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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Use dmy dates|date=June 2016}}
{{PBB_Controls
{{Infobox_gene}}
| update_page = yes
'''Disintegrin and metalloproteinase domain-containing protein 2''' or '''Beta-fertilin'''<ref name="fertilin">{{cite journal | vauthors = Fàbrega A, Guyonnet B, Dacheux JL, Gatti JL, Puigmulé M, Bonet S, Pinart E | title = Expression, immunolocalization and processing of fertilins ADAM-1 and ADAM-2 in the boar (Sus domesticus) spermatozoa during epididymal maturation | journal = Reproductive Biology and Endocrinology | volume = 9 | pages = 96 | date = June 2011 | pmid = 21718510 | doi = 10.1186/1477-7827-9-96 | pmc = 3141649 }}</ref> is an [[enzyme]] that in humans is encoded by the ''ADAM2'' [[gene]].<ref name="pmid8702389">{{cite journal | vauthors = Gupta SK, Alves K, Palladino LO, Mark GE, Hollis GF | title = Molecular cloning of the human fertilin beta subunit | journal = Biochemical and Biophysical Research Communications | volume = 224 | issue = 2 | pages = 318–26 | date = July 1996 | pmid = 8702389 | pmc =  | doi = 10.1006/bbrc.1996.1027 }}</ref><ref name="pmid9070941">{{cite journal | vauthors = Burkin HR, Burkin DJ, Davey PM, Griffin DK, Affara NA | title = Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB) | journal = Genomics | volume = 40 | issue = 1 | pages = 190–2 | date = February 1997 | pmid = 9070941 | pmc = | doi = 10.1006/geno.1996.4531 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2515| accessdate = }}</ref>
| require_manual_inspection = no
| update_protein_box = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ADAM metallopeptidase domain 2 (fertilin beta)
| HGNCid = 198
| Symbol = ADAM2
| AltSymbols =; CRYN1; CRYN2; FTNB; PH-30b; PH30
| OMIM = 601533
| ECnumber = 
| Homologene = 1127
| MGIid = 1340894
| GeneAtlas_image1 = PBB_GE_ADAM2_207664_at_tn.png
| Function = {{GNF_GO|id=GO:0004222 |text = metalloendopeptidase activity}} {{GNF_GO|id=GO:0005178 |text = integrin binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007155 |text = cell adhesion}} {{GNF_GO|id=GO:0007342 |text = fusion of sperm to egg plasma membrane}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2515
    | Hs_Ensembl = ENSG00000104755
    | Hs_RefseqProtein = NP_001455
    | Hs_RefseqmRNA = NM_001464
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 8
    | Hs_GenLoc_start = 39720414
    | Hs_GenLoc_end = 39814936
    | Hs_Uniprot = Q99965
    | Mm_EntrezGene = 11495
    | Mm_Ensembl = ENSMUSG00000022039
    | Mm_RefseqmRNA = NM_009618
    | Mm_RefseqProtein = NP_033748
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 64981442
    | Mm_GenLoc_end = 65031845
    | Mm_Uniprot = Q3TTP6
  }}
}}
'''ADAM metallopeptidase domain 2 (fertilin beta)''', also known as '''ADAM2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2515| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell–matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane [[heterodimer]] glycoprotein called [[fertilin]], which plays an important role in sperm-egg interactions.<ref name="entrez"/> The other subunit is [[ADAM1]] or alpha-fertilin.<ref name="fertilin"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane glycoprotein called fertilin, which plays an important role in sperm-egg interactions.<ref name="entrez">{{cite web | title = Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2515| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Eto K, Huet C, Tarui T, Kupriyanov S, Liu HZ, Puzon-McLaughlin W, Zhang XP, Sheppard D, Engvall E, Takada Y | title = Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions | journal = The Journal of Biological Chemistry | volume = 277 | issue = 20 | pages = 17804–10 | date = May 2002 | pmid = 11882657 | doi = 10.1074/jbc.M200086200 }}
| citations =
* {{cite journal | vauthors = Ikawa M, Nakanishi T, Yamada S, Wada I, Kominami K, Tanaka H, Nozaki M, Nishimune Y, Okabe M | title = Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility | journal = Developmental Biology | volume = 240 | issue = 1 | pages = 254–61 | date = December 2001 | pmid = 11784061 | doi = 10.1006/dbio.2001.0462 }}
*{{cite journal | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
* {{cite journal | vauthors = Cho C, Ge H, Branciforte D, Primakoff P, Myles DG | title = Analysis of mouse fertilin in wild-type and fertilin beta(-/-) sperm: evidence for C-terminal modification, alpha/beta dimerization, and lack of essential role of fertilin alpha in sperm-egg fusion | journal = Developmental Biology | volume = 222 | issue = 2 | pages = 289–95 | date = June 2000 | pmid = 10837118 | doi = 10.1006/dbio.2000.9703 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
* {{cite journal | vauthors = Chen MS, Tung KS, Coonrod SA, Takahashi Y, Bigler D, Chang A, Yamashita Y, Kincade PW, Herr JC, White JM | title = Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 96 | issue = 21 | pages = 11830–5 | date = October 1999 | pmid = 10518536 | pmc = 18372 | doi = 10.1073/pnas.96.21.11830 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Chen H, Sampson NS | title = Mediation of sperm-egg fusion: evidence that mouse egg alpha6beta1 integrin is the receptor for sperm fertilinbeta | journal = Chemistry & Biology | volume = 6 | issue = 1 | pages = 1–10 | date = January 1999 | pmid = 9889149 | doi = 10.1016/S1074-5521(99)80015-5 }}
*{{cite journal  | author=Eto K, Huet C, Tarui T, ''et al.'' |title=Functional classification of ADAMs based on a conserved motif for binding to integrin alpha 9beta 1: implications for sperm-egg binding and other cell interactions. |journal=J. Biol. Chem. |volume=277 |issue= 20 |pages= 17804-10 |year= 2002 |pmid= 11882657 |doi= 10.1074/jbc.M200086200 }}
* {{cite journal | vauthors = Vidaeus CM, von Kapp-Herr C, Golden WL, Eddy RL, Shows TB, Herr JC | title = Human fertilin beta: identification, characterization, and chromosomal mapping of an ADAM gene family member | journal = Molecular Reproduction and Development | volume = 46 | issue = 3 | pages = 363–9 | date = March 1997 | pmid = 9041139 | doi = 10.1002/(SICI)1098-2795(199703)46:3<363::AID-MRD15>3.0.CO;2-# }}
*{{cite journal | author=Ikawa M, Nakanishi T, Yamada S, ''et al.'' |title=Calmegin is required for fertilin alpha/beta heterodimerization and sperm fertility. |journal=Dev. Biol. |volume=240 |issue= 1 |pages= 254-61 |year= 2002 |pmid= 11784061 |doi= 10.1006/dbio.2001.0462 }}
* {{cite journal | vauthors = Dawson SJ, White LA | title = Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin | journal = The Journal of Infection | volume = 24 | issue = 3 | pages = 317–20 | date = May 1992 | pmid = 1602151 | doi = 10.1016/S0163-4453(05)80037-4 }}
*{{cite journal | author=Cho C, Ge H, Branciforte D, ''et al.'' |title=Analysis of mouse fertilin in wild-type and fertilin beta(-/-) sperm: evidence for C-terminal modification, alpha/beta dimerization, and lack of essential role of fertilin alpha in sperm-egg fusion. |journal=Dev. Biol. |volume=222 |issue= 2 |pages= 289-95 |year= 2000 |pmid= 10837118 |doi= 10.1006/dbio.2000.9703 }}
*{{cite journal | author=Chen MS, Tung KS, Coonrod SA, ''et al.'' |title=Role of the integrin-associated protein CD9 in binding between sperm ADAM 2 and the egg integrin alpha6beta1: implications for murine fertilization. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 21 |pages= 11830-5 |year= 1999 |pmid= 10518536 |doi= }}
*{{cite journal | author=Chen H, Sampson NS |title=Mediation of sperm-egg fusion: evidence that mouse egg alpha6beta1 integrin is the receptor for sperm fertilinbeta. |journal=Chem. Biol. |volume=6 |issue= 1 |pages= 1-10 |year= 1999 |pmid= 9889149 |doi= 10.1016/S1074-5521(99)80015-5 }}
*{{cite journal | author=Burkin HR, Burkin DJ, Davey PM, ''et al.'' |title=Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB). |journal=Genomics |volume=40 |issue= 1 |pages= 190-2 |year= 1997 |pmid= 9070941 |doi= 10.1006/geno.1996.4531 }}
*{{cite journal  | author=Vidaeus CM, von Kapp-Herr C, Golden WL, ''et al.'' |title=Human fertilin beta: identification, characterization, and chromosomal mapping of an ADAM gene family member. |journal=Mol. Reprod. Dev. |volume=46 |issue= 3 |pages= 363-9 |year= 1997 |pmid= 9041139 |doi= 10.1002/(SICI)1098-2795(199703)46:3<363::AID-MRD15>3.0.CO;2-# }}
*{{cite journal | author=Gupta SK, Alves K, Palladino LO, ''et al.'' |title=Molecular cloning of the human fertilin beta subunit. |journal=Biochem. Biophys. Res. Commun. |volume=224 |issue= 2 |pages= 318-26 |year= 1996 |pmid= 8702389 |doi= 10.1006/bbrc.1996.1027 }}
*{{cite journal  | author=Dawson SJ, White LA |title=Treatment of Haemophilus aphrophilus endocarditis with ciprofloxacin. |journal=J. Infect. |volume=24 |issue= 3 |pages= 317-20 |year= 1992 |pmid= 1602151 |doi= }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
== External links ==
{{WikiDoc Sources}}
* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=M12.950 M12.950]
* {{UCSC gene info|ADAM2}}
 
{{Metalloendopeptidases}}
{{Enzymes}}
{{Portal bar|Molecular and Cellular Biology|border=no}}
 
{{DEFAULTSORT:Adam2}}
[[Category:Peptidase]]
[[Category:Human proteins]]
[[Category:EC 3.4.24]]
 
 
{{gene-8-stub}}

Latest revision as of 08:44, 10 January 2019

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Disintegrin and metalloproteinase domain-containing protein 2 or Beta-fertilin[1] is an enzyme that in humans is encoded by the ADAM2 gene.[2][3][4]

Function

This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins, and have been implicated in a variety of biological processes involving cell–cell and cell–matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a subunit of an integral sperm membrane heterodimer glycoprotein called fertilin, which plays an important role in sperm-egg interactions.[4] The other subunit is ADAM1 or alpha-fertilin.[1]

References

  1. ↑ 1.0 1.1 Fàbrega A, Guyonnet B, Dacheux JL, Gatti JL, Puigmulé M, Bonet S, Pinart E (June 2011). "Expression, immunolocalization and processing of fertilins ADAM-1 and ADAM-2 in the boar (Sus domesticus) spermatozoa during epididymal maturation". Reproductive Biology and Endocrinology. 9: 96. doi:10.1186/1477-7827-9-96. PMC 3141649. PMID 21718510.
  2. ↑ Gupta SK, Alves K, Palladino LO, Mark GE, Hollis GF (July 1996). "Molecular cloning of the human fertilin beta subunit". Biochemical and Biophysical Research Communications. 224 (2): 318–26. doi:10.1006/bbrc.1996.1027. PMID 8702389.
  3. ↑ Burkin HR, Burkin DJ, Davey PM, Griffin DK, Affara NA (February 1997). "Mapping, sequence, and expression analysis of the human fertilin beta gene (FTNB)". Genomics. 40 (1): 190–2. doi:10.1006/geno.1996.4531. PMID 9070941.
  4. ↑ 4.0 4.1 "Entrez Gene: ADAM2 ADAM metallopeptidase domain 2 (fertilin beta)".

Further reading

External links


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