SMARCD3: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3''' is a [[protein]] that in humans is encoded by the ''SMARCD3'' [[gene]].<ref name="pmid8804307">{{cite journal | vauthors = Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR | title = Diversity and specialization of mammalian SWI/SNF complexes | journal = Genes & Development | volume = 10 | issue = 17 | pages = 2117–30 | date = September 1996 | pmid = 8804307 | pmc =  | doi = 10.1101/gad.10.17.2117 }}</ref><ref name="pmid9693044">{{cite journal | vauthors = Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U | title = Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome | journal = Genomics | volume = 51 | issue = 1 | pages = 140–3 | date = July 1998 | pmid = 9693044 | pmc =  | doi = 10.1006/geno.1998.5343 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6604| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3
| HGNCid = 11108
| Symbol = SMARCD3
| AltSymbols =; Rsc6p; BAF60C; CRACD3; MGC111010
| OMIM = 601737
| ECnumber = 
| Homologene = 2314
| MGIid = 1914243
| GeneAtlas_image1 = PBB_GE_SMARCD3_204099_at_tn.png
| Function = {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005102 |text = receptor binding}} {{GNF_GO|id=GO:0008134 |text = transcription factor binding}} {{GNF_GO|id=GO:0030528 |text = transcription regulator activity}} {{GNF_GO|id=GO:0035257 |text = nuclear hormone receptor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005654 |text = nucleoplasm}} {{GNF_GO|id=GO:0016514 |text = SWI/SNF complex}}
| Process = {{GNF_GO|id=GO:0006338 |text = chromatin remodeling}} {{GNF_GO|id=GO:0006350 |text = transcription}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6604
    | Hs_Ensembl = ENSG00000082014
    | Hs_RefseqProtein = NP_001003801
    | Hs_RefseqmRNA = NM_001003801
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 7
    | Hs_GenLoc_start = 150566995
    | Hs_GenLoc_end = 150603952
    | Hs_Uniprot = Q6STE5
    | Mm_EntrezGene = 66993
    | Mm_Ensembl = ENSMUSG00000028949
    | Mm_RefseqmRNA = NM_025891
    | Mm_RefseqProtein = NP_080167
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 5
    | Mm_GenLoc_start = 24102695
    | Mm_GenLoc_end = 24112077
    | Mm_Uniprot = Q6P9Z1
  }}
}}
'''SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3''', also known as '''SMARCD3''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6604| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene.<ref name="entrez" /> Mutually exclusive incorporation of the variants into the larger SWI/SNF complex are thought to direct the complex to remodel particular sites in chromatin, leading to alterations in gene activity that dictate cell behavior or differentiation during development and disease.<ref>{{cite journal | vauthors = Puri PL, Mercola M | title = BAF60 A, B, and Cs of muscle determination and renewal | journal = Genes & Development | volume = 26 | issue = 24 | pages = 2673–83 | date = December 2012 | pmid = 23222103 | pmc = 3533072 | doi = 10.1101/gad.207415.112 }}</ref>
{{PBB_Summary
| section_title =
| summary_text = The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined.<ref name="entrez">{{cite web | title = Entrez Gene: SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6604| accessdate = }}</ref>
}}


==References==
== References ==
{{reflist|2}}
{{reflist}}
==Further reading==
 
== Further reading ==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading
* {{cite journal | vauthors = Wang W, Côté J, Xue Y, Zhou S, Khavari PA, Biggar SR, Muchardt C, Kalpana GV, Goff SP, Yaniv M, Workman JL, Crabtree GR | title = Purification and biochemical heterogeneity of the mammalian SWI-SNF complex | journal = The EMBO Journal | volume = 15 | issue = 19 | pages = 5370–82 | date = October 1996 | pmid = 8895581 | pmc = 452280 | doi = }}
| citations =
* {{cite journal | vauthors = Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E | title = Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest | journal = Molecular and Cellular Biology | volume = 19 | issue = 2 | pages = 1460–9 | date = February 1999 | pmid = 9891079 | pmc = 116074 | doi = 10.1128/mcb.19.2.1460 }}
*{{cite journal | author=Wang W, Xue Y, Zhou S, ''et al.'' |title=Diversity and specialization of mammalian SWI/SNF complexes. |journal=Genes Dev. |volume=10 |issue= 17 |pages= 2117-30 |year= 1996 |pmid= 8804307 |doi=  }}
* {{cite journal | vauthors = Barker N, Hurlstone A, Musisi H, Miles A, Bienz M, Clevers H | title = The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation | journal = The EMBO Journal | volume = 20 | issue = 17 | pages = 4935–43 | date = September 2001 | pmid = 11532957 | pmc = 125268 | doi = 10.1093/emboj/20.17.4935 }}
*{{cite journal  | author=Wang W, Côté J, Xue Y, ''et al.'' |title=Purification and biochemical heterogeneity of the mammalian SWI-SNF complex. |journal=EMBO J. |volume=15 |issue= 19 |pages= 5370-82 |year= 1996 |pmid= 8895581 |doi=  }}
* {{cite journal | vauthors = Otsuki T, Furukawa Y, Ikeda K, Endo H, Yamashita T, Shinohara A, Iwamatsu A, Ozawa K, Liu JM | title = Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex | journal = Human Molecular Genetics | volume = 10 | issue = 23 | pages = 2651–60 | date = November 2001 | pmid = 11726552 | doi = 10.1093/hmg/10.23.2651 }}
*{{cite journal  | author=Ring HZ, Vameghi-Meyers V, Wang W, ''et al.'' |title=Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome. |journal=Genomics |volume=51 |issue= 1 |pages= 140-3 |year= 1998 |pmid= 9693044 |doi= 10.1006/geno.1998.5343 }}
* {{cite journal | vauthors = Nagaraja GM, Kandpal RP | title = Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins | journal = Biochemical and Biophysical Research Communications | volume = 313 | issue = 3 | pages = 654–65 | date = January 2004 | pmid = 14697242 | doi = 10.1016/j.bbrc.2003.12.001 }}
*{{cite journal | author=Shanahan F, Seghezzi W, Parry D, ''et al.'' |title=Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest. |journal=Mol. Cell. Biol. |volume=19 |issue= 2 |pages= 1460-9 |year= 1999 |pmid= 9891079 |doi= }}
* {{cite journal | vauthors = Debril MB, Gelman L, Fayard E, Annicotte JS, Rocchi S, Auwerx J | title = Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit | journal = The Journal of Biological Chemistry | volume = 279 | issue = 16 | pages = 16677–86 | date = April 2004 | pmid = 14701856 | doi = 10.1074/jbc.M312288200 }}
*{{cite journal | author=Barker N, Hurlstone A, Musisi H, ''et al.'' |title=The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation. |journal=EMBO J. |volume=20 |issue= 17 |pages= 4935-43 |year= 2001 |pmid= 11532957 |doi= 10.1093/emboj/20.17.4935 }}
* {{cite journal | vauthors = Mahmoudi T, Parra M, Vries RG, Kauder SE, Verrijzer CP, Ott M, Verdin E | title = The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter | journal = The Journal of Biological Chemistry | volume = 281 | issue = 29 | pages = 19960–8 | date = July 2006 | pmid = 16687403 | doi = 10.1074/jbc.M603336200 }}
*{{cite journal | author=Otsuki T, Furukawa Y, Ikeda K, ''et al.'' |title=Fanconi anemia protein, FANCA, associates with BRG1, a component of the human SWI/SNF complex. |journal=Hum. Mol. Genet. |volume=10 |issue= 23 |pages= 2651-60 |year= 2002 |pmid= 11726552 |doi=  }}
* {{cite journal | vauthors = Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M | title = Global, in vivo, and site-specific phosphorylation dynamics in signaling networks | journal = Cell | volume = 127 | issue = 3 | pages = 635–48 | date = November 2006 | pmid = 17081983 | doi = 10.1016/j.cell.2006.09.026 }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Scherer SW, Cheung J, MacDonald JR, ''et al.'' |title=Human chromosome 7: DNA sequence and biology. |journal=Science |volume=300 |issue= 5620 |pages= 767-72 |year= 2003 |pmid= 12690205 |doi= 10.1126/science.1083423 }}
*{{cite journal  | author=Hillier LW, Fulton RS, Fulton LA, ''et al.'' |title=The DNA sequence of human chromosome 7. |journal=Nature |volume=424 |issue= 6945 |pages= 157-64 |year= 2003 |pmid= 12853948 |doi= 10.1038/nature01782 }}
*{{cite journal | author=Nagaraja GM, Kandpal RP |title=Chromosome 13q12 encoded Rho GTPase activating protein suppresses growth of breast carcinoma cells, and yeast two-hybrid screen shows its interaction with several proteins. |journal=Biochem. Biophys. Res. Commun. |volume=313 |issue= 3 |pages= 654-65 |year= 2004 |pmid= 14697242 |doi= }}
*{{cite journal | author=Debril MB, Gelman L, Fayard E, ''et al.'' |title=Transcription factors and nuclear receptors interact with the SWI/SNF complex through the BAF60c subunit. |journal=J. Biol. Chem. |volume=279 |issue= 16 |pages= 16677-86 |year= 2004 |pmid= 14701856 |doi= 10.1074/jbc.M312288200 }}
*{{cite journal | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Mahmoudi T, Parra M, Vries RG, ''et al.'' |title=The SWI/SNF chromatin-remodeling complex is a cofactor for Tat transactivation of the HIV promoter. |journal=J. Biol. Chem. |volume=281 |issue= 29 |pages= 19960-8 |year= 2006 |pmid= 16687403 |doi= 10.1074/jbc.M603336200 }}
*{{cite journal | author=Olsen JV, Blagoev B, Gnad F, ''et al.'' |title=Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. |journal=Cell |volume=127 |issue= 3 |pages= 635-48 |year= 2006 |pmid= 17081983 |doi= 10.1016/j.cell.2006.09.026 }}
}}
{{refend}}
{{refend}}


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Latest revision as of 06:39, 11 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily D member 3 is a protein that in humans is encoded by the SMARCD3 gene.[1][2][3]

Function

The protein encoded by this gene is a member of the SWI/SNF family of proteins, whose members display helicase and ATPase activities and which are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI and has sequence similarity to the yeast Swp73 protein. Multiple alternatively spliced transcript variants have been found for this gene.[3] Mutually exclusive incorporation of the variants into the larger SWI/SNF complex are thought to direct the complex to remodel particular sites in chromatin, leading to alterations in gene activity that dictate cell behavior or differentiation during development and disease.[4]

References

  1. ↑ Wang W, Xue Y, Zhou S, Kuo A, Cairns BR, Crabtree GR (September 1996). "Diversity and specialization of mammalian SWI/SNF complexes". Genes & Development. 10 (17): 2117–30. doi:10.1101/gad.10.17.2117. PMID 8804307.
  2. ↑ Ring HZ, Vameghi-Meyers V, Wang W, Crabtree GR, Francke U (July 1998). "Five SWI/SNF-related, matrix-associated, actin-dependent regulator of chromatin (SMARC) genes are dispersed in the human genome". Genomics. 51 (1): 140–3. doi:10.1006/geno.1998.5343. PMID 9693044.
  3. ↑ 3.0 3.1 "Entrez Gene: SMARCD3 SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily d, member 3".
  4. ↑ Puri PL, Mercola M (December 2012). "BAF60 A, B, and Cs of muscle determination and renewal". Genes & Development. 26 (24): 2673–83. doi:10.1101/gad.207415.112. PMC 3533072. PMID 23222103.

Further reading

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