SNX9: Difference between revisions

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{{Infobox_gene}}
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'''Sorting nexin-9''' is a [[protein]] that in humans is encoded by the ''SNX9'' [[gene]].<ref name="pmid10531379">{{cite journal |author1=Howard L |author2=Nelson KK |author3=Maciewicz RA |author4=Blobel CP | title = Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1 | journal = J Biol Chem | volume = 274 | issue = 44 | pages = 31693–9 |date=Dec 1999 | pmid = 10531379 | pmc = | doi =10.1074/jbc.274.44.31693 }}</ref><ref name="pmid17609109">{{cite journal |author1=Yarar D |author2=Waterman-Storer CM |author3=Schmid SL | title = SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis | journal = Dev Cell | volume = 13 | issue = 1 | pages = 43–56 |date=Jul 2007 | pmid = 17609109 | pmc =  | doi = 10.1016/j.devcel.2007.04.014 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: SNX9 sorting nexin 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51429| accessdate = }}</ref>
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{{GNF_Protein_box
| image = 
| image_source =
| PDB =  
| Name = Sorting nexin 9
| HGNCid = 14973
| Symbol = SNX9
| AltSymbols =; SDP1; MST155; MSTP155; SH3PX1; SH3PXD3A; WISP
| OMIM = 605952
| ECnumber =
| Homologene = 49454
| MGIid = 1913866
| GeneAtlas_image1 = PBB_GE_SNX9_gnf1h00218_at_tn.png
| Function = {{GNF_GO|id=GO:0005070 |text = SH3/SH2 adaptor activity}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0035091 |text = phosphoinositide binding}}
  | Component = {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005737 |text = cytoplasm}} {{GNF_GO|id=GO:0005792 |text = microsome}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}}
| Process = {{GNF_GO|id=GO:0006886 |text = intracellular protein transport}} {{GNF_GO|id=GO:0007154 |text = cell communication}} {{GNF_GO|id=GO:0008104 |text = protein localization}}
  | Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 51429
    | Hs_Ensembl = ENSG00000130340
    | Hs_RefseqProtein = NP_057308
    | Hs_RefseqmRNA = NM_016224
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 6
    | Hs_GenLoc_start = 158164282
    | Hs_GenLoc_end = 158286097
    | Hs_Uniprot = Q9Y5X1
    | Mm_EntrezGene = 66616
    | Mm_Ensembl = ENSMUSG00000002365
    | Mm_RefseqmRNA = XM_973143
    | Mm_RefseqProtein = XP_978237
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 17
    | Mm_GenLoc_start = 5797862
    | Mm_GenLoc_end = 5887223
    | Mm_Uniprot = Q3TZU7
  }}
}}
'''Sorting nexin 9''', also known as '''SNX9''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: SNX9 sorting nexin 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51429| accessdate = }}</ref>


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{{PBB_Summary
{{PBB_Summary
| section_title =  
| section_title =  
| summary_text = This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein.<ref name="entrez">{{cite web | title = Entrez Gene: SNX9 sorting nexin 9| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51429| accessdate = }}</ref>
| summary_text = This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein.<ref name="entrez">{{cite web | title = Entrez Gene: SNX9 sorting nexin 9| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=51429| accessdate = }}</ref>
}}
}}
==Interactions==
SNX9 has been shown to [[Protein-protein interaction|interact]] with [[ADAM9]],<ref name=pmid10531379 /> [[DNM2]]<ref name=pmid12952949>{{cite journal |last=Lundmark |first=Richard |authorlink= |author2=Carlsson Sven R  |date=Nov 2003 |title=Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components |journal=J. Biol. Chem. |volume=278 |issue=47 |pages=46772–81 |publisher= |location = United States| issn = 0021-9258| pmid = 12952949 |doi = 10.1074/jbc.M307334200 | bibcode = | oclc =| id = | url = | language = | format = | accessdate = | laysummary = | laysource = | laydate = | quote = }}</ref> and [[ADAM15]].<ref name=pmid10531379/>


==References==
==References==
{{reflist|2}}
{{reflist}}
 
==Further reading==
==Further reading==
{{refbegin | 2}}
{{refbegin | 2}}
{{PBB_Further_reading  
{{PBB_Further_reading  
| citations =  
| citations =  
*{{cite journal | author=Howard L, Nelson KK, Maciewicz RA, Blobel CP |title=Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1. |journal=J. Biol. Chem. |volume=274 |issue= 44 |pages= 31693-9 |year= 1999 |pmid= 10531379 |doi=  }}
*{{cite journal   |vauthors=Teasdale RD, Loci D, Houghton F, etal |title=A large family of endosome-localized proteins related to sorting nexin 1. |journal=Biochem. J. |volume=358 |issue= Pt 1 |pages= 7–16 |year= 2001 |pmid= 11485546 |doi=10.1042/0264-6021:3580007  | pmc=1222026 }}
*{{cite journal  | author=Teasdale RD, Loci D, Houghton F, ''et al.'' |title=A large family of endosome-localized proteins related to sorting nexin 1. |journal=Biochem. J. |volume=358 |issue= Pt 1 |pages= 7-16 |year= 2001 |pmid= 11485546 |doi=  }}
*{{cite journal  |author1=Lin Q |author2=Lo CG |author3=Cerione RA |author4=Yang W |title=The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10134–8 |year= 2002 |pmid= 11799118 |doi=10.1074/jbc.M110329200 }}
*{{cite journal  | author=Lin Q, Lo CG, Cerione RA, Yang W |title=The Cdc42 target ACK2 interacts with sorting nexin 9 (SH3PX1) to regulate epidermal growth factor receptor degradation. |journal=J. Biol. Chem. |volume=277 |issue= 12 |pages= 10134-8 |year= 2002 |pmid= 11799118 |doi= 10.1074/jbc. M110329200 }}
*{{cite journal  |author1=Lundmark R |author2=Carlsson SR |title=The beta-appendages of the four adaptor-protein (AP) complexes: structure and binding properties, and identification of sorting nexin 9 as an accessory protein to AP-2. |journal=Biochem. J. |volume=362 |issue= Pt 3 |pages= 597–607 |year= 2002 |pmid= 11879186 |doi=10.1042/0264-6021:3620597  | pmc=1222423  }}
*{{cite journal | author=Lundmark R, Carlsson SR |title=The beta-appendages of the four adaptor-protein (AP) complexes: structure and binding properties, and identification of sorting nexin 9 as an accessory protein to AP-2. |journal=Biochem. J. |volume=362 |issue= Pt 3 |pages= 597-607 |year= 2002 |pmid= 11879186 |doi=  }}
*{{cite journal   |vauthors=Strausberg RL, Feingold EA, Grouse LH, etal |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 | pmc=139241 |bibcode=2002PNAS...9916899M }}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
*{{cite journal  |author1=Lundmark R |author2=Carlsson SR |title=Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components. |journal=J. Biol. Chem. |volume=278 |issue= 47 |pages= 46772–81 |year= 2004 |pmid= 12952949 |doi=10.1074/jbc.M307334200  }}
*{{cite journal | author=Lundmark R, Carlsson SR |title=Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components. |journal=J. Biol. Chem. |volume=278 |issue= 47 |pages= 46772-81 |year= 2004 |pmid= 12952949 |doi= 10.1074/jbc. M307334200 }}
*{{cite journal   |vauthors=Mungall AJ, Palmer SA, Sims SK, etal |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805–11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  | author=Mungall AJ, Palmer SA, Sims SK, ''et al.'' |title=The DNA sequence and analysis of human chromosome 6. |journal=Nature |volume=425 |issue= 6960 |pages= 805-11 |year= 2003 |pmid= 14574404 |doi= 10.1038/nature02055 }}
*{{cite journal  |author1=Schulze WX |author2=Mann M |title=A novel proteomic screen for peptide-protein interactions. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10756–64 |year= 2004 |pmid= 14679214 |doi= 10.1074/jbc.M309909200 }}
*{{cite journal | author=Schulze WX, Mann M |title=A novel proteomic screen for peptide-protein interactions. |journal=J. Biol. Chem. |volume=279 |issue= 11 |pages= 10756-64 |year= 2004 |pmid= 14679214 |doi= 10.1074/jbc. M309909200 }}
*{{cite journal   |vauthors=Ota T, Suzuki Y, Nishikawa T, etal |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  | author=Ota T, Suzuki Y, Nishikawa T, ''et al.'' |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285 }}
*{{cite journal  |author1=Lehner B |author2=Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315–23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004  | pmc=442147 }}
*{{cite journal  | author=Lehner B, Sanderson CM |title=A protein interaction framework for human mRNA degradation. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1315-23 |year= 2004 |pmid= 15231747 |doi= 10.1101/gr.2122004 }}
*{{cite journal  |author1=Lundmark R |author2=Carlsson SR |title=Regulated membrane recruitment of dynamin-2 mediated by sorting nexin 9. |journal=J. Biol. Chem. |volume=279 |issue= 41 |pages= 42694–702 |year= 2004 |pmid= 15299020 |doi=10.1074/jbc.M407430200  }}
*{{cite journal | author=Lundmark R, Carlsson SR |title=Regulated membrane recruitment of dynamin-2 mediated by sorting nexin 9. |journal=J. Biol. Chem. |volume=279 |issue= 41 |pages= 42694-702 |year= 2004 |pmid= 15299020 |doi= 10.1074/jbc. M407430200 }}
*{{cite journal   |vauthors=Gerhard DS, Wagner L, Feingold EA, etal |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504  | pmc=528928 }}
*{{cite journal  | author=Gerhard DS, Wagner L, Feingold EA, ''et al.'' |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121-7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504 }}
*{{cite journal  |author1=Soulet F |author2=Yarar D |author3=Leonard M |author4=Schmid SL |title=SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. |journal=Mol. Biol. Cell |volume=16 |issue= 4 |pages= 2058–67 |year= 2005 |pmid= 15703209 |doi= 10.1091/mbc.E04-11-1016| pmc=1073683 }}
*{{cite journal  | author=Soulet F, Yarar D, Leonard M, Schmid SL |title=SNX9 regulates dynamin assembly and is required for efficient clathrin-mediated endocytosis. |journal=Mol. Biol. Cell |volume=16 |issue= 4 |pages= 2058-67 |year= 2005 |pmid= 15703209 |doi= 10.1091/mbc. E04-11-1016 }}
*{{cite journal  |author1=Yeow-Fong L |author2=Lim L |author3=Manser E |title=SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1. |journal=FEBS Lett. |volume=579 |issue= 22 |pages= 5040–8 |year= 2005 |pmid= 16137687 |doi= 10.1016/j.febslet.2005.07.093 }}
*{{cite journal | author=Yeow-Fong L, Lim L, Manser E |title=SNX9 as an adaptor for linking synaptojanin-1 to the Cdc42 effector ACK1. |journal=FEBS Lett. |volume=579 |issue= 22 |pages= 5040-8 |year= 2005 |pmid= 16137687 |doi= 10.1016/j.febslet.2005.07.093 }}
*{{cite journal   |vauthors=Rual JF, Venkatesan K, Hao T, etal |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 |bibcode=2005Natur.437.1173R }}
*{{cite journal  | author=Rual JF, Venkatesan K, Hao T, ''et al.'' |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173-8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209 }}
*{{cite journal  |author1=Childress C |author2=Lin Q |author3=Yang W |title=Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2. |journal=Biochem. J. |volume=394 |issue= Pt 3 |pages= 693–8 |year= 2006 |pmid= 16316319 |doi= 10.1042/BJ20050576  | pmc=1383719 }}
*{{cite journal | author=Childress C, Lin Q, Yang W |title=Dimerization is required for SH3PX1 tyrosine phosphorylation in response to epidermal growth factor signalling and interaction with ACK2. |journal=Biochem. J. |volume=394 |issue= Pt 3 |pages= 693-8 |year= 2006 |pmid= 16316319 |doi= 10.1042/BJ20050576 }}
*{{cite journal   |vauthors=Marchès O, Batchelor M, Shaw RK, etal |title=EspF of enteropathogenic Escherichia coli binds sorting nexin 9. |journal=J. Bacteriol. |volume=188 |issue= 8 |pages= 3110–5 |year= 2006 |pmid= 16585770 |doi= 10.1128/JB.188.8.3110-3115.2006  | pmc=1447016 }}
*{{cite journal | author=Marchès O, Batchelor M, Shaw RK, ''et al.'' |title=EspF of enteropathogenic Escherichia coli binds sorting nexin 9. |journal=J. Bacteriol. |volume=188 |issue= 8 |pages= 3110-5 |year= 2006 |pmid= 16585770 |doi= 10.1128/JB.188.8.3110-3115.2006 }}
*{{cite journal   |vauthors=Schmid EM, Ford MG, Burtey A, etal |title=Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. |journal=PLoS Biol. |volume=4 |issue= 9 |pages= e262 |year= 2007 |pmid= 16903783 |doi= 10.1371/journal.pbio.0040262  | pmc=1540706 }}
*{{cite journal | author=Schmid EM, Ford MG, Burtey A, ''et al.'' |title=Role of the AP2 beta-appendage hub in recruiting partners for clathrin-coated vesicle assembly. |journal=PLoS Biol. |volume=4 |issue= 9 |pages= e262 |year= 2007 |pmid= 16903783 |doi= 10.1371/journal.pbio.0040262 }}
*{{cite journal   |vauthors=Badour K, McGavin MK, Zhang J, etal |title=Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 5 |pages= 1593–8 |year= 2007 |pmid= 17242350 |doi= 10.1073/pnas.0610543104 | pmc=1785243 |bibcode=2007PNAS..104.1593B }}
*{{cite journal | author=Badour K, McGavin MK, Zhang J, ''et al.'' |title=Interaction of the Wiskott-Aldrich syndrome protein with sorting nexin 9 is required for CD28 endocytosis and cosignaling in T cells. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=104 |issue= 5 |pages= 1593-8 |year= 2007 |pmid= 17242350 |doi= 10.1073/pnas.0610543104 }}
*{{cite journal  | author=Yarar D, Waterman-Storer CM, Schmid SL |title=SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis. |journal=Dev. Cell |volume=13 |issue= 1 |pages= 43-56 |year= 2007 |pmid= 17609109 |doi= 10.1016/j.devcel.2007.04.014 }}
}}
}}
{{refend}}
{{refend}}


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{{Sorting nexins}}
 
 
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Latest revision as of 04:42, 26 June 2018

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Sorting nexin-9 is a protein that in humans is encoded by the SNX9 gene.[1][2][3]

This gene encodes a member of the sorting nexin family. Members of this family contain a phox (PX) domain, which is a phosphoinositide binding domain, and are involved in intracellular trafficking. This protein does not contain a coiled coil region, like some family members, but does contain an SH3 domain near its N-terminus. This protein interacts with the cytoplasmic domains of the precursor but not the processed forms of a disintegrin and metalloprotease domain 9 and 15. This protein binds the beta-appendage domain of adaptor protein 2 and may function to assist adaptor protein 2 in its role at the plasma membrane. This protein interacts with activated Cdc42-associated kinase-2 to regulate the degradation of epidermal growth factor receptor protein.[3]

Interactions

SNX9 has been shown to interact with ADAM9,[1] DNM2[4] and ADAM15.[1]

References

  1. ↑ 1.0 1.1 1.2 Howard L; Nelson KK; Maciewicz RA; Blobel CP (Dec 1999). "Interaction of the metalloprotease disintegrins MDC9 and MDC15 with two SH3 domain-containing proteins, endophilin I and SH3PX1". J Biol Chem. 274 (44): 31693–9. doi:10.1074/jbc.274.44.31693. PMID 10531379.
  2. ↑ Yarar D; Waterman-Storer CM; Schmid SL (Jul 2007). "SNX9 couples actin assembly to phosphoinositide signals and is required for membrane remodeling during endocytosis". Dev Cell. 13 (1): 43–56. doi:10.1016/j.devcel.2007.04.014. PMID 17609109.
  3. ↑ 3.0 3.1 "Entrez Gene: SNX9 sorting nexin 9".
  4. ↑ Lundmark, Richard; Carlsson Sven R (Nov 2003). "Sorting nexin 9 participates in clathrin-mediated endocytosis through interactions with the core components". J. Biol. Chem. United States. 278 (47): 46772–81. doi:10.1074/jbc.M307334200. ISSN 0021-9258. PMID 12952949.

Further reading



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