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<!-- The PBB_Controls template provides controls for Protein Box Bot, please see Template:PBB_Controls for details. -->
{{Infobox_gene}}
{{PBB_Controls
'''Transducin-like enhancer protein 1''' is a [[protein]] that in humans is encoded by the ''TLE1'' [[gene]].<ref name="pmid8365415">{{cite journal | vauthors = Miyasaka H, Choudhury BK, Hou EW, Li SS | title = Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein | journal = European Journal of Biochemistry / FEBS | volume = 216 | issue = 1 | pages = 343–52 | date = Aug 1993 | pmid = 8365415 | pmc =  | doi = 10.1111/j.1432-1033.1993.tb18151.x }}</ref><ref name="pmid8808280">{{cite journal | vauthors = Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S | title = Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia | journal = Genomics | volume = 31 | issue = 1 | pages = 58–64 | date = Jan 1996 | pmid = 8808280 | pmc =  | doi = 10.1006/geno.1996.0009 }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7088| accessdate = }}</ref>
| update_page = yes
| require_manual_inspection = no
| update_protein_box = yes
| update_summary = yes
| update_citations = yes
}}


<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Interactions ==
{{GNF_Protein_box
| image = PBB_Protein_TLE1_image.jpg
| image_source = [[Protein_Data_Bank|PDB]] rendering based on 1gxr.
| PDB = {{PDB2|1gxr}}, {{PDB2|2ce8}}, {{PDB2|2ce9}}
| Name = Transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)
| HGNCid = 11837
| Symbol = TLE1
| AltSymbols =; ESG; ESG1; GRG1
| OMIM = 600189
| ECnumber = 
| Homologene = 21058
| MGIid = 104636
| GeneAtlas_image1 = PBB_GE_TLE1_203221_at_tn.png
| GeneAtlas_image2 = PBB_GE_TLE1_203220_s_at_tn.png
| GeneAtlas_image3 = PBB_GE_TLE1_203222_s_at_tn.png
| Function = {{GNF_GO|id=GO:0008134 |text = transcription factor binding}}
| Component = {{GNF_GO|id=GO:0005634 |text = nucleus}}
| Process = {{GNF_GO|id=GO:0006355 |text = regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007222 |text = Wnt receptor signaling pathway}} {{GNF_GO|id=GO:0007275 |text = multicellular organismal development}} {{GNF_GO|id=GO:0009887 |text = organ morphogenesis}} {{GNF_GO|id=GO:0016481 |text = negative regulation of transcription}} {{GNF_GO|id=GO:0030178 |text = negative regulation of Wnt receptor signaling pathway}}
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 7088
    | Hs_Ensembl = ENSG00000196781
    | Hs_RefseqProtein = NP_005068
    | Hs_RefseqmRNA = NM_005077
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 9
    | Hs_GenLoc_start = 83388418
    | Hs_GenLoc_end = 83494270
    | Hs_Uniprot = Q04724
    | Mm_EntrezGene = 21885
    | Mm_Ensembl = ENSMUSG00000008305
    | Mm_RefseqmRNA = XM_984048
    | Mm_RefseqProtein = XP_989142
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 4
    | Mm_GenLoc_start = 71603503
    | Mm_GenLoc_end = 71687218
    | Mm_Uniprot = Q5SQA2
  }}
}}
'''Transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)''', also known as '''TLE1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7088| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
TLE1 has been shown to [[Protein-protein interaction|interact]] with:
{{PBB_Summary
{{div col|colwidth=20em}}
| section_title =  
* [[Glycoprotein 130]],<ref name = pmid12030375>{{cite journal | vauthors = Liu F, Liu Y, Li D, Zhu Y, Ouyang W, Xie X, Jin B | title = The transcription co-repressor TLE1 interacted with the intracellular region of gpl30 through its Q domain | journal = Molecular and Cellular Biochemistry | volume = 232 | issue = 1–2 | pages = 163–7 | date = Mar 2002 | pmid = 12030375 | doi =  10.1023/A:1014880813692}}</ref>
| summary_text =  
* [[HES6]],<ref name = pmid11551980>{{cite journal | vauthors = Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R | title = HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program | journal = The Journal of Cell Biology | volume = 154 | issue = 6 | pages = 1161–71 | date = Sep 2001 | pmid = 11551980 | pmc = 2150829 | doi = 10.1083/jcb.200104058 }}</ref>
}}
* [[RUNX1]],<ref name = pmid9751710/>
* [[RUNX3]],<ref name = pmid9751710>{{cite journal | vauthors = Levanon D, Goldstein RE, Bernstein Y, Tang H, Goldenberg D, Stifani S, Paroush Z, Groner Y | title = Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 20 | pages = 11590–5 | date = Sep 1998 | pmid = 9751710 | pmc = 21685 | doi =  10.1073/pnas.95.20.11590| bibcode = 1998PNAS...9511590L }}</ref>
* [[SIX3]]<ref name = pmid12441302>{{cite journal | vauthors = López-Ríos J, Tessmar K, Loosli F, Wittbrodt J, Bovolenta P | title = Six3 and Six6 activity is modulated by members of the groucho family | journal = Development | volume = 130 | issue = 1 | pages = 185–95 | date = Jan 2003 | pmid = 12441302 | doi = 10.1242/dev.00185}}</ref>
* [[TLE2]],<ref name = pmid9874198>{{cite journal | vauthors = Grbavec D, Lo R, Liu Y, Stifani S | title = Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development | journal = European Journal of Biochemistry / FEBS | volume = 258 | issue = 2 | pages = 339–49 | date = Dec 1998 | pmid = 9874198 | doi =  10.1046/j.1432-1327.1998.2580339.x}}</ref> and
* [[UTY (gene)|UTY]].<ref name = pmid9854018>{{cite journal | vauthors = Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S | title = Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms | journal = The Biochemical Journal | volume = 337 | issue =  1| pages = 13–7 | date = Jan 1999 | pmid = 9854018 | pmc = 1219929 | doi = 10.1042/0264-6021:3370013}}</ref>
{{Div col end}}


==References==
== References ==
{{reflist|2}}
{{Reflist}}
==Further reading==
{{clear}}
{{refbegin | 2}}
{{PBB_Further_reading
| citations =
*{{cite journal  | author=Eastman Q, Grosschedl R |title=Regulation of LEF-1/TCF transcription factors by Wnt and other signals. |journal=Curr. Opin. Cell Biol. |volume=11 |issue= 2 |pages= 233-40 |year= 1999 |pmid= 10209158 |doi=  }}
*{{cite journal  | author=Stifani S, Blaumueller CM, Redhead NJ, ''et al.'' |title=Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins. |journal=Nat. Genet. |volume=2 |issue= 2 |pages= 119-27 |year= 1993 |pmid= 1303260 |doi= 10.1038/ng1092-119 }}
*{{cite journal  | author=Miyasaka H, Choudhury BK, Hou EW, Li SS |title=Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein. |journal=Eur. J. Biochem. |volume=216 |issue= 1 |pages= 343-52 |year= 1993 |pmid= 8365415 |doi=  }}
*{{cite journal  | author=Grbavec D, Stifani S |title=Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif. |journal=Biochem. Biophys. Res. Commun. |volume=223 |issue= 3 |pages= 701-5 |year= 1996 |pmid= 8687460 |doi= 10.1006/bbrc.1996.0959 }}
*{{cite journal  | author=Husain J, Lo R, Grbavec D, Stifani S |title=Affinity for the nuclear compartment and expression during cell differentiation implicate phosphorylated Groucho/TLE1 forms of higher molecular mass in nuclear functions. |journal=Biochem. J. |volume=317 ( Pt 2) |issue=  |pages= 523-31 |year= 1996 |pmid= 8713081 |doi=  }}
*{{cite journal  | author=Liu Y, Dehni G, Purcell KJ, ''et al.'' |title=Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia. |journal=Genomics |volume=31 |issue= 1 |pages= 58-64 |year= 1996 |pmid= 8808280 |doi= 10.1006/geno.1996.0009 }}
*{{cite journal  | author=Palaparti A, Baratz A, Stifani S |title=The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3. |journal=J. Biol. Chem. |volume=272 |issue= 42 |pages= 26604-10 |year= 1997 |pmid= 9334241 |doi=  }}
*{{cite journal  | author=Levanon D, Goldstein RE, Bernstein Y, ''et al.'' |title=Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 20 |pages= 11590-5 |year= 1998 |pmid= 9751710 |doi=  }}
*{{cite journal  | author=Grbavec D, Lo R, Liu Y, ''et al.'' |title=Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms. |journal=Biochem. J. |volume=337 ( Pt 1) |issue=  |pages= 13-7 |year= 1999 |pmid= 9854018 |doi=  }}
*{{cite journal  | author=Grbavec D, Lo R, Liu Y, Stifani S |title=Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development. |journal=Eur. J. Biochem. |volume=258 |issue= 2 |pages= 339-49 |year= 1999 |pmid= 9874198 |doi=  }}
*{{cite journal  | author=Ren B, Chee KJ, Kim TH, Maniatis T |title=PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins. |journal=Genes Dev. |volume=13 |issue= 1 |pages= 125-37 |year= 1999 |pmid= 9887105 |doi=  }}
*{{cite journal  | author=Tetsuka T, Uranishi H, Imai H, ''et al.'' |title=Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats. |journal=J. Biol. Chem. |volume=275 |issue= 6 |pages= 4383-90 |year= 2000 |pmid= 10660609 |doi=  }}
*{{cite journal  | author=Wang JC, Waltner-Law M, Yamada K, ''et al.'' |title=Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta. |journal=J. Biol. Chem. |volume=275 |issue= 24 |pages= 18418-23 |year= 2000 |pmid= 10748198 |doi= 10.1074/jbc.M910211199 }}
*{{cite journal  | author=Yao J, Lai E, Stifani S |title=The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription. |journal=Mol. Cell. Biol. |volume=21 |issue= 6 |pages= 1962-72 |year= 2001 |pmid= 11238932 |doi= 10.1128/MCB.21.6.1962-1972.2001 }}
*{{cite journal  | author=Gao X, Chandra T, Gratton MO, ''et al.'' |title=HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program. |journal=J. Cell Biol. |volume=154 |issue= 6 |pages= 1161-71 |year= 2001 |pmid= 11551980 |doi= 10.1083/jcb.200104058 }}
*{{cite journal  | author=Dasen JS, Barbera JP, Herman TS, ''et al.'' |title=Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis. |journal=Genes Dev. |volume=15 |issue= 23 |pages= 3193-207 |year= 2001 |pmid= 11731482 |doi= 10.1101/gad.932601 }}
*{{cite journal  | author=Dintilhac A, Bernués J |title=HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7021-8 |year= 2002 |pmid= 11748221 |doi= 10.1074/jbc.M108417200 }}
*{{cite journal  | author=Liu F, Liu Y, Li D, ''et al.'' |title=The transcription co-repressor TLE1 interacted with the intracellular region of gpl30 through its Q domain. |journal=Mol. Cell. Biochem. |volume=232 |issue= 1-2 |pages= 163-7 |year= 2003 |pmid= 12030375 |doi=  }}
*{{cite journal  | author=Pickles LM, Roe SM, Hemingway EJ, ''et al.'' |title=Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor. |journal=Structure |volume=10 |issue= 6 |pages= 751-61 |year= 2003 |pmid= 12057191 |doi=  }}
}}
{{refend}}


{{protein-stub}}
== Further reading ==
{{WikiDoc Sources}}
{{Refbegin | 2}}
* {{cite journal | vauthors = Eastman Q, Grosschedl R | title = Regulation of LEF-1/TCF transcription factors by Wnt and other signals | journal = Current Opinion in Cell Biology | volume = 11 | issue = 2 | pages = 233–40 | date = Apr 1999 | pmid = 10209158 | doi = 10.1016/S0955-0674(99)80031-3 }}
* {{cite journal | vauthors = Stifani S, Blaumueller CM, Redhead NJ, Hill RE, Artavanis-Tsakonas S | title = Human homologs of a Drosophila Enhancer of split gene product define a novel family of nuclear proteins | journal = Nature Genetics | volume = 2 | issue = 2 | pages = 119–27 | date = Oct 1992 | pmid = 1303260 | doi = 10.1038/ng1092-119 }}
* {{cite journal | vauthors = Grbavec D, Stifani S | title = Molecular interaction between TLE1 and the carboxyl-terminal domain of HES-1 containing the WRPW motif | journal = Biochemical and Biophysical Research Communications | volume = 223 | issue = 3 | pages = 701–5 | date = Jun 1996 | pmid = 8687460 | doi = 10.1006/bbrc.1996.0959 }}
* {{cite journal | vauthors = Husain J, Lo R, Grbavec D, Stifani S | title = Affinity for the nuclear compartment and expression during cell differentiation implicate phosphorylated Groucho/TLE1 forms of higher molecular mass in nuclear functions | journal = The Biochemical Journal | volume = 317 | issue = Pt 2 | pages = 523–31 | date = Jul 1996 | pmid = 8713081 | pmc = 1217518 | doi =  10.1042/bj3170523}}
* {{cite journal | vauthors = Palaparti A, Baratz A, Stifani S | title = The Groucho/transducin-like enhancer of split transcriptional repressors interact with the genetically defined amino-terminal silencing domain of histone H3 | journal = The Journal of Biological Chemistry | volume = 272 | issue = 42 | pages = 26604–10 | date = Oct 1997 | pmid = 9334241 | doi = 10.1074/jbc.272.42.26604 }}
* {{cite journal | vauthors = Levanon D, Goldstein RE, Bernstein Y, Tang H, Goldenberg D, Stifani S, Paroush Z, Groner Y | title = Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 95 | issue = 20 | pages = 11590–5 | date = Sep 1998 | pmid = 9751710 | pmc = 21685 | doi = 10.1073/pnas.95.20.11590 | bibcode = 1998PNAS...9511590L }}
* {{cite journal | vauthors = Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S | title = Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms | journal = The Biochemical Journal | volume = 337 | issue = Pt 1 | pages = 13–7 | date = Jan 1999 | pmid = 9854018 | pmc = 1219929 | doi = 10.1042/0264-6021:3370013 }}
* {{cite journal | vauthors = Grbavec D, Lo R, Liu Y, Stifani S | title = Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development | journal = European Journal of Biochemistry / FEBS | volume = 258 | issue = 2 | pages = 339–49 | date = Dec 1998 | pmid = 9874198 | doi = 10.1046/j.1432-1327.1998.2580339.x }}
* {{cite journal | vauthors = Ren B, Chee KJ, Kim TH, Maniatis T | title = PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins | journal = Genes & Development | volume = 13 | issue = 1 | pages = 125–37 | date = Jan 1999 | pmid = 9887105 | pmc = 316372 | doi = 10.1101/gad.13.1.125 }}
* {{cite journal | vauthors = Tetsuka T, Uranishi H, Imai H, Ono T, Sonta S, Takahashi N, Asamitsu K, Okamoto T | title = Inhibition of nuclear factor-kappaB-mediated transcription by association with the amino-terminal enhancer of split, a Groucho-related protein lacking WD40 repeats | journal = The Journal of Biological Chemistry | volume = 275 | issue = 6 | pages = 4383–90 | date = Feb 2000 | pmid = 10660609 | doi = 10.1074/jbc.275.6.4383 }}
* {{cite journal | vauthors = Wang JC, Waltner-Law M, Yamada K, Osawa H, Stifani S, Granner DK | title = Transducin-like enhancer of split proteins, the human homologs of Drosophila groucho, interact with hepatic nuclear factor 3beta | journal = The Journal of Biological Chemistry | volume = 275 | issue = 24 | pages = 18418–23 | date = Jun 2000 | pmid = 10748198 | doi = 10.1074/jbc.M910211199 }}
* {{cite journal | vauthors = Yao J, Lai E, Stifani S | title = The winged-helix protein brain factor 1 interacts with groucho and hes proteins to repress transcription | journal = Molecular and Cellular Biology | volume = 21 | issue = 6 | pages = 1962–72 | date = Mar 2001 | pmid = 11238932 | pmc = 86788 | doi = 10.1128/MCB.21.6.1962-1972.2001 }}
* {{cite journal | vauthors = Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R | title = HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program | journal = The Journal of Cell Biology | volume = 154 | issue = 6 | pages = 1161–71 | date = Sep 2001 | pmid = 11551980 | pmc = 2150829 | doi = 10.1083/jcb.200104058 }}
* {{cite journal | vauthors = Dasen JS, Martinez Barbera JP, Herman TS, Connell SO, Olson L, Ju B, Tollkuhn J, Baek SH, Rose DW, Rosenfeld MG | title = Temporal regulation of a paired-like homeodomain repressor/TLE corepressor complex and a related activator is required for pituitary organogenesis | journal = Genes & Development | volume = 15 | issue = 23 | pages = 3193–207 | date = Dec 2001 | pmid = 11731482 | pmc = 312840 | doi = 10.1101/gad.932601 }}
* {{cite journal | vauthors = Dintilhac A, Bernués J | title = HMGB1 interacts with many apparently unrelated proteins by recognizing short amino acid sequences | journal = The Journal of Biological Chemistry | volume = 277 | issue = 9 | pages = 7021–8 | date = Mar 2002 | pmid = 11748221 | doi = 10.1074/jbc.M108417200 }}
* {{cite journal | vauthors = Liu F, Liu Y, Li D, Zhu Y, Ouyang W, Xie X, Jin B | title = The transcription co-repressor TLE1 interacted with the intracellular region of gpl30 through its Q domain | journal = Molecular and Cellular Biochemistry | volume = 232 | issue = 1–2 | pages = 163–7 | date = Mar 2002 | pmid = 12030375 | doi = 10.1023/A:1014880813692 }}
* {{cite journal | vauthors = Pickles LM, Roe SM, Hemingway EJ, Stifani S, Pearl LH | title = Crystal structure of the C-terminal WD40 repeat domain of the human Groucho/TLE1 transcriptional corepressor | journal = Structure | volume = 10 | issue = 6 | pages = 751–61 | date = Jun 2002 | pmid = 12057191 | doi = 10.1016/S0969-2126(02)00768-2 }}
{{Refend}}
 
{{PDB Gallery|geneid=7088}}

Latest revision as of 01:47, 11 January 2019

VALUE_ERROR (nil)
Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

n/a

n/a

Ensembl

n/a

n/a

UniProt

n/a

n/a

RefSeq (mRNA)

n/a

n/a

RefSeq (protein)

n/a

n/a

Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

Transducin-like enhancer protein 1 is a protein that in humans is encoded by the TLE1 gene.[1][2][3]

Interactions

TLE1 has been shown to interact with:

References

  1. ↑ Miyasaka H, Choudhury BK, Hou EW, Li SS (Aug 1993). "Molecular cloning and expression of mouse and human cDNA encoding AES and ESG proteins with strong similarity to Drosophila enhancer of split groucho protein". European Journal of Biochemistry / FEBS. 216 (1): 343–52. doi:10.1111/j.1432-1033.1993.tb18151.x. PMID 8365415.
  2. ↑ Liu Y, Dehni G, Purcell KJ, Sokolow J, Carcangiu ML, Artavanis-Tsakonas S, Stifani S (Jan 1996). "Epithelial expression and chromosomal location of human TLE genes: implications for notch signaling and neoplasia". Genomics. 31 (1): 58–64. doi:10.1006/geno.1996.0009. PMID 8808280.
  3. ↑ "Entrez Gene: TLE1 transducin-like enhancer of split 1 (E(sp1) homolog, Drosophila)".
  4. ↑ Liu F, Liu Y, Li D, Zhu Y, Ouyang W, Xie X, Jin B (Mar 2002). "The transcription co-repressor TLE1 interacted with the intracellular region of gpl30 through its Q domain". Molecular and Cellular Biochemistry. 232 (1–2): 163–7. doi:10.1023/A:1014880813692. PMID 12030375.
  5. ↑ Gao X, Chandra T, Gratton MO, Quélo I, Prud'homme J, Stifani S, St-Arnaud R (Sep 2001). "HES6 acts as a transcriptional repressor in myoblasts and can induce the myogenic differentiation program". The Journal of Cell Biology. 154 (6): 1161–71. doi:10.1083/jcb.200104058. PMC 2150829. PMID 11551980.
  6. ↑ 6.0 6.1 Levanon D, Goldstein RE, Bernstein Y, Tang H, Goldenberg D, Stifani S, Paroush Z, Groner Y (Sep 1998). "Transcriptional repression by AML1 and LEF-1 is mediated by the TLE/Groucho corepressors". Proceedings of the National Academy of Sciences of the United States of America. 95 (20): 11590–5. Bibcode:1998PNAS...9511590L. doi:10.1073/pnas.95.20.11590. PMC 21685. PMID 9751710.
  7. ↑ López-Ríos J, Tessmar K, Loosli F, Wittbrodt J, Bovolenta P (Jan 2003). "Six3 and Six6 activity is modulated by members of the groucho family". Development. 130 (1): 185–95. doi:10.1242/dev.00185. PMID 12441302.
  8. ↑ Grbavec D, Lo R, Liu Y, Stifani S (Dec 1998). "Transducin-like Enhancer of split 2, a mammalian homologue of Drosophila Groucho, acts as a transcriptional repressor, interacts with Hairy/Enhancer of split proteins, and is expressed during neuronal development". European Journal of Biochemistry / FEBS. 258 (2): 339–49. doi:10.1046/j.1432-1327.1998.2580339.x. PMID 9874198.
  9. ↑ Grbavec D, Lo R, Liu Y, Greenfield A, Stifani S (Jan 1999). "Groucho/transducin-like enhancer of split (TLE) family members interact with the yeast transcriptional co-repressor SSN6 and mammalian SSN6-related proteins: implications for evolutionary conservation of transcription repression mechanisms". The Biochemical Journal. 337 (1): 13–7. doi:10.1042/0264-6021:3370013. PMC 1219929. PMID 9854018.

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=TLE1&oldid=1541871"