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'''For patient information click [[Antithrombin III deficiency (patient information)|here]]'''
'''For patient information click [[Antithrombin III deficiency (patient information)|here]]'''
{{Antithrombin III deficiency}}
{{Antithrombin III deficiency}}
{{CMG}}
{{CMG}}; {{AE}}{{MKA}}, {{S.G.}}


==Overview==
{{SK}} Antithrombin 3 deficiency, Congenital AT-III Deficiancy,
'''Antithrombin III deficiency''' is a [[rare disease|rare]] [[hereditary disorder]] that generally comes to light when a patient suffers recurrent venous [[thrombosis]] and [[pulmonary embolism]].
==[[Antithrombin III deficiency overview|Overview]]==


This was first described by Egeberg in 1965.<ref>Egeberg O. ''Inherited antithrombin deficiency causing thrombophilia.'' Thromb Diath Haemorrh 1965;13:516–520. PMID 14347873.</ref>
==[[Antithrombin III deficiency historical perspective|Historical Perspective]]==


The patients are treated with [[anticoagulant]]s or, more rarely, with antithrombin concentrate.
==[[Antithrombin III deficiency pathophysiology|Pathophysiology]]==


In [[renal failure]], especially [[nephrotic syndrome]], antithrombin is lost in the urine, leading to a higher activity of [[Factor II]] and [[Factor X]] and in increased tendency to [[thrombosis]].
==[[Antithrombin III deficiency causes|Causes]]==
 
==[[Antithrombin III deficiency differential diagnosis|Differentiating Antithrombin III deficiency from other Diseases]]==
 
==[[Antithrombin III deficiency epidemiology and demographics|Epidemiology and Demographics]]==
 
==[[Antithrombin III deficiency risk factors|Risk Factors]]==
 
==[[Antithrombin III deficiency screening|Screening]]==
 
==[[Antithrombin III deficiency natural history, complications and prognosis|Natural History, Complications and Prognosis]]==
 
==Diagnosis==
[[Antithrombin III deficiency history and symptoms|History and Symptoms]] | [[Antithrombin III deficiency physical examination|Physical Examination]] | [[Antithrombin III deficiency laboratory findings|Laboratory Findings]] | [[Antithrombin III deficiency other diagnostic studies|Other Diagnostic Studies]]
==Treatment==
[[Antithrombin III deficiency medical therapy|Medical Therapy]] | [[Antithrombin III deficiency prevention|Prevention]] | [[Antithrombin III deficiency cost-effectiveness of therapy|Cost-Effectiveness of Therapy]] | [[Antithrombin III deficiency future or investigational therapies|Future or Investigational Therapies]]
==Case Studies==
[[Antithrombin III deficiency case study one|Case #1]]


==Related Chapters==
==Related Chapters==
* [[Antithrombin]]
* [[Antithrombin]]
==References==
{{reflist|2}}
==External links==
* [http://www-admin.med.uiuc.edu/hematology/PtAntithrombin.htm Patient's pages on antithrombin]




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Latest revision as of 22:48, 14 July 2020

Antithrombin III deficiency
ICD-9 289.81
OMIM 107300
DiseasesDB 783
MeSH D020152

For patient information click here

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Overview

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Case #1

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: M. Khurram Afzal, MD [2], Sogand Goudarzi, MD [3]

Synonyms and keywords: Antithrombin 3 deficiency, Congenital AT-III Deficiancy,

Overview

Historical Perspective

Pathophysiology

Causes

Differentiating Antithrombin III deficiency from other Diseases

Epidemiology and Demographics

Risk Factors

Screening

Natural History, Complications and Prognosis

Diagnosis

History and Symptoms | Physical Examination | Laboratory Findings | Other Diagnostic Studies

Treatment

Medical Therapy | Prevention | Cost-Effectiveness of Therapy | Future or Investigational Therapies

Case Studies

Case #1

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