RAP2A: Difference between revisions

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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Ras-related protein Rap-2a''' is a [[protein]] that in humans is encoded by the ''RAP2A'' [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAP2A RAP2A, member of RAS oncogene family| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5911| accessdate = }}</ref> RAP2A is a member of the [[Rap GTP-binding protein|Ras-related protein]] family.
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| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_RAP2A_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1kao.
| PDB = {{PDB2|1kao}}, {{PDB2|2rap}}, {{PDB2|3rap}}
| Name = RAP2A, member of RAS oncogene family
| HGNCid = 9861
| Symbol = RAP2A
| AltSymbols =; K-REV; KREV; RAP2; RbBP-30
| OMIM = 179540
| ECnumber = 
| Homologene = 10875
| MGIid = 97855
| GeneAtlas_image1 = PBB_GE_RAP2A_214487_s_at_tn.png
| GeneAtlas_image2 = PBB_GE_RAP2A_221830_at_tn.png
| Function = {{GNF_GO|id=GO:0000166 |text = nucleotide binding}} {{GNF_GO|id=GO:0003924 |text = GTPase activity}} {{GNF_GO|id=GO:0005525 |text = GTP binding}}
| Component = {{GNF_GO|id=GO:0005622 |text = intracellular}} {{GNF_GO|id=GO:0016020 |text = membrane}}
| Process = {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007264 |text = small GTPase mediated signal transduction}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 5911
    | Hs_Ensembl = ENSG00000125249
    | Hs_RefseqProtein = NP_066361
    | Hs_RefseqmRNA = NM_021033
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 13
    | Hs_GenLoc_start = 96884475
    | Hs_GenLoc_end = 96918243
    | Hs_Uniprot = P10114
    | Mm_EntrezGene = 76108
    | Mm_Ensembl = ENSMUSG00000051615
    | Mm_RefseqmRNA = NM_029519
    | Mm_RefseqProtein = NP_083795
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 119613624
    | Mm_GenLoc_end = 119642370
    | Mm_Uniprot = Q80ZJ1
  }}
}}
'''RAP2A, member of RAS oncogene family''', also known as '''RAP2A''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RAP2A RAP2A, member of RAS oncogene family| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=5911| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates. -->
RAP2A has been shown to [[Protein-protein interaction|interact]] with [[RUNDC3A]],<ref name=pmid9523700>{{cite journal | vauthors = Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J | title = Identification of a specific effector of the small GTP-binding protein Rap2 | journal = European Journal of Biochemistry / FEBS | volume = 252 | issue = 2 | pages = 290–8 | date = Mar 1998 | pmid = 9523700 | doi = 10.1046/j.1432-1327.1998.2520290.x }}</ref> [[RASSF5]]<ref name=pmid11857081>{{cite journal | vauthors = Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J | title = The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1 | journal = Oncogene | volume = 21 | issue = 9 | pages = 1381–90 | date = Feb 2002 | pmid = 11857081 | doi = 10.1038/sj.onc.1205192 }}</ref> and [[RALGDS]].<ref name=pmid10085114>{{cite journal | vauthors = Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J | title = Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2 | journal = The Journal of Biological Chemistry | volume = 274 | issue = 13 | pages = 8737–45 | date = Mar 1999 | pmid = 10085114 | doi = 10.1074/jbc.274.13.8737 }}</ref>
{{PBB_Summary
| section_title =  
| summary_text =  
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Lerosey I, Chardin P, de Gunzburg J, Tavitian A | title = The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis | journal = The Journal of Biological Chemistry | volume = 266 | issue = 7 | pages = 4315–21 | date = Mar 1991 | pmid = 1900290 | doi =  }}
| citations =
* {{cite journal | vauthors = Pizon V, Chardin P, Lerosey I, Olofsson B, Tavitian A | title = Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region | journal = Oncogene | volume = 3 | issue = 2 | pages = 201–4 | date = Aug 1988 | pmid = 3045729 | doi =  }}
*{{cite journal | author=Lerosey I, Chardin P, de Gunzburg J, Tavitian A |title=The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis. |journal=J. Biol. Chem. |volume=266 |issue= 7 |pages= 4315-21 |year= 1991 |pmid= 1900290 |doi=  }}
* {{cite journal | vauthors = Farrell FX, Yamamoto K, Lapetina EG | title = Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated | journal = The Biochemical Journal | volume = 289 ( Pt 2) | issue = Pt 2 | pages = 349–55 | date = Jan 1993 | pmid = 8424780 | pmc = 1132174 | doi =  }}
*{{cite journal | author=Pizon V, Chardin P, Lerosey I, ''et al.'' |title=Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region. |journal=Oncogene |volume=3 |issue= 2 |pages= 201-4 |year= 1988 |pmid= 3045729 |doi=  }}
* {{cite journal | vauthors = Cherfils J, Ménétrey J, Le Bras G, Janoueix-Lerosey I, de Gunzburg J, Garel JR, Auzat I | title = Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS | journal = The EMBO Journal | volume = 16 | issue = 18 | pages = 5582–91 | date = Sep 1997 | pmid = 9312017 | pmc = 1170190 | doi = 10.1093/emboj/16.18.5582 }}
*{{cite journal | author=Farrell FX, Yamamoto K, Lapetina EG |title=Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated. |journal=Biochem. J. |volume=289 ( Pt 2) |issue= |pages= 349-55 |year= 1993 |pmid= 8424780 |doi=  }}
* {{cite journal | vauthors = Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J | title = Identification of a specific effector of the small GTP-binding protein Rap2 | journal = European Journal of Biochemistry / FEBS | volume = 252 | issue = 2 | pages = 290–8 | date = Mar 1998 | pmid = 9523700 | doi = 10.1046/j.1432-1327.1998.2520290.x }}
*{{cite journal | author=Cherfils J, Ménétrey J, Le Bras G, ''et al.'' |title=Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS. |journal=EMBO J. |volume=16 |issue= 18 |pages= 5582-91 |year= 1997 |pmid= 9312017 |doi= 10.1093/emboj/16.18.5582 }}
* {{cite journal | vauthors = Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J | title = Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2 | journal = The Journal of Biological Chemistry | volume = 274 | issue = 13 | pages = 8737–45 | date = Mar 1999 | pmid = 10085114 | doi = 10.1074/jbc.274.13.8737 }}
*{{cite journal | author=Janoueix-Lerosey I, Pasheva E, de Tand MF, ''et al.'' |title=Identification of a specific effector of the small GTP-binding protein Rap2. |journal=Eur. J. Biochem. |volume=252 |issue= 2 |pages= 290-8 |year= 1998 |pmid= 9523700 |doi= }}
* {{cite journal | vauthors = Linnemann T, Geyer M, Jaitner BK, Block C, Kalbitzer HR, Wittinghofer A, Herrmann C | title = Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily | journal = The Journal of Biological Chemistry | volume = 274 | issue = 19 | pages = 13556–62 | date = May 1999 | pmid = 10224125 | doi = 10.1074/jbc.274.19.13556 }}
*{{cite journal | author=Nancy V, Wolthuis RM, de Tand MF, ''et al.'' |title=Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2. |journal=J. Biol. Chem. |volume=274 |issue= 13 |pages= 8737-45 |year= 1999 |pmid= 10085114 |doi= }}
* {{cite journal | vauthors = Ménétrey J, Cherfils J | title = Structure of the small G protein Rap2 in a non-catalytic complex with GTP | journal = Proteins | volume = 37 | issue = 3 | pages = 465–73 | date = Nov 1999 | pmid = 10591105 | doi = 10.1002/(SICI)1097-0134(19991115)37:3<465::AID-PROT13>3.0.CO;2-O }}
*{{cite journal | author=Linnemann T, Geyer M, Jaitner BK, ''et al.'' |title=Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily. |journal=J. Biol. Chem. |volume=274 |issue= 19 |pages= 13556-62 |year= 1999 |pmid= 10224125 |doi= }}
* {{cite journal | vauthors = de Rooij J, Rehmann H, van Triest M, Cool RH, Wittinghofer A, Bos JL | title = Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs | journal = The Journal of Biological Chemistry | volume = 275 | issue = 27 | pages = 20829–36 | date = Jul 2000 | pmid = 10777494 | doi = 10.1074/jbc.M001113200 }}
*{{cite journal | author=Ménétrey J, Cherfils J |title=Structure of the small G protein Rap2 in a non-catalytic complex with GTP. |journal=Proteins |volume=37 |issue= 3 |pages= 465-73 |year= 2000 |pmid= 10591105 |doi= }}
* {{cite journal | vauthors = Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG | title = Proteomic analysis of NMDA receptor-adhesion protein signaling complexes | journal = Nature Neuroscience | volume = 3 | issue = 7 | pages = 661–9 | date = Jul 2000 | pmid = 10862698 | doi = 10.1038/76615 }}
*{{cite journal | author=de Rooij J, Rehmann H, van Triest M, ''et al.'' |title=Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs. |journal=J. Biol. Chem. |volume=275 |issue= 27 |pages= 20829-36 |year= 2000 |pmid= 10777494 |doi= 10.1074/jbc.M001113200 }}
* {{cite journal | vauthors = Traver S, Bidot C, Spassky N, Baltauss T, De Tand MF, Thomas JL, Zalc B, Janoueix-Lerosey I, Gunzburg JD | title = RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao | journal = The Biochemical Journal | volume = 350 Pt 1 | issue = Pt 1 | pages = 19–29 | date = Aug 2000 | pmid = 10926822 | pmc = 1221220 | doi = 10.1042/0264-6021:3500019 }}
*{{cite journal | author=Husi H, Ward MA, Choudhary JS, ''et al.'' |title=Proteomic analysis of NMDA receptor-adhesion protein signaling complexes. |journal=Nat. Neurosci. |volume=3 |issue= 7 |pages= 661-9 |year= 2000 |pmid= 10862698 |doi= 10.1038/76615 }}
* {{cite journal | vauthors = Gao X, Satoh T, Liao Y, Song C, Hu CD, Kariya Ki K, Kataoka T | title = Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras | journal = The Journal of Biological Chemistry | volume = 276 | issue = 45 | pages = 42219–25 | date = Nov 2001 | pmid = 11524421 | doi = 10.1074/jbc.M105760200 }}
*{{cite journal | author=Traver S, Bidot C, Spassky N, ''et al.'' |title=RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao. |journal=Biochem. J. |volume=350 Pt 1 |issue= |pages= 19-29 |year= 2001 |pmid= 10926822 |doi= }}
* {{cite journal | vauthors = Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J | title = The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1 | journal = Oncogene | volume = 21 | issue = 9 | pages = 1381–90 | date = Feb 2002 | pmid = 11857081 | doi = 10.1038/sj.onc.1205192 }}
*{{cite journal | author=Gao X, Satoh T, Liao Y, ''et al.'' |title=Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras. |journal=J. Biol. Chem. |volume=276 |issue= 45 |pages= 42219-25 |year= 2001 |pmid= 11524421 |doi= 10.1074/jbc.M105760200 }}
* {{cite journal | vauthors = Song C, Satoh T, Edamatsu H, Wu D, Tadano M, Gao X, Kataoka T | title = Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon | journal = Oncogene | volume = 21 | issue = 53 | pages = 8105–13 | date = Nov 2002 | pmid = 12444546 | doi = 10.1038/sj.onc.1206003 }}
*{{cite journal | author=Ortiz-Vega S, Khokhlatchev A, Nedwidek M, ''et al.'' |title=The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1. |journal=Oncogene |volume=21 |issue= 9 |pages= 1381-90 |year= 2002 |pmid= 11857081 |doi= 10.1038/sj.onc.1205192 }}
* {{cite journal | vauthors = Kuiperij HB, de Rooij J, Rehmann H, van Triest M, Wittinghofer A, Bos JL, Zwartkruis FJ | title = Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2 | journal = Biochimica et Biophysica Acta | volume = 1593 | issue = 2-3 | pages = 141–9 | date = Feb 2003 | pmid = 12581858 | doi = 10.1016/S0167-4889(02)00365-8 }}
*{{cite journal | author=Song C, Satoh T, Edamatsu H, ''et al.'' |title=Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon. |journal=Oncogene |volume=21 |issue= 53 |pages= 8105-13 |year= 2002 |pmid= 12444546 |doi= 10.1038/sj.onc.1206003 }}
* {{cite journal | vauthors = Machida N, Umikawa M, Takei K, Sakima N, Myagmar BE, Taira K, Uezato H, Ogawa Y, Kariya K | title = Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase | journal = The Journal of Biological Chemistry | volume = 279 | issue = 16 | pages = 15711–4 | date = Apr 2004 | pmid = 14966141 | doi = 10.1074/jbc.C300542200 }}
*{{cite journal | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
* {{cite journal | vauthors = Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ | title = Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization | journal = The Journal of Biological Chemistry | volume = 279 | issue = 21 | pages = 22353–61 | date = May 2004 | pmid = 15031288 | doi = 10.1074/jbc.M312867200 }}
*{{cite journal | author=Kuiperij HB, de Rooij J, Rehmann H, ''et al.'' |title=Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2. |journal=Biochim. Biophys. Acta |volume=1593 |issue= 2-3 |pages= 141-9 |year= 2003 |pmid= 12581858 |doi= }}
*{{cite journal | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Machida N, Umikawa M, Takei K, ''et al.'' |title=Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase. |journal=J. Biol. Chem. |volume=279 |issue= 16 |pages= 15711-4 |year= 2004 |pmid= 14966141 |doi= 10.1074/jbc.C300542200 }}
*{{cite journal  | author=Mitin NY, Ramocki MB, Zullo AJ, ''et al.'' |title=Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. |journal=J. Biol. Chem. |volume=279 |issue= 21 |pages= 22353-61 |year= 2004 |pmid= 15031288 |doi= 10.1074/jbc.M312867200 }}
*{{cite journal  | author=Dunham A, Matthews LH, Burton J, ''et al.'' |title=The DNA sequence and analysis of human chromosome 13. |journal=Nature |volume=428 |issue= 6982 |pages= 522-8 |year= 2004 |pmid= 15057823 |doi= 10.1038/nature02379 }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=5911}}
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{{gene-13-stub}}

Latest revision as of 08:54, 10 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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n/a

Ensembl

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UniProt

n/a

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RefSeq (mRNA)

n/a

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ras-related protein Rap-2a is a protein that in humans is encoded by the RAP2A gene.[1] RAP2A is a member of the Ras-related protein family.

Interactions

RAP2A has been shown to interact with RUNDC3A,[2] RASSF5[3] and RALGDS.[4]

References

  1. ↑ "Entrez Gene: RAP2A RAP2A, member of RAS oncogene family".
  2. ↑ Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J (Mar 1998). "Identification of a specific effector of the small GTP-binding protein Rap2". European Journal of Biochemistry / FEBS. 252 (2): 290–8. doi:10.1046/j.1432-1327.1998.2520290.x. PMID 9523700.
  3. ↑ Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.
  4. ↑ Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (Mar 1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". The Journal of Biological Chemistry. 274 (13): 8737–45. doi:10.1074/jbc.274.13.8737. PMID 10085114.

Further reading

  • Lerosey I, Chardin P, de Gunzburg J, Tavitian A (Mar 1991). "The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis". The Journal of Biological Chemistry. 266 (7): 4315–21. PMID 1900290.
  • Pizon V, Chardin P, Lerosey I, Olofsson B, Tavitian A (Aug 1988). "Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region". Oncogene. 3 (2): 201–4. PMID 3045729.
  • Farrell FX, Yamamoto K, Lapetina EG (Jan 1993). "Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated". The Biochemical Journal. 289 ( Pt 2) (Pt 2): 349–55. PMC 1132174. PMID 8424780.
  • Cherfils J, Ménétrey J, Le Bras G, Janoueix-Lerosey I, de Gunzburg J, Garel JR, Auzat I (Sep 1997). "Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS". The EMBO Journal. 16 (18): 5582–91. doi:10.1093/emboj/16.18.5582. PMC 1170190. PMID 9312017.
  • Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J (Mar 1998). "Identification of a specific effector of the small GTP-binding protein Rap2". European Journal of Biochemistry / FEBS. 252 (2): 290–8. doi:10.1046/j.1432-1327.1998.2520290.x. PMID 9523700.
  • Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J (Mar 1999). "Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2". The Journal of Biological Chemistry. 274 (13): 8737–45. doi:10.1074/jbc.274.13.8737. PMID 10085114.
  • Linnemann T, Geyer M, Jaitner BK, Block C, Kalbitzer HR, Wittinghofer A, Herrmann C (May 1999). "Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily". The Journal of Biological Chemistry. 274 (19): 13556–62. doi:10.1074/jbc.274.19.13556. PMID 10224125.
  • Ménétrey J, Cherfils J (Nov 1999). "Structure of the small G protein Rap2 in a non-catalytic complex with GTP". Proteins. 37 (3): 465–73. doi:10.1002/(SICI)1097-0134(19991115)37:3<465::AID-PROT13>3.0.CO;2-O. PMID 10591105.
  • de Rooij J, Rehmann H, van Triest M, Cool RH, Wittinghofer A, Bos JL (Jul 2000). "Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs". The Journal of Biological Chemistry. 275 (27): 20829–36. doi:10.1074/jbc.M001113200. PMID 10777494.
  • Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG (Jul 2000). "Proteomic analysis of NMDA receptor-adhesion protein signaling complexes". Nature Neuroscience. 3 (7): 661–9. doi:10.1038/76615. PMID 10862698.
  • Traver S, Bidot C, Spassky N, Baltauss T, De Tand MF, Thomas JL, Zalc B, Janoueix-Lerosey I, Gunzburg JD (Aug 2000). "RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao". The Biochemical Journal. 350 Pt 1 (Pt 1): 19–29. doi:10.1042/0264-6021:3500019. PMC 1221220. PMID 10926822.
  • Gao X, Satoh T, Liao Y, Song C, Hu CD, Kariya Ki K, Kataoka T (Nov 2001). "Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras". The Journal of Biological Chemistry. 276 (45): 42219–25. doi:10.1074/jbc.M105760200. PMID 11524421.
  • Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J (Feb 2002). "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 (9): 1381–90. doi:10.1038/sj.onc.1205192. PMID 11857081.
  • Song C, Satoh T, Edamatsu H, Wu D, Tadano M, Gao X, Kataoka T (Nov 2002). "Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon". Oncogene. 21 (53): 8105–13. doi:10.1038/sj.onc.1206003. PMID 12444546.
  • Kuiperij HB, de Rooij J, Rehmann H, van Triest M, Wittinghofer A, Bos JL, Zwartkruis FJ (Feb 2003). "Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2". Biochimica et Biophysica Acta. 1593 (2–3): 141–9. doi:10.1016/S0167-4889(02)00365-8. PMID 12581858.
  • Machida N, Umikawa M, Takei K, Sakima N, Myagmar BE, Taira K, Uezato H, Ogawa Y, Kariya K (Apr 2004). "Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase". The Journal of Biological Chemistry. 279 (16): 15711–4. doi:10.1074/jbc.C300542200. PMID 14966141.
  • Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ (May 2004). "Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization". The Journal of Biological Chemistry. 279 (21): 22353–61. doi:10.1074/jbc.M312867200. PMID 15031288.


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