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{{ | '''ERBB receptor feedback inhibitor 1''' is a [[protein]] that in humans is encoded by the ''ERRFI1'' [[gene]].<ref name="pmid10749885">{{cite journal | vauthors = Makkinje A, Quinn DA, Chen A, Cadilla CL, Force T, Bonventre JV, Kyriakis JM | title = Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress | journal = J Biol Chem | volume = 275 | issue = 23 | pages = 17838–17847 |date=Jul 2000 | pmid = 10749885 | pmc = 3668664| doi = 10.1074/jbc.M909735199 }}</ref><ref name="pmid2780291">{{cite journal | vauthors = Chrapkiewicz NB, Davis CM, Chu DT, Caldwell CM, Granner DK | title = Rat gene 33: analysis of its structure, messenger RNA and basal promoter activity | journal = Nucleic Acids Res | volume = 17 | issue = 16 | pages = 6651–6667 |date=Oct 1989 | pmid = 2780291 | pmc = 318357 | doi =10.1093/nar/17.16.6651 }}</ref><ref name="pmid12226756">{{cite journal | vauthors = Fiorini M, Ballaro C, Sala G, Falcone G, Alema S, Segatto O | title = Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control | journal = Oncogene | volume = 21 | issue = 42 | pages = 6530–6539 |date=Sep 2002 | pmid = 12226756 | pmc = | doi = 10.1038/sj.onc.1205823 }}</ref><ref name="pmid11003669">{{cite journal | vauthors = Fiorentino L, Pertica C, Fiorini M, Talora C, Crescenzi M, Castellani L, Alema S, Benedetti P, Segatto O | title = Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain | journal = Mol Cell Biol | volume = 20 | issue = 20 | pages = 7735–7750 |date=Oct 2000 | pmid = 11003669 | pmc = 86354 | doi =10.1128/MCB.20.20.7735-7750.2000 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=54206| accessdate = }}</ref> | ||
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| summary_text = MIG6 is a | | summary_text = MIG6 is a [[Cytoplasmic]] [[protein]] whose expression is upregulated with cell growth (Wick et al., 1995). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000; Fiorentino et al., 2000).[supplied by OMIM]<ref name="entrez" /> | ||
}} | }} | ||
==Interactions== | |||
ERRFI1 has been shown to [[Protein-protein interaction|interact]] with [[Stratifin]]<ref name=pmid15778465>{{cite journal |last=Benzinger |first=Anne |author2=Muster Nemone |author3=Koch Heike B |author4=Yates John R |author5=Hermeking Heiko |date=Jun 2005 |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer |journal=Mol. Cell. Proteomics |volume=4 |issue=6 |pages=785–795 |publisher= |location = United States| issn = 1535-9476| pmid = 15778465 |doi = 10.1074/mcp.M500021-MCP200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[CDC42]].<ref name=pmid10749885 /> | |||
==References== | ==References== | ||
{{reflist | {{reflist}} | ||
==Further reading== | ==Further reading== | ||
{{refbegin | 2}} | {{refbegin | 2}} | ||
{{PBB_Further_reading | {{PBB_Further_reading | ||
| citations = | | citations = | ||
*{{cite journal | | *{{cite journal | vauthors=Zhang YW, Vande Woude GF |title=Mig-6, signal transduction, stress response and cancer |journal=Cell Cycle |volume=6 |issue= 5 |pages= 507–13 |year= 2007 |pmid= 17351343 |doi=10.4161/cc.6.5.3928 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Wick M, Bürger C, Funk M, Müller R |title=Identification of a novel mitogen-inducible gene (mig-6): regulation during G1 progression and differentiation |journal=Exp. Cell Res. |volume=219 |issue= 2 |pages= 527–535 |year= 1995 |pmid= 7641805 |doi= 10.1006/excr.1995.1261 }} | ||
*{{cite journal | | *{{cite journal | vauthors=Hackel PO, Gishizky M, Ullrich A |title=Mig-6 is a negative regulator of the epidermal growth factor receptor signal |journal=Biol. Chem. |volume=382 |issue= 12 |pages= 1649–1662 |year= 2002 |pmid= 11843178 |doi=10.1515/BC.2001.200 }} | ||
*{{cite journal | author= | *{{cite journal | author=Tsunoda T |title=A novel mechanism of nuclear factor kappaB activation through the binding between inhibitor of nuclear factor-kappaBalpha and the processed NH(2)-terminal region of Mig-6 |journal=Cancer Res. |volume=62 |issue= 20 |pages= 5668–71 |year= 2002 |pmid= 12384522 |doi= |name-list-format=vanc| author2=Inokuchi J | author3=Baba I | display-authors=3 | last4=Okumura | first4=K | last5=Naito | first5=S | last6=Sasazuki | first6=T | last7=Shirasawa | first7=S }} | ||
*{{cite journal | vauthors=Saarikoski ST, Rivera SP, Hankinson O |title=Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia |journal=FEBS Lett. |volume=530 |issue= 1–3 |pages= 186–190 |year= 2002 |pmid= 12387890 |doi=10.1016/S0014-5793(02)03475-0 }} | |||
*{{cite journal | | *{{cite journal | author=Strausberg RL |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–16903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |name-list-format=vanc| author2=Feingold EA | author3=Grouse LH | display-authors=3 | last4=Derge | first4=JG | last5=Klausner | first5=RD | last6=Collins | first6=FS | last7=Wagner | first7=L | last8=Shenmen | first8=CM | last9=Schuler | first9=GD |bibcode=2002PNAS...9916899M}} | ||
*{{cite journal | author= | *{{cite journal | author=Anastasi S |title=Feedback inhibition by RALT controls signal output by the ErbB network |journal=Oncogene |volume=22 |issue= 27 |pages= 4221–4234 |year= 2003 |pmid= 12833145 |doi= 10.1038/sj.onc.1206516 |name-list-format=vanc| author2=Fiorentino L | author3=Fiorini M | display-authors=3 | last4=Fraioli | first4=Rocco | last5=Sala | first5=Gianluca | last6=Castellani | first6=L | last7=Alemà | first7=Stefano | last8=Alimandi | first8=Maurizio | last9=Segatto | first9=Oreste }} | ||
*{{cite journal | author=Ota T |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–45 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 |name-list-format=vanc| author2=Suzuki Y | author3=Nishikawa T | display-authors=3 | last4=Otsuki | first4=Tetsuji | last5=Sugiyama | first5=Tomoyasu | last6=Irie | first6=Ryotaro | last7=Wakamatsu | first7=Ai | last8=Hayashi | first8=Koji | last9=Sato | first9=Hiroyuki }} | |||
*{{cite journal | author= | *{{cite journal | author=Gerhard DS |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–2127 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 |name-list-format=vanc| author2=Wagner L | author3=Feingold EA | display-authors=3 | last4=Shenmen | first4=CM | last5=Grouse | first5=LH | last6=Schuler | first6=G | last7=Klein | first7=SL | last8=Old | first8=S | last9=Rasooly | first9=R }} | ||
*{{cite journal | vauthors=Xu D, Makkinje A, Kyriakis JM |title=Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function |journal=J. Biol. Chem. |volume=280 |issue= 4 |pages= 2924–2933 |year= 2005 |pmid= 15556944 |doi= 10.1074/jbc.M408907200 }} | |||
*{{cite journal | author= | *{{cite journal | vauthors=Keeton AB, Messina JL |title=Modulation of Elk-dependent-transcription by Gene33 |journal=J. Cell. Biochem. |volume=94 |issue= 6 |pages= 1190–1198 |year= 2005 |pmid= 15696545 |doi= 10.1002/jcb.20370 }} | ||
*{{cite journal | author=Benzinger A |title=Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer |journal=Mol. Cell. Proteomics |volume=4 |issue= 6 |pages= 785–795 |year= 2005 |pmid= 15778465 |doi= 10.1074/mcp.M500021-MCP200 |name-list-format=vanc| author2=Muster N | author3=Koch HB | display-authors=3 | last4=Yates Jr | first4=3rd | last5=Hermeking | first5=H }} | |||
*{{cite journal | author=Gerhard DS | *{{cite journal | author=Anastasi S |title=Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin |journal=Oncogene |volume=24 |issue= 28 |pages= 4540–4548 |year= 2005 |pmid= 15856022 |doi= 10.1038/sj.onc.1208658 |name-list-format=vanc| author2=Sala G | author3=Huiping C | display-authors=3 | last4=Caprini | first4=Elisabetta | last5=Russo | first5=Giandomenico | last6=Iacovelli | first6=Stefano | last7=Lucini | first7=Fabiana | last8=Ingvarsson | first8=Sigurdur | last9=Segatto | first9=Oreste }} | ||
*{{cite journal | author=Ballarò C |title=Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype |journal=EMBO Rep. |volume=6 |issue= 8 |pages= 755–761 |year= 2006 |pmid= 16007071 |doi= 10.1038/sj.embor.7400458 | pmc=1369136 |name-list-format=vanc| author2=Ceccarelli S | author3=Tiveron C | display-authors=3 | last4=Tatangelo | first4=Laura | last5=Salvatore | first5=Anna Maria | last6=Segatto | first6=Oreste | last7=Alemà | first7=Stefano }} | |||
*{{cite journal | | *{{cite journal | author=Gregory SG |title=The DNA sequence and biological annotation of human chromosome 1 |journal=Nature |volume=441 |issue= 7091 |pages= 315–321 |year= 2006 |pmid= 16710414 |doi= 10.1038/nature04727 |name-list-format=vanc| author2=Barlow KF | author3=McLay KE | display-authors=3 | last4=Kaul | first4=R. | last5=Swarbreck | first5=D. | last6=Dunham | first6=A. | last7=Scott | first7=C. E. | last8=Howe | first8=K. L. | last9=Woodfine | first9=K. |bibcode=2006Natur.441..315G}} | ||
*{{cite journal | | *{{cite journal | author=Zhang YW |title=Evidence that MIG-6 is a tumor-suppressor gene |journal=Oncogene |volume=26 |issue= 2 |pages= 269–276 |year= 2007 |pmid= 16819504 |doi= 10.1038/sj.onc.1209790 |name-list-format=vanc| author2=Staal B | author3=Su Y | display-authors=3 | last4=Swiatek | first4=P | last5=Zhao | first5=P | last6=Cao | first6=B | last7=Resau | first7=J | last8=Sigler | first8=R | last9=Bronson | first9=R }} | ||
*{{cite journal | author= | |||
}} | }} | ||
{{refend}} | {{refend}} | ||
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Latest revision as of 10:17, 23 June 2018
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External IDs | GeneCards: [1] | ||||||
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Species | Human | Mouse | |||||
Entrez |
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Ensembl |
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UniProt |
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RefSeq (mRNA) |
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RefSeq (protein) |
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Location (UCSC) | n/a | n/a | |||||
PubMed search | n/a | n/a | |||||
Wikidata | |||||||
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ERBB receptor feedback inhibitor 1 is a protein that in humans is encoded by the ERRFI1 gene.[1][2][3][4][5]
MIG6 is a Cytoplasmic protein whose expression is upregulated with cell growth (Wick et al., 1995). It shares significant homology with the protein product of rat gene-33, which is induced during cell stress and mediates cell signaling (Makkinje et al., 2000; Fiorentino et al., 2000).[supplied by OMIM][5]
Interactions
ERRFI1 has been shown to interact with Stratifin[6] and CDC42.[1]
References
- ↑ 1.0 1.1 Makkinje A, Quinn DA, Chen A, Cadilla CL, Force T, Bonventre JV, Kyriakis JM (Jul 2000). "Gene 33/Mig-6, a transcriptionally inducible adapter protein that binds GTP-Cdc42 and activates SAPK/JNK. A potential marker transcript for chronic pathologic conditions, such as diabetic nephropathy. Possible role in the response to persistent stress". J Biol Chem. 275 (23): 17838–17847. doi:10.1074/jbc.M909735199. PMC 3668664. PMID 10749885.
- ↑ Chrapkiewicz NB, Davis CM, Chu DT, Caldwell CM, Granner DK (Oct 1989). "Rat gene 33: analysis of its structure, messenger RNA and basal promoter activity". Nucleic Acids Res. 17 (16): 6651–6667. doi:10.1093/nar/17.16.6651. PMC 318357. PMID 2780291.
- ↑ Fiorini M, Ballaro C, Sala G, Falcone G, Alema S, Segatto O (Sep 2002). "Expression of RALT, a feedback inhibitor of ErbB receptors, is subjected to an integrated transcriptional and post-translational control". Oncogene. 21 (42): 6530–6539. doi:10.1038/sj.onc.1205823. PMID 12226756.
- ↑ Fiorentino L, Pertica C, Fiorini M, Talora C, Crescenzi M, Castellani L, Alema S, Benedetti P, Segatto O (Oct 2000). "Inhibition of ErbB-2 mitogenic and transforming activity by RALT, a mitogen-induced signal transducer which binds to the ErbB-2 kinase domain". Mol Cell Biol. 20 (20): 7735–7750. doi:10.1128/MCB.20.20.7735-7750.2000. PMC 86354. PMID 11003669.
- ↑ 5.0 5.1 "Entrez Gene: ERRFI1 ERBB receptor feedback inhibitor 1".
- ↑ Benzinger, Anne; Muster Nemone; Koch Heike B; Yates John R; Hermeking Heiko (Jun 2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. United States. 4 (6): 785–795. doi:10.1074/mcp.M500021-MCP200. ISSN 1535-9476. PMID 15778465.
Further reading
- Zhang YW, Vande Woude GF (2007). "Mig-6, signal transduction, stress response and cancer". Cell Cycle. 6 (5): 507–13. doi:10.4161/cc.6.5.3928. PMID 17351343.
- Wick M, Bürger C, Funk M, Müller R (1995). "Identification of a novel mitogen-inducible gene (mig-6): regulation during G1 progression and differentiation". Exp. Cell Res. 219 (2): 527–535. doi:10.1006/excr.1995.1261. PMID 7641805.
- Hackel PO, Gishizky M, Ullrich A (2002). "Mig-6 is a negative regulator of the epidermal growth factor receptor signal". Biol. Chem. 382 (12): 1649–1662. doi:10.1515/BC.2001.200. PMID 11843178.
- Tsunoda T, Inokuchi J, Baba I, et al. (2002). "A novel mechanism of nuclear factor kappaB activation through the binding between inhibitor of nuclear factor-kappaBalpha and the processed NH(2)-terminal region of Mig-6". Cancer Res. 62 (20): 5668–71. PMID 12384522.
- Saarikoski ST, Rivera SP, Hankinson O (2002). "Mitogen-inducible gene 6 (MIG-6), adipophilin and tuftelin are inducible by hypoxia". FEBS Lett. 530 (1–3): 186–190. doi:10.1016/S0014-5793(02)03475-0. PMID 12387890.
- Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–16903. Bibcode:2002PNAS...9916899M. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
- Anastasi S, Fiorentino L, Fiorini M, et al. (2003). "Feedback inhibition by RALT controls signal output by the ErbB network". Oncogene. 22 (27): 4221–4234. doi:10.1038/sj.onc.1206516. PMID 12833145.
- Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–45. doi:10.1038/ng1285. PMID 14702039.
- Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–2127. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
- Xu D, Makkinje A, Kyriakis JM (2005). "Gene 33 is an endogenous inhibitor of epidermal growth factor (EGF) receptor signaling and mediates dexamethasone-induced suppression of EGF function". J. Biol. Chem. 280 (4): 2924–2933. doi:10.1074/jbc.M408907200. PMID 15556944.
- Keeton AB, Messina JL (2005). "Modulation of Elk-dependent-transcription by Gene33". J. Cell. Biochem. 94 (6): 1190–1198. doi:10.1002/jcb.20370. PMID 15696545.
- Benzinger A, Muster N, Koch HB, et al. (2005). "Targeted proteomic analysis of 14-3-3 sigma, a p53 effector commonly silenced in cancer". Mol. Cell. Proteomics. 4 (6): 785–795. doi:10.1074/mcp.M500021-MCP200. PMID 15778465.
- Anastasi S, Sala G, Huiping C, et al. (2005). "Loss of RALT/MIG-6 expression in ERBB2-amplified breast carcinomas enhances ErbB-2 oncogenic potency and favors resistance to Herceptin". Oncogene. 24 (28): 4540–4548. doi:10.1038/sj.onc.1208658. PMID 15856022.
- Ballarò C, Ceccarelli S, Tiveron C, et al. (2006). "Targeted expression of RALT in mouse skin inhibits epidermal growth factor receptor signalling and generates a Waved-like phenotype". EMBO Rep. 6 (8): 755–761. doi:10.1038/sj.embor.7400458. PMC 1369136. PMID 16007071.
- Gregory SG, Barlow KF, McLay KE, et al. (2006). "The DNA sequence and biological annotation of human chromosome 1". Nature. 441 (7091): 315–321. Bibcode:2006Natur.441..315G. doi:10.1038/nature04727. PMID 16710414.
- Zhang YW, Staal B, Su Y, et al. (2007). "Evidence that MIG-6 is a tumor-suppressor gene". Oncogene. 26 (2): 269–276. doi:10.1038/sj.onc.1209790. PMID 16819504.
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