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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''SNW domain-containing protein 1''' is a [[protein]] that in humans is encoded by the ''SNW1'' [[gene]].<ref name="pmid8973337">{{cite journal | vauthors = Folk P, Půta F, Krpejsová L, Blahůsková A, Markos A, Rabino M, Dottin RP | title = The homolog of chromatin binding protein Bx42 identified in Dictyostelium | journal = Gene | volume = 181 | issue = 1-2 | pages = 229–31 | date = Nov 1996 | pmid = 8973337 | pmc =  | doi = 10.1016/S0378-1119(96)00483-0 }}</ref><ref name="pmid9632709">{{cite journal | vauthors = Baudino TA, Kraichely DM, Jefcoat SC, Winchester SK, Partridge NC, MacDonald PN | title = Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription | journal = The Journal of Biological Chemistry | volume = 273 | issue = 26 | pages = 16434–41 | date = Jun 1998 | pmid = 9632709 | pmc = | doi = 10.1074/jbc.273.26.16434 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SNW1 SNW domain containing 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22938| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = SNW domain containing 1
| HGNCid = 16696
| Symbol = SNW1
| AltSymbols =; Bx42; MGC119379; NCOA-62; PRPF45; Prp45; SKIIP; SKIP
| OMIM = 603055
| ECnumber = 
| Homologene = 56557
| MGIid = 
| GeneAtlas_image1 = PBB_GE_SNW1_201575_at_tn.png
| GeneAtlas_image2 = PBB_GE_SNW1_215424_s_at_tn.png
| Function = {{GNF_GO|id=GO:0003713 |text = transcription coactivator activity}} {{GNF_GO|id=GO:0005112 |text = Notch binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}} {{GNF_GO|id=GO:0005681 |text = spliceosome}}
| Process = {{GNF_GO|id=GO:0000398 |text = nuclear mRNA splicing, via spliceosome}} {{GNF_GO|id=GO:0006357 |text = regulation of transcription from RNA polymerase II promoter}} {{GNF_GO|id=GO:0008380 |text = RNA splicing}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 22938
    | Hs_Ensembl = ENSG00000100603
    | Hs_RefseqProtein = NP_036377
    | Hs_RefseqmRNA = NM_012245
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 14
    | Hs_GenLoc_start = 77253717
    | Hs_GenLoc_end = 77297250
    | Hs_Uniprot = Q13573
    | Mm_EntrezGene = 
    | Mm_Ensembl = 
    | Mm_RefseqmRNA = 
    | Mm_RefseqProtein = 
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 
    | Mm_GenLoc_start = 
    | Mm_GenLoc_end = 
    | Mm_Uniprot = 
  }}
}}
'''SNW domain containing 1''', also known as '''SNW1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SNW1 SNW domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22938| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.<ref name="entrez">{{cite web | title = Entrez Gene: SNW1 SNW domain containing 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=22938| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Folk P, Půta F, Krpejsová L, ''et al.'' |title=The homolog of chromatin binding protein Bx42 identified in Dictyostelium. |journal=Gene |volume=181 |issue= 1-2 |pages= 229-31 |year= 1997 |pmid= 8973337 |doi=  }}
*{{cite journal  | author=Dahl R, Wani B, Hayman MJ |title=The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42. |journal=Oncogene |volume=16 |issue= 12 |pages= 1579-86 |year= 1998 |pmid= 9569025 |doi= 10.1038/sj.onc.1201687 }}
*{{cite journal  | author=Baudino TA, Kraichely DM, Jefcoat SC, ''et al.'' |title=Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription. |journal=J. Biol. Chem. |volume=273 |issue= 26 |pages= 16434-41 |year= 1998 |pmid= 9632709 |doi=  }}
*{{cite journal  | author=Zhou S, Fujimuro M, Hsieh JJ, ''et al.'' |title=A role for SKIP in EBNA2 activation of CBF1-repressed promoters. |journal=J. Virol. |volume=74 |issue= 4 |pages= 1939-47 |year= 2000 |pmid= 10644367 |doi=  }}
*{{cite journal  | author=Zhou S, Fujimuro M, Hsieh JJ, ''et al.'' |title=SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. |journal=Mol. Cell. Biol. |volume=20 |issue= 7 |pages= 2400-10 |year= 2000 |pmid= 10713164 |doi=  }}
*{{cite journal  | author=Leong GM, Subramaniam N, Figueroa J, ''et al.'' |title=Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription. |journal=J. Biol. Chem. |volume=276 |issue= 21 |pages= 18243-8 |year= 2001 |pmid= 11278756 |doi= 10.1074/jbc.M010815200 }}
*{{cite journal  | author=Kim YJ, Noguchi S, Hayashi YK, ''et al.'' |title=The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression. |journal=Hum. Mol. Genet. |volume=10 |issue= 11 |pages= 1129-39 |year= 2001 |pmid= 11371506 |doi=  }}
*{{cite journal  | author=Beatus P, Lundkvist J, Oberg C, ''et al.'' |title=The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity. |journal=Mech. Dev. |volume=104 |issue= 1-2 |pages= 3-20 |year= 2001 |pmid= 11404076 |doi=  }}
*{{cite journal  | author=Zhou S, Hayward SD |title=Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex. |journal=Mol. Cell. Biol. |volume=21 |issue= 18 |pages= 6222-32 |year= 2001 |pmid= 11509665 |doi=  }}
*{{cite journal  | author=Zhang C, Baudino TA, Dowd DR, ''et al.'' |title=Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription. |journal=J. Biol. Chem. |volume=276 |issue= 44 |pages= 40614-20 |year= 2001 |pmid= 11514567 |doi= 10.1074/jbc.M106263200 }}
*{{cite journal  | author=Prathapam T, Kühne C, Hayman M, Banks L |title=Ski interacts with the evolutionarily conserved SNW domain of Skip. |journal=Nucleic Acids Res. |volume=29 |issue= 17 |pages= 3469-76 |year= 2001 |pmid= 11522815 |doi=  }}
*{{cite journal  | author=Jurica MS, Licklider LJ, Gygi SR, ''et al.'' |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426-39 |year= 2002 |pmid= 11991638 |doi=  }}
*{{cite journal  | author=Wardell SE, Boonyaratanakornkit V, Adelman JS, ''et al.'' |title=Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator. |journal=Mol. Cell. Biol. |volume=22 |issue= 15 |pages= 5451-66 |year= 2002 |pmid= 12101239 |doi=  }}
*{{cite journal  | author=Prathapam T, Kühne C, Banks L |title=Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity. |journal=Nucleic Acids Res. |volume=30 |issue= 23 |pages= 5261-8 |year= 2002 |pmid= 12466551 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Petersen HH, Hilpert J, Militz D, ''et al.'' |title=Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule. |journal=J. Cell. Sci. |volume=116 |issue= Pt 3 |pages= 453-61 |year= 2003 |pmid= 12508107 |doi=  }}
*{{cite journal  | author=Heilig R, Eckenberg R, Petit JL, ''et al.'' |title=The DNA sequence and analysis of human chromosome 14. |journal=Nature |volume=421 |issue= 6923 |pages= 601-7 |year= 2003 |pmid= 12508121 |doi= 10.1038/nature01348 }}
*{{cite journal  | author=Barry JB, Leong GM, Church WB, ''et al.'' |title=Interactions of SKIP/NCoA-62, TFIIB, and retinoid X receptor with vitamin D receptor helix H10 residues. |journal=J. Biol. Chem. |volume=278 |issue= 10 |pages= 8224-8 |year= 2003 |pmid= 12529369 |doi= 10.1074/jbc.C200712200 }}
*{{cite journal  | author=Zhang C, Dowd DR, Staal A, ''et al.'' |title=Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing. |journal=J. Biol. Chem. |volume=278 |issue= 37 |pages= 35325-36 |year= 2003 |pmid= 12840015 |doi= 10.1074/jbc.M305191200 }}
*{{cite journal  | author=Leong GM, Subramaniam N, Issa LL, ''et al.'' |title=Ski-interacting protein, a bifunctional nuclear receptor coregulator that interacts with N-CoR/SMRT and p300. |journal=Biochem. Biophys. Res. Commun. |volume=315 |issue= 4 |pages= 1070-6 |year= 2004 |pmid= 14985122 |doi= 10.1016/j.bbrc.2004.02.004 }}
}}
{{refend}}


{{protein-stub}}
SNW1 has been shown to [[Protein-protein interaction|interact]] with:
{{WikiDoc Sources}}
{{div col|colwidth=20em}}
* [[CIR (gene)|CIR]],<ref name = pmid10644367/>
* [[Calcitriol receptor]],<ref name = pmid9632709 /><ref name = pmid11514567/>
* [[Histone deacetylase 2]],<ref name = pmid10644367>{{cite journal | vauthors = Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD | title = A role for SKIP in EBNA2 activation of CBF1-repressed promoters | journal = Journal of Virology | volume = 74 | issue = 4 | pages = 1939–47 | date = Feb 2000 | pmid = 10644367 | pmc = 111672 | doi =  10.1128/jvi.74.4.1939-1947.2000}}</ref>
* [[Mothers against decapentaplegic homolog 2]],<ref name = pmid11278756/>
* [[Mothers against decapentaplegic homolog 3]],<ref name = pmid11278756/>
* [[NOTCH1]]<ref name = pmid10713164/><ref name = pmid11404076>{{cite journal | vauthors = Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U | title = The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity | journal = Mechanisms of Development | volume = 104 | issue = 1-2 | pages = 3–20 | date = Jun 2001 | pmid = 11404076 | doi =  10.1016/s0925-4773(01)00373-2}}</ref>
* [[Nuclear receptor co-repressor 2]],<ref name = pmid10644367/><ref name = pmid10713164/>
* [[Nuclear receptor coactivator 1]],<ref name = pmid11514567>{{cite journal | vauthors = Zhang C, Baudino TA, Dowd DR, Tokumaru H, Wang W, MacDonald PN | title = Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription | journal = The Journal of Biological Chemistry | volume = 276 | issue = 44 | pages = 40614–20 | date = Nov 2001 | pmid = 11514567 | doi = 10.1074/jbc.M106263200 }}</ref>
* [[PABPN1]],<ref name = pmid11371506>{{cite journal | vauthors = Kim YJ, Noguchi S, Hayashi YK, Tsukahara T, Shimizu T, Arahata K | title = The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression | journal = Human Molecular Genetics | volume = 10 | issue = 11 | pages = 1129–39 | date = May 2001 | pmid = 11371506 | doi =  10.1093/hmg/10.11.1129}}</ref>
* [[RBPJ]],<ref name = pmid10644367/><ref name = pmid10713164>{{cite journal | vauthors = Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD | title = SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function | journal = Molecular and Cellular Biology | volume = 20 | issue = 7 | pages = 2400–10 | date = Apr 2000 | pmid = 10713164 | pmc = 85419 | doi =  10.1128/mcb.20.7.2400-2410.2000}}</ref>
* [[Retinoblastoma protein]],<ref name = pmid12466551>{{cite journal | vauthors = Prathapam T, Kühne C, Banks L | title = Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity | journal = Nucleic Acids Research | volume = 30 | issue = 23 | pages = 5261–8 | date = Dec 2002 | pmid = 12466551 | pmc = 137971 | doi =  10.1093/nar/gkf658}}</ref>  and
* [[SKI protein]].<ref name = pmid11522815>{{cite journal | vauthors = Prathapam T, Kühne C, Hayman M, Banks L | title = Ski interacts with the evolutionarily conserved SNW domain of Skip | journal = Nucleic Acids Research | volume = 29 | issue = 17 | pages = 3469–76 | date = Sep 2001 | pmid = 11522815 | pmc = 55893 | doi =  10.1093/nar/29.17.3469}}</ref><ref name = pmid9569025>{{cite journal | vauthors = Dahl R, Wani B, Hayman MJ | title = The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42 | journal = Oncogene | volume = 16 | issue = 12 | pages = 1579–86 | date = Mar 1998 | pmid = 9569025 | doi = 10.1038/sj.onc.1201687 }}</ref><ref name = pmid11278756>{{cite journal | vauthors = Leong GM, Subramaniam N, Figueroa J, Flanagan JL, Hayman MJ, Eisman JA, Kouzmenko AP | title = Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription | journal = The Journal of Biological Chemistry | volume = 276 | issue = 21 | pages = 18243–8 | date = May 2001 | pmid = 11278756 | doi = 10.1074/jbc.M010815200 }}</ref>
{{Div col end}}
 
== References ==
{{Reflist}}
 
== Further reading ==
{{Refbegin | 2}}
* {{cite journal | vauthors = Dahl R, Wani B, Hayman MJ | title = The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42 | journal = Oncogene | volume = 16 | issue = 12 | pages = 1579–86 | date = Mar 1998 | pmid = 9569025 | doi = 10.1038/sj.onc.1201687 }}
* {{cite journal | vauthors = Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD | title = A role for SKIP in EBNA2 activation of CBF1-repressed promoters | journal = Journal of Virology | volume = 74 | issue = 4 | pages = 1939–47 | date = Feb 2000 | pmid = 10644367 | pmc = 111672 | doi = 10.1128/JVI.74.4.1939-1947.2000 }}
* {{cite journal | vauthors = Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD | title = SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function | journal = Molecular and Cellular Biology | volume = 20 | issue = 7 | pages = 2400–10 | date = Apr 2000 | pmid = 10713164 | pmc = 85419 | doi = 10.1128/MCB.20.7.2400-2410.2000 }}
* {{cite journal | vauthors = Leong GM, Subramaniam N, Figueroa J, Flanagan JL, Hayman MJ, Eisman JA, Kouzmenko AP | title = Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription | journal = The Journal of Biological Chemistry | volume = 276 | issue = 21 | pages = 18243–8 | date = May 2001 | pmid = 11278756 | doi = 10.1074/jbc.M010815200 }}
* {{cite journal | vauthors = Kim YJ, Noguchi S, Hayashi YK, Tsukahara T, Shimizu T, Arahata K | title = The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression | journal = Human Molecular Genetics | volume = 10 | issue = 11 | pages = 1129–39 | date = May 2001 | pmid = 11371506 | doi = 10.1093/hmg/10.11.1129 }}
* {{cite journal | vauthors = Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U | title = The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity | journal = Mechanisms of Development | volume = 104 | issue = 1-2 | pages = 3–20 | date = Jun 2001 | pmid = 11404076 | doi = 10.1016/S0925-4773(01)00373-2 }}
* {{cite journal | vauthors = Zhou S, Hayward SD | title = Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex | journal = Molecular and Cellular Biology | volume = 21 | issue = 18 | pages = 6222–32 | date = Sep 2001 | pmid = 11509665 | pmc = 87339 | doi = 10.1128/MCB.21.18.6222-6232.2001 }}
* {{cite journal | vauthors = Zhang C, Baudino TA, Dowd DR, Tokumaru H, Wang W, MacDonald PN | title = Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription | journal = The Journal of Biological Chemistry | volume = 276 | issue = 44 | pages = 40614–20 | date = Nov 2001 | pmid = 11514567 | doi = 10.1074/jbc.M106263200 }}
* {{cite journal | vauthors = Prathapam T, Kühne C, Hayman M, Banks L | title = Ski interacts with the evolutionarily conserved SNW domain of Skip | journal = Nucleic Acids Research | volume = 29 | issue = 17 | pages = 3469–76 | date = Sep 2001 | pmid = 11522815 | pmc = 55893 | doi = 10.1093/nar/29.17.3469 }}
* {{cite journal | vauthors = Jurica MS, Licklider LJ, Gygi SR, Grigorieff N, Moore MJ | title = Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis | journal = RNA | volume = 8 | issue = 4 | pages = 426–39 | date = Apr 2002 | pmid = 11991638 | pmc = 1370266 | doi = 10.1017/S1355838202021088 }}
* {{cite journal | vauthors = Wardell SE, Boonyaratanakornkit V, Adelman JS, Aronheim A, Edwards DP | title = Jun dimerization protein 2 functions as a progesterone receptor N-terminal domain coactivator | journal = Molecular and Cellular Biology | volume = 22 | issue = 15 | pages = 5451–66 | date = Aug 2002 | pmid = 12101239 | pmc = 133955 | doi = 10.1128/MCB.22.15.5451-5466.2002 }}
* {{cite journal | vauthors = Prathapam T, Kühne C, Banks L | title = Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity | journal = Nucleic Acids Research | volume = 30 | issue = 23 | pages = 5261–8 | date = Dec 2002 | pmid = 12466551 | pmc = 137971 | doi = 10.1093/nar/gkf658 }}
* {{cite journal | vauthors = Petersen HH, Hilpert J, Militz D, Zandler V, Jacobsen C, Roebroek AJ, Willnow TE | title = Functional interaction of megalin with the megalinbinding protein (MegBP), a novel tetratrico peptide repeat-containing adaptor molecule | journal = Journal of Cell Science | volume = 116 | issue = Pt 3 | pages = 453–61 | date = Feb 2003 | pmid = 12508107 | doi = 10.1242/jcs.00243 }}
* {{cite journal | vauthors = Barry JB, Leong GM, Church WB, Issa LL, Eisman JA, Gardiner EM | title = Interactions of SKIP/NCoA-62, TFIIB, and retinoid X receptor with vitamin D receptor helix H10 residues | journal = The Journal of Biological Chemistry | volume = 278 | issue = 10 | pages = 8224–8 | date = Mar 2003 | pmid = 12529369 | doi = 10.1074/jbc.C200712200 }}
* {{cite journal | vauthors = Zhang C, Dowd DR, Staal A, Gu C, Lian JB, van Wijnen AJ, Stein GS, MacDonald PN | title = Nuclear coactivator-62 kDa/Ski-interacting protein is a nuclear matrix-associated coactivator that may couple vitamin D receptor-mediated transcription and RNA splicing | journal = The Journal of Biological Chemistry | volume = 278 | issue = 37 | pages = 35325–36 | date = Sep 2003 | pmid = 12840015 | doi = 10.1074/jbc.M305191200 }}
* {{cite journal | vauthors = Leong GM, Subramaniam N, Issa LL, Barry JB, Kino T, Driggers PH, Hayman MJ, Eisman JA, Gardiner EM | title = Ski-interacting protein, a bifunctional nuclear receptor coregulator that interacts with N-CoR/SMRT and p300 | journal = Biochemical and Biophysical Research Communications | volume = 315 | issue = 4 | pages = 1070–6 | date = Mar 2004 | pmid = 14985122 | doi = 10.1016/j.bbrc.2004.02.004 }}
{{Refend}}

Latest revision as of 06:24, 10 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

SNW domain-containing protein 1 is a protein that in humans is encoded by the SNW1 gene.[1][2][3]

Function

This gene, a member of the SNW gene family, encodes a coactivator that enhances transcription from some Pol II promoters. This coactivator can bind to the ligand-binding domain of the vitamin D receptor and to retinoid receptors to enhance vitamin D-, retinoic acid-, estrogen-, and glucocorticoid-mediated gene expression. It can also function as a splicing factor by interacting with poly(A)-binding protein 2 to directly control the expression of muscle-specific genes at the transcriptional level. Finally, the protein may be involved in oncogenesis since it interacts with a region of SKI oncoproteins that is required for transforming activity.[3]

Interactions

SNW1 has been shown to interact with:

References

  1. ↑ Folk P, Půta F, Krpejsová L, Blahůsková A, Markos A, Rabino M, Dottin RP (Nov 1996). "The homolog of chromatin binding protein Bx42 identified in Dictyostelium". Gene. 181 (1–2): 229–31. doi:10.1016/S0378-1119(96)00483-0. PMID 8973337.
  2. ↑ 2.0 2.1 Baudino TA, Kraichely DM, Jefcoat SC, Winchester SK, Partridge NC, MacDonald PN (Jun 1998). "Isolation and characterization of a novel coactivator protein, NCoA-62, involved in vitamin D-mediated transcription". The Journal of Biological Chemistry. 273 (26): 16434–41. doi:10.1074/jbc.273.26.16434. PMID 9632709.
  3. ↑ 3.0 3.1 "Entrez Gene: SNW1 SNW domain containing 1".
  4. ↑ 4.0 4.1 4.2 4.3 Zhou S, Fujimuro M, Hsieh JJ, Chen L, Hayward SD (Feb 2000). "A role for SKIP in EBNA2 activation of CBF1-repressed promoters". Journal of Virology. 74 (4): 1939–47. doi:10.1128/jvi.74.4.1939-1947.2000. PMC 111672. PMID 10644367.
  5. ↑ 5.0 5.1 Zhang C, Baudino TA, Dowd DR, Tokumaru H, Wang W, MacDonald PN (Nov 2001). "Ternary complexes and cooperative interplay between NCoA-62/Ski-interacting protein and steroid receptor coactivators in vitamin D receptor-mediated transcription". The Journal of Biological Chemistry. 276 (44): 40614–20. doi:10.1074/jbc.M106263200. PMID 11514567.
  6. ↑ 6.0 6.1 6.2 Leong GM, Subramaniam N, Figueroa J, Flanagan JL, Hayman MJ, Eisman JA, Kouzmenko AP (May 2001). "Ski-interacting protein interacts with Smad proteins to augment transforming growth factor-beta-dependent transcription". The Journal of Biological Chemistry. 276 (21): 18243–8. doi:10.1074/jbc.M010815200. PMID 11278756.
  7. ↑ 7.0 7.1 7.2 Zhou S, Fujimuro M, Hsieh JJ, Chen L, Miyamoto A, Weinmaster G, Hayward SD (Apr 2000). "SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function". Molecular and Cellular Biology. 20 (7): 2400–10. doi:10.1128/mcb.20.7.2400-2410.2000. PMC 85419. PMID 10713164.
  8. ↑ Beatus P, Lundkvist J, Oberg C, Pedersen K, Lendahl U (Jun 2001). "The origin of the ankyrin repeat region in Notch intracellular domains is critical for regulation of HES promoter activity". Mechanisms of Development. 104 (1–2): 3–20. doi:10.1016/s0925-4773(01)00373-2. PMID 11404076.
  9. ↑ Kim YJ, Noguchi S, Hayashi YK, Tsukahara T, Shimizu T, Arahata K (May 2001). "The product of an oculopharyngeal muscular dystrophy gene, poly(A)-binding protein 2, interacts with SKIP and stimulates muscle-specific gene expression". Human Molecular Genetics. 10 (11): 1129–39. doi:10.1093/hmg/10.11.1129. PMID 11371506.
  10. ↑ Prathapam T, Kühne C, Banks L (Dec 2002). "Skip interacts with the retinoblastoma tumor suppressor and inhibits its transcriptional repression activity". Nucleic Acids Research. 30 (23): 5261–8. doi:10.1093/nar/gkf658. PMC 137971. PMID 12466551.
  11. ↑ Prathapam T, Kühne C, Hayman M, Banks L (Sep 2001). "Ski interacts with the evolutionarily conserved SNW domain of Skip". Nucleic Acids Research. 29 (17): 3469–76. doi:10.1093/nar/29.17.3469. PMC 55893. PMID 11522815.
  12. ↑ Dahl R, Wani B, Hayman MJ (Mar 1998). "The Ski oncoprotein interacts with Skip, the human homolog of Drosophila Bx42". Oncogene. 16 (12): 1579–86. doi:10.1038/sj.onc.1201687. PMID 9569025.

Further reading

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