PDCD1LG2

VALUE_ERROR (nil)
Identifiers
Aliases
External IDs	GeneCards: [1]
Orthologs
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	n/a
	Wikidata
View/Edit Human

Programmed cell death 1 ligand 2 (also known as PD-L2, B7-DC) is a protein that in humans is encoded by the PDCD1LG2 gene.^[1]^[2] PDCD1LG2 has also been designated as CD273 (cluster of differentiation 273).

References

↑ Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno BM, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe AH, Freeman GJ (Mar 2001). "PD-L2 is a second ligand for PD-1 and inhibits T cell activation". Nat Immunol. 2 (3): 261–8. doi:10.1038/85330. PMID 11224527.
↑ "Entrez Gene: PDCD1LG2 programmed cell death 1 ligand 2".

Tseng SY, Otsuji M, Gorski K, et al. (2001). "B7-DC, a new dendritic cell molecule with potent costimulatory properties for T cells". J. Exp. Med. 193 (7): 839–46. doi:10.1084/jem.193.7.839. PMC 2193370. PMID 11283156.
Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932.
Brown JA, Dorfman DM, Ma FR, et al. (2003). "Blockade of programmed death-1 ligands on dendritic cells enhances T cell activation and cytokine production". J. Immunol. 170 (3): 1257–66. doi:10.4049/jimmunol.170.3.1257. PMID 12538684.
Youngnak P, Kozono Y, Kozono H, et al. (2003). "Differential binding properties of B7-H1 and B7-DC to programmed death-1". Biochem. Biophys. Res. Commun. 307 (3): 672–7. doi:10.1016/S0006-291X(03)01257-9. PMID 12893276.
Tsushima F, Iwai H, Otsuki N, et al. (2003). "Preferential contribution of B7-H1 to programmed death-1-mediated regulation of hapten-specific allergic inflammatory responses". Eur. J. Immunol. 33 (10): 2773–82. doi:10.1002/eji.200324084. PMID 14515261.
Ota T, Suzuki Y, Nishikawa T, et al. (2004). "Complete sequencing and characterization of 21,243 full-length human cDNAs". Nat. Genet. 36 (1): 40–5. doi:10.1038/ng1285. PMID 14702039.
Aramaki O, Shirasugi N, Takayama T, et al. (2004). "Programmed death-1-programmed death-L1 interaction is essential for induction of regulatory cells by intratracheal delivery of alloantigen". Transplantation. 77 (1): 6–12. doi:10.1097/01.TP.0000108637.65091.4B. PMID 14724428.
Humphray SJ, Oliver K, Hunt AR, et al. (2004). "DNA sequence and analysis of human chromosome 9". Nature. 429 (6990): 369–74. doi:10.1038/nature02465. PMC 2734081. PMID 15164053.
He XH, Liu Y, Xu LH, Zeng YY (2004). "Cloning and identification of two novel splice variants of human PD-L2". Acta Biochim. Biophys. Sin. (Shanghai). 36 (4): 284–9. doi:10.1093/abbs/36.4.284. PMID 15253154.
Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci. 13 (10): 2819–24. doi:10.1110/ps.04682504. PMC 2286551. PMID 15340161.
Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334.
Ohigashi Y, Sho M, Yamada Y, et al. (2005). "Clinical significance of programmed death-1 ligand-1 and programmed death-1 ligand-2 expression in human esophageal cancer". Clin. Cancer Res. 11 (8): 2947–53. doi:10.1158/1078-0432.CCR-04-1469. PMID 15837746.
Saunders PA, Hendrycks VR, Lidinsky WA, Woods ML (2006). "PD-L2:PD-1 involvement in T cell proliferation, cytokine production, and integrin-mediated adhesion". Eur. J. Immunol. 35 (12): 3561–9. doi:10.1002/eji.200526347. PMID 16278812.
Pfistershammer K, Klauser C, Pickl WF, et al. (2006). "No evidence for dualism in function and receptors: PD-L2/B7-DC is an inhibitory regulator of human T cell activation". Eur. J. Immunol. 36 (5): 1104–13. doi:10.1002/eji.200535344. PMC 2975063. PMID 16598819.
Abelson AK, Johansson CM, Kozyrev SV, et al. (2007). "No evidence of association between genetic variants of the PDCD1 ligands and SLE". Genes Immun. 8 (1): 69–74. doi:10.1038/sj.gene.6364360. PMID 17136123.
Mataki N, Kikuchi K, Kawai T, et al. (2007). "Expression of PD-1, PD-L1, and PD-L2 in the liver in autoimmune liver diseases". Am. J. Gastroenterol. 102 (2): 302–12. doi:10.1111/j.1572-0241.2006.00948.x. PMID 17311651.
Wang SC, Lin CH, Ou TT, et al. (2007). "Ligands for programmed cell death 1 gene in patients with systemic lupus erythematosus". J. Rheumatol. 34 (4): 721–5. doi:10.1093/rheumatology/34.8.721. PMID 17343323.

External links

PDCD1LG2+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH)

Stub icon

This membrane protein–related article is a stub. You can help Wikipedia by expanding it.

[pmid11224527-1] Latchman Y, Wood CR, Chernova T, Chaudhary D, Borde M, Chernova I, Iwai Y, Long AJ, Brown JA, Nunes R, Greenfield EA, Bourque K, Boussiotis VA, Carter LL, Carreno BM, Malenkovich N, Nishimura H, Okazaki T, Honjo T, Sharpe AH, Freeman GJ (Mar 2001). "PD-L2 is a second ligand for PD-1 and inhibits T cell activation". Nat Immunol. 2 (3): 261–8. doi:10.1038/85330. PMID 11224527.

[entrez-2] "Entrez Gene: PDCD1LG2 programmed cell death 1 ligand 2".

[1]

[2]

v t e Proteins: clusters of differentiation (see also list of human clusters of differentiation)
1-50	CD1 a-c 1A 1D 1E CD2 CD3 γ δ ε CD4 CD5 CD6 CD7 CD8 a CD9 CD10 CD11 a b c d CD13 CD14 CD15 CD16 A B CD18 CD19 CD20 CD21 CD22 CD23 CD24 CD25 CD26 CD27 CD28 CD29 CD30 CD31 CD32 A B CD33 CD34 CD35 CD36 CD37 CD38 CD39 CD40 CD41 CD42 a b c d CD43 CD44 CD45 CD46 CD47 CD48 CD49 a b c d e f CD50
51-100	CD51 CD52 CD53 CD54 CD55 CD56 CD57 CD58 CD59 CD61 CD62 E L P CD63 CD64 A B C CD66 a b c d e f CD68 CD69 CD70 CD71 CD72 CD73 CD74 CD78 CD79 a b CD80 CD81 CD82 CD83 CD84 CD85 a d e h j k CD86 CD87 CD88 CD89 CD90 CD91 - CD92 CD93 CD94 CD95 CD96 CD97 CD98 CD99 CD100
101-150	CD101 CD102 CD103 CD104 CD105 CD106 CD107 a b CD108 CD109 CD110 CD111 CD112 CD113 CD114 CD115 CD116 CD117 CD118 CD119 CD120 a b CD121 a b CD122 CD123 CD124 CD125 CD126 CD127 CD129 CD130 CD131 CD132 CD133 CD134 CD135 CD136 CD137 CD138 CD140b CD141 CD142 CD143 CD144 CD146 CD147 CD148 CD150
151-200	CD151 CD152 CD153 CD154 CD155 CD156 a b c CD157 CD158 (a d e i k) CD159 a c CD160 CD161 CD162 CD163 CD164 CD166 CD167 a b CD168 CD169 CD170 CD171 CD172 a b g CD174 CD177 CD178 CD179 a b CD180 CD181 CD182 CD183 CD184 CD185 CD186 CD191 CD192 CD193 CD194 CD195 CD196 CD197 CDw198 CDw199 CD200
201-250	CD201 CD202b CD204 CD205 CD206 CD207 CD208 CD209 CDw210 a b CD212 CD213a 1 2 CD217 CD218 (a b) CD220 CD221 CD222 CD223 CD224 CD225 CD226 CD227 CD228 CD229 CD230 CD233 CD234 CD235 a b CD236 CD238 CD239 CD240CE CD240D CD241 CD243 CD244 CD246 CD247 - CD248 CD249
251-300	CD252 CD253 CD254 CD256 CD257 CD258 CD261 CD262 CD263 CD264 CD265 CD266 CD267 CD268 CD269 CD271 CD272 CD273 CD274 CD275 CD276 CD278 CD279 CD280 CD281 CD282 CD283 CD284 CD286 CD288 CD289 CD290 CD292 CDw293 CD294 CD295 CD297 CD298 CD299
301-350	CD300A CD301 CD302 CD303 CD304 CD305 CD306 CD307 CD309 CD312 CD314 CD315 CD316 CD317 CD318 CD320 CD321 CD322 CD324 CD325 CD326 CD328 CD329 CD331 CD332 CD333 CD334 CD335 CD336 CD337 CD338 CD339 CD340 CD344 CD349 CD350

PDCD1LG2

References

Further reading

External links

Navigation menu