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{{Infobox_gene}}
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'''Calpain-5''' is a [[protein]] that in humans is encoded by the ''CAPN5'' [[gene]].<ref name="pmid9503024">{{cite journal | vauthors = Matena K, Boehm T, Dear N | title = Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily | journal = Genomics | volume = 48 | issue = 1 | pages = 117–20 |date=Apr 1998 | pmid = 9503024 | pmc =  | doi =10.1006/geno.1997.5133 }}</ref><ref name="pmid9367857">{{cite journal | vauthors = Mugita N, Kimura Y, Ogawa M, Saya H, Nakao M | title = Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene | journal = Biochem Biophys Res Commun | volume = 239 | issue = 3 | pages = 845–50 |date=Dec 1997 | pmid = 9367857 | pmc =  | doi = 10.1006/bbrc.1997.7571 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: CAPN5 calpain 5| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=726| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Calpain 5
| HGNCid = 1482
| Symbol = CAPN5
| AltSymbols =; FLJ46245; HTRA3; nCL-3
| OMIM = 602537
| ECnumber =
| Homologene = 31212
| MGIid = 1100859
  | GeneAtlas_image1 = PBB_GE_CAPN5_205166_at_tn.png
  | Function = {{GNF_GO|id=GO:0004198 |text = calpain activity}}  
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}}
| Process = {{GNF_GO|id=GO:0006508 |text = proteolysis}} {{GNF_GO|id=GO:0007165 |text = signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 726
    | Hs_Ensembl = ENSG00000149260
    | Hs_RefseqProtein = NP_004046
    | Hs_RefseqmRNA = NM_004055
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 11
    | Hs_GenLoc_start = 76455659
    | Hs_GenLoc_end = 76514844
    | Hs_Uniprot = O15484
    | Mm_EntrezGene = 12337
    | Mm_Ensembl = ENSMUSG00000035547
    | Mm_RefseqmRNA = NM_007602
    | Mm_RefseqProtein = NP_031628
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 7
    | Mm_GenLoc_start = 97996757
    | Mm_GenLoc_end = 98053385
    | Mm_Uniprot = Q3TDS7
  }}
}}
'''Calpain 5''', also known as '''CAPN5''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CAPN5 calpain 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=726| accessdate = }}</ref>


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{{PBB_Summary
{{PBB Summary
| section_title =  
| section_title =  
| summary_text = Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.<ref name="entrez">{{cite web | title = Entrez Gene: CAPN5 calpain 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=726| accessdate = }}</ref>
| summary_text = Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.<ref name="entrez" />
}}
}}


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Vanderklish PW, Bahr BA |title=The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states. |journal=International journal of experimental pathology |volume=81 |issue= 5 |pages= 323-39 |year= 2001 |pmid= 11168679 |doi= }}
*{{cite journal  | vauthors=Vanderklish PW, Bahr BA |title=The pathogenic activation of calpain: a marker and mediator of cellular toxicity and disease states |journal=International journal of experimental pathology |volume=81 |issue= 5 |pages= 323–39 |year= 2001 |pmid= 11168679 |doi=10.1111/j.1365-2613.2000.00169.x |pmc=2517738}}
*{{cite journal  | author=Sato K, Kawashima S |title=Calpain function in the modulation of signal transduction molecules. |journal=Biol. Chem. |volume=382 |issue= 5 |pages= 743-51 |year= 2002 |pmid= 11517927 |doi=  }}
*{{cite journal  | vauthors=Sato K, Kawashima S |title=Calpain function in the modulation of signal transduction molecules |journal=Biol. Chem. |volume=382 |issue= 5 |pages= 743–51 |year= 2002 |pmid= 11517927 |doi=10.1515/BC.2001.090 }}
*{{cite journal  | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791-806 |year= 1997 |pmid= 8889548 |doi=  }}
*{{cite journal  | vauthors=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=10.1101/gr.6.9.791 }}
*{{cite journal  | author=Dear N, Matena K, Vingron M, Boehm T |title=A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution. |journal=Genomics |volume=45 |issue= 1 |pages= 175-84 |year= 1997 |pmid= 9339374 |doi= 10.1006/geno.1997.4870 }}
*{{cite journal  | vauthors=Dear N, Matena K, Vingron M, Boehm T |title=A new subfamily of vertebrate calpains lacking a calmodulin-like domain: implications for calpain regulation and evolution |journal=Genomics |volume=45 |issue= 1 |pages= 175–84 |year= 1997 |pmid= 9339374 |doi= 10.1006/geno.1997.4870 }}
*{{cite journal  | author=Mugita N, Kimura Y, Ogawa M, ''et al.'' |title=Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene. |journal=Biochem. Biophys. Res. Commun. |volume=239 |issue= 3 |pages= 845-50 |year= 1997 |pmid= 9367857 |doi= 10.1006/bbrc.1997.7571 }}
*{{cite journal  | vauthors=Strausberg RL, Feingold EA, Grouse LH |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |display-authors=etal}}
*{{cite journal  | author=Matena K, Boehm T, Dear N |title=Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily. |journal=Genomics |volume=48 |issue= 1 |pages= 117-20 |year= 1998 |pmid= 9503024 |doi=  }}
*{{cite journal  | vauthors=Ota T, Suzuki Y, Nishikawa T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |display-authors=etal}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Waghray A, Wang DS, McKinsey D |title=Molecular cloning and characterization of rat and human calpain-5 |journal=Biochem. Biophys. Res. Commun. |volume=324 |issue= 1 |pages= 46–51 |year= 2004 |pmid= 15464980 |doi= 10.1016/j.bbrc.2004.09.012 |display-authors=etal}}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | vauthors=Gerhard DS, Wagner L, Feingold EA |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |display-authors=etal}}
*{{cite journal  | author=Waghray A, Wang DS, McKinsey D, ''et al.'' |title=Molecular cloning and characterization of rat and human calpain-5. |journal=Biochem. Biophys. Res. Commun. |volume=324 |issue= 1 |pages= 46-51 |year= 2004 |pmid= 15464980 |doi= 10.1016/j.bbrc.2004.09.012 }}
*{{cite journal  | vauthors=González A, Sáez ME, Aragón MJ |title=Specific haplotypes of the CALPAIN-5 gene are associated with polycystic ovary syndrome |journal=Hum. Reprod. |volume=21 |issue= 4 |pages= 943–51 |year= 2006 |pmid= 16396936 |doi= 10.1093/humrep/dei443 |display-authors=etal}}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | vauthors=Sáez ME, Martínez-Larrad MT, Ramírez-Lorca R |title=Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels |journal=BMC Med. Genet. |volume=8|pages= 1 |year= 2007 |pmid= 17227582 |doi= 10.1186/1471-2350-8-1 | pmc=1783645 |display-authors=etal}}
*{{cite journal  | author=González A, Sáez ME, Aragón MJ, ''et al.'' |title=Specific haplotypes of the CALPAIN-5 gene are associated with polycystic ovary syndrome. |journal=Hum. Reprod. |volume=21 |issue= 4 |pages= 943-51 |year= 2006 |pmid= 16396936 |doi= 10.1093/humrep/dei443 }}
*{{cite journal  | author=Sáez ME, Martínez-Larrad MT, Ramírez-Lorca R, ''et al.'' |title=Calpain-5 gene variants are associated with diastolic blood pressure and cholesterol levels. |journal=BMC Med. Genet. |volume=8 |issue=  |pages= 1 |year= 2007 |pmid= 17227582 |doi= 10.1186/1471-2350-8-1 }}
}}
}}
{{refend}}
{{refend}}


{{protein-stub}}
==External links==
{{WikiDoc Sources}}
* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=C02.011 C02.011]
* {{UCSC gene info|CAPN5}}
* {{UCSC gene info|HTRA3}}
 
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{{Cysteine proteases}}
 
 
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Latest revision as of 09:11, 30 August 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Calpain-5 is a protein that in humans is encoded by the CAPN5 gene.[1][2][3]

Calpains are calcium-dependent cysteine proteases involved in signal transduction in a variety of cellular processes. A functional calpain protein consists of an invariant small subunit and 1 of a family of large subunits. CAPN5 is one of the large subunits. Unlike some of the calpains, CAPN5 and CAPN6 lack a calmodulin-like domain IV. Because of the significant similarity to Caenorhabditis elegans sex determination gene tra-3, CAPN5 is also called as HTRA3.[3]

References

  1. ↑ Matena K, Boehm T, Dear N (Apr 1998). "Genomic organization of mouse Capn5 and Capn6 genes confirms that they are a distinct calpain subfamily". Genomics. 48 (1): 117–20. doi:10.1006/geno.1997.5133. PMID 9503024.
  2. ↑ Mugita N, Kimura Y, Ogawa M, Saya H, Nakao M (Dec 1997). "Identification of a novel, tissue-specific calpain htra-3; a human homologue of the Caenorhabditis elegans sex determination gene". Biochem Biophys Res Commun. 239 (3): 845–50. doi:10.1006/bbrc.1997.7571. PMID 9367857.
  3. ↑ 3.0 3.1 "Entrez Gene: CAPN5 calpain 5".

Further reading

External links



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