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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1''' is an [[enzyme]] that in humans is encoded by the ''PLCB1'' [[gene]].<ref name="pmid10760467">{{cite journal | vauthors = Peruzzi D, Calabrese G, Faenza I, Manzoli L, Matteucci A, Gianfrancesco F, Billi AM, Stuppia L, Palka G, Cocco L | title = Identification and chromosomal localisation by fluorescence in situ hybridisation of human gene of phosphoinositide-specific phospholipase C beta(1) | journal = Biochim. Biophys. Acta | volume = 1484 | issue = 2-3 | pages = 175–82  | date = Jun 2000 | pmid = 10760467 | pmc =  | doi = 10.1016/s1388-1981(00)00012-3 }}</ref><ref name="pmid11118617">{{cite journal | vauthors = Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC | title = Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1) | journal = Biochim. Biophys. Acta | volume = 1517 | issue = 1 | pages = 63–72 | date = Jan 2001 | pmid = 11118617 | pmc = | doi = 10.1016/S0167-4781(00)00260-8 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23236| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Phospholipase C, beta 1 (phosphoinositide-specific)
| HGNCid = 15917
| Symbol = PLCB1
| AltSymbols =; PI-PLC; FLJ45792; PLC-154; PLC-I
| OMIM = 607120
| ECnumber = 
| Homologene = 22876
| MGIid = 97613
| GeneAtlas_image1 = PBB_GE_PLCB1_211925_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_PLCB1_213222_at_tn.png
| GeneAtlas_image3 = PBB_GE_PLCB1_215687_x_at_tn.png
| Function = {{GNF_GO|id=GO:0004435 |text = phosphoinositide phospholipase C activity}} {{GNF_GO|id=GO:0004871 |text = signal transducer activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0000074 |text = regulation of progression through cell cycle}} {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}} {{GNF_GO|id=GO:0016042 |text = lipid catabolic process}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 23236
    | Hs_Ensembl = ENSG00000182621
    | Hs_RefseqProtein = NP_056007
    | Hs_RefseqmRNA = NM_015192
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 20
    | Hs_GenLoc_start = 8060908
    | Hs_GenLoc_end = 8813547
    | Hs_Uniprot = Q9NQ66
    | Mm_EntrezGene = 18795
    | Mm_Ensembl = ENSMUSG00000051177
    | Mm_RefseqmRNA = NM_019677
    | Mm_RefseqProtein = NP_062651
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 2
    | Mm_GenLoc_start = 134477974
    | Mm_GenLoc_end = 135163721
    | Mm_Uniprot = Q2M4J2
  }}
}}
'''Phospholipase C, beta 1 (phosphoinositide-specific)''', also known as '''PLCB1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23236| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene catalyzes the formation of [[Inositol trisphosphate|inositol 1,4,5-trisphosphate]] and [[diglyceride|diacylglycerol]] from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.<ref name="entrez">{{cite web | title = Entrez Gene: PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23236| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
 
==Further reading==
PLCB1 has been shown to [[Protein-protein interaction|interact]] with [[TRPM7]].<ref name=pmid11941371>{{cite journal | vauthors = Runnels LW, Yue L, Clapham DE | title = The TRPM7 channel is inactivated by PIP(2) hydrolysis | journal = Nat. Cell Biol. | volume = 4 | issue = 5 | pages = 329–36  | date = May 2002 | pmid = 11941371 | doi = 10.1038/ncb781 }}</ref>
 
== Pathology ==
 
Homozygous PLCB1 deletion is associated with malignant migrating partial [[seizure]]s in infancy.<ref>{{cite journal | vauthors = Poduri A, Chopra SS, Neilan EG, Elhosary PC, Kurian MA, Meyer E, Barry BJ, Khwaja OS, Salih MA, Stödberg T, Scheffer IE, Maher ER, Sahin M, Wu BL, Berry GT, Walsh CA, Picker J, Kothare SV | title = Homozygous PLCB1 deletion associated with malignant migrating partial seizures in infancy | journal = Epilepsia | volume = 53 | issue = 8 | pages = e146-50 | year = 2012 | pmid = 22690784 | pmc = 3851296 | doi = 10.1111/j.1528-1167.2012.03538.x }}</ref>
 
== References ==
{{reflist}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T | title = Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones | journal = DNA Res. | volume = 9 | issue = 3 | pages = 99–106 | year = 2002 | pmid = 12168954 | doi = 10.1093/dnares/9.3.99 }}
| citations =
* {{cite journal | vauthors = Martelli AM, Fiume R, Faenza I, Tabellini G, Evangelista C, Bortul R, Follo MY, Falà F, Cocco L | title = Nuclear phosphoinositide specific phospholipase C (PI-PLC)-beta 1: a central intermediary in nuclear lipid-dependent signal transduction | journal = Histol. Histopathol. | volume = 20 | issue = 4 | pages = 1251–60 | year = 2005 | pmid = 16136505 | doi =  }}
*{{cite journal | author=Nakajima D, Okazaki N, Yamakawa H, ''et al.'' |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi= }}
* {{cite journal | vauthors = Cocco L, Follo MY, Faenza I, Bavelloni A, Billi AM, Martelli AM, Manzoli L | title = Nuclear inositide signaling: an appraisal of phospholipase C beta 1 behavior in myelodysplastic and leukemia cells | journal = Adv. Enzyme Regul. | volume = 47 | issue =  | pages = 2–9 | year = 2007 | pmid = 17335878 | doi = 10.1016/j.advenzreg.2006.12.003 }}
*{{cite journal | author=Martelli AM, Fiume R, Faenza I, ''et al.'' |title=Nuclear phosphoinositide specific phospholipase C (PI-PLC)-beta 1: a central intermediary in nuclear lipid-dependent signal transduction. |journal=Histol. Histopathol. |volume=20 |issue= 4 |pages= 1251-60 |year= 2006 |pmid= 16136505 |doi=  }}
* {{cite journal | vauthors = Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G | title = Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway | journal = J. Clin. Invest. | volume = 86 | issue = 6 | pages = 2117–24 | year = 1990 | pmid = 1979339 | pmc = 329852 | doi = 10.1172/JCI114950 }}
*{{cite journal | author=Cocco L, Follo MY, Faenza I, ''et al.'' |title=Nuclear inositide signaling: an appraisal of phospholipase C beta 1 behavior in myelodysplastic and leukemia cells. |journal=Adv. Enzyme Regul. |volume=47 |issue=  |pages= 2-9 |year= 2007 |pmid= 17335878 |doi= 10.1016/j.advenzreg.2006.12.003 }}
* {{cite journal | vauthors = Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S | title = Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line | journal = Eur. J. Immunol. | volume = 25 | issue = 9 | pages = 2695–700 | year = 1995 | pmid = 7589147 | doi = 10.1002/eji.1830250944 }}
*{{cite journal | author=Cefai D, Debre P, Kaczorek M, ''et al.'' |title=Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. |journal=J. Clin. Invest. |volume=86 |issue= 6 |pages= 2117-24 |year= 1991 |pmid= 1979339 |doi= }}
* {{cite journal | vauthors = Hwang SC, Park KH, Ha MJ, Noh IS, Park TB, Lee YH | title = Distribution of phospholipase C isozymes in normal human lung tissue and their immunohistochemical localization | journal = J. Korean Med. Sci. | volume = 11 | issue = 4 | pages = 305–13 | year = 1996 | pmid = 8878798 | pmc = 3054083 | doi =  10.3346/jkms.1996.11.4.305}}
*{{cite journal | author=Zauli G, Previati M, Caramelli E, ''et al.'' |title=Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line. |journal=Eur. J. Immunol. |volume=25 |issue= 9 |pages= 2695-700 |year= 1995 |pmid= 7589147 |doi= }}
* {{cite journal | vauthors = Chen P, Mayne M, Power C, Nath A | title = The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases | journal = J. Biol. Chem. | volume = 272 | issue = 36 | pages = 22385–8 | year = 1997 | pmid = 9278385 | doi = 10.1074/jbc.272.36.22385 }}
*{{cite journal | author=Hwang SC, Park KH, Ha MJ, ''et al.'' |title=Distribution of phospholipase C isozymes in normal human lung tissue and their immunohistochemical localization. |journal=J. Korean Med. Sci. |volume=11 |issue= 4 |pages= 305-13 |year= 1997 |pmid= 8878798 |doi=  }}
* {{cite journal | vauthors = Nagase T, Ishikawa K, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O | title = Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro | journal = DNA Res. | volume = 5 | issue = 1 | pages = 31–9 | year = 1998 | pmid = 9628581 | doi = 10.1093/dnares/5.1.31 }}
*{{cite journal | author=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385-8 |year= 1997 |pmid= 9278385 |doi= }}
* {{cite journal | vauthors = Snow BE, Hall RA, Krumins AM, Brothers GM, Bouchard D, Brothers CA, Chung S, Mangion J, Gilman AG, Lefkowitz RJ, Siderovski DP | title = GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain | journal = J. Biol. Chem. | volume = 273 | issue = 28 | pages = 17749–55 | year = 1998 | pmid = 9651375 | doi = 10.1074/jbc.273.28.17749 }}
*{{cite journal | author=Nagase T, Ishikawa K, Miyajima N, ''et al.'' |title=Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. |journal=DNA Res. |volume=5 |issue= 1 |pages= 31-9 |year= 1998 |pmid= 9628581 |doi= }}
* {{cite journal | vauthors = Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C | title = HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease | journal = Neuroimmunomodulation | volume = 5 | issue = 3-4 | pages = 184–92 | year = 1998 | pmid = 9730685 | doi = 10.1159/000026336 }}
*{{cite journal | author=Snow BE, Hall RA, Krumins AM, ''et al.'' |title=GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. |journal=J. Biol. Chem. |volume=273 |issue= 28 |pages= 17749-55 |year= 1998 |pmid= 9651375 |doi= }}
* {{cite journal | vauthors = Haughey NJ, Holden CP, Nath A, Geiger JD | title = Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat | journal = J. Neurochem. | volume = 73 | issue = 4 | pages = 1363–74 | year = 1999 | pmid = 10501179 | doi = 10.1046/j.1471-4159.1999.0731363.x }}
*{{cite journal | author=Mayne M, Bratanich AC, Chen P, ''et al.'' |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. |journal=Neuroimmunomodulation |volume=5 |issue= 3-4 |pages= 184-92 |year= 1998 |pmid= 9730685 |doi= }}
* {{cite journal | vauthors = Mayne M, Holden CP, Nath A, Geiger JD | title = Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages | journal = J. Immunol. | volume = 164 | issue = 12 | pages = 6538–42 | year = 2000 | pmid = 10843712 | doi = 10.4049/jimmunol.164.12.6538 }}
*{{cite journal | author=Haughey NJ, Holden CP, Nath A, Geiger JD |title=Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat. |journal=J. Neurochem. |volume=73 |issue= 4 |pages= 1363-74 |year= 1999 |pmid= 10501179 |doi= }}
* {{cite journal | vauthors = Tang Y, Tang J, Chen Z, Trost C, Flockerzi V, Li M, Ramesh V, Zhu MX | title = Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF | journal = J. Biol. Chem. | volume = 275 | issue = 48 | pages = 37559–64 | year = 2000 | pmid = 10980202 | doi = 10.1074/jbc.M006635200 }}
*{{cite journal | author=Peruzzi D, Calabrese G, Faenza I, ''et al.'' |title=Identification and chromosomal localisation by fluorescence in situ hybridisation of human gene of phosphoinositide-specific phospholipase C beta(1). |journal=Biochim. Biophys. Acta |volume=1484 |issue= 2-3 |pages= 175-82 |year= 2000 |pmid= 10760467 |doi= }}
* {{cite journal | vauthors = Dowal L, Elliott J, Popov S, Wilkie TM, Scarlata S | title = Determination of the contact energies between a regulator of G protein signaling and G protein subunits and phospholipase C beta 1 | journal = Biochemistry | volume = 40 | issue = 2 | pages = 414–21 | year = 2001 | pmid = 11148035 | doi = 10.1021/bi001923 }}
*{{cite journal | author=Mayne M, Holden CP, Nath A, Geiger JD |title=Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages. |journal=J. Immunol. |volume=164 |issue= 12 |pages= 6538-42 |year= 2000 |pmid= 10843712 |doi= }}
* {{cite journal | vauthors = Xu A, Wang Y, Xu LY, Gilmour RS | title = Protein kinase C alpha -mediated negative feedback regulation is responsible for the termination of insulin-like growth factor I-induced activation of nuclear phospholipase C beta1 in Swiss 3T3 cells | journal = J. Biol. Chem. | volume = 276 | issue = 18 | pages = 14980–6 | year = 2001 | pmid = 11278470 | doi = 10.1074/jbc.M009144200 }}
*{{cite journal | author=Tang Y, Tang J, Chen Z, ''et al.'' |title=Association of mammalian trp4 and phospholipase C isozymes with a PDZ domain-containing protein, NHERF. |journal=J. Biol. Chem. |volume=275 |issue= 48 |pages= 37559-64 |year= 2001 |pmid= 10980202 |doi= 10.1074/jbc.M006635200 }}
* {{cite journal | vauthors = Xu A, Suh PG, Marmy-Conus N, Pearson RB, Seok OY, Cocco L, Gilmour RS | title = Phosphorylation of nuclear phospholipase C beta1 by extracellular signal-regulated kinase mediates the mitogenic action of insulin-like growth factor I | journal = Mol. Cell. Biol. | volume = 21 | issue = 9 | pages = 2981–90 | year = 2001 | pmid = 11287604 | pmc = 86927 | doi = 10.1128/MCB.21.9.2981-2990.2001 }}
*{{cite journal | author=Caricasole A, Sala C, Roncarati R, ''et al.'' |title=Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1). |journal=Biochim. Biophys. Acta |volume=1517 |issue= 1 |pages= 63-72 |year= 2001 |pmid= 11118617 |doi= }}
* {{cite journal | vauthors = Vitale M, Matteucci A, Manzoli L, Rodella L, Mariani AR, Zauli G, Falconi M, Billi AM, Martelli AM, Gilmour RS, Cocco L | title = Interleukin 2 activates nuclear phospholipase Cbeta by mitogen-activated protein kinase-dependent phosphorylation in human natural killer cells | journal = FASEB J. | volume = 15 | issue = 10 | pages = 1789–91 | year = 2001 | pmid = 11481231 | doi = 10.1096/fj.01-0008fje }}
*{{cite journal | author=Dowal L, Elliott J, Popov S, ''et al.'' |title=Determination of the contact energies between a regulator of G protein signaling and G protein subunits and phospholipase C beta 1. |journal=Biochemistry |volume=40 |issue= 2 |pages= 414-21 |year= 2001 |pmid= 11148035 |doi= }}
* {{cite journal | vauthors = Singer AU, Waldo GL, Harden TK, Sondek J | title = A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q | journal = Nat. Struct. Biol. | volume = 9 | issue = 1 | pages = 32–6 | year = 2002 | pmid = 11753430 | doi = 10.1038/nsb731 }}
*{{cite journal | author=Xu A, Wang Y, Xu LY, Gilmour RS |title=Protein kinase C alpha -mediated negative feedback regulation is responsible for the termination of insulin-like growth factor I-induced activation of nuclear phospholipase C beta1 in Swiss 3T3 cells. |journal=J. Biol. Chem. |volume=276 |issue= 18 |pages= 14980-6 |year= 2001 |pmid= 11278470 |doi= 10.1074/jbc.M009144200 }}
*{{cite journal  | author=Xu A, Suh PG, Marmy-Conus N, ''et al.'' |title=Phosphorylation of nuclear phospholipase C beta1 by extracellular signal-regulated kinase mediates the mitogenic action of insulin-like growth factor I. |journal=Mol. Cell. Biol. |volume=21 |issue= 9 |pages= 2981-90 |year= 2001 |pmid= 11287604 |doi= 10.1128/MCB.21.9.2981-2990.2001 }}
*{{cite journal  | author=Vitale M, Matteucci A, Manzoli L, ''et al.'' |title=Interleukin 2 activates nuclear phospholipase Cbeta by mitogen-activated protein kinase-dependent phosphorylation in human natural killer cells. |journal=FASEB J. |volume=15 |issue= 10 |pages= 1789-91 |year= 2001 |pmid= 11481231 |doi=  }}
*{{cite journal | author=Singer AU, Waldo GL, Harden TK, Sondek J |title=A unique fold of phospholipase C-beta mediates dimerization and interaction with G alpha q. |journal=Nat. Struct. Biol. |volume=9 |issue= 1 |pages= 32-6 |year= 2002 |pmid= 11753430 |doi= 10.1038/nsb731 }}
}}
{{refend}}
{{refend}}


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[[Category:EC 3.1.4]]

Latest revision as of 01:49, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase beta-1 is an enzyme that in humans is encoded by the PLCB1 gene.[1][2][3]

Function

The protein encoded by this gene catalyzes the formation of inositol 1,4,5-trisphosphate and diacylglycerol from phosphatidylinositol 4,5-bisphosphate. This reaction uses calcium as a cofactor and plays an important role in the intracellular transduction of many extracellular signals. This gene is activated by two G-protein alpha subunits, alpha-q and alpha-11. Two transcript variants encoding different isoforms have been found for this gene.[3]

Interactions

PLCB1 has been shown to interact with TRPM7.[4]

Pathology

Homozygous PLCB1 deletion is associated with malignant migrating partial seizures in infancy.[5]

References

  1. ↑ Peruzzi D, Calabrese G, Faenza I, Manzoli L, Matteucci A, Gianfrancesco F, Billi AM, Stuppia L, Palka G, Cocco L (Jun 2000). "Identification and chromosomal localisation by fluorescence in situ hybridisation of human gene of phosphoinositide-specific phospholipase C beta(1)". Biochim. Biophys. Acta. 1484 (2–3): 175–82. doi:10.1016/s1388-1981(00)00012-3. PMID 10760467.
  2. ↑ Caricasole A, Sala C, Roncarati R, Formenti E, Terstappen GC (Jan 2001). "Cloning and characterization of the human phosphoinositide-specific phospholipase C-beta 1 (PLC beta 1)". Biochim. Biophys. Acta. 1517 (1): 63–72. doi:10.1016/S0167-4781(00)00260-8. PMID 11118617.
  3. ↑ 3.0 3.1 "Entrez Gene: PLCB1 phospholipase C, beta 1 (phosphoinositide-specific)".
  4. ↑ Runnels LW, Yue L, Clapham DE (May 2002). "The TRPM7 channel is inactivated by PIP(2) hydrolysis". Nat. Cell Biol. 4 (5): 329–36. doi:10.1038/ncb781. PMID 11941371.
  5. ↑ Poduri A, Chopra SS, Neilan EG, Elhosary PC, Kurian MA, Meyer E, Barry BJ, Khwaja OS, Salih MA, Stödberg T, Scheffer IE, Maher ER, Sahin M, Wu BL, Berry GT, Walsh CA, Picker J, Kothare SV (2012). "Homozygous PLCB1 deletion associated with malignant migrating partial seizures in infancy". Epilepsia. 53 (8): e146–50. doi:10.1111/j.1528-1167.2012.03538.x. PMC 3851296. PMID 22690784.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=PLCB1&oldid=1419482"