OR4D2: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Olfactory receptor 4D2''' is a [[protein]] that in humans is encoded by the ''OR4D2'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR4D2 olfactory receptor, family 4, subfamily D, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=124538| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Olfactory receptor, family 4, subfamily D, member 2
| HGNCid = 8294
| Symbol = OR4D2
| AltSymbols =; BC2009; OR17-24
| OMIM = 
| ECnumber = 
| Homologene = 64870
| MGIid = 3030297
| GeneAtlas_image1 = PBB_GE_OR4D2_gnf1h07005_at_tn.png
| Function = {{GNF_GO|id=GO:0004872 |text = receptor activity}} {{GNF_GO|id=GO:0004984 |text = olfactory receptor activity}}
| Component = {{GNF_GO|id=GO:0016020 |text = membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007186 |text = G-protein coupled receptor protein signaling pathway}} {{GNF_GO|id=GO:0007608 |text = sensory perception of smell}} {{GNF_GO|id=GO:0050896 |text = response to stimulus}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 124538
    | Hs_Ensembl = ENSG00000153951
    | Hs_RefseqProtein = NP_001004707
    | Hs_RefseqmRNA = NM_001004707
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 53601761
    | Hs_GenLoc_end = 53603689
    | Hs_Uniprot = P58180
    | Mm_EntrezGene = 258408
    | Mm_Ensembl = ENSMUSG00000058075
    | Mm_RefseqmRNA = XM_001002742
    | Mm_RefseqProtein = XP_001002742
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 87709182
    | Mm_GenLoc_end = 87710117
    | Mm_Uniprot = 
  }}
}}
'''Olfactory receptor, family 4, subfamily D, member 2''', also known as '''OR4D2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: OR4D2 olfactory receptor, family 4, subfamily D, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=124538| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
[[Olfactory receptor]]s interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of [[G-protein-coupled receptor]]s (GPCR) arising from single coding-[[exon]] genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR4D2 olfactory receptor, family 4, subfamily D, member 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=124538| accessdate = }}</ref>
{{PBB_Summary
| section_title =
| summary_text = Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.<ref name="entrez">{{cite web | title = Entrez Gene: OR4D2 olfactory receptor, family 4, subfamily D, member 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=124538| accessdate = }}</ref>
}}


==See also==
== See also ==
* [[Olfactory receptor]]
* [[Olfactory receptor]]


==References==
== References ==
{{reflist|2}}
{{reflist}}


==Further reading==
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Fuchs T, Malecova B, Linhart C, Sharan R, Khen M, Herwig R, Shmulevich D, Elkon R, Steinfath M, O'Brien JK, Radelof U, Lehrach H, Lancet D, Shamir R | title = DEFOG: a practical scheme for deciphering families of genes | journal = Genomics | volume = 80 | issue = 3 | pages = 295–302 | date = September 2002 | pmid = 12213199 | doi = 10.1006/geno.2002.6830 }}
| citations =
* {{cite journal | vauthors = Malnic B, Godfrey PA, Buck LB | title = The human olfactory receptor gene family | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 8 | pages = 2584–9 | date = February 2004 | pmid = 14983052 | pmc = 356993 | doi = 10.1073/pnas.0307882100 }}
*{{cite journal | author=Fuchs T, Malecova B, Linhart C, ''et al.'' |title=DEFOG: a practical scheme for deciphering families of genes. |journal=Genomics |volume=80 |issue= 3 |pages= 295-302 |year= 2003 |pmid= 12213199 |doi= }}
*{{cite journal | author=Malnic B, Godfrey PA, Buck LB |title=The human olfactory receptor gene family. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 8 |pages= 2584-9 |year= 2004 |pmid= 14983052 |doi=  }}
*{{cite journal  | author=Zody MC, Garber M, Adams DJ, ''et al.'' |title=DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage. |journal=Nature |volume=440 |issue= 7087 |pages= 1045-9 |year= 2006 |pmid= 16625196 |doi= 10.1038/nature04689 }}
}}
{{refend}}
{{refend}}


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{{Olfactory receptors}}
{{Olfactory receptors}}
[[Category:G protein coupled receptors]]
 
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Latest revision as of 02:41, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
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Wikidata
View/Edit Human

Olfactory receptor 4D2 is a protein that in humans is encoded by the OR4D2 gene.[1]

Function

Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms.[1]

See also

References

  1. ↑ 1.0 1.1 "Entrez Gene: OR4D2 olfactory receptor, family 4, subfamily D, member 2".

Further reading

External links

This article incorporates text from the United States National Library of Medicine, which is in the public domain.


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