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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Low-density lipoprotein receptor-related protein 1B''' is a [[protein]] that in humans is encoded by the ''LRP1B'' [[gene]].<ref name="pmid10766186">{{cite journal |vauthors=Liu CX, Musco S, Lisitsina NM, Forgacs E, Minna JD, Lisitsyn NA | title = LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines | journal = Cancer Res | volume = 60 | issue = 7 | pages = 1961–7 |date=May 2000 | pmid = 10766186 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: LRP1B low density lipoprotein-related protein 1B (deleted in tumors)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53353| accessdate = }}</ref>
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Low density lipoprotein-related protein 1B (deleted in tumors)
| HGNCid = 6693
| Symbol = LRP1B
| AltSymbols =; LRP-DIT; LRPDIT
| OMIM = 608766
| ECnumber = 
| Homologene = 56810
| MGIid = 2151136
| GeneAtlas_image1 = PBB_GE_LRP1B_219643_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0005041 |text = low-density lipoprotein receptor activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0006898 |text = receptor-mediated endocytosis}} {{GNF_GO|id=GO:0015031 |text = protein transport}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 53353
    | Hs_Ensembl = ENSG00000168702
    | Hs_RefseqProtein = NP_061027
    | Hs_RefseqmRNA = NM_018557
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 2
    | Hs_GenLoc_start = 140707225
    | Hs_GenLoc_end = 142604768
    | Hs_Uniprot = Q9NZR2
    | Mm_EntrezGene = 94217
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = XM_985447
    | Mm_RefseqProtein = XP_990541
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''Low density lipoprotein-related protein 1B (deleted in tumors)''', also known as '''LRP1B''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: LRP1B low density lipoprotein-related protein 1B (deleted in tumors)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53353| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
LRP1B belongs to the [[LDL receptor]] gene family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands.<ref name="pmid11384978">{{cite journal |vauthors=Liu CX, Li Y, Obermoeller-McCormick LM, Schwartz AL, Bu G | title = The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein | journal = J. Biol. Chem. | volume = 276 | issue = 31 | pages = 28889–96 |date=August 2001 | pmid = 11384978 | doi = 10.1074/jbc.M102727200 | url = | issn = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = LRP1B belongs to the low density lipoprotein (LDL) receptor gene family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands (Liu et al., 2001).[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: LRP1B low density lipoprotein-related protein 1B (deleted in tumors)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=53353| accessdate = }}</ref>
}}


==References==
==References==
{{reflist|2}}
{{reflist|2}}
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
*{{cite journal   |vauthors=Liu CX, Musco S, Lisitsina NM, etal |title=Genomic organization of a new candidate tumor suppressor gene, LRP1B |journal=Genomics |volume=69 |issue= 2 |pages= 271–4 |year= 2001 |pmid= 11031110 |doi= 10.1006/geno.2000.6331 }}
| citations =
*{{cite journal   |vauthors=Langbein S, Szakacs O, Wilhelm M, etal |title=Alteration of the LRP1B gene region is associated with high grade of urothelial cancer |journal=Lab. Invest. |volume=82 |issue= 5 |pages= 639–43 |year= 2002 |pmid= 12004004 |doi=10.1038/labinvest.3780458 }}
*{{cite journal | author=Liu CX, Musco S, Lisitsina NM, ''et al.'' |title=LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines. |journal=Cancer Res. |volume=60 |issue= 7 |pages= 1961-7 |year= 2000 |pmid= 10766186 |doi=  }}
*{{cite journal   |vauthors=Li Y, Knisely JM, Lu W, etal |title=Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration |journal=J. Biol. Chem. |volume=277 |issue= 44 |pages= 42366–71 |year= 2003 |pmid= 12194987 |doi= 10.1074/jbc.M207705200 }}
*{{cite journal  | author=Liu CX, Musco S, Lisitsina NM, ''et al.'' |title=Genomic organization of a new candidate tumor suppressor gene, LRP1B. |journal=Genomics |volume=69 |issue= 2 |pages= 271-4 |year= 2001 |pmid= 11031110 |doi= 10.1006/geno.2000.6331 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal | author=Liu CX, Li Y, Obermoeller-McCormick LM, ''et al.'' |title=The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein. |journal=J. Biol. Chem. |volume=276 |issue= 31 |pages= 28889-96 |year= 2001 |pmid= 11384978 |doi= 10.1074/jbc.M102727200 }}
*{{cite journal   |vauthors=Cam JA, Zerbinatti CV, Knisely JM, etal |title=The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 29639–46 |year= 2004 |pmid= 15126508 |doi= 10.1074/jbc.M313893200 }}
*{{cite journal  | author=Langbein S, Szakacs O, Wilhelm M, ''et al.'' |title=Alteration of the LRP1B gene region is associated with high grade of urothelial cancer. |journal=Lab. Invest. |volume=82 |issue= 5 |pages= 639-43 |year= 2002 |pmid= 12004004 |doi=  }}
*{{cite journal   |vauthors=Tanaga K, Bujo H, Zhu Y, etal |title=LRP1B attenuates the migration of smooth muscle cells by reducing membrane localization of urokinase and PDGF receptors |journal=Arterioscler. Thromb. Vasc. Biol. |volume=24 |issue= 8 |pages= 1422–8 |year= 2005 |pmid= 15166012 |doi= 10.1161/01.ATV.0000133607.80554.09 }}
*{{cite journal | author=Li Y, Knisely JM, Lu W, ''et al.'' |title=Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration. |journal=J. Biol. Chem. |volume=277 |issue= 44 |pages= 42366-71 |year= 2003 |pmid= 12194987 |doi= 10.1074/jbc.M207705200 }}
*{{cite journal   |vauthors=Sonoda I, Imoto I, Inoue J, etal |title=Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma |journal=Cancer Res. |volume=64 |issue= 11 |pages= 3741–7 |year= 2004 |pmid= 15172977 |doi= 10.1158/0008-5472.CAN-04-0172 }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |vauthors=Li Y, Lu W, Bu G |title=Striking differences of LDL receptor-related protein 1B expression in mouse and human |journal=Biochem. Biophys. Res. Commun. |volume=333 |issue= 3 |pages= 868–73 |year= 2005 |pmid= 15963947 |doi= 10.1016/j.bbrc.2005.05.170 }}
*{{cite journal | author=Cam JA, Zerbinatti CV, Knisely JM, ''et al.'' |title=The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production. |journal=J. Biol. Chem. |volume=279 |issue= 28 |pages= 29639-46 |year= 2004 |pmid= 15126508 |doi= 10.1074/jbc.M313893200 }}
*{{cite journal   |vauthors=Pastrana DV, Hanson AJ, Knisely J, etal |title=LRP 1 B functions as a receptor for Pseudomonas exotoxin |journal=Biochim. Biophys. Acta |volume=1741 |issue= 3 |pages= 234–9 |year= 2006 |pmid= 16095885 |doi= 10.1016/j.bbadis.2005.06.007 }}
*{{cite journal | author=Tanaga K, Bujo H, Zhu Y, ''et al.'' |title=LRP1B attenuates the migration of smooth muscle cells by reducing membrane localization of urokinase and PDGF receptors. |journal=Arterioscler. Thromb. Vasc. Biol. |volume=24 |issue= 8 |pages= 1422-8 |year= 2005 |pmid= 15166012 |doi= 10.1161/01.ATV.0000133607.80554.09 }}
*{{cite journal   |vauthors=Nakagawa T, Pimkhaokham A, Suzuki E, etal |title=Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma |journal=Cancer Sci. |volume=97 |issue= 10 |pages= 1070–4 |year= 2006 |pmid= 16918994 |doi= 10.1111/j.1349-7006.2006.00283.x }}
*{{cite journal | author=Sonoda I, Imoto I, Inoue J, ''et al.'' |title=Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma. |journal=Cancer Res. |volume=64 |issue= 11 |pages= 3741-7 |year= 2004 |pmid= 15172977 |doi= 10.1158/0008-5472.CAN-04-0172 }}
*{{cite journal  |vauthors=Liu CX, Ranganathan S, Robinson S, Strickland DK |title=gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells |journal=J. Biol. Chem. |volume=282 |issue= 10 |pages= 7504–11 |year= 2007 |pmid= 17227771 |doi= 10.1074/jbc.M608088200 }}
*{{cite journal  | author=Li Y, Lu W, Bu G |title=Striking differences of LDL receptor-related protein 1B expression in mouse and human. |journal=Biochem. Biophys. Res. Commun. |volume=333 |issue= 3 |pages= 868-73 |year= 2005 |pmid= 15963947 |doi= 10.1016/j.bbrc.2005.05.170 }}
*{{cite journal | author=Pastrana DV, Hanson AJ, Knisely J, ''et al.'' |title=LRP 1 B functions as a receptor for Pseudomonas exotoxin. |journal=Biochim. Biophys. Acta |volume=1741 |issue= 3 |pages= 234-9 |year= 2006 |pmid= 16095885 |doi= 10.1016/j.bbadis.2005.06.007 }}
*{{cite journal | author=Nakagawa T, Pimkhaokham A, Suzuki E, ''et al.'' |title=Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma. |journal=Cancer Sci. |volume=97 |issue= 10 |pages= 1070-4 |year= 2006 |pmid= 16918994 |doi= 10.1111/j.1349-7006.2006.00283.x }}
*{{cite journal  | author=Liu CX, Ranganathan S, Robinson S, Strickland DK |title=gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells. |journal=J. Biol. Chem. |volume=282 |issue= 10 |pages= 7504-11 |year= 2007 |pmid= 17227771 |doi= 10.1074/jbc.M608088200 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{Lipoprotein metabolism}}
{{WikiDoc Sources}}
 
 
{{gene-2-stub}}

Latest revision as of 02:37, 27 October 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Low-density lipoprotein receptor-related protein 1B is a protein that in humans is encoded by the LRP1B gene.[1][2]

Function

LRP1B belongs to the LDL receptor gene family. These receptors play a wide variety of roles in normal cell function and development due to their interactions with multiple ligands.[3]

References

  1. ↑ Liu CX, Musco S, Lisitsina NM, Forgacs E, Minna JD, Lisitsyn NA (May 2000). "LRP-DIT, a putative endocytic receptor gene, is frequently inactivated in non-small cell lung cancer cell lines". Cancer Res. 60 (7): 1961–7. PMID 10766186.
  2. ↑ "Entrez Gene: LRP1B low density lipoprotein-related protein 1B (deleted in tumors)".
  3. ↑ Liu CX, Li Y, Obermoeller-McCormick LM, Schwartz AL, Bu G (August 2001). "The putative tumor suppressor LRP1B, a novel member of the low density lipoprotein (LDL) receptor family, exhibits both overlapping and distinct properties with the LDL receptor-related protein". J. Biol. Chem. 276 (31): 28889–96. doi:10.1074/jbc.M102727200. PMID 11384978.

Further reading

  • Liu CX, Musco S, Lisitsina NM, et al. (2001). "Genomic organization of a new candidate tumor suppressor gene, LRP1B". Genomics. 69 (2): 271–4. doi:10.1006/geno.2000.6331. PMID 11031110.
  • Langbein S, Szakacs O, Wilhelm M, et al. (2002). "Alteration of the LRP1B gene region is associated with high grade of urothelial cancer". Lab. Invest. 82 (5): 639–43. doi:10.1038/labinvest.3780458. PMID 12004004.
  • Li Y, Knisely JM, Lu W, et al. (2003). "Low density lipoprotein (LDL) receptor-related protein 1B impairs urokinase receptor regeneration on the cell surface and inhibits cell migration". J. Biol. Chem. 277 (44): 42366–71. doi:10.1074/jbc.M207705200. PMID 12194987.
  • Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
  • Cam JA, Zerbinatti CV, Knisely JM, et al. (2004). "The low density lipoprotein receptor-related protein 1B retains beta-amyloid precursor protein at the cell surface and reduces amyloid-beta peptide production". J. Biol. Chem. 279 (28): 29639–46. doi:10.1074/jbc.M313893200. PMID 15126508.
  • Tanaga K, Bujo H, Zhu Y, et al. (2005). "LRP1B attenuates the migration of smooth muscle cells by reducing membrane localization of urokinase and PDGF receptors". Arterioscler. Thromb. Vasc. Biol. 24 (8): 1422–8. doi:10.1161/01.ATV.0000133607.80554.09. PMID 15166012.
  • Sonoda I, Imoto I, Inoue J, et al. (2004). "Frequent silencing of low density lipoprotein receptor-related protein 1B (LRP1B) expression by genetic and epigenetic mechanisms in esophageal squamous cell carcinoma". Cancer Res. 64 (11): 3741–7. doi:10.1158/0008-5472.CAN-04-0172. PMID 15172977.
  • Li Y, Lu W, Bu G (2005). "Striking differences of LDL receptor-related protein 1B expression in mouse and human". Biochem. Biophys. Res. Commun. 333 (3): 868–73. doi:10.1016/j.bbrc.2005.05.170. PMID 15963947.
  • Pastrana DV, Hanson AJ, Knisely J, et al. (2006). "LRP 1 B functions as a receptor for Pseudomonas exotoxin". Biochim. Biophys. Acta. 1741 (3): 234–9. doi:10.1016/j.bbadis.2005.06.007. PMID 16095885.
  • Nakagawa T, Pimkhaokham A, Suzuki E, et al. (2006). "Genetic or epigenetic silencing of low density lipoprotein receptor-related protein 1B expression in oral squamous cell carcinoma". Cancer Sci. 97 (10): 1070–4. doi:10.1111/j.1349-7006.2006.00283.x. PMID 16918994.
  • Liu CX, Ranganathan S, Robinson S, Strickland DK (2007). "gamma-Secretase-mediated release of the low density lipoprotein receptor-related protein 1B intracellular domain suppresses anchorage-independent growth of neuroglioma cells". J. Biol. Chem. 282 (10): 7504–11. doi:10.1074/jbc.M608088200. PMID 17227771.


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