OR1D2: Difference between revisions

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{{Infobox_gene}}
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'''Olfactory receptor 1D2''' is a [[protein]] that in humans is encoded by the ''OR1D2'' [[gene]].<ref name="pmid1370859">{{cite journal | vauthors = Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J| title = Expression of members of the putative olfactory receptor gene family in mammalian germ cells | journal = Nature | volume = 355 | issue = 6359 | pages = 453–5 |date=Mar 1992 | pmid = 1370859 | pmc =  | doi = 10.1038/355453a0 |display-authors=etal}}</ref><ref name="pmid1840504">{{cite journal | vauthors = Buck L, Axel R | title = A novel multigene family may encode odorant receptors: a molecular basis for odor recognition | journal = Cell | volume = 65 | issue = 1 | pages = 175–87 |date=May 1991 | pmid = 1840504 | pmc =  | doi =10.1016/0092-8674(91)90418-X }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OR1D2 olfactory receptor, family 1, subfamily D, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4991| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Olfactory receptor, family 1, subfamily D, member 2
| HGNCid = 8183
| Symbol = OR1D2
| AltSymbols =; MGC119942; MGC119943; OLFR1; OR17-4
| OMIM = 164342
| ECnumber = 
| Homologene = 37634
| MGIid = 3030246
| GeneAtlas_image1 = PBB_GE_OR1D2_221464_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}}
  | Process = {{GNF_GO|id=GO:0006928 |text = cell motility}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4991
    | Hs_Ensembl = ENSG00000184166
    | Hs_RefseqProtein = NP_002539
    | Hs_RefseqmRNA = NM_002548
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 2942102
    | Hs_GenLoc_end = 2943040
    | Hs_Uniprot = P34982
    | Mm_EntrezGene = 258153
    | Mm_Ensembl = ENSMUSG00000058275
    | Mm_RefseqmRNA = NM_001011851
    | Mm_RefseqProtein = NP_001011851
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 74180866
    | Mm_GenLoc_end = 74181804
    | Mm_Uniprot =   
  }}
}}
'''Olfactory receptor, family 1, subfamily D, member 2''', also known as '''OR1D2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR1D2 olfactory receptor, family 1, subfamily D, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4991| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR1D2 olfactory receptor, family 1, subfamily D, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4991| accessdate = }}</ref>
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez"/>
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal  | author=Selbie LA, Townsend-Nicholson A, Iismaa TP, Shine J |title=Novel G protein-coupled receptors: a gene family of putative human olfactory receptor sequences. |journal=Brain Res. Mol. Brain Res. |volume=13 |issue= 1-2 |pages= 159-63 |year= 1992 |pmid= 1315913 |doi=  }}
*{{cite journal  | vauthors=Selbie LA, Townsend-Nicholson A, Iismaa TP, Shine J |title=Novel G protein-coupled receptors: a gene family of putative human olfactory receptor sequences. |journal=Brain Res. Mol. Brain Res. |volume=13 |issue= 1–2 |pages= 159–63 |year= 1992 |pmid= 1315913 |doi=10.1016/0169-328X(92)90057-I }}
*{{cite journal  | author=Parmentier M, Libert F, Schurmans S, ''et al.'' |title=Expression of members of the putative olfactory receptor gene family in mammalian germ cells. |journal=Nature |volume=355 |issue= 6359 |pages= 453-5 |year= 1992 |pmid= 1370859 |doi= 10.1038/355453a0 }}
*{{cite journal   |vauthors=Ben-Arie N, Lancet D, Taylor C, etal |title=Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire |journal=Hum. Mol. Genet. |volume=3 |issue= 2 |pages= 229–35 |year= 1994 |pmid= 8004088 |doi=10.1093/hmg/3.2.229 }}
*{{cite journal  | author=Buck L, Axel R |title=A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. |journal=Cell |volume=65 |issue= 1 |pages= 175-87 |year= 1991 |pmid= 1840504 |doi= }}
*{{cite journal   |vauthors=Schurmans S, Muscatelli F, Miot F, etal |title=The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13→p12 region of the human genome and reveals an MspI restriction fragment length polymorphism |journal=Cytogenet. Cell Genet. |volume=63 |issue= 3 |pages= 200–4 |year= 1993 |pmid= 8097991 |doi=10.1159/000133534 }}
*{{cite journal | author=Ben-Arie N, Lancet D, Taylor C, ''et al.'' |title=Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. |journal=Hum. Mol. Genet. |volume=3 |issue= 2 |pages= 229-35 |year= 1994 |pmid= 8004088 |doi=  }}
*{{cite journal   |vauthors=Nekrasova E, Sosinskaya A, Natochin M, etal |title=Overexpression, solubilization and purification of rat and human olfactory receptors |journal=Eur. J. Biochem. |volume=238 |issue= 1 |pages= 28–37 |year= 1996 |pmid= 8665947 |doi=10.1111/j.1432-1033.1996.0028q.x }}
*{{cite journal | author=Schurmans S, Muscatelli F, Miot F, ''et al.'' |title=The OLFR1 gene encoding the HGMP07E putative olfactory receptor maps to the 17p13-->p12 region of the human genome and reveals an MspI restriction fragment length polymorphism. |journal=Cytogenet. Cell Genet. |volume=63 |issue= 3 |pages= 200-4 |year= 1993 |pmid= 8097991 |doi=  }}
*{{cite journal   |vauthors=Glusman G, Sosinsky A, Ben-Asher E, etal |title=Sequence, structure, and evolution of a complete human olfactory receptor gene cluster |journal=Genomics |volume=63 |issue= 2 |pages= 227–45 |year= 2000 |pmid= 10673334 |doi= 10.1006/geno.1999.6030 }}
*{{cite journal | author=Nekrasova E, Sosinskaya A, Natochin M, ''et al.'' |title=Overexpression, solubilization and purification of rat and human olfactory receptors. |journal=Eur. J. Biochem. |volume=238 |issue= 1 |pages= 28-37 |year= 1996 |pmid= 8665947 |doi=  }}
*{{cite journal   |vauthors=Fuchs T, Malecova B, Linhart C, etal |title=DEFOG: a practical scheme for deciphering families of genes |journal=Genomics |volume=80 |issue= 3 |pages= 295–302 |year= 2003 |pmid= 12213199 |doi=10.1006/geno.2002.6830 }}
*{{cite journal | author=Glusman G, Sosinsky A, Ben-Asher E, ''et al.'' |title=Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. |journal=Genomics |volume=63 |issue= 2 |pages= 227-45 |year= 2000 |pmid= 10673334 |doi= 10.1006/geno.1999.6030 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi=  }}
*{{cite journal   |vauthors=Spehr M, Gisselmann G, Poplawski A, etal |title=Identification of a testicular odorant receptor mediating human sperm chemotaxis |journal=Science |volume=299 |issue= 5615 |pages= 2054–8 |year= 2003 |pmid= 12663925 |doi= 10.1126/science.1080376 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | vauthors=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584–9 |year= 2004 |pmid= 14983052 |doi=10.1073/pnas.0307882100  | pmc=356993 }}
*{{cite journal | author=Spehr M, Gisselmann G, Poplawski A, ''et al.'' |title=Identification of a testicular odorant receptor mediating human sperm chemotaxis. |journal=Science |volume=299 |issue= 5615 |pages= 2054-8 |year= 2003 |pmid= 12663925 |doi= 10.1126/science.1080376 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi=  }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
}}
}}
{{refend}}
{{refend}}
== External links ==
* {{MeshName|OR1D2+protein,+human}}


{{NLM content}}
{{NLM content}}
{{membrane-protein-stub}}
 
{{Olfactory receptors}}
{{Olfactory receptors}}
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[[Category:Olfactory receptors]]




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Latest revision as of 00:28, 7 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Olfactory receptor 1D2 is a protein that in humans is encoded by the OR1D2 gene.[1][2][3]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]

See also

References

  1. ↑ Parmentier M, Libert F, Schurmans S, Schiffmann S, Lefort A, Eggerickx D, Ledent C, Mollereau C, Gerard C, Perret J, et al. (Mar 1992). "Expression of members of the putative olfactory receptor gene family in mammalian germ cells". Nature. 355 (6359): 453–5. doi:10.1038/355453a0. PMID 1370859.
  2. ↑ Buck L, Axel R (May 1991). "A novel multigene family may encode odorant receptors: a molecular basis for odor recognition". Cell. 65 (1): 175–87. doi:10.1016/0092-8674(91)90418-X. PMID 1840504.
  3. ↑ 3.0 3.1 "Entrez Gene: OR1D2 olfactory receptor, family 1, subfamily D, member 2".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.



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