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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Ribonuclease pancreatic''' is an [[enzyme]] that in humans is encoded by the ''RNASE1'' [[gene]].<ref name="pmid8588814">{{cite journal | vauthors = Kochetov AV, Lukasheva VV, Filipenko ML, Mertvetsov NP, Rivkin MI | title = [Primary structure of the coding part of the gene for human pancreatic ribonuclease and its chromosomal location] | journal = Bioorganicheskaia Khimiia | volume = 21 | issue = 9 | pages = 691–4 | date = Sep 1995 | pmid = 8588814 | pmc =  | doi =  }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: RNASE1 ribonuclease, RNase A family, 1 (pancreatic)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6035| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image = PBB_Protein_RNASE1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1dza.
| PDB = {{PDB2|1dza}}, {{PDB2|1e21}}, {{PDB2|1h8x}}, {{PDB2|1z7x}}
| Name = Ribonuclease, RNase A family, 1 (pancreatic)
| HGNCid = 10044
| Symbol = RNASE1
| AltSymbols =; MGC12408; RIB1; RNS1
| OMIM = 180440
| ECnumber = 
| Homologene = 7919
| MGIid = 97919
| GeneAtlas_image1 = PBB_GE_RNASE1_201785_at_tn.png
| Function = {{GNF_GO|id=GO:0003723 |text = RNA binding}} {{GNF_GO|id=GO:0004519 |text = endonuclease activity}} {{GNF_GO|id=GO:0004522 |text = pancreatic ribonuclease activity}} {{GNF_GO|id=GO:0016787 |text = hydrolase activity}}
| Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}}
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6035
    | Hs_Ensembl = ENSG00000129538
    | Hs_RefseqProtein = NP_002924
    | Hs_RefseqmRNA = NM_002933
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 20339356
    | Hs_GenLoc_end = 20340876
    | Hs_Uniprot = P07998
    | Mm_EntrezGene = 19752
    | Mm_Ensembl = ENSMUSG00000035896
    | Mm_RefseqmRNA = NM_011271
    | Mm_RefseqProtein = NP_035401
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 14
    | Mm_GenLoc_start = 50066953
    | Mm_GenLoc_end = 50068718
    | Mm_Uniprot = Q8C6G3
  }}
}}
'''Ribonuclease, RNase A family, 1 (pancreatic)''', also known as '''RNASE1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: RNASE1 ribonuclease, RNase A family, 1 (pancreatic)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6035| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the pancreatic-type of secretory [[ribonuclease]]s, a subset of the [[ribonuclease A]] super-family. The encoded [[endonuclease]] cleaves internal [[phosphodiester bond|phosphodiester RNA bond]]s on the 3'-side of [[pyrimidine]] bases. It prefers poly(C) as a substrate and hydrolyses 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ss-RNA over ds-RNA. [[Alternative splicing]] occurs at this locus and four transcript variants encoding the same protein have been identified.<ref name="entrez"/>
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A superfamily. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyzes 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ds-RNA over ss-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.<ref name="entrez">{{cite web | title = Entrez Gene: RNASE1 ribonuclease, RNase A family, 1 (pancreatic)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6035| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Nogués MV, Vilanova M, Cuchillo CM | title = Bovine pancreatic ribonuclease A as a model of an enzyme with multiple substrate binding sites | journal = Biochimica et Biophysica Acta | volume = 1253 | issue = 1 | pages = 16–24 | date = Nov 1995 | pmid = 7492594 | doi = 10.1016/0167-4838(95)00138-k }}
| citations =
* {{cite journal | vauthors = Schienman JE, Holt RA, Auerbach MR, Stewart CB | title = Duplication and divergence of 2 distinct pancreatic ribonuclease genes in leaf-eating African and Asian colobine monkeys | journal = Molecular Biology and Evolution | volume = 23 | issue = 8 | pages = 1465–79 | date = Aug 2006 | pmid = 16751256 | doi = 10.1093/molbev/msl025 }}
*{{cite journal | author=Nogués MV, Vilanova M, Cuchillo CM |title=Bovine pancreatic ribonuclease A as a model of an enzyme with multiple substrate binding sites. |journal=Biochim. Biophys. Acta |volume=1253 |issue= 1 |pages= 16-24 |year= 1996 |pmid= 7492594 |doi= }}
* {{cite journal | vauthors = Sakakibara R, Hashida K, Kitahara T, Ishiguro M | title = Characterization of a unique nonsecretory ribonuclease from urine of pregnant women | journal = Journal of Biochemistry | volume = 111 | issue = 3 | pages = 325–30 | date = Mar 1992 | pmid = 1587793 | doi =  }}
*{{cite journal | author=Schienman JE, Holt RA, Auerbach MR, Stewart CB |title=Duplication and divergence of 2 distinct pancreatic ribonuclease genes in leaf-eating African and Asian colobine monkeys. |journal=Mol. Biol. Evol. |volume=23 |issue= 8 |pages= 1465-79 |year= 2006 |pmid= 16751256 |doi= 10.1093/molbev/msl025 }}
* {{cite journal | vauthors = Haugg M, Schein CH | title = The DNA sequences of the human and hamster secretory ribonucleases determined with the polymerase chain reaction (PCR) | journal = Nucleic Acids Research | volume = 20 | issue = 3 | pages = 612 | date = Feb 1992 | pmid = 1741299 | pmc = 310435 | doi = 10.1093/nar/20.3.612 }}
*{{cite journal | author=Sakakibara R, Hashida K, Kitahara T, Ishiguro M |title=Characterization of a unique nonsecretory ribonuclease from urine of pregnant women. |journal=J. Biochem. |volume=111 |issue= 3 |pages= 325-30 |year= 1992 |pmid= 1587793 |doi=  }}
* {{cite journal | vauthors = Sakakibara R, Hashida K, Tominaga N, Sakai K, Ishiguro M, Imamura S, Ohmatsu F, Sato E | title = A putative mouse oocyte maturation inhibitory protein from urine of pregnant women: N-terminal sequence homology with human nonsecretory ribonuclease | journal = Chemical & Pharmaceutical Bulletin | volume = 39 | issue = 1 | pages = 146–9 | date = Jan 1991 | pmid = 2049798 | doi = 10.1248/cpb.39.146 }}
*{{cite journal | author=Haugg M, Schein CH |title=The DNA sequences of the human and hamster secretory ribonucleases determined with the polymerase chain reaction (PCR). |journal=Nucleic Acids Res. |volume=20 |issue= 3 |pages= 612 |year= 1992 |pmid= 1741299 |doi= }}
* {{cite journal | vauthors = Mizuta K, Awazu S, Yasuda T, Kishi K | title = Purification and characterization of three ribonucleases from human kidney: comparison with urine ribonucleases | journal = Archives of Biochemistry and Biophysics | volume = 281 | issue = 1 | pages = 144–51 | date = Aug 1990 | pmid = 2383019 | doi = 10.1016/0003-9861(90)90424-W }}
*{{cite journal | author=Sakakibara R, Hashida K, Tominaga N, ''et al.'' |title=A putative mouse oocyte maturation inhibitory protein from urine of pregnant women: N-terminal sequence homology with human nonsecretory ribonuclease. |journal=Chem. Pharm. Bull. |volume=39 |issue= 1 |pages= 146-9 |year= 1991 |pmid= 2049798 |doi= }}
* {{cite journal | vauthors = Beintema JJ, Blank A, Schieven GL, Dekker CA, Sorrentino S, Libonati M | title = Differences in glycosylation pattern of human secretory ribonucleases | journal = The Biochemical Journal | volume = 255 | issue = 2 | pages = 501–5 | date = Oct 1988 | pmid = 3202829 | pmc = 1135256 | doi =  }}
*{{cite journal | author=Mizuta K, Awazu S, Yasuda T, Kishi K |title=Purification and characterization of three ribonucleases from human kidney: comparison with urine ribonucleases. |journal=Arch. Biochem. Biophys. |volume=281 |issue= 1 |pages= 144-51 |year= 1990 |pmid= 2383019 |doi= }}
* {{cite journal | vauthors = Beintema JJ, Wietzes P, Weickmann JL, Glitz DG | title = The amino acid sequence of human pancreatic ribonuclease | journal = Analytical Biochemistry | volume = 136 | issue = 1 | pages = 48–64 | date = Jan 1984 | pmid = 6201087 | doi = 10.1016/0003-2697(84)90306-3 }}
*{{cite journal | author=Beintema JJ, Blank A, Schieven GL, ''et al.'' |title=Differences in glycosylation pattern of human secretory ribonucleases. |journal=Biochem. J. |volume=255 |issue= 2 |pages= 501-5 |year= 1989 |pmid= 3202829 |doi=  }}
* {{cite journal | vauthors = Russo N, de Nigris M, Ciardiello A, Di Donato A, D'Alessio G | title = Expression in mammalian cells, purification and characterization of recombinant human pancreatic ribonuclease | journal = FEBS Letters | volume = 369 | issue = 2-3 | pages = 352 | date = Aug 1995 | pmid = 7649283 | doi = 10.1016/0014-5793(95)96890-G }}
*{{cite journal | author=Beintema JJ, Wietzes P, Weickmann JL, Glitz DG |title=The amino acid sequence of human pancreatic ribonuclease. |journal=Anal. Biochem. |volume=136 |issue= 1 |pages= 48-64 |year= 1984 |pmid= 6201087 |doi= }}
* {{cite journal | vauthors = Seno M, Futami J, Kosaka M, Seno S, Yamada H | title = Nucleotide sequence encoding human pancreatic ribonuclease | journal = Biochimica et Biophysica Acta | volume = 1218 | issue = 3 | pages = 466–8 | date = Aug 1994 | pmid = 8049276 | doi = 10.1016/0167-4781(94)90208-9 }}
*{{cite journal | author=Russo N, de Nigris M, Ciardiello A, ''et al.'' |title=Expression in mammalian cells, purification and characterization of recombinant human pancreatic ribonuclease. |journal=FEBS Lett. |volume=369 |issue= 2-3 |pages= 352 |year= 1995 |pmid= 7649283 |doi= }}
* {{cite journal | vauthors = Yasuda T, Nadano D, Takeshita H, Kishi K | title = Two distinct secretory ribonucleases from human cerebrum: purification, characterization and relationships to other ribonucleases | journal = The Biochemical Journal | volume = 296 | issue = 3 | pages = 617–25 | date = Dec 1993 | pmid = 8280059 | pmc = 1137742 | doi =  10.1042/bj2960617}}
*{{cite journal | author=Seno M, Futami J, Kosaka M, ''et al.'' |title=Nucleotide sequence encoding human pancreatic ribonuclease. |journal=Biochim. Biophys. Acta |volume=1218 |issue= 3 |pages= 466-8 |year= 1994 |pmid= 8049276 |doi= }}
* {{cite journal | vauthors = Papageorgiou AC, Shapiro R, Acharya KR | title = Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution | journal = The EMBO Journal | volume = 16 | issue = 17 | pages = 5162–77 | date = Sep 1997 | pmid = 9311977 | pmc = 1170149 | doi = 10.1093/emboj/16.17.5162 }}
*{{cite journal | author=Yasuda T, Nadano D, Takeshita H, Kishi K |title=Two distinct secretory ribonucleases from human cerebrum: purification, characterization and relationships to other ribonucleases. |journal=Biochem. J. |volume=296 ( Pt 3) |issue= |pages= 617-25 |year= 1994 |pmid= 8280059 |doi= }}
* {{cite journal | vauthors = Klink TA, Woycechowsky KJ, Taylor KM, Raines RT | title = Contribution of disulfide bonds to the conformational stability and catalytic activity of ribonuclease A | journal = European Journal of Biochemistry / FEBS | volume = 267 | issue = 2 | pages = 566–72 | date = Jan 2000 | pmid = 10632727 | doi = 10.1046/j.1432-1327.2000.01037.x }}
*{{cite journal  | author=Kochetov AV, Lukasheva VV, Filipenko ML, ''et al.'' |title=[Primary structure of the coding part of the gene for human pancreatic ribonuclease and its chromosomal location] |journal=Bioorg. Khim. |volume=21 |issue= 9 |pages= 691-4 |year= 1996 |pmid= 8588814 |doi=  }}
* {{cite journal | vauthors = Pous J, Canals A, Terzyan SS, Guasch A, Benito A, Ribó M, Vilanova M, Coll M | title = Three-dimensional structure of a human pancreatic ribonuclease variant, a step forward in the design of cytotoxic ribonucleases | journal = Journal of Molecular Biology | volume = 303 | issue = 1 | pages = 49–60 | date = Oct 2000 | pmid = 11021969 | doi = 10.1006/jmbi.2000.4506 }}
*{{cite journal | author=Papageorgiou AC, Shapiro R, Acharya KR |title=Molecular recognition of human angiogenin by placental ribonuclease inhibitor--an X-ray crystallographic study at 2.0 A resolution. |journal=EMBO J. |volume=16 |issue= 17 |pages= 5162-77 |year= 1997 |pmid= 9311977 |doi= 10.1093/emboj/16.17.5162 }}
* {{cite journal | vauthors = Pous J, Mallorquí-Fernández G, Peracaula R, Terzyan SS, Futami J, Tada H, Yamada H, Seno M, de Llorens R, Gomis-Rüth FX, Coll M | title = Three-dimensional structure of human RNase 1 delta N7 at 1.9 A resolution | journal = Acta Crystallographica Section D | volume = 57 | issue = Pt 4 | pages = 498–505 | date = Apr 2001 | pmid = 11264578 | doi = 10.1107/S0907444901001147 }}
*{{cite journal | author=Klink TA, Woycechowsky KJ, Taylor KM, Raines RT |title=Contribution of disulfide bonds to the conformational stability and catalytic activity of ribonuclease A. |journal=Eur. J. Biochem. |volume=267 |issue= 2 |pages= 566-72 |year= 2000 |pmid= 10632727 |doi= }}
* {{cite journal | vauthors = Gaur D, Swaminathan S, Batra JK | title = Interaction of human pancreatic ribonuclease with human ribonuclease inhibitor. Generation of inhibitor-resistant cytotoxic variants | journal = The Journal of Biological Chemistry | volume = 276 | issue = 27 | pages = 24978–84 | date = Jul 2001 | pmid = 11342552 | doi = 10.1074/jbc.M102440200 }}
*{{cite journal | author=Pous J, Canals A, Terzyan SS, ''et al.'' |title=Three-dimensional structure of a human pancreatic ribonuclease variant, a step forward in the design of cytotoxic ribonucleases. |journal=J. Mol. Biol. |volume=303 |issue= 1 |pages= 49-60 |year= 2000 |pmid= 11021969 |doi= 10.1006/jmbi.2000.4506 }}
* {{cite journal | vauthors = Futami J, Maeda T, Kitazoe M, Nukui E, Tada H, Seno M, Kosaka M, Yamada H | title = Preparation of potent cytotoxic ribonucleases by cationization: enhanced cellular uptake and decreased interaction with ribonuclease inhibitor by chemical modification of carboxyl groups | journal = Biochemistry | volume = 40 | issue = 25 | pages = 7518–24 | date = Jun 2001 | pmid = 11412105 | doi = 10.1021/bi010248g }}
*{{cite journal | author=Pous J, Mallorquí-Fernández G, Peracaula R, ''et al.'' |title=Three-dimensional structure of human RNase 1 delta N7 at 1.9 A resolution. |journal=Acta Crystallogr. D Biol. Crystallogr. |volume=57 |issue= Pt 4 |pages= 498-505 |year= 2001 |pmid= 11264578 |doi= }}
* {{cite journal | vauthors = Canals A, Pous J, Guasch A, Benito A, Ribó M, Vilanova M, Coll M | title = The structure of an engineered domain-swapped ribonuclease dimer and its implications for the evolution of proteins toward oligomerization | journal = Structure | volume = 9 | issue = 10 | pages = 967–76 | date = Oct 2001 | pmid = 11591351 | doi = 10.1016/S0969-2126(01)00659-1 }}
*{{cite journal | author=Gaur D, Swaminathan S, Batra JK |title=Interaction of human pancreatic ribonuclease with human ribonuclease inhibitor. Generation of inhibitor-resistant cytotoxic variants. |journal=J. Biol. Chem. |volume=276 |issue= 27 |pages= 24978-84 |year= 2001 |pmid= 11342552 |doi= 10.1074/jbc.M102440200 }}
*{{cite journal | author=Futami J, Maeda T, Kitazoe M, ''et al.'' |title=Preparation of potent cytotoxic ribonucleases by cationization: enhanced cellular uptake and decreased interaction with ribonuclease inhibitor by chemical modification of carboxyl groups. |journal=Biochemistry |volume=40 |issue= 25 |pages= 7518-24 |year= 2001 |pmid= 11412105 |doi= }}
*{{cite journal | author=Canals A, Pous J, Guasch A, ''et al.'' |title=The structure of an engineered domain-swapped ribonuclease dimer and its implications for the evolution of proteins toward oligomerization. |journal=Structure |volume=9 |issue= 10 |pages= 967-76 |year= 2002 |pmid= 11591351 |doi= }}
}}
{{refend}}
{{refend}}


{{protein-stub}}
{{PDB Gallery|geneid=6035}}
{{WikiDoc Sources}}
{{Nucleases}}
 
 
{{gene-14-stub}}

Latest revision as of 21:32, 1 November 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

n/a

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Ribonuclease pancreatic is an enzyme that in humans is encoded by the RNASE1 gene.[1][2]

Function

This gene encodes a member of the pancreatic-type of secretory ribonucleases, a subset of the ribonuclease A super-family. The encoded endonuclease cleaves internal phosphodiester RNA bonds on the 3'-side of pyrimidine bases. It prefers poly(C) as a substrate and hydrolyses 2',3'-cyclic nucleotides, with a pH optimum near 8.0. The encoded protein is monomeric and more commonly acts to degrade ss-RNA over ds-RNA. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified.[2]

References

  1. ↑ Kochetov AV, Lukasheva VV, Filipenko ML, Mertvetsov NP, Rivkin MI (Sep 1995). "[Primary structure of the coding part of the gene for human pancreatic ribonuclease and its chromosomal location]". Bioorganicheskaia Khimiia. 21 (9): 691–4. PMID 8588814.
  2. ↑ 2.0 2.1 "Entrez Gene: RNASE1 ribonuclease, RNase A family, 1 (pancreatic)".

Further reading


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