OR3A1: Difference between revisions

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{{Infobox_gene}}
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'''Olfactory receptor 3A1''' is a [[protein]] that in humans is encoded by the ''OR3A1'' [[gene]].<ref name="pmid8921386">{{cite journal | vauthors = Glusman G, Clifton S, Roe B, Lancet D | title = Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity | journal = Genomics | volume = 37 | issue = 2 | pages = 147–60 |date=Feb 1997 | pmid = 8921386 | pmc =  | doi = 10.1006/geno.1996.0536 }}</ref><ref name="pmid8647456">{{cite journal | vauthors = Crowe ML, Perry BN, Connerton IF | title = Olfactory receptor-encoding genes and pseudogenes are expressed in humans | journal = Gene | volume = 169 | issue = 2 | pages = 247–9 |date=Jul 1996 | pmid = 8647456 | pmc =  | doi =10.1016/0378-1119(95)00849-7 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: OR3A1 olfactory receptor, family 3, subfamily A, member 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4994| accessdate = }}</ref>
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{{GNF_Protein_box
| image =
| image_source = 
| PDB =
| Name = Olfactory receptor, family 3, subfamily A, member 1
| HGNCid = 8282
| Symbol = OR3A1
| AltSymbols =; OLFRA03; OR17-40; OR17-82; OR40
| OMIM = 
| ECnumber = 
| Homologene = 1915
| MGIid = 3030236
| GeneAtlas_image1 = PBB_GE_OR3A1_221353_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}}{{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0005887 |text = integral to plasma membrane}} {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
  | Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 4994
    | Hs_Ensembl = ENSG00000180090
    | Hs_RefseqProtein = NP_002541
    | Hs_RefseqmRNA = NM_002550
    | Hs_GenLoc_db =   
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 3141679
    | Hs_GenLoc_end = 3142626
    | Hs_Uniprot = P47881
    | Mm_EntrezGene = 258703
    | Mm_Ensembl = ENSMUSG00000070379
    | Mm_RefseqmRNA = NM_146708
    | Mm_RefseqProtein = NP_666919
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 73971351
    | Mm_GenLoc_end = 73972298
    | Mm_Uniprot =   
  }}
}}
'''Olfactory receptor, family 3, subfamily A, member 1''', also known as '''OR3A1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR3A1 olfactory receptor, family 3, subfamily A, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4994| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR3A1 olfactory receptor, family 3, subfamily A, member 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4994| accessdate = }}</ref>
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez" />
}}
}}


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==References==
==References==
{{reflist|2}}
{{reflist}}


==Further reading==
==Further reading==
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| citations =  
| citations =  
*{{cite journal | author=Marrakchi M, Vidic J, Jaffrezic-Renault N, ''et al.'' |title=A new concept of olfactory biosensor based on interdigitated microelectrodes and immobilized yeasts expressing the human receptor OR17-40. |journal=Eur. Biophys. J. |volume=36 |issue= 8 |pages= 1015-8 |year= 2008 |pmid= 17579849 |doi= 10.1007/s00249-007-0187-6 }}
*{{cite journal   |vauthors=Marrakchi M, Vidic J, Jaffrezic-Renault N, etal |title=A new concept of olfactory biosensor based on interdigitated microelectrodes and immobilized yeasts expressing the human receptor OR17-40 |journal=Eur. Biophys. J. |volume=36 |issue= 8 |pages= 1015–8 |year= 2008 |pmid= 17579849 |doi= 10.1007/s00249-007-0187-6 }}
*{{cite journal | author=Jacquier V, Prummer M, Segura JM, ''et al.'' |title=Visualizing odorant receptor trafficking in living cells down to the single-molecule level. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 39 |pages= 14325-30 |year= 2006 |pmid= 16980412 |doi= 10.1073/pnas.0603942103 }}
*{{cite journal   |vauthors=Jacquier V, Prummer M, Segura JM, etal |title=Visualizing odorant receptor trafficking in living cells down to the single-molecule level |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 39 |pages= 14325–30 |year= 2006 |pmid= 16980412 |doi= 10.1073/pnas.0603942103 | pmc=1599963 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 | pmc=528928 }}
*{{cite journal  | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi=  }}
*{{cite journal  | vauthors=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584–9 |year= 2004 |pmid= 14983052 |doi=10.1073/pnas.0307882100  | pmc=356993 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 }}
*{{cite journal | author=Glusman G, Sosinsky A, Ben-Asher E, ''et al.'' |title=Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. |journal=Genomics |volume=63 |issue= 2 |pages= 227-45 |year= 2000 |pmid= 10673334 |doi= 10.1006/geno.1999.6030 }}
*{{cite journal   |vauthors=Glusman G, Sosinsky A, Ben-Asher E, etal |title=Sequence, structure, and evolution of a complete human olfactory receptor gene cluster |journal=Genomics |volume=63 |issue= 2 |pages= 227–45 |year= 2000 |pmid= 10673334 |doi= 10.1006/geno.1999.6030 }}
*{{cite journal | author=Glusman G, Clifton S, Roe B, Lancet D |title=Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity. |journal=Genomics |volume=37 |issue= 2 |pages= 147-60 |year= 1997 |pmid= 8921386 |doi= 10.1006/geno.1996.0536 }}
*{{cite journal   |vauthors=Ben-Arie N, Lancet D, Taylor C, etal |title=Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire |journal=Hum. Mol. Genet. |volume=3 |issue= 2 |pages= 229–35 |year= 1994 |pmid= 8004088 |doi=10.1093/hmg/3.2.229 }}
*{{cite journal  | author=Crowe ML, Perry BN, Connerton IF |title=Olfactory receptor-encoding genes and pseudogenes are expressed in humans. |journal=Gene |volume=169 |issue= 2 |pages= 247-9 |year= 1996 |pmid= 8647456 |doi=  }}
*{{cite journal  | author=Ben-Arie N, Lancet D, Taylor C, ''et al.'' |title=Olfactory receptor gene cluster on human chromosome 17: possible duplication of an ancestral receptor repertoire. |journal=Hum. Mol. Genet. |volume=3 |issue= 2 |pages= 229-35 |year= 1994 |pmid= 8004088 |doi=  }}
}}
}}
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{{NLM content}}
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{{membrane-protein-stub}}
 
{{Olfactory receptors}}
{{Olfactory receptors}}
[[Category:G protein coupled receptors]]
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[[Category:Olfactory receptors]]

Latest revision as of 00:30, 7 September 2017

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SpeciesHumanMouse
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Ensembl

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View/Edit Human

Olfactory receptor 3A1 is a protein that in humans is encoded by the OR3A1 gene.[1][2][3]

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[3]

See also

References

  1. ↑ Glusman G, Clifton S, Roe B, Lancet D (Feb 1997). "Sequence analysis in the olfactory receptor gene cluster on human chromosome 17: recombinatorial events affecting receptor diversity". Genomics. 37 (2): 147–60. doi:10.1006/geno.1996.0536. PMID 8921386.
  2. ↑ Crowe ML, Perry BN, Connerton IF (Jul 1996). "Olfactory receptor-encoding genes and pseudogenes are expressed in humans". Gene. 169 (2): 247–9. doi:10.1016/0378-1119(95)00849-7. PMID 8647456.
  3. ↑ 3.0 3.1 "Entrez Gene: OR3A1 olfactory receptor, family 3, subfamily A, member 1".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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