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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Sorting nexin-2''' is a [[protein]] that in humans is encoded by the ''SNX2'' [[gene]].<ref name="pmid9819414">{{cite journal | vauthors = Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI | title = Identification of a family of sorting nexin molecules and characterization of their association with receptors | journal = Molecular and Cellular Biology | volume = 18 | issue = 12 | pages = 7278–87 | date = Dec 1998 | pmid = 9819414 | pmc = 109309 | doi =  10.1128/mcb.18.12.7278}}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SNX2 sorting nexin 2| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6643| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = Sorting nexin 2
| HGNCid = 11173
| Symbol = SNX2
| AltSymbols =; MGC5204; TRG-9
| OMIM = 605929
| ECnumber = 
| Homologene = 2332
| MGIid = 1915054
| GeneAtlas_image1 = PBB_GE_SNX2_202114_at_tn.png
| GeneAtlas_image2 = PBB_GE_SNX2_202113_s_at_tn.png
| Function = {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008565 |text = protein transporter activity}} {{GNF_GO|id=GO:0035091 |text = phosphoinositide binding}}
| Component = {{GNF_GO|id=GO:0005737 |text = cytoplasm}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0006897 |text = endocytosis}} {{GNF_GO|id=GO:0007154 |text = cell communication}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 6643
    | Hs_Ensembl = ENSG00000205302
    | Hs_RefseqProtein = NP_003091
    | Hs_RefseqmRNA = NM_003100
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 5
    | Hs_GenLoc_start = 122138649
    | Hs_GenLoc_end = 122193699
    | Hs_Uniprot = O60749
    | Mm_EntrezGene = 67804
    | Mm_Ensembl = ENSMUSG00000034484
    | Mm_RefseqmRNA = NM_026386
    | Mm_RefseqProtein = NP_080662
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 18
    | Mm_GenLoc_start = 53301734
    | Mm_GenLoc_end = 53346229
    | Mm_Uniprot = Q3U5L3
  }}
}}
'''Sorting nexin 2''', also known as '''SNX2''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SNX2 sorting nexin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6643| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
This gene encodes a member of the [[sorting nexin]] family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members.<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members.<ref name="entrez">{{cite web | title = Entrez Gene: SNX2 sorting nexin 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6643| accessdate = }}</ref>
}}


==References==
== Interactions ==
{{reflist|2}}
==Further reading==
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi=  }}
*{{cite journal  | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi=  }}
*{{cite journal  | author=Haft CR, de la Luz Sierra M, Barr VA, ''et al.'' |title=Identification of a family of sorting nexin molecules and characterization of their association with receptors. |journal=Mol. Cell. Biol. |volume=18 |issue= 12 |pages= 7278-87 |year= 1998 |pmid= 9819414 |doi=  }}
*{{cite journal  | author=Haft CR, de la Luz Sierra M, Bafford R, ''et al.'' |title=Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes. |journal=Mol. Biol. Cell |volume=11 |issue= 12 |pages= 4105-16 |year= 2001 |pmid= 11102511 |doi=  }}
*{{cite journal  | author=Parks WT, Frank DB, Huff C, ''et al.'' |title=Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases. |journal=J. Biol. Chem. |volume=276 |issue= 22 |pages= 19332-9 |year= 2001 |pmid= 11279102 |doi= 10.1074/jbc.M100606200 }}
*{{cite journal  | author=Fuchs U, Rehkamp G, Haas OA, ''et al.'' |title=The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=98 |issue= 15 |pages= 8756-61 |year= 2001 |pmid= 11438682 |doi= 10.1073/pnas.121433898 }}
*{{cite journal  | author=Teasdale RD, Loci D, Houghton F, ''et al.'' |title=A large family of endosome-localized proteins related to sorting nexin 1. |journal=Biochem. J. |volume=358 |issue= Pt 1 |pages= 7-16 |year= 2001 |pmid= 11485546 |doi=  }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  | author=Fuchs U, Rehkamp GF, Slany R, ''et al.'' |title=The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance. |journal=FEBS Lett. |volume=554 |issue= 1-2 |pages= 10-6 |year= 2003 |pmid= 14596906 |doi=  }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Gullapalli A, Garrett TA, Paing MM, ''et al.'' |title=A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking. |journal=Mol. Biol. Cell |volume=15 |issue= 5 |pages= 2143-55 |year= 2005 |pmid= 14978220 |doi= 10.1091/mbc.E03-09-0711 }}
*{{cite journal  | author=Beausoleil SA, Jedrychowski M, Schwartz D, ''et al.'' |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130-5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  | author=Schaaf CP, Benzing J, Schmitt T, ''et al.'' |title=Novel interaction partners of the TPR/MET tyrosine kinase. |journal=FASEB J. |volume=19 |issue= 2 |pages= 267-9 |year= 2005 |pmid= 15546961 |doi= 10.1096/fj.04-1558fje }}
*{{cite journal  | author=Abdul-Ghani M, Hartman KL, Ngsee JK |title=Abstrakt interacts with and regulates the expression of sorting nexin-2. |journal=J. Cell. Physiol. |volume=204 |issue= 1 |pages= 210-8 |year= 2005 |pmid= 15690390 |doi= 10.1002/jcp.20285 }}
*{{cite journal  | author=Carlton JG, Bujny MV, Peter BJ, ''et al.'' |title=Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport. |journal=J. Cell. Sci. |volume=118 |issue= Pt 19 |pages= 4527-39 |year= 2006 |pmid= 16179610 |doi= 10.1242/jcs.02568 }}
*{{cite journal  | author=Beausoleil SA, Villén J, Gerber SA, ''et al.'' |title=A probability-based approach for high-throughput protein phosphorylation analysis and site localization. |journal=Nat. Biotechnol. |volume=24 |issue= 10 |pages= 1285-92 |year= 2006 |pmid= 16964243 |doi= 10.1038/nbt1240 }}
*{{cite journal  | author=Rojas R, Kametaka S, Haft CR, Bonifacino JS |title=Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors. |journal=Mol. Cell. Biol. |volume=27 |issue= 3 |pages= 1112-24 |year= 2007 |pmid= 17101778 |doi= 10.1128/MCB.00156-06 }}
*{{cite journal  | author=Skånland SS, Wälchli S, Utskarpen A, ''et al.'' |title=Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins. |journal=Traffic |volume=8 |issue= 3 |pages= 297-309 |year= 2007 |pmid= 17319803 |doi= 10.1111/j.1600-0854.2006.00527.x }}
}}
{{refend}}


{{protein-stub}}
SNX2 has been shown to [[Protein-protein interaction|interact]] with [[FNBP1]].<ref name=pmid14596906>{{cite journal | vauthors = Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A | title = The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance | journal = FEBS Letters | volume = 554 | issue = 1-2 | pages = 10–6 | date = Nov 2003 | pmid = 14596906 | doi = 10.1016/S0014-5793(03)01063-9 }}</ref><ref name=pmid11438682>{{cite journal | vauthors = Fuchs U, Rehkamp G, Haas OA, Slany R, Kōnig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A | title = The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 15 | pages = 8756–61 | date = Jul 2001 | pmid = 11438682 | pmc = 37508 | doi = 10.1073/pnas.121433898 }}</ref>
{{WikiDoc Sources}}
 
== References ==
{{Reflist}}
{{Clear}}
 
== Further reading ==
{{Refbegin|33em}}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = Jan 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = Oct 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
* {{cite journal | vauthors = Haft CR, de la Luz Sierra M, Bafford R, Lesniak MA, Barr VA, Taylor SI | title = Human orthologs of yeast vacuolar protein sorting proteins Vps26, 29, and 35: assembly into multimeric complexes | journal = Molecular Biology of the Cell | volume = 11 | issue = 12 | pages = 4105–16 | date = Dec 2000 | pmid = 11102511 | pmc = 15060 | doi = 10.1091/mbc.11.12.4105 }}
* {{cite journal | vauthors = Parks WT, Frank DB, Huff C, Renfrew Haft C, Martin J, Meng X, de Caestecker MP, McNally JG, Reddi A, Taylor SI, Roberts AB, Wang T, Lechleider RJ | title = Sorting nexin 6, a novel SNX, interacts with the transforming growth factor-beta family of receptor serine-threonine kinases | journal = The Journal of Biological Chemistry | volume = 276 | issue = 22 | pages = 19332–9 | date = Jun 2001 | pmid = 11279102 | doi = 10.1074/jbc.M100606200 }}
* {{cite journal | vauthors = Fuchs U, Rehkamp G, Haas OA, Slany R, Kōnig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A | title = The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 98 | issue = 15 | pages = 8756–61 | date = Jul 2001 | pmid = 11438682 | pmc = 37508 | doi = 10.1073/pnas.121433898 }}
* {{cite journal | vauthors = Teasdale RD, Loci D, Houghton F, Karlsson L, Gleeson PA | title = A large family of endosome-localized proteins related to sorting nexin 1 | journal = The Biochemical Journal | volume = 358 | issue = Pt 1 | pages = 7–16 | date = Aug 2001 | pmid = 11485546 | pmc = 1222026 | doi = 10.1042/0264-6021:3580007 }}
* {{cite journal | vauthors = Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A | title = The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance | journal = FEBS Letters | volume = 554 | issue = 1-2 | pages = 10–6 | date = Nov 2003 | pmid = 14596906 | doi = 10.1016/S0014-5793(03)01063-9 }}
* {{cite journal | vauthors = Gullapalli A, Garrett TA, Paing MM, Griffin CT, Yang Y, Trejo J | title = A role for sorting nexin 2 in epidermal growth factor receptor down-regulation: evidence for distinct functions of sorting nexin 1 and 2 in protein trafficking | journal = Molecular Biology of the Cell | volume = 15 | issue = 5 | pages = 2143–55 | date = May 2004 | pmid = 14978220 | pmc = 404011 | doi = 10.1091/mbc.E03-09-0711 }}
* {{cite journal | vauthors = Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP | title = Large-scale characterization of HeLa cell nuclear phosphoproteins | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 101 | issue = 33 | pages = 12130–5 | date = Aug 2004 | pmid = 15302935 | pmc = 514446 | doi = 10.1073/pnas.0404720101 }}
* {{cite journal | vauthors = Schaaf CP, Benzing J, Schmitt T, Erz DH, Tewes M, Bartram CR, Janssen JW | title = Novel interaction partners of the TPR/MET tyrosine kinase | journal = FASEB Journal | volume = 19 | issue = 2 | pages = 267–9 | date = Feb 2005 | pmid = 15546961 | doi = 10.1096/fj.04-1558fje }}
* {{cite journal | vauthors = Abdul-Ghani M, Hartman KL, Ngsee JK | title = Abstrakt interacts with and regulates the expression of sorting nexin-2 | journal = Journal of Cellular Physiology | volume = 204 | issue = 1 | pages = 210–8 | date = Jul 2005 | pmid = 15690390 | pmc = 2963638 | doi = 10.1002/jcp.20285 }}
* {{cite journal | vauthors = Carlton JG, Bujny MV, Peter BJ, Oorschot VM, Rutherford A, Arkell RS, Klumperman J, McMahon HT, Cullen PJ | title = Sorting nexin-2 is associated with tubular elements of the early endosome, but is not essential for retromer-mediated endosome-to-TGN transport | journal = Journal of Cell Science | volume = 118 | issue = Pt 19 | pages = 4527–39 | date = Oct 2005 | pmid = 16179610 | pmc = 1904489 | doi = 10.1242/jcs.02568 }}
* {{cite journal | vauthors = Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP | title = A probability-based approach for high-throughput protein phosphorylation analysis and site localization | journal = Nature Biotechnology | volume = 24 | issue = 10 | pages = 1285–92 | date = Oct 2006 | pmid = 16964243 | doi = 10.1038/nbt1240 }}
* {{cite journal | vauthors = Rojas R, Kametaka S, Haft CR, Bonifacino JS | title = Interchangeable but essential functions of SNX1 and SNX2 in the association of retromer with endosomes and the trafficking of mannose 6-phosphate receptors | journal = Molecular and Cellular Biology | volume = 27 | issue = 3 | pages = 1112–24 | date = Feb 2007 | pmid = 17101778 | pmc = 1800681 | doi = 10.1128/MCB.00156-06 }}
* {{cite journal | vauthors = Skånland SS, Wälchli S, Utskarpen A, Wandinger-Ness A, Sandvig K | title = Phosphoinositide-regulated retrograde transport of ricin: crosstalk between hVps34 and sorting nexins | journal = Traffic | volume = 8 | issue = 3 | pages = 297–309 | date = Mar 2007 | pmid = 17319803 | doi = 10.1111/j.1600-0854.2006.00527.x }}
{{Refend}}
 
{{Sorting nexins}}
 
 
{{Gene-5-stub}}

Latest revision as of 06:47, 11 September 2017

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

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RefSeq (protein)

n/a

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sorting nexin-2 is a protein that in humans is encoded by the SNX2 gene.[1][2]

Function

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein associates with formin-binding protein 17, but its function is unknown. This protein may form oligomeric complexes with family members.[2]

Interactions

SNX2 has been shown to interact with FNBP1.[3][4]

References

  1. ↑ Haft CR, de la Luz Sierra M, Barr VA, Haft DH, Taylor SI (Dec 1998). "Identification of a family of sorting nexin molecules and characterization of their association with receptors". Molecular and Cellular Biology. 18 (12): 7278–87. doi:10.1128/mcb.18.12.7278. PMC 109309. PMID 9819414.
  2. ↑ 2.0 2.1 "Entrez Gene: SNX2 sorting nexin 2".
  3. ↑ Fuchs U, Rehkamp GF, Slany R, Follo M, Borkhardt A (Nov 2003). "The formin-binding protein 17, FBP17, binds via a TNKS binding motif to tankyrase, a protein involved in telomere maintenance". FEBS Letters. 554 (1–2): 10–6. doi:10.1016/S0014-5793(03)01063-9. PMID 14596906.
  4. ↑ Fuchs U, Rehkamp G, Haas OA, Slany R, Kōnig M, Bojesen S, Bohle RM, Damm-Welk C, Ludwig WD, Harbott J, Borkhardt A (Jul 2001). "The human formin-binding protein 17 (FBP17) interacts with sorting nexin, SNX2, and is an MLL-fusion partner in acute myelogeneous leukemia". Proceedings of the National Academy of Sciences of the United States of America. 98 (15): 8756–61. doi:10.1073/pnas.121433898. PMC 37508. PMID 11438682.

Further reading


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