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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''DNA replication licensing factor MCM7''' is a [[protein]] that in humans is encoded by the ''MCM7'' [[gene]].<ref name="pmid7842741">{{cite journal | vauthors = Nakatsuru S, Sudo K, Nakamura Y | title = Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication | journal = Cytogenet Cell Genet | volume = 68 | issue = 3-4 | pages = 226–30 | date = March 1995 | pmid = 7842741 | pmc = | doi = 10.1159/000133918 }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)
| HGNCid = 6950
| Symbol = MCM7
| AltSymbols =; MCM2; CDABP0042; CDC47; P1.1-MCM3; P1CDC47; P85MCM; PNAS-146
| OMIM = 600592
| ECnumber = 
| Homologene = 4323
| MGIid = 1298398
| GeneAtlas_image1 = PBB_GE_MCM7_208795_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_MCM7_210983_s_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003677 |text = DNA binding}} {{GNF_GO|id=GO:0003678 |text = DNA helicase activity}} {{GNF_GO|id=GO:0003697 |text = single-stranded DNA binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0005524 |text = ATP binding}} {{GNF_GO|id=GO:0008094 |text = DNA-dependent ATPase activity}} {{GNF_GO|id=GO:0017111 |text = nucleoside-triphosphatase activity}}
| Component = {{GNF_GO|id=GO:0000785 |text = chromatin}} {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0006268 |text = DNA unwinding during replication}} {{GNF_GO|id=GO:0006270 |text = DNA replication initiation}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007049 |text = cell cycle}} {{GNF_GO|id=GO:0008283 |text = cell proliferation}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4176
    | Hs_Ensembl = ENSG00000166508
    | Hs_RefseqProtein = NP_005907
    | Hs_RefseqmRNA = NM_005916
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 99528340
    | Hs_GenLoc_end = 99537363
    | Hs_Uniprot = P33993
    | Mm_EntrezGene = 17220
    | Mm_Ensembl = ENSMUSG00000029730
    | Mm_RefseqmRNA = NM_008568
    | Mm_RefseqProtein = NP_032594
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 138394377
    | Mm_GenLoc_end = 138401650
    | Mm_Uniprot = Q3U4T8
  }}
}}
'''MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)''', also known as '''MCM7''', is a human [[gene]].


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the [[pre-replication complex]] (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: MCM7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4176| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.<ref name="entrez">{{cite web | title = Entrez Gene: MCM7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4176| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
MCM7 has been shown to [[Protein-protein interaction|interact]] with:
{{div col|colwidth=20em}}
* [[CDC45-related protein]]<ref name = pmid12614612/><ref name = pmid10518787>{{cite journal | vauthors = Kukimoto I, Igaki H, Kanda T | title = Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha | journal = Eur. J. Biochem. | volume = 265 | issue = 3 | pages = 936–43 | date = November 1999 | pmid = 10518787 | doi =  10.1046/j.1432-1327.1999.00791.x}}</ref>
* [[CDC6]],<ref name = pmid12614612/><ref name = pmid10464337/>
* [[Cell division cycle 7-related protein kinase]],<ref name = pmid12614612/>
* [[DBF4]],<ref name = pmid12614612/>
* [[MCM2]],<ref name = pmid12614612/><ref name = pmid9099751/><ref name = pmid12694531/><ref name = pmid12207017/><ref name = pmid10567526>{{cite journal | vauthors = You Z, Komamura Y, Ishimi Y | title = Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity | journal = Mol. Cell. Biol. | volume = 19 | issue = 12 | pages = 8003–15 | date = December 1999 | pmid = 10567526 | pmc = 84885 | doi =  }}</ref>
* [[MCM3]],<ref name = pmid12614612/><ref name = pmid10464337>{{cite journal | vauthors = Fujita M, Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M, Tsurumi T | title = Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation | journal = J. Biol. Chem. | volume = 274 | issue = 36 | pages = 25927–32 | date = September 1999 | pmid = 10464337 | doi =  10.1074/jbc.274.36.25927}}</ref><ref name = pmid9099751/><ref name = pmid11779870>{{cite journal | vauthors = Fujita M, Ishimi Y, Nakamura H, Kiyono T, Tsurumi T | title = Nuclear organization of DNA replication initiation proteins in mammalian cells | journal = J. Biol. Chem. | volume = 277 | issue = 12 | pages = 10354–61 | date = March 2002 | pmid = 11779870 | doi = 10.1074/jbc.M111398200 }}</ref>
* [[MCM4]],<ref name = pmid9099751/><ref name = pmid12694531/><ref name = pmid12207017/><ref name = pmid8798650>{{cite journal | vauthors = Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H | title = Binding of human minichromosome maintenance proteins with histone H3 | journal = J. Biol. Chem. | volume = 271 | issue = 39 | pages = 24115–22 | date = September 1996 | pmid = 8798650 | doi =  10.1074/jbc.271.39.24115}}</ref>
* [[MCM5]],<ref name = pmid12614612/><ref name = pmid9099751>{{cite journal | vauthors = Fujita M, Kiyono T, Hayashi Y, Ishibashi M | title = In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP | journal = J. Biol. Chem. | volume = 272 | issue = 16 | pages = 10928–35 | date = April 1997 | pmid = 9099751 | doi =  10.1074/jbc.272.16.10928}}</ref><ref name = pmid11248027>{{cite journal | vauthors = DaFonseca CJ, Shu F, Zhang JJ | title = Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 98 | issue = 6 | pages = 3034–9 | date = March 2001 | pmid = 11248027 | pmc = 30602 | doi = 10.1073/pnas.061487598 }}</ref>
* [[MCM6]],<ref name = pmid12614612/><ref name = pmid9099751/><ref name = pmid12694531>{{cite journal | vauthors = Yabuta N, Kajimura N, Mayanagi K, Sato M, Gotow T, Uchiyama Y, Ishimi Y, Nojima H | title = Mammalian Mcm2/4/6/7 complex forms a toroidal structure | journal = Genes Cells | volume = 8 | issue = 5 | pages = 413–21 | date = May 2003 | pmid = 12694531 | doi =  10.1046/j.1365-2443.2003.00645.x}}</ref><ref name = pmid12207017>{{cite journal | vauthors = You Z, Ishimi Y, Masai H, Hanaoka F | title = Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex | journal = J. Biol. Chem. | volume = 277 | issue = 45 | pages = 42471–9 | date = November 2002 | pmid = 12207017 | doi = 10.1074/jbc.M205769200 }}</ref>
* [[MNAT1]],<ref name = pmid11056214>{{cite journal | vauthors = Wang Y, Xu F, Hall FL | title = The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor | journal = FEBS Lett. | volume = 484 | issue = 1 | pages = 17–21 | date = October 2000 | pmid = 11056214 | doi =  10.1016/s0014-5793(00)02117-7}}</ref>
* [[ORC1L]],<ref name = pmid12614612/>
* [[ORC2L]],<ref name = pmid12614612/>
* [[ORC3L]],<ref name = pmid12614612/>
* [[ORC5L]],<ref name = pmid12614612/>
* [[Replication protein A1]],<ref name = pmid12614612>{{cite journal | vauthors = Kneissl M, Pütter V, Szalay AA, Grummt F | title = Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells | journal = J. Mol. Biol. | volume = 327 | issue = 1 | pages = 111–28 | date = March 2003 | pmid = 12614612 | doi =  10.1016/s0022-2836(03)00079-2}}</ref>
* [[Retinoblastoma protein]],<ref name = pmid9566894>{{cite journal | vauthors = Sterner JM, Dew-Knight S, Musahl C, Kornbluth S, Horowitz JM | title = Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7 | journal = Mol. Cell. Biol. | volume = 18 | issue = 5 | pages = 2748–57 | date = May 1998 | pmid = 9566894 | pmc = 110654 | doi =  10.1128/mcb.18.5.2748}}</ref>  and
* [[UBE3A]].<ref name = pmid9852095>{{cite journal | vauthors = Kühne C, Banks L | title = E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box | journal = J. Biol. Chem. | volume = 273 | issue = 51 | pages = 34302–9 | date = December 1998 | pmid = 9852095 | doi =  10.1074/jbc.273.51.34302}}</ref>
{{Div col end}}
 
== See also ==
* [[Mini Chromosome Maintenance]]
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Todorov IT, Lavigne J, Sakr F, Kaneva R, Foisy S, Bibor-Hardy V | title = Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle. | journal = Biochem. Biophys. Res. Commun. | volume = 177 | issue = 1 | pages = 395–400 | year = 1991 | pmid = 1710453 | doi = 10.1016/0006-291X(91)91996-P }}
| citations =
* {{cite journal | vauthors = Musahl C, Schulte D, Burkhart R, Knippers R | title = A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins. | journal = Eur. J. Biochem. | volume = 230 | issue = 3 | pages = 1096–101 | year = 1995 | pmid = 7601140 | doi = 10.1111/j.1432-1033.1995.tb20660.x }}
*{{cite journal | author=Todorov IT, Lavigne J, Sakr F, ''et al.'' |title=Nuclear matrix protein mitotin messenger RNA is expressed at constant levels during the cell cycle. |journal=Biochem. Biophys. Res. Commun. |volume=177 |issue= 1 |pages= 395-400 |year= 1991 |pmid= 1710453 |doi= }}
* {{cite journal | vauthors = Mincheva A, Todorov I, Werner D, Fink TM, Lichter P | title = The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21. | journal = Cytogenet. Cell Genet. | volume = 65 | issue = 4 | pages = 276–7 | year = 1994 | pmid = 8258304 | doi = 10.1159/000133647 }}
*{{cite journal | author=Musahl C, Schulte D, Burkhart R, Knippers R |title=A human homologue of the yeast replication protein Cdc21. Interactions with other Mcm proteins. |journal=Eur. J. Biochem. |volume=230 |issue= 3 |pages= 1096-101 |year= 1995 |pmid= 7601140 |doi= }}
* {{cite journal | vauthors = Hu B, Burkhart R, Schulte D, Musahl C, Knippers R | title = The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins. | journal = Nucleic Acids Res. | volume = 21 | issue = 23 | pages = 5289–93 | year = 1994 | pmid = 8265339 | pmc = 310560 | doi = 10.1093/nar/21.23.5289-a }}
*{{cite journal | author=Nakatsuru S, Sudo K, Nakamura Y |title=Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication. |journal=Cytogenet. Cell Genet. |volume=68 |issue= 3-4 |pages= 226-30 |year= 1995 |pmid= 7842741 |doi= }}
* {{cite journal | vauthors = Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA | title = A "double adaptor" method for improved shotgun library construction. | journal = Anal. Biochem. | volume = 236 | issue = 1 | pages = 107–13 | year = 1996 | pmid = 8619474 | doi = 10.1006/abio.1996.0138 }}
*{{cite journal | author=Mincheva A, Todorov I, Werner D, ''et al.'' |title=The human gene for nuclear protein BM28 (CDCL1), a new member of the early S-phase family of proteins, maps to chromosome band 3q21. |journal=Cytogenet. Cell Genet. |volume=65 |issue= 4 |pages= 276-7 |year= 1994 |pmid= 8258304 |doi= }}
* {{cite journal | vauthors = Fujita M, Kiyono T, Hayashi Y, Ishibashi M | title = hCDC47, a human member of the MCM family. Dissociation of the nucleus-bound form during S phase. | journal = J. Biol. Chem. | volume = 271 | issue = 8 | pages = 4349–54 | year = 1996 | pmid = 8626784 | doi = 10.1074/jbc.271.8.4349 }}
*{{cite journal | author=Hu B, Burkhart R, Schulte D, ''et al.'' |title=The P1 family: a new class of nuclear mammalian proteins related to the yeast Mcm replication proteins. |journal=Nucleic Acids Res. |volume=21 |issue= 23 |pages= 5289-93 |year= 1994 |pmid= 8265339 |doi= }}
* {{cite journal | vauthors = Schulte D, Richter A, Burkhart R, Musahl C, Knippers R | title = Properties of the human nuclear protein p85Mcm. Expression, nuclear localization and interaction with other Mcm proteins. | journal = Eur. J. Biochem. | volume = 235 | issue = 1-2 | pages = 144–51 | year = 1996 | pmid = 8631321 | doi = 10.1111/j.1432-1033.1996.00144.x }}
*{{cite journal | author=Andersson B, Wentland MA, Ricafrente JY, ''et al.'' |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107-13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138 }}
* {{cite journal | vauthors = Kiyono T, Fujita M, Hayashi Y, Ishibashi M | title = Cloning of a cDNA encoding a human homologue of CDC47, a member of the MCM family. | journal = Biochim. Biophys. Acta | volume = 1307 | issue = 1 | pages = 31–4 | year = 1996 | pmid = 8652665 | doi = 10.1016/0167-4781(96)00057-7 }}
*{{cite journal | author=Fujita M, Kiyono T, Hayashi Y, Ishibashi M |title=hCDC47, a human member of the MCM family. Dissociation of the nucleus-bound form during S phase. |journal=J. Biol. Chem. |volume=271 |issue= 8 |pages= 4349-54 |year= 1996 |pmid= 8626784 |doi= }}
* {{cite journal | vauthors = Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H | title = Binding of human minichromosome maintenance proteins with histone H3. | journal = J. Biol. Chem. | volume = 271 | issue = 39 | pages = 24115–22 | year = 1996 | pmid = 8798650 | doi = 10.1074/jbc.271.39.24115 }}
*{{cite journal | author=Schulte D, Richter A, Burkhart R, ''et al.'' |title=Properties of the human nuclear protein p85Mcm. Expression, nuclear localization and interaction with other Mcm proteins. |journal=Eur. J. Biochem. |volume=235 |issue= 1-2 |pages= 144-51 |year= 1996 |pmid= 8631321 |doi= }}
* {{cite journal | vauthors = Fujita M, Kiyono T, Hayashi Y, Ishibashi M | title = In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP. | journal = J. Biol. Chem. | volume = 272 | issue = 16 | pages = 10928–35 | year = 1997 | pmid = 9099751 | doi = 10.1074/jbc.272.16.10928 }}
*{{cite journal | author=Kiyono T, Fujita M, Hayashi Y, Ishibashi M |title=Cloning of a cDNA encoding a human homologue of CDC47, a member of the MCM family. |journal=Biochim. Biophys. Acta |volume=1307 |issue= 1 |pages= 31-4 |year= 1996 |pmid= 8652665 |doi= }}
* {{cite journal | vauthors = Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA | title = Large-scale concatenation cDNA sequencing. | journal = Genome Res. | volume = 7 | issue = 4 | pages = 353–8 | year = 1997 | pmid = 9110174 | pmc = 139146 | doi = 10.1101/gr.7.4.353 }}
*{{cite journal | author=Ishimi Y, Ichinose S, Omori A, ''et al.'' |title=Binding of human minichromosome maintenance proteins with histone H3. |journal=J. Biol. Chem. |volume=271 |issue= 39 |pages= 24115-22 |year= 1996 |pmid= 8798650 |doi= }}
* {{cite journal | vauthors = Hiraiwa A, Fujita M, Nagasaka T, Adachi A, Ohashi M, Ishibashi M | title = Immunolocalization of hCDC47 protein in normal and neoplastic human tissues and its relation to growth. | journal = Int. J. Cancer | volume = 74 | issue = 2 | pages = 180–4 | year = 1997 | pmid = 9133452 | doi = 10.1002/(SICI)1097-0215(19970422)74:2<180::AID-IJC7>3.0.CO;2-V }}
*{{cite journal | author=Fujita M, Kiyono T, Hayashi Y, Ishibashi M |title=In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP. |journal=J. Biol. Chem. |volume=272 |issue= 16 |pages= 10928-35 |year= 1997 |pmid= 9099751 |doi= }}
* {{cite journal | vauthors = Ishimi Y | title = A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex. | journal = J. Biol. Chem. | volume = 272 | issue = 39 | pages = 24508–13 | year = 1997 | pmid = 9305914 | doi = 10.1074/jbc.272.39.24508 }}
*{{cite journal | author=Yu W, Andersson B, Worley KC, ''et al.'' |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353-8 |year= 1997 |pmid= 9110174 |doi= }}
* {{cite journal | vauthors = Sterner JM, Dew-Knight S, Musahl C, Kornbluth S, Horowitz JM | title = Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. | journal = Mol. Cell. Biol. | volume = 18 | issue = 5 | pages = 2748–57 | year = 1998 | pmid = 9566894 | pmc = 110654 | doi =  10.1128/mcb.18.5.2748}}
*{{cite journal | author=Hiraiwa A, Fujita M, Nagasaka T, ''et al.'' |title=Immunolocalization of hCDC47 protein in normal and neoplastic human tissues and its relation to growth. |journal=Int. J. Cancer |volume=74 |issue= 2 |pages= 180-4 |year= 1997 |pmid= 9133452 |doi= }}
* {{cite journal | vauthors = Suzuki S, Adachi A, Hiraiwa A, Ohashi M, Ishibashi M, Kiyono T | title = Cloning and characterization of human MCM7 promoter. | journal = Gene | volume = 216 | issue = 1 | pages = 85–91 | year = 1998 | pmid = 9714754 | doi = 10.1016/S0378-1119(98)00323-0 }}
*{{cite journal | author=Ishimi Y |title=A DNA helicase activity is associated with an MCM4, -6, and -7 protein complex. |journal=J. Biol. Chem. |volume=272 |issue= 39 |pages= 24508-13 |year= 1997 |pmid= 9305914 |doi=  }}
* {{cite journal | vauthors = Kühne C, Banks L | title = E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box. | journal = J. Biol. Chem. | volume = 273 | issue = 51 | pages = 34302–9 | year = 1999 | pmid = 9852095 | doi = 10.1074/jbc.273.51.34302 }}
*{{cite journal | author=Sterner JM, Dew-Knight S, Musahl C, ''et al.'' |title=Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7. |journal=Mol. Cell. Biol. |volume=18 |issue= 5 |pages= 2748-57 |year= 1998 |pmid= 9566894 |doi= }}
* {{cite journal | vauthors = Fujita M, Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M, Tsurumi T | title = Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation. | journal = J. Biol. Chem. | volume = 274 | issue = 36 | pages = 25927–32 | year = 1999 | pmid = 10464337 | doi = 10.1074/jbc.274.36.25927 }}
*{{cite journal | author=Suzuki S, Adachi A, Hiraiwa A, ''et al.'' |title=Cloning and characterization of human MCM7 promoter. |journal=Gene |volume=216 |issue= 1 |pages= 85-91 |year= 1998 |pmid= 9714754 |doi= }}
* {{cite journal | vauthors = Freeman A, Morris LS, Mills AD, Stoeber K, Laskey RA, Williams GH, Coleman N | title = Minichromosome maintenance proteins as biological markers of dysplasia and malignancy. | journal = Clin. Cancer Res. | volume = 5 | issue = 8 | pages = 2121–32 | year = 1999 | pmid = 10473096 | doi =  }}
*{{cite journal | author=Kühne C, Banks L |title=E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box. |journal=J. Biol. Chem. |volume=273 |issue= 51 |pages= 34302-9 |year= 1999 |pmid= 9852095 |doi= }}
* {{cite journal | vauthors = Kukimoto I, Igaki H, Kanda T | title = Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha. | journal = Eur. J. Biochem. | volume = 265 | issue = 3 | pages = 936–43 | year = 1999 | pmid = 10518787 | doi = 10.1046/j.1432-1327.1999.00791.x }}
*{{cite journal | author=Fujita M, Yamada C, Goto H, ''et al.'' |title=Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation. |journal=J. Biol. Chem. |volume=274 |issue= 36 |pages= 25927-32 |year= 1999 |pmid= 10464337 |doi=  }}
*{{cite journal | author=Freeman A, Morris LS, Mills AD, ''et al.'' |title=Minichromosome maintenance proteins as biological markers of dysplasia and malignancy. |journal=Clin. Cancer Res. |volume=5 |issue= 8 |pages= 2121-32 |year= 1999 |pmid= 10473096 |doi= }}
*{{cite journal  | author=Kukimoto I, Igaki H, Kanda T |title=Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha. |journal=Eur. J. Biochem. |volume=265 |issue= 3 |pages= 936-43 |year= 1999 |pmid= 10518787 |doi=  }}
}}
{{refend}}
{{refend}}
{{protein-stub}}
{{WikiDoc Sources}}

Latest revision as of 06:16, 4 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

DNA replication licensing factor MCM7 is a protein that in humans is encoded by the MCM7 gene.[1]

Function

The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre-RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumor suppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported.[2]

Interactions

MCM7 has been shown to interact with:

See also

References

  1. ↑ Nakatsuru S, Sudo K, Nakamura Y (March 1995). "Isolation and mapping of a human gene (MCM2) encoding a product homologous to yeast proteins involved in DNA replication". Cytogenet Cell Genet. 68 (3–4): 226–30. doi:10.1159/000133918. PMID 7842741.
  2. ↑ "Entrez Gene: MCM7 MCM7 minichromosome maintenance deficient 7 (S. cerevisiae)".
  3. ↑ 3.00 3.01 3.02 3.03 3.04 3.05 3.06 3.07 3.08 3.09 3.10 3.11 3.12 Kneissl M, Pütter V, Szalay AA, Grummt F (March 2003). "Interaction and assembly of murine pre-replicative complex proteins in yeast and mouse cells". J. Mol. Biol. 327 (1): 111–28. doi:10.1016/s0022-2836(03)00079-2. PMID 12614612.
  4. ↑ Kukimoto I, Igaki H, Kanda T (November 1999). "Human CDC45 protein binds to minichromosome maintenance 7 protein and the p70 subunit of DNA polymerase alpha". Eur. J. Biochem. 265 (3): 936–43. doi:10.1046/j.1432-1327.1999.00791.x. PMID 10518787.
  5. ↑ 5.0 5.1 Fujita M, Yamada C, Goto H, Yokoyama N, Kuzushima K, Inagaki M, Tsurumi T (September 1999). "Cell cycle regulation of human CDC6 protein. Intracellular localization, interaction with the human mcm complex, and CDC2 kinase-mediated hyperphosphorylation". J. Biol. Chem. 274 (36): 25927–32. doi:10.1074/jbc.274.36.25927. PMID 10464337.
  6. ↑ 6.0 6.1 6.2 6.3 6.4 Fujita M, Kiyono T, Hayashi Y, Ishibashi M (April 1997). "In vivo interaction of human MCM heterohexameric complexes with chromatin. Possible involvement of ATP". J. Biol. Chem. 272 (16): 10928–35. doi:10.1074/jbc.272.16.10928. PMID 9099751.
  7. ↑ 7.0 7.1 7.2 Yabuta N, Kajimura N, Mayanagi K, Sato M, Gotow T, Uchiyama Y, Ishimi Y, Nojima H (May 2003). "Mammalian Mcm2/4/6/7 complex forms a toroidal structure". Genes Cells. 8 (5): 413–21. doi:10.1046/j.1365-2443.2003.00645.x. PMID 12694531.
  8. ↑ 8.0 8.1 8.2 You Z, Ishimi Y, Masai H, Hanaoka F (November 2002). "Roles of Mcm7 and Mcm4 subunits in the DNA helicase activity of the mouse Mcm4/6/7 complex". J. Biol. Chem. 277 (45): 42471–9. doi:10.1074/jbc.M205769200. PMID 12207017.
  9. ↑ You Z, Komamura Y, Ishimi Y (December 1999). "Biochemical analysis of the intrinsic Mcm4-Mcm6-mcm7 DNA helicase activity". Mol. Cell. Biol. 19 (12): 8003–15. PMC 84885. PMID 10567526.
  10. ↑ Fujita M, Ishimi Y, Nakamura H, Kiyono T, Tsurumi T (March 2002). "Nuclear organization of DNA replication initiation proteins in mammalian cells". J. Biol. Chem. 277 (12): 10354–61. doi:10.1074/jbc.M111398200. PMID 11779870.
  11. ↑ Ishimi Y, Ichinose S, Omori A, Sato K, Kimura H (September 1996). "Binding of human minichromosome maintenance proteins with histone H3". J. Biol. Chem. 271 (39): 24115–22. doi:10.1074/jbc.271.39.24115. PMID 8798650.
  12. ↑ DaFonseca CJ, Shu F, Zhang JJ (March 2001). "Identification of two residues in MCM5 critical for the assembly of MCM complexes and Stat1-mediated transcription activation in response to IFN-gamma". Proc. Natl. Acad. Sci. U.S.A. 98 (6): 3034–9. doi:10.1073/pnas.061487598. PMC 30602. PMID 11248027.
  13. ↑ Wang Y, Xu F, Hall FL (October 2000). "The MAT1 cyclin-dependent kinase-activating kinase (CAK) assembly/targeting factor interacts physically with the MCM7 DNA licensing factor". FEBS Lett. 484 (1): 17–21. doi:10.1016/s0014-5793(00)02117-7. PMID 11056214.
  14. ↑ Sterner JM, Dew-Knight S, Musahl C, Kornbluth S, Horowitz JM (May 1998). "Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7". Mol. Cell. Biol. 18 (5): 2748–57. doi:10.1128/mcb.18.5.2748. PMC 110654. PMID 9566894.
  15. ↑ Kühne C, Banks L (December 1998). "E3-ubiquitin ligase/E6-AP links multicopy maintenance protein 7 to the ubiquitination pathway by a novel motif, the L2G box". J. Biol. Chem. 273 (51): 34302–9. doi:10.1074/jbc.273.51.34302. PMID 9852095.

Further reading

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