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{{Infobox_gene}}
{{PBB_Controls
'''1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3''' is an [[enzyme]] that in humans is encoded by the ''PLCD3'' [[gene]].<ref name="pmid10702670">{{cite journal | vauthors = Kim H, Suh PG, Ryu SH, Park SH | title = Assignment of the human PLC delta3 gene (PLCD3) to human chromosome band 17q21 by fluorescence in situ hybridization | journal = Cytogenetics and Cell Genetics | volume = 87 | issue = 3-4 | pages = 209–10 | date = Apr 2000 | pmid = 10702670 | pmc =  | doi = 10.1159/000015469 }}</ref><ref name="pmid9056492">{{cite journal | vauthors = Ghosh S, Pawelczyk T, Lowenstein JM | title = Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties | journal = Protein Expression and Purification | volume = 9 | issue = 2 | pages = 262–78 | date = Mar 1997 | pmid = 9056492 | pmc = | doi = 10.1006/prep.1996.0682 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: PLCD3 phospholipase C, delta 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=113026| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Phospholipase C, delta 3
| HGNCid = 9061
| Symbol = PLCD3
| AltSymbols =; MGC71172
| OMIM = 608795
| ECnumber = 
| Homologene = 14858
| MGIid = 107451
| Function = {{GNF_GO|id=GO:0004435 |text = phosphoinositide phospholipase C activity}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}}
| Component =
| Process = {{GNF_GO|id=GO:0006629 |text = lipid metabolic process}} {{GNF_GO|id=GO:0007242 |text = intracellular signaling cascade}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 113026
    | Hs_Ensembl = ENSG00000161714
    | Hs_RefseqProtein = NP_588614
    | Hs_RefseqmRNA = NM_133373
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 17
    | Hs_GenLoc_start = 40544544
    | Hs_GenLoc_end = 40565407
    | Hs_Uniprot = 
    | Mm_EntrezGene = 72469
    | Mm_Ensembl = ENSMUSG00000020937
    | Mm_RefseqmRNA = XM_985682
    | Mm_RefseqProtein = XP_990776
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 11
    | Mm_GenLoc_start = 102886394
    | Mm_GenLoc_end = 102917748
    | Mm_Uniprot = 
  }}
}}
'''Phospholipase C, delta 3''', also known as '''PLCD3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: PLCD3 phospholipase C, delta 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=113026| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the [[phospholipase C]] family, which catalyze the hydrolysis of [[phosphatidylinositol 4,5-bisphosphate]] to generate the second messengers [[diacylglycerol]] and [[inositol 1,4,5-trisphosphate]] (IP<sub>3</sub>). Diacylglycerol and IP<sub>3</sub> mediate a variety of cellular responses to extracellular stimuli by inducing [[protein kinase C]] and increasing cytosolic [[calcium in biology|Ca<sup>2+</sup>]] concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by [[spermine]], [[sphingosine]], and several [[phospholipid]]s.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca(2+) concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids.<ref name="entrez">{{cite web | title = Entrez Gene: PLCD3 phospholipase C, delta 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=113026| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
{{Clear}}
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G | title = Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway | journal = The Journal of Clinical Investigation | volume = 86 | issue = 6 | pages = 2117–24 | date = Dec 1990 | pmid = 1979339 | pmc = 329852 | doi = 10.1172/JCI114950 }}
| citations =
* {{cite journal | vauthors = Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S | title = Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line | journal = European Journal of Immunology | volume = 25 | issue = 9 | pages = 2695–700 | date = Sep 1995 | pmid = 7589147 | doi = 10.1002/eji.1830250944 }}
*{{cite journal | author=Cefai D, Debre P, Kaczorek M, ''et al.'' |title=Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway. |journal=J. Clin. Invest. |volume=86 |issue= 6 |pages= 2117-24 |year= 1991 |pmid= 1979339 |doi= }}
* {{cite journal | vauthors = Chen P, Mayne M, Power C, Nath A | title = The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases | journal = The Journal of Biological Chemistry | volume = 272 | issue = 36 | pages = 22385–8 | date = Sep 1997 | pmid = 9278385 | doi = 10.1074/jbc.272.36.22385 }}
*{{cite journal | author=Zauli G, Previati M, Caramelli E, ''et al.'' |title=Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line. |journal=Eur. J. Immunol. |volume=25 |issue= 9 |pages= 2695-700 |year= 1995 |pmid= 7589147 |doi= }}
* {{cite journal | vauthors = Pawełczyk T, Matecki A | title = Expression, purification and kinetic properties of human recombinant phospholipase C delta 3 | journal = Acta Biochimica Polonica | volume = 44 | issue = 2 | pages = 221–9 | year = 1998 | pmid = 9360711 | doi =  }}
*{{cite journal  | author=Ghosh S, Pawelczyk T, Lowenstein JM |title=Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties. |journal=Protein Expr. Purif. |volume=9 |issue= 2 |pages= 262-78 |year= 1997 |pmid= 9056492 |doi=  }}
* {{cite journal | vauthors = Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C | title = HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease | journal = Neuroimmunomodulation | volume = 5 | issue = 3-4 | pages = 184–92 | year = 1998 | pmid = 9730685 | doi = 10.1159/000026336 }}
*{{cite journal | author=Chen P, Mayne M, Power C, Nath A |title=The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases. |journal=J. Biol. Chem. |volume=272 |issue= 36 |pages= 22385-8 |year= 1997 |pmid= 9278385 |doi= }}
* {{cite journal | vauthors = Pawelczyk T, Matecki A | title = Localization of phospholipase C delta3 in the cell and regulation of its activity by phospholipids and calcium | journal = European Journal of Biochemistry / FEBS | volume = 257 | issue = 1 | pages = 169–77 | date = Oct 1998 | pmid = 9799116 | doi = 10.1046/j.1432-1327.1998.2570169.x }}
*{{cite journal | author=Pawełczyk T, Matecki A |title=Expression, purification and kinetic properties of human recombinant phospholipase C delta 3. |journal=Acta Biochim. Pol. |volume=44 |issue= 2 |pages= 221-9 |year= 1998 |pmid= 9360711 |doi=  }}
* {{cite journal | vauthors = Pawelczyk T, Matecki A | title = Phospholipase C-delta3 binds with high specificity to phosphatidylinositol 4,5-bisphosphate and phosphatidic acid in bilayer membranes | journal = European Journal of Biochemistry / FEBS | volume = 262 | issue = 2 | pages = 291–8 | date = Jun 1999 | pmid = 10336610 | doi = 10.1046/j.1432-1327.1999.00388.x }}
*{{cite journal | author=Mayne M, Bratanich AC, Chen P, ''et al.'' |title=HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease. |journal=Neuroimmunomodulation |volume=5 |issue= 3-4 |pages= 184-92 |year= 1998 |pmid= 9730685 |doi= }}
* {{cite journal | vauthors = Haughey NJ, Holden CP, Nath A, Geiger JD | title = Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat | journal = Journal of Neurochemistry | volume = 73 | issue = 4 | pages = 1363–74 | date = Oct 1999 | pmid = 10501179 | doi = 10.1046/j.1471-4159.1999.0731363.x }}
*{{cite journal | author=Pawelczyk T, Matecki A |title=Localization of phospholipase C delta3 in the cell and regulation of its activity by phospholipids and calcium. |journal=Eur. J. Biochem. |volume=257 |issue= 1 |pages= 169-77 |year= 1998 |pmid= 9799116 |doi= }}
* {{cite journal | vauthors = Mayne M, Holden CP, Nath A, Geiger JD | title = Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages | journal = Journal of Immunology | volume = 164 | issue = 12 | pages = 6538–42 | date = Jun 2000 | pmid = 10843712 | doi = 10.4049/jimmunol.164.12.6538 }}
*{{cite journal | author=Pawelczyk T, Matecki A |title=Phospholipase C-delta3 binds with high specificity to phosphatidylinositol 4,5-bisphosphate and phosphatidic acid in bilayer membranes. |journal=Eur. J. Biochem. |volume=262 |issue= 2 |pages= 291-8 |year= 1999 |pmid= 10336610 |doi= }}
* {{cite journal | vauthors = Lin FG, Cheng HF, Lee IF, Kao HJ, Loh SH, Lee WH | title = Downregulation of phospholipase C delta3 by cAMP and calcium | journal = Biochemical and Biophysical Research Communications | volume = 286 | issue = 2 | pages = 274–80 | date = Aug 2001 | pmid = 11500033 | doi = 10.1006/bbrc.2001.5371 }}
*{{cite journal | author=Haughey NJ, Holden CP, Nath A, Geiger JD |title=Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat. |journal=J. Neurochem. |volume=73 |issue= 4 |pages= 1363-74 |year= 1999 |pmid= 10501179 |doi= }}
* {{cite journal | vauthors = Ananthanarayanan B, Das S, Rhee SG, Murray D, Cho W | title = Membrane targeting of C2 domains of phospholipase C-delta isoforms | journal = The Journal of Biological Chemistry | volume = 277 | issue = 5 | pages = 3568–75 | date = Feb 2002 | pmid = 11706040 | doi = 10.1074/jbc.M109705200 }}
*{{cite journal  | author=Kim H, Suh PG, Ryu SH, Park SH |title=Assignment of the human PLC delta3 gene (PLCD3) to human chromosome band 17q21 by fluorescence in situ hybridization. |journal=Cytogenet. Cell Genet. |volume=87 |issue= 3-4 |pages= 209-10 |year= 2000 |pmid= 10702670 |doi=  }}
* {{cite journal | vauthors = Nagase T, Kikuno R, Ohara O | title = Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins | journal = DNA Research | volume = 8 | issue = 6 | pages = 319–27 | date = Dec 2001 | pmid = 11853319 | doi = 10.1093/dnares/8.6.319 }}
*{{cite journal | author=Mayne M, Holden CP, Nath A, Geiger JD |title=Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages. |journal=J. Immunol. |volume=164 |issue= 12 |pages= 6538-42 |year= 2000 |pmid= 10843712 |doi= }}
* {{cite journal | vauthors = Bennasser Y, Badou A, Tkaczuk J, Bahraoui E | title = Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha | journal = Virology | volume = 303 | issue = 1 | pages = 174–80 | date = Nov 2002 | pmid = 12482669 | doi = 10.1006/viro.2002.1676 }}
*{{cite journal | author=Lin FG, Cheng HF, Lee IF, ''et al.'' |title=Downregulation of phospholipase C delta3 by cAMP and calcium. |journal=Biochem. Biophys. Res. Commun. |volume=286 |issue= 2 |pages= 274-80 |year= 2001 |pmid= 11500033 |doi= 10.1006/bbrc.2001.5371 }}
* {{cite journal | vauthors = Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM | title = Functional proteomics mapping of a human signaling pathway | journal = Genome Research | volume = 14 | issue = 7 | pages = 1324–32 | date = Jul 2004 | pmid = 15231748 | pmc = 442148 | doi = 10.1101/gr.2334104 }}
*{{cite journal | author=Ananthanarayanan B, Das S, Rhee SG, ''et al.'' |title=Membrane targeting of C2 domains of phospholipase C-delta isoforms. |journal=J. Biol. Chem. |volume=277 |issue= 5 |pages= 3568-75 |year= 2002 |pmid= 11706040 |doi= 10.1074/jbc.M109705200 }}
*{{cite journal | author=Nagase T, Kikuno R, Ohara O |title=Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins. |journal=DNA Res. |volume=8 |issue= 6 |pages= 319-27 |year= 2002 |pmid= 11853319 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal | author=Bennasser Y, Badou A, Tkaczuk J, Bahraoui E |title=Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha. |journal=Virology |volume=303 |issue= 1 |pages= 174-80 |year= 2003 |pmid= 12482669 |doi= }}
*{{cite journal | author=Colland F, Jacq X, Trouplin V, ''et al.'' |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324-32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104 }}
*{{cite journal  | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
}}
{{refend}}
{{refend}}


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[[Category:EC 3.1.4]]

Latest revision as of 02:13, 27 October 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-3 is an enzyme that in humans is encoded by the PLCD3 gene.[1][2][3]

Function

This gene encodes a member of the phospholipase C family, which catalyze the hydrolysis of phosphatidylinositol 4,5-bisphosphate to generate the second messengers diacylglycerol and inositol 1,4,5-trisphosphate (IP3). Diacylglycerol and IP3 mediate a variety of cellular responses to extracellular stimuli by inducing protein kinase C and increasing cytosolic Ca2+ concentrations. This enzyme localizes to the plasma membrane and requires calcium for activation. Its activity is inhibited by spermine, sphingosine, and several phospholipids.[3]

References

  1. ↑ Kim H, Suh PG, Ryu SH, Park SH (Apr 2000). "Assignment of the human PLC delta3 gene (PLCD3) to human chromosome band 17q21 by fluorescence in situ hybridization". Cytogenetics and Cell Genetics. 87 (3–4): 209–10. doi:10.1159/000015469. PMID 10702670.
  2. ↑ Ghosh S, Pawelczyk T, Lowenstein JM (Mar 1997). "Phospholipase C isoforms delta 1 and delta 3 from human fibroblasts. High-yield expression in Escherichia coli, simple purification, and properties". Protein Expression and Purification. 9 (2): 262–78. doi:10.1006/prep.1996.0682. PMID 9056492.
  3. ↑ 3.0 3.1 "Entrez Gene: PLCD3 phospholipase C, delta 3".

Further reading

  • Cefai D, Debre P, Kaczorek M, Idziorek T, Autran B, Bismuth G (Dec 1990). "Human immunodeficiency virus-1 glycoproteins gp120 and gp160 specifically inhibit the CD3/T cell-antigen receptor phosphoinositide transduction pathway". The Journal of Clinical Investigation. 86 (6): 2117–24. doi:10.1172/JCI114950. PMC 329852. PMID 1979339.
  • Zauli G, Previati M, Caramelli E, Bassini A, Falcieri E, Gibellini D, Bertolaso L, Bosco D, Robuffo I, Capitani S (Sep 1995). "Exogenous human immunodeficiency virus type-1 Tat protein selectively stimulates a phosphatidylinositol-specific phospholipase C nuclear pathway in the Jurkat T cell line". European Journal of Immunology. 25 (9): 2695–700. doi:10.1002/eji.1830250944. PMID 7589147.
  • Chen P, Mayne M, Power C, Nath A (Sep 1997). "The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases". The Journal of Biological Chemistry. 272 (36): 22385–8. doi:10.1074/jbc.272.36.22385. PMID 9278385.
  • Pawełczyk T, Matecki A (1998). "Expression, purification and kinetic properties of human recombinant phospholipase C delta 3". Acta Biochimica Polonica. 44 (2): 221–9. PMID 9360711.
  • Mayne M, Bratanich AC, Chen P, Rana F, Nath A, Power C (1998). "HIV-1 tat molecular diversity and induction of TNF-alpha: implications for HIV-induced neurological disease". Neuroimmunomodulation. 5 (3–4): 184–92. doi:10.1159/000026336. PMID 9730685.
  • Pawelczyk T, Matecki A (Oct 1998). "Localization of phospholipase C delta3 in the cell and regulation of its activity by phospholipids and calcium". European Journal of Biochemistry / FEBS. 257 (1): 169–77. doi:10.1046/j.1432-1327.1998.2570169.x. PMID 9799116.
  • Pawelczyk T, Matecki A (Jun 1999). "Phospholipase C-delta3 binds with high specificity to phosphatidylinositol 4,5-bisphosphate and phosphatidic acid in bilayer membranes". European Journal of Biochemistry / FEBS. 262 (2): 291–8. doi:10.1046/j.1432-1327.1999.00388.x. PMID 10336610.
  • Haughey NJ, Holden CP, Nath A, Geiger JD (Oct 1999). "Involvement of inositol 1,4,5-trisphosphate-regulated stores of intracellular calcium in calcium dysregulation and neuron cell death caused by HIV-1 protein tat". Journal of Neurochemistry. 73 (4): 1363–74. doi:10.1046/j.1471-4159.1999.0731363.x. PMID 10501179.
  • Mayne M, Holden CP, Nath A, Geiger JD (Jun 2000). "Release of calcium from inositol 1,4,5-trisphosphate receptor-regulated stores by HIV-1 Tat regulates TNF-alpha production in human macrophages". Journal of Immunology. 164 (12): 6538–42. doi:10.4049/jimmunol.164.12.6538. PMID 10843712.
  • Lin FG, Cheng HF, Lee IF, Kao HJ, Loh SH, Lee WH (Aug 2001). "Downregulation of phospholipase C delta3 by cAMP and calcium". Biochemical and Biophysical Research Communications. 286 (2): 274–80. doi:10.1006/bbrc.2001.5371. PMID 11500033.
  • Ananthanarayanan B, Das S, Rhee SG, Murray D, Cho W (Feb 2002). "Membrane targeting of C2 domains of phospholipase C-delta isoforms". The Journal of Biological Chemistry. 277 (5): 3568–75. doi:10.1074/jbc.M109705200. PMID 11706040.
  • Nagase T, Kikuno R, Ohara O (Dec 2001). "Prediction of the coding sequences of unidentified human genes. XXII. The complete sequences of 50 new cDNA clones which code for large proteins". DNA Research. 8 (6): 319–27. doi:10.1093/dnares/8.6.319. PMID 11853319.
  • Bennasser Y, Badou A, Tkaczuk J, Bahraoui E (Nov 2002). "Signaling pathways triggered by HIV-1 Tat in human monocytes to induce TNF-alpha". Virology. 303 (1): 174–80. doi:10.1006/viro.2002.1676. PMID 12482669.
  • Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM (Jul 2004). "Functional proteomics mapping of a human signaling pathway". Genome Research. 14 (7): 1324–32. doi:10.1101/gr.2334104. PMC 442148. PMID 15231748.
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