VTCN1: Difference between revisions

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{{Infobox_gene}}
{{PBB_Controls
'''V-set domain-containing T-cell activation inhibitor 1''' is a [[protein]] that in humans is encoded by the ''VTCN1'' [[gene]].<ref name="pmid12818165">{{cite journal | vauthors = Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H, Chapoval AI, Flies DB, Bajorath J, Chen L | title = B7-H4, a molecule of the B7 family, negatively regulates T cell immunity | journal = Immunity | volume = 18 | issue = 6 | pages = 849–61 | date = June 2003 | pmid = 12818165 | pmc =  | doi = 10.1016/S1074-7613(03)00152-3 }}</ref><ref name="pmid12818166">{{cite journal | vauthors = Prasad DV, Richards S, Mai XM, Dong C | title = B7S1, a novel B7 family member that negatively regulates T cell activation | journal = Immunity | volume = 18 | issue = 6 | pages = 863–73 | date = June 2003 | pmid = 12818166 | pmc = | doi = 10.1016/S1074-7613(03)00147-X }}</ref><ref name="entrez">{{cite web | title = Entrez Gene: VTCN1 V-set domain containing T cell activation inhibitor 1| url = https://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79679| accessdate = }}</ref>
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<!-- The GNF_Protein_box is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
== Function ==
{{GNF_Protein_box
| image =
| image_source =
| PDB =
| Name = V-set domain containing T cell activation inhibitor 1
| HGNCid = 28873
| Symbol = VTCN1
| AltSymbols =; B7-H4; B7H4; B7S1; B7X; B7h.5; FLJ22418; PRO1291; RP11-229A19.4; VCTN1
| OMIM = 608162
| ECnumber = 
| Homologene = 11627
| MGIid = 3039619
| GeneAtlas_image1 = PBB_GE_VTCN1_219768_at_tn.png
| Function =  
| Component =
| Process =
| Orthologs = {{GNF_Ortholog_box
    | Hs_EntrezGene = 79679
    | Hs_Ensembl = ENSG00000134258
    | Hs_RefseqProtein = NP_078902
    | Hs_RefseqmRNA = NM_024626
    | Hs_GenLoc_db = 
    | Hs_GenLoc_chr = 1
    | Hs_GenLoc_start = 117487732
    | Hs_GenLoc_end = 117555079
    | Hs_Uniprot = 
    | Mm_EntrezGene = 242122
    | Mm_Ensembl = ENSMUSG00000051076
    | Mm_RefseqmRNA = NM_178594
    | Mm_RefseqProtein = NP_848709
    | Mm_GenLoc_db = 
    | Mm_GenLoc_chr = 3
    | Mm_GenLoc_start = 100954540
    | Mm_GenLoc_end = 101024733
    | Mm_Uniprot = 
  }}
}}
'''V-set domain containing T cell activation inhibitor 1''', also known as '''VTCN1''', is a human [[gene]].<ref name="entrez">{{cite web | title = Entrez Gene: VTCN1 V-set domain containing T cell activation inhibitor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79679| accessdate = }}</ref>


<!-- The PBB_Summary template is automatically maintained by Protein Box Bot.  See Template:PBB_Controls to Stop updates. -->
B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.[supplied by OMIM]<ref name="entrez" />
{{PBB_Summary
| section_title =
| summary_text = B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.[supplied by OMIM]<ref name="entrez">{{cite web | title = Entrez Gene: VTCN1 V-set domain containing T cell activation inhibitor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=79679| accessdate = }}</ref>
}}


==References==
B7-H4 is an [[immune checkpoint]] molecule.
{{reflist|2}}
 
==Further reading==
== See also ==
{{refbegin | 2}}
* [[B7 (protein)]]
{{PBB_Further_reading
 
| citations =
== References ==
*{{cite journal | author=Maruyama K, Sugano S |title=Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. |journal=Gene |volume=138 |issue= 1-2 |pages= 171-4 |year= 1994 |pmid= 8125298 |doi= }}
{{reflist}}
*{{cite journal | author=Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, ''et al.'' |title=Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. |journal=Gene |volume=200 |issue= 1-2 |pages= 149-56 |year= 1997 |pmid= 9373149 |doi= }}
{{clear}}
*{{cite journal  | author=Strausberg RL, Feingold EA, Grouse LH, ''et al.'' |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899 }}
== Further reading ==
*{{cite journal | author=Watanabe N, Gavrieli M, Sedy JR, ''et al.'' |title=BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1. |journal=Nat. Immunol. |volume=4 |issue= 7 |pages= 670-9 |year= 2003 |pmid= 12796776 |doi= 10.1038/ni944 }}
{{refbegin|33em}}
*{{cite journal | author=Sica GL, Choi IH, Zhu G, ''et al.'' |title=B7-H4, a molecule of the B7 family, negatively regulates T cell immunity. |journal=Immunity |volume=18 |issue= 6 |pages= 849-61 |year= 2003 |pmid= 12818165 |doi=  }}
* {{cite journal | vauthors = Maruyama K, Sugano S | title = Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides | journal = Gene | volume = 138 | issue = 1-2 | pages = 171–4 | date = January 1994 | pmid = 8125298 | doi = 10.1016/0378-1119(94)90802-8 }}
*{{cite journal  | author=Prasad DV, Richards S, Mai XM, Dong C |title=B7S1, a novel B7 family member that negatively regulates T cell activation. |journal=Immunity |volume=18 |issue= 6 |pages= 863-73 |year= 2003 |pmid= 12818166 |doi=  }}
* {{cite journal | vauthors = Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S | title = Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library | journal = Gene | volume = 200 | issue = 1-2 | pages = 149–56 | date = October 1997 | pmid = 9373149 | doi = 10.1016/S0378-1119(97)00411-3 }}
*{{cite journal  | author=Zang X, Loke P, Kim J, ''et al.'' |title=B7x: a widely expressed B7 family member that inhibits T cell activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=100 |issue= 18 |pages= 10388-92 |year= 2003 |pmid= 12920180 |doi= 10.1073/pnas.1434299100 }}
* {{cite journal | vauthors = Watanabe N, Gavrieli M, Sedy JR, Yang J, Fallarino F, Loftin SK, Hurchla MA, Zimmerman N, Sim J, Zang X, Murphy TL, Russell JH, Allison JP, Murphy KM | title = BTLA is a lymphocyte inhibitory receptor with similarities to CTLA-4 and PD-1 | journal = Nature Immunology | volume = 4 | issue = 7 | pages = 670–9 | date = July 2003 | pmid = 12796776 | doi = 10.1038/ni944 }}
*{{cite journal | author=Clark HF, Gurney AL, Abaya E, ''et al.'' |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265-70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003 }}
* {{cite journal | vauthors = Zang X, Loke P, Kim J, Murphy K, Waitz R, Allison JP | title = B7x: a widely expressed B7 family member that inhibits T cell activation | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 100 | issue = 18 | pages = 10388–92 | date = September 2003 | pmid = 12920180 | pmc = 193571 | doi = 10.1073/pnas.1434299100 }}
*{{cite journal  | author=Choi IH, Zhu G, Sica GL, ''et al.'' |title=Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family. |journal=J. Immunol. |volume=171 |issue= 9 |pages= 4650-4 |year= 2004 |pmid= 14568939 |doi= }}
* {{cite journal | vauthors = Choi IH, Zhu G, Sica GL, Strome SE, Cheville JC, Lau JS, Zhu Y, Flies DB, Tamada K, Chen L | title = Genomic organization and expression analysis of B7-H4, an immune inhibitory molecule of the B7 family | journal = Journal of Immunology | volume = 171 | issue = 9 | pages = 4650–4 | date = November 2003 | pmid = 14568939 | doi = 10.4049/jimmunol.171.9.4650 }}
*{{cite journal | author=Brandenberger R, Wei H, Zhang S, ''et al.'' |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707-16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971 }}
* {{cite journal | vauthors = Brandenberger R, Wei H, Zhang S, Lei S, Murage J, Fisk GJ, Li Y, Xu C, Fang R, Guegler K, Rao MS, Mandalam R, Lebkowski J, Stanton LW | title = Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation | journal = Nature Biotechnology | volume = 22 | issue = 6 | pages = 707–16 | date = June 2004 | pmid = 15146197 | doi = 10.1038/nbt971 }}
*{{cite journal | author=Salceda S, Tang T, Kmet M, ''et al.'' |title=The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation. |journal=Exp. Cell Res. |volume=306 |issue= 1 |pages= 128-41 |year= 2005 |pmid= 15878339 |doi= 10.1016/j.yexcr.2005.01.018 }}
* {{cite journal | vauthors = Salceda S, Tang T, Kmet M, Munteanu A, Ghosh M, Macina R, Liu W, Pilkington G, Papkoff J | title = The immunomodulatory protein B7-H4 is overexpressed in breast and ovarian cancers and promotes epithelial cell transformation | journal = Experimental Cell Research | volume = 306 | issue = 1 | pages = 128–41 | date = May 2005 | pmid = 15878339 | doi = 10.1016/j.yexcr.2005.01.018 }}
*{{cite journal | author=Kimura K, Wakamatsu A, Suzuki Y, ''et al.'' |title=Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. |journal=Genome Res. |volume=16 |issue= 1 |pages= 55-65 |year= 2006 |pmid= 16344560 |doi= 10.1101/gr.4039406 }}
* {{cite journal | vauthors = Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S | title = Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes | journal = Genome Research | volume = 16 | issue = 1 | pages = 55–65 | date = January 2006 | pmid = 16344560 | pmc = 1356129 | doi = 10.1101/gr.4039406 }}
*{{cite journal | author=Kryczek I, Zou L, Rodriguez P, ''et al.'' |title=B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma. |journal=J. Exp. Med. |volume=203 |issue= 4 |pages= 871-81 |year= 2006 |pmid= 16606666 |doi= 10.1084/jem.20050930 }}
* {{cite journal | vauthors = Kryczek I, Zou L, Rodriguez P, Zhu G, Wei S, Mottram P, Brumlik M, Cheng P, Curiel T, Myers L, Lackner A, Alvarez X, Ochoa A, Chen L, Zou W | title = B7-H4 expression identifies a novel suppressive macrophage population in human ovarian carcinoma | journal = The Journal of Experimental Medicine | volume = 203 | issue = 4 | pages = 871–81 | date = April 2006 | pmid = 16606666 | pmc = 2118300 | doi = 10.1084/jem.20050930 }}
*{{cite journal | author=Kryczek I, Wei S, Zou L, ''et al.'' |title=Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells. |journal=J. Immunol. |volume=177 |issue= 1 |pages= 40-4 |year= 2006 |pmid= 16785496 |doi=  }}
* {{cite journal | vauthors = Kryczek I, Wei S, Zou L, Zhu G, Mottram P, Xu H, Chen L, Zou W | title = Cutting edge: induction of B7-H4 on APCs through IL-10: novel suppressive mode for regulatory T cells | journal = Journal of Immunology | volume = 177 | issue = 1 | pages = 40–4 | date = July 2006 | pmid = 16785496 | doi =  }}
*{{cite journal | author=Krambeck AE, Thompson RH, Dong H, ''et al.'' |title=B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=103 |issue= 27 |pages= 10391-6 |year= 2006 |pmid= 16798883 |doi= 10.1073/pnas.0600937103 }}
* {{cite journal | vauthors = Krambeck AE, Thompson RH, Dong H, Lohse CM, Park ES, Kuntz SM, Leibovich BC, Blute ML, Cheville JC, Kwon ED | title = B7-H4 expression in renal cell carcinoma and tumor vasculature: associations with cancer progression and survival | journal = Proceedings of the National Academy of Sciences of the United States of America | volume = 103 | issue = 27 | pages = 10391–6 | date = July 2006 | pmid = 16798883 | pmc = 1502468 | doi = 10.1073/pnas.0600937103 }}
*{{cite journal | author=Chen Y, Yang C, Xie Z, ''et al.'' |title=Expression of the novel co-stimulatory molecule B7-H4 by renal tubular epithelial cells. |journal=Kidney Int. |volume=70 |issue= 12 |pages= 2092-9 |year= 2007 |pmid= 17051145 |doi= 10.1038/sj.ki.5001867 }}
* {{cite journal | vauthors = Chen Y, Yang C, Xie Z, Zou L, Ruan Z, Zhang X, Tang Y, Fei L, Jia Z, Wu Y | title = Expression of the novel co-stimulatory molecule B7-H4 by renal tubular epithelial cells | journal = Kidney International | volume = 70 | issue = 12 | pages = 2092–9 | date = December 2006 | pmid = 17051145 | doi = 10.1038/sj.ki.5001867 }}
*{{cite journal | author=Simon I, Katsaros D, Rigault de la Longrais I, ''et al.'' |title=B7-H4 is over-expressed in early-stage ovarian cancer and is independent of CA125 expression. |journal=Gynecol. Oncol. |volume=106 |issue= 2 |pages= 334-41 |year= 2007 |pmid= 17498784 |doi= 10.1016/j.ygyno.2007.03.035 }}
* {{cite journal | vauthors = Simon I, Katsaros D, Rigault de la Longrais I, Massobrio M, Scorilas A, Kim NW, Sarno MJ, Wolfert RL, Diamandis EP | title = B7-H4 is over-expressed in early-stage ovarian cancer and is independent of CA125 expression | journal = Gynecologic Oncology | volume = 106 | issue = 2 | pages = 334–41 | date = August 2007 | pmid = 17498784 | doi = 10.1016/j.ygyno.2007.03.035 }}
*{{cite journal | author=Miyatake T, Tringler B, Liu W, ''et al.'' |title=B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration. |journal=Gynecol. Oncol. |volume=106 |issue= 1 |pages= 119-27 |year= 2007 |pmid= 17509674 |doi= 10.1016/j.ygyno.2007.03.039 }}
* {{cite journal | vauthors = Miyatake T, Tringler B, Liu W, Liu SH, Papkoff J, Enomoto T, Torkko KC, Dehn DL, Swisher A, Shroyer KR | title = B7-H4 (DD-O110) is overexpressed in high risk uterine endometrioid adenocarcinomas and inversely correlated with tumor T-cell infiltration | journal = Gynecologic Oncology | volume = 106 | issue = 1 | pages = 119–27 | date = July 2007 | pmid = 17509674 | doi = 10.1016/j.ygyno.2007.03.039 }}
}}
{{refend}}
{{refend}}


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{{B7 family}}
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Latest revision as of 15:42, 17 September 2017

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Identifiers
Aliases
External IDsGeneCards: [1]
Orthologs
SpeciesHumanMouse
Entrez

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Ensembl

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UniProt

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RefSeq (mRNA)

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RefSeq (protein)

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Location (UCSC)n/an/a
PubMed searchn/an/a
Wikidata
View/Edit Human

V-set domain-containing T-cell activation inhibitor 1 is a protein that in humans is encoded by the VTCN1 gene.[1][2][3]

Function

B7H4 belongs to the B7 family (see CD80; MIM 112203) of costimulatory proteins. These proteins are expressed on the surface of antigen-presenting cells and interact with ligands (e.g., CD28; MIM 186760) on T lymphocytes.[supplied by OMIM][3]

B7-H4 is an immune checkpoint molecule.

See also

References

  1. ↑ Sica GL, Choi IH, Zhu G, Tamada K, Wang SD, Tamura H, Chapoval AI, Flies DB, Bajorath J, Chen L (June 2003). "B7-H4, a molecule of the B7 family, negatively regulates T cell immunity". Immunity. 18 (6): 849–61. doi:10.1016/S1074-7613(03)00152-3. PMID 12818165.
  2. ↑ Prasad DV, Richards S, Mai XM, Dong C (June 2003). "B7S1, a novel B7 family member that negatively regulates T cell activation". Immunity. 18 (6): 863–73. doi:10.1016/S1074-7613(03)00147-X. PMID 12818166.
  3. ↑ 3.0 3.1 "Entrez Gene: VTCN1 V-set domain containing T cell activation inhibitor 1".

Further reading

Retrieved from "https://www.wikidoc.org/index.php?title=VTCN1&oldid=1411174"