Endometrial cancer natural history: Difference between revisions
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{{Endometrial cancer}} | {{Endometrial cancer}} | ||
{{CMG}} | {{CMG}}; '''Associate Editor(s)-in-Chief:''' [[User: Shankar Kumar |Shankar Kumar, M.B.B.S.]] [mailto:kumarshankar@wikidoc.org]] | ||
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==Overview== | ==Overview== | ||
==Natural History== | ==Natural History== | ||
==Complications== | ==Complications== | ||
* | Complications are usually due to the therapy. They can be classified as - | ||
* Intra-operative- | |||
**Uterine perforation following [[D&C]] or biopsy. | |||
**[[Hemorrhage]] after [[lymphadenectomy]] | |||
*Post-operative- typically common as many females have comorbid conditions like obesity, increased age, etc when they develop endometrial cancer. Of note is [[thromboembolism]]. | |||
==Prognosis== | ==Prognosis== | ||
Of all prognostic factors to consider in endometrial cancer, staging is the most important one. Surgical histopathology contributes to it. [[Clear cell]] and [[papillary]] [[serous]] types are associated with a poor prognosis and are included in the histological category of poorly differentiated variety. As far as [[squamous]] types are concerned, it is just the [[adeno]] component which plays a key role in prognosis. More the adeno component, worse the prognosis. | |||
It is the depth and not the grade of [[myometrial]] invasion that is important, as with increasing depth, there are high chances of extra-uterine spread. Lymph node metastasis is equally important and must be correlated with other prognostic factors. A positive [[peritoneal]] [[cytology]] needs only to be reported but it does not change the stage. | |||
Because endometrial cancer is usually diagnosed in the early stages (70 % to 75 % of cases are in stage 1 at diagnosis; 10 % to 15 % of cases are in stage 2; 10 % to 15 % of cases are in stage 3 or 4), there is a better probable outcome associated with it than with other types of [[gynecologic oncology|gynecological cancers]] such as [[cervical cancer|cervical]] or [[ovarian cancer]]. While endometrial cancers are 40% more common in Caucasian women, an African American woman who is diagnosed with uterine cancer is twice as likely to die, possibly due to the higher frequency of aggressive subtypes in that population. | Because endometrial cancer is usually diagnosed in the early stages (70 % to 75 % of cases are in stage 1 at diagnosis; 10 % to 15 % of cases are in stage 2; 10 % to 15 % of cases are in stage 3 or 4), there is a better probable outcome associated with it than with other types of [[gynecologic oncology|gynecological cancers]] such as [[cervical cancer|cervical]] or [[ovarian cancer]]. While endometrial cancers are 40% more common in Caucasian women, an African American woman who is diagnosed with uterine cancer is twice as likely to die, possibly due to the higher frequency of aggressive subtypes in that population. | ||
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[[Category:Types of cancer]] | [[Category:Types of cancer]] | ||
[[Category:Gynecology]] | [[Category:Gynecology]] | ||
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[[Category:Grammar]] | |||
{{WikiDoc Help Menu}} | {{WikiDoc Help Menu}} | ||
{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
complications and prognosis | |||
Latest revision as of 22:15, 26 November 2017
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Endometrial cancer Microchapters |
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Diagnosis |
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Treatment |
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Case Studies |
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Endometrial cancer natural history On the Web |
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American Roentgen Ray Society Images of Endometrial cancer natural history |
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Risk calculators and risk factors for Endometrial cancer natural history |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Shankar Kumar, M.B.B.S. [2]]
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Overview
Natural History
Complications
Complications are usually due to the therapy. They can be classified as -
- Intra-operative-
- Uterine perforation following D&C or biopsy.
- Hemorrhage after lymphadenectomy
- Post-operative- typically common as many females have comorbid conditions like obesity, increased age, etc when they develop endometrial cancer. Of note is thromboembolism.
Prognosis
Of all prognostic factors to consider in endometrial cancer, staging is the most important one. Surgical histopathology contributes to it. Clear cell and papillary serous types are associated with a poor prognosis and are included in the histological category of poorly differentiated variety. As far as squamous types are concerned, it is just the adeno component which plays a key role in prognosis. More the adeno component, worse the prognosis.
It is the depth and not the grade of myometrial invasion that is important, as with increasing depth, there are high chances of extra-uterine spread. Lymph node metastasis is equally important and must be correlated with other prognostic factors. A positive peritoneal cytology needs only to be reported but it does not change the stage.
Because endometrial cancer is usually diagnosed in the early stages (70 % to 75 % of cases are in stage 1 at diagnosis; 10 % to 15 % of cases are in stage 2; 10 % to 15 % of cases are in stage 3 or 4), there is a better probable outcome associated with it than with other types of gynecological cancers such as cervical or ovarian cancer. While endometrial cancers are 40% more common in Caucasian women, an African American woman who is diagnosed with uterine cancer is twice as likely to die, possibly due to the higher frequency of aggressive subtypes in that population.
Survival rates
The 5-year survival rate for endometrial cancer following appropriate treatment is:
- 75% to 95% for stage 1
- 50% for stage 2
- 30% for stage 3
- less than 5% for stage 4
References
complications and prognosis