Hypoalbuminemia, Hypoproteinemia, Kwashiorkor, Malnutrition

Protein loss, Protein-losing enteropathy, Reduced albumin synthesis, Refeeding edema, Sodium overload, Tropical sprue, Water overload

Obstetric/Gynecologic Eclampsia, Estrogens, Haemolytic disease of the newborn, Ovarian hyperstimulation syndrome,Pregnancy
Oncologic Malignant ascites
Opthalmologic No underlying causes
Overdose / Toxicity Water intoxication
Psychiatric No underlying causes
Pulmonary No underlying causes
Renal / Electrolyte Nephrotic syndrome
Rheum / Immune / Allergy Haemolytic disease of the newborn, Autoimmune hepatitis
Sexual No underlying causes
Trauma Trauma
Urologic No underlying causes
Miscellaneous No underlying causes

Causes in Alphabetical Order

References

Template:WH Template:WS

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