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{{Infobox_gene}}
{{PBB_Controls
'''Brefeldin A-inhibited guanine nucleotide-exchange protein 2''' is a [[protein]] that in humans is encoded by the ''ARFGEF2'' [[gene]].<ref name="pmid10212200">{{cite journal | vauthors = Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M | title = Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors | journal = The Journal of Biological Chemistry | volume = 274 | issue = 18 | pages = 12308–15 | date = Apr 1999 | pmid = 10212200 | pmc =  | doi = 10.1074/jbc.274.18.12308 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10564| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)
| HGNCid = 15853
| Symbol = ARFGEF2
| AltSymbols =; BIG2; FLJ23723; dJ1164I10.1
| OMIM = 605371
| ECnumber = 
| Homologene = 21287
| MGIid = 2139354
| GeneAtlas_image1 = PBB_GE_ARFGEF2_218098_at_tn.png
| GeneAtlas_image2 = PBB_GE_ARFGEF2_215931_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005086 |text = ARF guanyl-nucleotide exchange factor activity}}
| Component = {{GNF_GO|id=GO:0000139 |text = Golgi membrane}} {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0005829 |text = cytosol}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0006887 |text = exocytosis}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0032012 |text = regulation of ARF protein signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 10564
    | Hs_Ensembl = ENSG00000124198
    | Hs_RefseqProtein = NP_006411
    | Hs_RefseqmRNA = NM_006420
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 46971834
    | Hs_GenLoc_end = 47086637
    | Hs_Uniprot = Q9Y6D5
    | Mm_EntrezGene = 99371
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_130646
    | Mm_RefseqProtein = XP_130646
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)''', also known as '''ARFGEF2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10564| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[ADP-ribosylation factor]]s (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in [[Golgi apparatus|Golgi]] transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.<ref name="entrez">{{cite web | title = Entrez Gene: ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=10564| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
ARFGEF2 has been shown to [[Protein-protein interaction|interact]] with [[ARFGEF1]],<ref name=pmid10716990>{{cite journal | vauthors = Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M | title = Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 6 | pages = 2567–72 | date = Mar 2000 | pmid = 10716990 | pmc = 15969 | doi = 10.1073/pnas.97.6.2567 }}</ref> [[PRKAR1A]]<ref name=pmid12571360>{{cite journal | vauthors = Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M | title = Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2) | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 4 | pages = 1627–32 | date = Feb 2003 | pmid = 12571360 | pmc = 149883 | doi = 10.1073/pnas.0337678100 }}</ref> and [[PRKAR2A]].<ref name=pmid12571360/>
 
== References ==
{{reflist}}
 
==External links==
* {{UCSC gene info|ARFGEF2}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M | title = Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 97 | issue = 6 | pages = 2567–72 | date = Mar 2000 | pmid = 10716990 | pmc = 15969 | doi = 10.1073/pnas.97.6.2567 }}
| citations =
* {{cite journal | vauthors = Kamei Y, Takeda Y, Teramoto K, Tsutsumi O, Taketani Y, Watanabe K | title = Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members | journal = Genomics | volume = 69 | issue = 1 | pages = 113–9 | date = Oct 2000 | pmid = 11013081 | doi = 10.1006/geno.2000.6310 }}
*{{cite journal | author=Togawa A, Morinaga N, Ogasawara M, ''et al.'' |title=Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors. |journal=J. Biol. Chem. |volume=274 |issue= 18 |pages= 12308-15 |year= 1999 |pmid= 10212200 |doi=  }}
* {{cite journal | vauthors = Pacheco-Rodriguez G, Moss J, Vaughan M | title = BIG1 and BIG2: brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors | journal = Methods in Enzymology | volume = 345 | issue =  | pages = 397–404 | year = 2002 | pmid = 11665623 | doi = 10.1016/S0076-6879(02)45032-X }}
*{{cite journal  | author=Yamaji R, Adamik R, Takeda K, ''et al.'' |title=Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 6 |pages= 2567-72 |year= 2000 |pmid= 10716990 |doi= }}
* {{cite journal | vauthors = Shinotsuka C, Yoshida Y, Kawamoto K, Takatsu H, Nakayama K | title = Overexpression of an ADP-ribosylation factor-guanine nucleotide exchange factor, BIG2, uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation | journal = The Journal of Biological Chemistry | volume = 277 | issue = 11 | pages = 9468–73 | date = Mar 2002 | pmid = 11777925 | doi = 10.1074/jbc.M112427200 }}
*{{cite journal | author=Kamei Y, Takeda Y, Teramoto K, ''et al.'' |title=Human NB-2 of the contactin subgroup molecules: chromosomal localization of the gene (CNTN5) and distinct expression pattern from other subgroup members. |journal=Genomics |volume=69 |issue= 1 |pages= 113-9 |year= 2001 |pmid= 11013081 |doi= 10.1006/geno.2000.6310 }}
* {{cite journal | vauthors = Shinotsuka C, Waguri S, Wakasugi M, Uchiyama Y, Nakayama K | title = Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins | journal = Biochemical and Biophysical Research Communications | volume = 294 | issue = 2 | pages = 254–60 | date = Jun 2002 | pmid = 12051703 | doi = 10.1016/S0006-291X(02)00456-4 }}
*{{cite journal | author=Pacheco-Rodriguez G, Moss J, Vaughan M |title=BIG1 and BIG2: brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors. |journal=Meth. Enzymol. |volume=345 |issue=  |pages= 397-404 |year= 2002 |pmid= 11665623 |doi= }}
* {{cite journal | vauthors = Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M | title = Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2) | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 4 | pages = 1627–32 | date = Feb 2003 | pmid = 12571360 | pmc = 149883 | doi = 10.1073/pnas.0337678100 }}
*{{cite journal | author=Shinotsuka C, Yoshida Y, Kawamoto K, ''et al.'' |title=Overexpression of an ADP-ribosylation factor-guanine nucleotide exchange factor, BIG2, uncouples brefeldin A-induced adaptor protein-1 coat dissociation and membrane tubulation. |journal=J. Biol. Chem. |volume=277 |issue= 11 |pages= 9468-73 |year= 2002 |pmid= 11777925 |doi= 10.1074/jbc.M112427200 }}
* {{cite journal | vauthors = Sheen VL, Ganesh VS, Topcu M, Sebire G, Bodell A, Hill RS, Grant PE, Shugart YY, Imitola J, Khoury SJ, Guerrini R, Walsh CA | title = Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex | journal = Nature Genetics | volume = 36 | issue = 1 | pages = 69–76 | date = Jan 2004 | pmid = 14647276 | doi = 10.1038/ng1276 }}
*{{cite journal | author=Deloukas P, Matthews LH, Ashurst J, ''et al.'' |title=The DNA sequence and comparative analysis of human chromosome 20. |journal=Nature |volume=414 |issue= 6866 |pages= 865-71 |year= 2002 |pmid= 11780052 |doi= 10.1038/414865a }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = Jul 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
*{{cite journal  | author=Shinotsuka C, Waguri S, Wakasugi M, ''et al.'' |title=Dominant-negative mutant of BIG2, an ARF-guanine nucleotide exchange factor, specifically affects membrane trafficking from the trans-Golgi network through inhibiting membrane association of AP-1 and GGA coat proteins. |journal=Biochem. Biophys. Res. Commun. |volume=294 |issue= 2 |pages= 254-60 |year= 2002 |pmid= 12051703 |doi= 10.1016/S0006-291X(02)00456-4 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Xu KF, Shen X, Li H, Pacheco-Rodriguez G, Moss J, Vaughan M | title = Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70 | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 102 | issue = 8 | pages = 2784–9 | date = Feb 2005 | pmid = 15705715 | pmc = 549493 | doi = 10.1073/pnas.0409871102 }}
*{{cite journal  | author=Li H, Adamik R, Pacheco-Rodriguez G, ''et al.'' |title=Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2). |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 4 |pages= 1627-32 |year= 2003 |pmid= 12571360 |doi= 10.1073/pnas.0337678100 }}
* {{cite journal | vauthors = Lu J, Tiao G, Folkerth R, Hecht J, Walsh C, Sheen V | title = Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia | journal = The Journal of Comparative Neurology | volume = 494 | issue = 3 | pages = 476–84 | date = Jan 2006 | pmid = 16320251 | doi = 10.1002/cne.20806 }}
*{{cite journal | author=Sheen VL, Ganesh VS, Topcu M, ''et al.'' |title=Mutations in ARFGEF2 implicate vesicle trafficking in neural progenitor proliferation and migration in the human cerebral cortex. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 69-76 |year= 2004 |pmid= 14647276 |doi= 10.1038/ng1276 }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = Nov 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
* {{cite journal | vauthors = Islam A, Shen X, Hiroi T, Moss J, Vaughan M, Levine SJ | title = The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles | journal = The Journal of Biological Chemistry | volume = 282 | issue = 13 | pages = 9591–9 | date = Mar 2007 | pmid = 17276987 | doi = 10.1074/jbc.M607122200 }}
*{{cite journal  | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
* {{cite journal | vauthors = Kuroda F, Moss J, Vaughan M | title = Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 104 | issue = 9 | pages = 3201–6 | date = Feb 2007 | pmid = 17360629 | pmc = 1805514 | doi = 10.1073/pnas.0611696104 }}
*{{cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal | author=Xu KF, Shen X, Li H, ''et al.'' |title=Interaction of BIG2, a brefeldin A-inhibited guanine nucleotide-exchange protein, with exocyst protein Exo70. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=102 |issue= 8 |pages= 2784-9 |year= 2005 |pmid= 15705715 |doi= 10.1073/pnas.0409871102 }}
*{{cite journal | author=Lu J, Tiao G, Folkerth R, ''et al.'' |title=Overlapping expression of ARFGEF2 and Filamin A in the neuroependymal lining of the lateral ventricles: insights into the cause of periventricular heterotopia. |journal=J. Comp. Neurol. |volume=494 |issue= 3 |pages= 476-84 |year= 2006 |pmid= 16320251 |doi= 10.1002/cne.20806 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
*{{cite journal | author=Islam A, Shen X, Hiroi T, ''et al.'' |title=The brefeldin A-inhibited guanine nucleotide-exchange protein, BIG2, regulates the constitutive release of TNFR1 exosome-like vesicles. |journal=J. Biol. Chem. |volume=282 |issue= 13 |pages= 9591-9 |year= 2007 |pmid= 17276987 |doi= 10.1074/jbc.M607122200 }}
*{{cite journal | author=Kuroda F, Moss J, Vaughan M |title=Regulation of brefeldin A-inhibited guanine nucleotide-exchange protein 1 (BIG1) and BIG2 activity via PKA and protein phosphatase 1gamma. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 9 |pages= 3201-6 |year= 2007 |pmid= 17360629 |doi= 10.1073/pnas.0611696104 }}
}}
{{refend}}
{{refend}}


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{{WikiDoc Sources}}
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Latest revision as of 02:11, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Brefeldin A-inhibited guanine nucleotide-exchange protein 2 is a protein that in humans is encoded by the ARFGEF2 gene.[1][2]

Function

ADP-ribosylation factors (ARFs) play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP and is involved in Golgi transport. It contains a Sec7 domain, which may be responsible for its guanine-nucleotide exchange activity and also brefeldin A inhibition.[2]

Interactions

ARFGEF2 has been shown to interact with ARFGEF1,[3] PRKAR1A[4] and PRKAR2A.[4]

References

  1. ↑ Togawa A, Morinaga N, Ogasawara M, Moss J, Vaughan M (Apr 1999). "Purification and cloning of a brefeldin A-inhibited guanine nucleotide-exchange protein for ADP-ribosylation factors". The Journal of Biological Chemistry. 274 (18): 12308–15. doi:10.1074/jbc.274.18.12308. PMID 10212200.
  2. ↑ 2.0 2.1 "Entrez Gene: ARFGEF2 ADP-ribosylation factor guanine nucleotide-exchange factor 2 (brefeldin A-inhibited)".
  3. ↑ Yamaji R, Adamik R, Takeda K, Togawa A, Pacheco-Rodriguez G, Ferrans VJ, Moss J, Vaughan M (Mar 2000). "Identification and localization of two brefeldin A-inhibited guanine nucleotide-exchange proteins for ADP-ribosylation factors in a macromolecular complex". Proceedings of the National Academy of Sciences of the United States of America. 97 (6): 2567–72. doi:10.1073/pnas.97.6.2567. PMC 15969. PMID 10716990.
  4. ↑ 4.0 4.1 Li H, Adamik R, Pacheco-Rodriguez G, Moss J, Vaughan M (Feb 2003). "Protein kinase A-anchoring (AKAP) domains in brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2)". Proceedings of the National Academy of Sciences of the United States of America. 100 (4): 1627–32. doi:10.1073/pnas.0337678100. PMC 149883. PMID 12571360.

External links

Further reading


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