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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''GDNF family receptor alpha-3''' ('''GFRα3'''), also known as the '''[[artemin]] receptor''', is a [[protein]] that in humans is encoded by the ''GFRA3'' [[gene]].<ref name="pmid9407096">{{cite journal | vauthors = Jing S, Yu Y, Fang M, Hu Z, Holst PL, Boone T, Delaney J, Schultz H, Zhou R, Fox GM | title = GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family | journal = The Journal of Biological Chemistry | volume = 272 | issue = 52 | pages = 33111–7 | date = Dec 1997 | pmid = 9407096 | pmc =  | doi = 10.1074/jbc.272.52.33111 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: GFRA3 GDNF family receptor alpha 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2676| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_GFRA3_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 2gh0.
| PDB = {{PDB2|2gh0}}
| Name = GDNF family receptor alpha 3
| HGNCid = 4245
| Symbol = GFRA3
| AltSymbols =;
| OMIM = 605710
| ECnumber = 
| Homologene = 1146
| MGIid = 1201403
| GeneAtlas_image1 = PBB_GE_GFRA3_214479_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0008046 |text = axon guidance receptor activity}} {{GNF_GO|id=GO:0048503 |text = GPI anchor binding}}
| Component = {{GNF_GO|id=GO:0009897 |text = external side of plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0019898 |text = extrinsic to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007411 |text = axon guidance}} {{GNF_GO|id=GO:0007422 |text = peripheral nervous system development}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 2676
    | Hs_Ensembl = ENSG00000146013
    | Hs_RefseqProtein = NP_001487
    | Hs_RefseqmRNA = NM_001496
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 137615970
    | Hs_GenLoc_end = 137638153
    | Hs_Uniprot = O60609
    | Mm_EntrezGene = 14587
    | Mm_Ensembl = ENSMUSG00000024366
    | Mm_RefseqmRNA = XM_989428
    | Mm_RefseqProtein = XP_994522
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 34814721
    | Mm_GenLoc_end = 34845204
    | Mm_Uniprot = Q9R2D0
  }}
}}
'''GDNF family receptor alpha 3''', also known as '''GFRA3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: GFRA3 GDNF family receptor alpha 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2676| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin.<ref name="entrez">{{cite web | title = Entrez Gene: GFRA3 GDNF family receptor alpha 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=2676| accessdate = }}</ref>
}}


==References==
== See also ==
{{reflist|2}}
* [[GFRα]]
==Further reading==
 
{{refbegin | 2}}
== References ==
{{PBB_Further_reading
{{reflist}}
| citations =
 
*{{cite journal | author=Wang X, Baloh RH, Milbrandt J, Garcia KC |title=Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors. |journal=Structure |volume=14 |issue= 6 |pages= 1083-92 |year= 2006 |pmid= 16765900 |doi= 10.1016/j.str.2006.05.010 }}
== Further reading ==
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
{{refbegin|35em}}
*{{cite journal  | author=Zhang Z, Henzel WJ |title=Signal peptide prediction based on analysis of experimentally verified cleavage sites. |journal=Protein Sci. |volume=13 |issue= 10 |pages= 2819-24 |year= 2005 |pmid= 15340161 |doi= 10.1110/ps.04682504 }}
* {{cite journal | vauthors = Wang X, Baloh RH, Milbrandt J, Garcia KC | title = Structure of artemin complexed with its receptor GFRalpha3: convergent recognition of glial cell line-derived neurotrophic factors | journal = Structure | volume = 14 | issue = 6 | pages = 1083–92  | date = Jun 2006 | pmid = 16765900 | doi = 10.1016/j.str.2006.05.010 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
* {{cite journal | vauthors = Zhang Z, Henzel WJ | title = Signal peptide prediction based on analysis of experimentally verified cleavage sites | journal = Protein Science | volume = 13 | issue = 10 | pages = 2819–24 | year = 2005 | date = Oct 2004 | pmid = 15340161 | pmc = 2286551 | doi = 10.1110/ps.04682504 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Gimm O, Dziema H, Brown J, Hoang-Vu C, Hinze R, Dralle H, Mulligan LM, Eng C | title = Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma | journal = Oncogene | volume = 20 | issue = 17 | pages = 2161–70  | date = Apr 2001 | pmid = 11360200 | doi = 10.1038/sj.onc.1204289 }}
*{{cite journal  | author=Gimm O, Dziema H, Brown J, ''et al.'' |title=Over-representation of a germline variant in the gene encoding RET co-receptor GFRalpha-1 but not GFRalpha-2 or GFRalpha-3 in cases with sporadic medullary thyroid carcinoma. |journal=Oncogene |volume=20 |issue= 17 |pages= 2161-70 |year= 2001 |pmid= 11360200 |doi= 10.1038/sj.onc.1204289 }}
* {{cite journal | vauthors = Onochie CI, Korngut LM, Vanhorne JB, Myers SM, Michaud D, Mulligan LM | title = Characterisation of the human GFRalpha-3 locus and investigation of the gene in Hirschsprung disease | journal = Journal of Medical Genetics | volume = 37 | issue = 9 | pages = 674–9  | date = Sep 2000 | pmid = 10978357 | pmc = 1734691 | doi = 10.1136/jmg.37.9.674 }}
*{{cite journal | author=Onochie CI, Korngut LM, Vanhorne JB, ''et al.'' |title=Characterisation of the human GFRalpha-3 locus and investigation of the gene in Hirschsprung disease. |journal=J. Med. Genet. |volume=37 |issue= 9 |pages= 674-9 |year= 2000 |pmid= 10978357 |doi= }}
* {{cite journal | vauthors = Baloh RH, Tansey MG, Lampe PA, Fahrner TJ, Enomoto H, Simburger KS, Leitner ML, Araki T, Johnson EM, Milbrandt J | title = Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex | journal = Neuron | volume = 21 | issue = 6 | pages = 1291–302 | year = 1999 | date = Dec 1998 | pmid = 9883723 | doi = 10.1016/S0896-6273(00)80649-2 }}
*{{cite journal | author=Baloh RH, Tansey MG, Lampe PA, ''et al.'' |title=Artemin, a novel member of the GDNF ligand family, supports peripheral and central neurons and signals through the GFRalpha3-RET receptor complex. |journal=Neuron |volume=21 |issue= 6 |pages= 1291-302 |year= 1999 |pmid= 9883723 |doi= }}
* {{cite journal | vauthors = Baloh RH, Gorodinsky A, Golden JP, Tansey MG, Keck CL, Popescu NC, Johnson EM, Milbrandt J | title = GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 10 | pages = 5801–6  | date = May 1998 | pmid = 9576965 | pmc = 20460 | doi = 10.1073/pnas.95.10.5801 }}
*{{cite journal | author=Baloh RH, Gorodinsky A, Golden JP, ''et al.'' |title=GFRalpha3 is an orphan member of the GDNF/neurturin/persephin receptor family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 10 |pages= 5801-6 |year= 1998 |pmid= 9576965 |doi= }}
* {{cite journal | vauthors = Masure S, Cik M, Pangalos MN, Bonaventure P, Verhasselt P, Lesage AS, Leysen JE, Gordon RD | title = Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3) | journal = European Journal of Biochemistry / FEBS | volume = 251 | issue = 3 | pages = 622–30  | date = Feb 1998 | pmid = 9490034 | doi = 10.1046/j.1432-1327.1998.2510622.x }}
*{{cite journal | author=Masure S, Cik M, Pangalos MN, ''et al.'' |title=Molecular cloning, expression and tissue distribution of glial-cell-line-derived neurotrophic factor family receptor alpha-3 (GFRalpha-3). |journal=Eur. J. Biochem. |volume=251 |issue= 3 |pages= 622-30 |year= 1998 |pmid= 9490034 |doi= }}
* {{cite journal | vauthors = Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, Bieber FR, Morton CC | title = Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening | journal = Genomics | volume = 23 | issue = 1 | pages = 42–50 | year = 1995 | date = Sep 1994 | pmid = 7829101 | doi = 10.1006/geno.1994.1457 }}
*{{cite journal  | author=Jing S, Yu Y, Fang M, ''et al.'' |title=GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family. |journal=J. Biol. Chem. |volume=272 |issue= 52 |pages= 33111-7 |year= 1998 |pmid= 9407096 |doi=  }}
*{{cite journal | author=Robertson NG, Khetarpal U, Gutiérrez-Espeleta GA, ''et al.'' |title=Isolation of novel and known genes from a human fetal cochlear cDNA library using subtractive hybridization and differential screening. |journal=Genomics |volume=23 |issue= 1 |pages= 42-50 |year= 1995 |pmid= 7829101 |doi= 10.1006/geno.1994.1457 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 03:12, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

GDNF family receptor alpha-3 (GFRα3), also known as the artemin receptor, is a protein that in humans is encoded by the GFRA3 gene.[1][2]

Function

The protein encoded by this gene is a glycosylphosphatidylinositol(GPI)-linked cell surface receptor and a member of the GDNF receptor family. It forms a signaling receptor complex with RET tyrosine kinase receptor and binds the ligand, artemin.[2]

See also

References

  1. ↑ Jing S, Yu Y, Fang M, Hu Z, Holst PL, Boone T, Delaney J, Schultz H, Zhou R, Fox GM (Dec 1997). "GFRalpha-2 and GFRalpha-3 are two new receptors for ligands of the GDNF family". The Journal of Biological Chemistry. 272 (52): 33111–7. doi:10.1074/jbc.272.52.33111. PMID 9407096.
  2. ↑ 2.0 2.1 "Entrez Gene: GFRA3 GDNF family receptor alpha 3".

Further reading


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