CENPA: Difference between revisions

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Latest revision as of 08:14, 24 October 2018

Centromere protein A, also known as CENPA, is a protein which in humans is encoded by the CENPA gene.^[1]

Function

Centromeres are the chromosomal domains that specify the mitotic behavior of chromosomes. The CENPA gene encodes a centromere protein which contains a histone H3 related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified nucleosome or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.^[1]

In higher eukaryotes, the recruitment of CENP-A nucleosomes to existing centromeres is an epigenetic process, independent of the underlying DNA sequence. In S. pombe, de novo recruitment of the CENP-A to the centromere is believed to be controlled by "centromeric" heterochromatin surrounding the centromere, and by an RNAi mechanism. The RNAi is cut to form siRNA; this complexes with the protein Chp1, which then binds the centromeric heterochromatin. This helps recruit other proteins, ultimately resulting in a protein complex that forms cohesin between two sister chromatids at the centromeric heterochromatin. This cohesin is believed to be essential in replacing the centromere H3 with CENP-A. CENP-A is one of the epigenetic changes that is believed to distinguish centromeric DNA from other DNA.^[2] Once the CENP-A has been added, the centromere becomes self-propagating, and the surrounding heterochromatin/RNAi mechanism is no longer necessary.^[3]

References

↑ ^1.0 ^1.1 EntrezGene 1058
↑ Chueh AC, Wong LH, Wong N, Choo KH (January 2005). "Variable and hierarchical size distribution of L1-retroelement-enriched CENP-A clusters within a functional human neocentromere". Hum. Mol. Genet. 14 (1): 85–93. doi:10.1093/hmg/ddi008. PMID 15537667.
↑ Folco HD, Pidoux AL, Urano T, Allshire RC (January 2008). "Heterochromatin and RNAi are required to establish CENP-A chromatin at centromeres". Science. 319 (5859): 94–7. doi:10.1126/science.1150944. PMC 2586718. PMID 18174443.

External links

Human CENPA genome location and CENPA gene details page in the UCSC Genome Browser.

Palmer DK, O'Day K, Trong HL, Charbonneau H, Margolis RL (1991). "Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone". Proc. Natl. Acad. Sci. U.S.A. 88 (9): 3734–8. doi:10.1073/pnas.88.9.3734. PMC 51527. PMID 2023923.
Sullivan KF, Hechenberger M, Masri K (1994). "Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere". J. Cell Biol. 127 (3): 581–92. doi:10.1083/jcb.127.3.581. PMC 2120219. PMID 7962047.
Shelby RD, Vafa O, Sullivan KF (1997). "Assembly of CENP-A into centromeric chromatin requires a cooperative array of nucleosomal DNA contact sites". J. Cell Biol. 136 (3): 501–13. doi:10.1083/jcb.136.3.501. PMC 2134286. PMID 9024683.
Valdivia MM, Figueroa J, Iglesias C, Ortíz M (1998). "A novel centromere monospecific serum to a human autoepitope on the histone H3-like protein CENP-A". FEBS Lett. 422 (1): 5–9. doi:10.1016/S0014-5793(97)01583-4. PMID 9475158.
Fowler KJ, Newson AJ, MacDonald AC, Kalitsis P, Lyu MS, Kozak CA, Choo KH (1998). "Chromosomal localization of mouse Cenpa gene". Cytogenet. Cell Genet. 79 (3–4): 298–301. doi:10.1159/000134748. PMID 9605877.
Muro Y, Azuma N, Onouchi H, Kunimatsu M, Tomita Y, Sasaki M, Sugimoto K (2000). "Autoepitopes on autoantigen centromere protein-A (CENP-A) are restricted to the N-terminal region, which has no homology with histone H3". Clin. Exp. Immunol. 120 (1): 218–23. doi:10.1046/j.1365-2249.2000.01189.x. PMC 1905620. PMID 10759786.
Lomonte P, Sullivan KF, Everett RD (2001). "Degradation of nucleosome-associated centromeric histone H3-like protein CENP-A induced by herpes simplex virus type 1 protein ICP0". J. Biol. Chem. 276 (8): 5829–35. doi:10.1074/jbc.M008547200. PMID 11053442.
Uren AG, Wong L, Pakusch M, Fowler KJ, Burrows FJ, Vaux DL, Choo KH (2001). "Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype". Curr. Biol. 10 (21): 1319–28. doi:10.1016/S0960-9822(00)00769-7. PMID 11084331.
Zeitlin SG, Shelby RD, Sullivan KF (2002). "CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis". J. Cell Biol. 155 (7): 1147–57. doi:10.1083/jcb.200108125. PMC 2199334. PMID 11756469.
Ando S, Yang H, Nozaki N, Okazaki T, Yoda K (2002). "CENP-A, -B, and -C chromatin complex that contains the I-type alpha-satellite array constitutes the prekinetochore in HeLa cells". Mol. Cell. Biol. 22 (7): 2229–41. doi:10.1128/MCB.22.7.2229-2241.2002. PMC 133672. PMID 11884609.
Saxena A, Saffery R, Wong LH, Kalitsis P, Choo KH (2002). "Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated". J. Biol. Chem. 277 (30): 26921–6. doi:10.1074/jbc.M200620200. PMID 12011073.
Figueroa J, Pendón C, Valdivia MM (2003). "Molecular cloning and sequence analysis of hamster CENP-A cDNA". BMC Genomics. 3: 11. doi:10.1186/1471-2164-3-11. PMC 113255. PMID 12019018.
Saxena A, Wong LH, Kalitsis P, Earle E, Shaffer LG, Choo KH (2003). "Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc". Hum. Mol. Genet. 11 (19): 2319–29. doi:10.1093/hmg/11.19.2319. PMID 12217960.
Tomonaga T, Matsushita K, Yamaguchi S, Oohashi T, Shimada H, Ochiai T, Yoda K, Nomura F (2003). "Overexpression and mistargeting of centromere protein-A in human primary colorectal cancer". Cancer Res. 63 (13): 3511–6. PMID 12839935.
Kunitoku N, Sasayama T, Marumoto T, Zhang D, Honda S, Kobayashi O, Hatakeyama K, Ushio Y, Saya H, Hirota T (2004). "CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function". Dev. Cell. 5 (6): 853–64. doi:10.1016/S1534-5807(03)00364-2. PMID 14667408.
Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K (2004). "Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase". Genes Cells. 9 (2): 105–20. doi:10.1111/j.1365-2443.2004.00705.x. PMID 15009096.
Yasuda S, Oceguera-Yanez F, Kato T, Okamoto M, Yonemura S, Terada Y, Ishizaki T, Narumiya S (2004). "Cdc42 and mDia3 regulate microtubule attachment to kinetochores". Nature. 428 (6984): 767–71. doi:10.1038/nature02452. PMID 15085137.
Black BE, Foltz DR, Chakravarthy S, Luger K, Woods VL Jr, Cleveland DW (2004). "Structural determinants for generating centromeric chromatin". Nature. 430 (6999): 578–82. doi:10.1038/nature02766. PMID 15282608.
Sullivan BA, Karpen GH (2004). "Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin". Nat. Struct. Mol. Biol. 11 (11): 1076–83. doi:10.1038/nsmb845. PMC 1283111. PMID 15475964.
Nikolina S, Basset EA, Robers DJ, Black BE (2010). "The structure of (CENP-A?H4)2 reveals physical features that mark centromeres". Nature. 467 (7313): 347–351. doi:10.1038/nature09323. PMC 2946842. PMID 20739937.

[gene_uid_1058-1] 1.0 ^1.1 EntrezGene 1058

[pmid15537667-2] Chueh AC, Wong LH, Wong N, Choo KH (January 2005). "Variable and hierarchical size distribution of L1-retroelement-enriched CENP-A clusters within a functional human neocentromere". Hum. Mol. Genet. 14 (1): 85–93. doi:10.1093/hmg/ddi008. PMID 15537667.

[pmid18174443-3] Folco HD, Pidoux AL, Urano T, Allshire RC (January 2008). "Heterochromatin and RNAi are required to establish CENP-A chromatin at centromeres". Science. 319 (5859): 94–7. doi:10.1126/science.1150944. PMC 2586718. PMID 18174443.

[1]

[2]

[3]

@@ Line 1: / Line 1: @@
-<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
+{{Infobox_gene}}
-{{PBB_Controls
+'''Centromere protein A''', also known as '''CENPA''', is a [[protein]] which in humans is encoded by the ''CENPA'' [[gene]].<ref name="gene uid 1058">{{EntrezGene|1058}}</ref>
-| update_page = yes
-| require_manual_inspection = no
-| update_protein_box = yes
-| update_summary = yes
-| update_citations = yes
-}}
-<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+== Function ==
-{{GNF_Protein_box
- | image =
- | image_source =
- | PDB =
- | Name = Centromere protein A
- | HGNCid = 1851
- | Symbol = CENPA
- | AltSymbols =;
- | OMIM = 117139
- | ECnumber =
- | Homologene = 1369
- | MGIid = 88375
- | Function = {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003682 |text = chromatin binding}}
- | Component = {{GNF_GO|id=GO:0000775 |text = chromosome, pericentric region}} {{GNF_GO|id=GO:0000786 |text = nucleosome}} {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005694 |text = chromosome}}
- | Process = {{GNF_GO|id=GO:0006334 |text = nucleosome assembly}} {{GNF_GO|id=GO:0007001 |text = chromosome organization and biogenesis (sensu Eukaryota)}}
- | Orthologs = {{GNF_Ortholog_box
-    | Hs_EntrezGene = 1058
-    | Hs_Ensembl =
-    | Hs_RefseqProtein = NP_001035891
-    | Hs_RefseqmRNA = NM_001042426
-    | Hs_GenLoc_db =
-    | Hs_GenLoc_chr =
-    | Hs_GenLoc_start =
-    | Hs_GenLoc_end =
-    | Hs_Uniprot =
-    | Mm_EntrezGene = 12615
-    | Mm_Ensembl = ENSMUSG00000029177
-    | Mm_RefseqmRNA = NM_007681
-    | Mm_RefseqProtein = NP_031707
-    | Mm_GenLoc_db =
-    | Mm_GenLoc_chr = 5
-    | Mm_GenLoc_start = 30943483
-    | Mm_GenLoc_end = 30951407
-    | Mm_Uniprot = O35216
-  }}
-}}
-'''Centromere protein A''', also known as '''CENPA''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: CENPA centromere protein A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1058| accessdate = }}</ref>
-<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
+[[Centromeres]] are the chromosomal domains that specify the mitotic behavior of chromosomes. The CENPA gene encodes a centromere protein which contains a [[histone H3]] related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified [[nucleosome]] or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. [[Alternative splicing]] results in multiple transcript variants encoding distinct [[isoform]]s.<ref name="gene uid 1058"/>
-{{PBB_Summary
-| section_title =
+In higher eukaryotes, the recruitment of CENP-A nucleosomes to existing centromeres is an epigenetic process, independent of the underlying DNA sequence. In ''S. pombe'', de novo recruitment of the CENP-A to the centromere is believed to be controlled by "centromeric" [[heterochromatin]] surrounding the centromere, and by an [[RNAi]] mechanism. The RNAi is cut to form [[siRNA]]; this complexes with the protein Chp1, which then binds the centromeric heterochromatin. This helps recruit other proteins, ultimately resulting in a protein complex that forms [[cohesin]] between two [[sister chromatids]] at the centromeric heterochromatin. This cohesin is believed to be essential in replacing the centromere H3 with CENP-A. CENP-A is one of the [[epigenetic]] changes that is believed to distinguish centromeric DNA from other DNA.<ref name="pmid15537667">{{cite journal | vauthors = Chueh AC, Wong LH, Wong N, Choo KH | title = Variable and hierarchical size distribution of L1-retroelement-enriched CENP-A clusters within a functional human neocentromere | journal = Hum. Mol. Genet. | volume = 14 | issue = 1 | pages = 85–93 |date=January 2005  | pmid = 15537667 | doi = 10.1093/hmg/ddi008 }}</ref> Once the CENP-A has been added, the centromere becomes self-propagating, and the surrounding heterochromatin/RNAi mechanism is no longer necessary.<ref name="pmid18174443">{{cite journal | vauthors = Folco HD, Pidoux AL, Urano T, Allshire RC | title = Heterochromatin and RNAi are required to establish CENP-A chromatin at centromeres | journal = Science | volume = 319 | issue = 5859 | pages = 94–7 |date=January 2008  | pmid = 18174443 | pmc = 2586718 | doi = 10.1126/science.1150944 }}</ref>
-| summary_text = [[Centromeres]] are the differentiated chromosomal domains that specify the mitotic behavior of chromosomes. CENPA encodes a centromere protein which contains a [[histone H3]] related histone fold domain that is required for targeting to the centromere. CENPA is proposed to be a component of a modified [[nucleosome]] or nucleosome-like structure in which it replaces 1 or both copies of conventional histone H3 in the (H3-H4)2 tetrameric core of the nucleosome particle. Alternative splicing results in multiple transcript variants encoding distinct isoforms.<ref name="entrez">{{cite web | title = Entrez Gene: CENPA centromere protein A| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=1058| accessdate = }}</ref>
-}}
 ==References==
-{{reflist|2}}
+{{reflist}}
+==External links==
+* {{UCSC gene info|CENPA}}
 ==Further reading==
 {{refbegin | 2}}
-{{PBB_Further_reading
+*{{cite journal  | vauthors=Palmer DK, O'Day K, Trong HL, Charbonneau H, Margolis RL |title=Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 9 |pages= 3734–8 |year= 1991 |pmid= 2023923 |doi=10.1073/pnas.88.9.3734  | pmc=51527  }}
-| citations =
+*{{cite journal  | vauthors=Sullivan KF, Hechenberger M, Masri K |title=Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere. |journal=J. Cell Biol. |volume=127 |issue= 3 |pages= 581–92 |year= 1994 |pmid= 7962047 |doi=10.1083/jcb.127.3.581  | pmc=2120219  }}
-*{{cite journal  | author=Palmer DK, O'Day K, Trong HL, ''et al.'' |title=Purification of the centromere-specific protein CENP-A and demonstration that it is a distinctive histone. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=88 |issue= 9 |pages= 3734-8 |year= 1991 |pmid= 2023923 |doi=  }}
+*{{cite journal  | vauthors=Shelby RD, Vafa O, Sullivan KF |title=Assembly of CENP-A into centromeric chromatin requires a cooperative array of nucleosomal DNA contact sites. |journal=J. Cell Biol. |volume=136 |issue= 3 |pages= 501–13 |year= 1997 |pmid= 9024683 |doi=10.1083/jcb.136.3.501  | pmc=2134286  }}
-*{{cite journal  | author=Sullivan KF, Hechenberger M, Masri K |title=Human CENP-A contains a histone H3 related histone fold domain that is required for targeting to the centromere. |journal=J. Cell Biol. |volume=127 |issue= 3 |pages= 581-92 |year= 1994 |pmid= 7962047 |doi=  }}
+*{{cite journal  | vauthors=Valdivia MM, Figueroa J, Iglesias C, Ortíz M |title=A novel centromere monospecific serum to a human autoepitope on the histone H3-like protein CENP-A. |journal=FEBS Lett. |volume=422 |issue= 1 |pages= 5–9 |year= 1998 |pmid= 9475158 |doi=10.1016/S0014-5793(97)01583-4  }}
-*{{cite journal  | author=Shelby RD, Vafa O, Sullivan KF |title=Assembly of CENP-A into centromeric chromatin requires a cooperative array of nucleosomal DNA contact sites. |journal=J. Cell Biol. |volume=136 |issue= 3 |pages= 501-13 |year= 1997 |pmid= 9024683 |doi=  }}
+*{{cite journal  | vauthors=Fowler KJ, Newson AJ, MacDonald AC, Kalitsis P, Lyu MS, Kozak CA, Choo KH |title=Chromosomal localization of mouse Cenpa gene. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 3–4 |pages= 298–301 |year= 1998 |pmid= 9605877 |doi=10.1159/000134748  }}
-*{{cite journal  | author=Valdivia MM, Figueroa J, Iglesias C, Ortíz M |title=A novel centromere monospecific serum to a human autoepitope on the histone H3-like protein CENP-A. |journal=FEBS Lett. |volume=422 |issue= 1 |pages= 5-9 |year= 1998 |pmid= 9475158 |doi=  }}
+*{{cite journal  | vauthors=Muro Y, Azuma N, Onouchi H, Kunimatsu M, Tomita Y, Sasaki M, Sugimoto K|title=Autoepitopes on autoantigen centromere protein-A (CENP-A) are restricted to the N-terminal region, which has no homology with histone H3 |journal=Clin. Exp. Immunol. |volume=120 |issue= 1 |pages= 218–23 |year= 2000 |pmid= 10759786 |doi=10.1046/j.1365-2249.2000.01189.x  | pmc=1905620  }}
-*{{cite journal  | author=Fowler KJ, Newson AJ, MacDonald AC, ''et al.'' |title=Chromosomal localization of mouse Cenpa gene. |journal=Cytogenet. Cell Genet. |volume=79 |issue= 3-4 |pages= 298-301 |year= 1998 |pmid= 9605877 |doi=  }}
+*{{cite journal  | vauthors=Lomonte P, Sullivan KF, Everett RD |title=Degradation of nucleosome-associated centromeric histone H3-like protein CENP-A induced by herpes simplex virus type 1 protein ICP0 |journal=J. Biol. Chem. |volume=276 |issue= 8 |pages= 5829–35 |year= 2001 |pmid= 11053442 |doi= 10.1074/jbc.M008547200 }}
-*{{cite journal  | author=Muro Y, Azuma N, Onouchi H, ''et al.'' |title=Autoepitopes on autoantigen centromere protein-A (CENP-A) are restricted to the N-terminal region, which has no homology with histone H3. |journal=Clin. Exp. Immunol. |volume=120 |issue= 1 |pages= 218-23 |year= 2000 |pmid= 10759786 |doi=  }}
+*{{cite journal  | vauthors=Uren AG, Wong L, Pakusch M, Fowler KJ, Burrows FJ, Vaux DL, Choo KH |title=Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype |journal=Curr. Biol. |volume=10 |issue= 21 |pages= 1319–28 |year= 2001 |pmid= 11084331 |doi=10.1016/S0960-9822(00)00769-7  }}
-*{{cite journal  | author=Lomonte P, Sullivan KF, Everett RD |title=Degradation of nucleosome-associated centromeric histone H3-like protein CENP-A induced by herpes simplex virus type 1 protein ICP0. |journal=J. Biol. Chem. |volume=276 |issue= 8 |pages= 5829-35 |year= 2001 |pmid= 11053442 |doi= 10.1074/jbc.M008547200 }}
+*{{cite journal  | vauthors=Zeitlin SG, Shelby RD, Sullivan KF |title=CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis |journal=J. Cell Biol. |volume=155 |issue= 7 |pages= 1147–57 |year= 2002 |pmid= 11756469 |doi= 10.1083/jcb.200108125  | pmc=2199334 }}
-*{{cite journal  | author=Uren AG, Wong L, Pakusch M, ''et al.'' |title=Survivin and the inner centromere protein INCENP show similar cell-cycle localization and gene knockout phenotype. |journal=Curr. Biol. |volume=10 |issue= 21 |pages= 1319-28 |year= 2001 |pmid= 11084331 |doi=  }}
+*{{cite journal  | vauthors=Ando S, Yang H, Nozaki N, Okazaki T, Yoda K |title=CENP-A, -B, and -C chromatin complex that contains the I-type alpha-satellite array constitutes the prekinetochore in HeLa cells |journal=Mol. Cell. Biol. |volume=22 |issue= 7 |pages= 2229–41 |year= 2002 |pmid= 11884609 |doi=10.1128/MCB.22.7.2229-2241.2002  | pmc=133672  }}
-*{{cite journal  | author=Zeitlin SG, Shelby RD, Sullivan KF |title=CENP-A is phosphorylated by Aurora B kinase and plays an unexpected role in completion of cytokinesis. |journal=J. Cell Biol. |volume=155 |issue= 7 |pages= 1147-57 |year= 2002 |pmid= 11756469 |doi= 10.1083/jcb.200108125 }}
+*{{cite journal  | vauthors=Saxena A, Saffery R, Wong LH, Kalitsis P, Choo KH |title=Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 26921–6 |year= 2002 |pmid= 12011073 |doi= 10.1074/jbc.M200620200 }}
-*{{cite journal  | author=Ando S, Yang H, Nozaki N, ''et al.'' |title=CENP-A, -B, and -C chromatin complex that contains the I-type alpha-satellite array constitutes the prekinetochore in HeLa cells. |journal=Mol. Cell. Biol. |volume=22 |issue= 7 |pages= 2229-41 |year= 2002 |pmid= 11884609 |doi=  }}
+*{{cite journal  | vauthors=Figueroa J, Pendón C, Valdivia MM |title=Molecular cloning and sequence analysis of hamster CENP-A cDNA |journal=BMC Genomics |volume=3 |pages= 11 |year= 2003 |pmid= 12019018 |doi=10.1186/1471-2164-3-11  | pmc=113255  }}
-*{{cite journal  | author=Saxena A, Saffery R, Wong LH, ''et al.'' |title=Centromere proteins Cenpa, Cenpb, and Bub3 interact with poly(ADP-ribose) polymerase-1 protein and are poly(ADP-ribosyl)ated. |journal=J. Biol. Chem. |volume=277 |issue= 30 |pages= 26921-6 |year= 2002 |pmid= 12011073 |doi= 10.1074/jbc.M200620200 }}
+*{{cite journal  | vauthors=Saxena A, Wong LH, Kalitsis P, Earle E, Shaffer LG, Choo KH |title=Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc |journal=Hum. Mol. Genet. |volume=11 |issue= 19 |pages= 2319–29 |year= 2003 |pmid= 12217960 |doi=10.1093/hmg/11.19.2319  }}
-*{{cite journal  | author=Figueroa J, Pendón C, Valdivia MM |title=Molecular cloning and sequence analysis of hamster CENP-A cDNA. |journal=BMC Genomics |volume=3 |issue= 1 |pages= 11 |year= 2003 |pmid= 12019018 |doi=  }}
+*{{cite journal  | vauthors=Tomonaga T, Matsushita K, Yamaguchi S, Oohashi T, Shimada H, Ochiai T, Yoda K, Nomura F |title=Overexpression and mistargeting of centromere protein-A in human primary colorectal cancer |journal=Cancer Res. |volume=63 |issue= 13 |pages= 3511–6 |year= 2003 |pmid= 12839935 |doi=  }}
-*{{cite journal  | author=Saxena A, Wong LH, Kalitsis P, ''et al.'' |title=Poly(ADP-ribose) polymerase 2 localizes to mammalian active centromeres and interacts with PARP-1, Cenpa, Cenpb and Bub3, but not Cenpc. |journal=Hum. Mol. Genet. |volume=11 |issue= 19 |pages= 2319-29 |year= 2003 |pmid= 12217960 |doi=  }}
+*{{cite journal  | vauthors=Kunitoku N, Sasayama T, Marumoto T, Zhang D, Honda S, Kobayashi O, Hatakeyama K, Ushio Y, Saya H, Hirota T |title=CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function |journal=Dev. Cell |volume=5 |issue= 6 |pages= 853–64 |year= 2004 |pmid= 14667408 |doi=10.1016/S1534-5807(03)00364-2  }}
-*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
+*{{cite journal  | vauthors=Obuse C, Yang H, Nozaki N, Goto S, Okazaki T, Yoda K |title=Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase |journal=Genes Cells |volume=9 |issue= 2 |pages= 105–20 |year= 2004 |pmid= 15009096 |doi=10.1111/j.1365-2443.2004.00705.x  }}
-*{{cite journal  | author=Tomonaga T, Matsushita K, Yamaguchi S, ''et al.'' |title=Overexpression and mistargeting of centromere protein-A in human primary colorectal cancer. |journal=Cancer Res. |volume=63 |issue= 13 |pages= 3511-6 |year= 2003 |pmid= 12839935 |doi=  }}
+*{{cite journal  | vauthors=Yasuda S, Oceguera-Yanez F, Kato T, Okamoto M, Yonemura S, Terada Y, Ishizaki T, Narumiya S |title=Cdc42 and mDia3 regulate microtubule attachment to kinetochores |journal=Nature |volume=428 |issue= 6984 |pages= 767–71 |year= 2004 |pmid= 15085137 |doi= 10.1038/nature02452 }}
-*{{cite journal  | author=Kunitoku N, Sasayama T, Marumoto T, ''et al.'' |title=CENP-A phosphorylation by Aurora-A in prophase is required for enrichment of Aurora-B at inner centromeres and for kinetochore function. |journal=Dev. Cell |volume=5 |issue= 6 |pages= 853-64 |year= 2004 |pmid= 14667408 |doi=  }}
+*{{cite journal  | vauthors=Black BE, Foltz DR, Chakravarthy S, Luger K, ((Woods VL Jr)), Cleveland DW |title=Structural determinants for generating centromeric chromatin |journal=Nature |volume=430 |issue= 6999 |pages= 578–82 |year= 2004 |pmid= 15282608 |doi= 10.1038/nature02766 }}
-*{{cite journal  | author=Obuse C, Yang H, Nozaki N, ''et al.'' |title=Proteomics analysis of the centromere complex from HeLa interphase cells: UV-damaged DNA binding protein 1 (DDB-1) is a component of the CEN-complex, while BMI-1 is transiently co-localized with the centromeric region in interphase. |journal=Genes Cells |volume=9 |issue= 2 |pages= 105-20 |year= 2004 |pmid= 15009096 |doi=  }}
+*{{cite journal  | vauthors=Sullivan BA, Karpen GH |title=Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 11 |pages= 1076–83 |year= 2004 |pmid= 15475964 |doi= 10.1038/nsmb845  | pmc=1283111 }}
-*{{cite journal  | author=Yasuda S, Oceguera-Yanez F, Kato T, ''et al.'' |title=Cdc42 and mDia3 regulate microtubule attachment to kinetochores. |journal=Nature |volume=428 |issue= 6984 |pages= 767-71 |year= 2004 |pmid= 15085137 |doi= 10.1038/nature02452 }}
+*{{cite journal  | vauthors=Nikolina S, Basset EA, Robers DJ, Black BE   |title=The structure of (CENP-A?H4)2 reveals physical features that mark centromeres |journal=Nature |volume=467 |issue=7313 |pages=347–351 |year=2010  | pmid=20739937  | pmc=2946842 |doi=10.1038/nature09323}}
-*{{cite journal  | author=Black BE, Foltz DR, Chakravarthy S, ''et al.'' |title=Structural determinants for generating centromeric chromatin. |journal=Nature |volume=430 |issue= 6999 |pages= 578-82 |year= 2004 |pmid= 15282608 |doi= 10.1038/nature02766 }}
-*{{cite journal  | author=Sullivan BA, Karpen GH |title=Centromeric chromatin exhibits a histone modification pattern that is distinct from both euchromatin and heterochromatin. |journal=Nat. Struct. Mol. Biol. |volume=11 |issue= 11 |pages= 1076-83 |year= 2004 |pmid= 15475964 |doi= 10.1038/nsmb845 }}
-}}
 {{refend}}
-{{protein-stub}}
 {{Chromosome genetics}}
-{{WikiDoc Sources}}

CENPA: Difference between revisions

Latest revision as of 08:14, 24 October 2018

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Function

References

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