Mantle cell lymphoma causes: Difference between revisions
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Created page with "__NOTOC__ {{ Mantle cell lymphoma }} {{CMG}} ==Overview== ==Causes== * Attempts to determine causes of MCL have failed. It is not known what causes the translocation damage ..." |
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__NOTOC__ | __NOTOC__ | ||
{{ Mantle cell lymphoma }} | {{Mantle cell lymphoma }} | ||
{{CMG}} | {{CMG}}; {{AE}} {{Akram}} {{AS}} | ||
==Overview== | ==Overview== | ||
The causes of mantle cell lymphoma have not been clearly identified. | |||
==Causes== | ==Causes== | ||
* | * Mantle cell lymphoma is thought to be caused when the somatic cells acquire non-inherited [[genetic mutations]]. | ||
* | * The typical [[mutation]] occurring in mantle cell lymphoma due to the “[[reciprocal translocation]]” between [[chromosome 11]] and [[chromosome 14]] t(11;14) causes the over expression of [[cyclin D1]] which results in uncontrolled growth of [[B cells]] leading to [[lymphoma]] development. | ||
* | * However, the initiating factors of these [[genetic]] alterations are generally not identifiable. People with no particular risk factors for [[lymphoma]] development are commonly affected by these alterations. | ||
==References== | ==References== | ||
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{{WH}} | {{WH}} | ||
{{WS}} | {{WS}} | ||
[[Category:Up-To-Date]] | |||
[[Category:Oncology]] | |||
[[Category:Medicine]] | |||
[[Category:Hematology]] | |||
[[Category:Immunology]] | |||
Latest revision as of 19:47, 7 January 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ali Akram, M.B.B.S.[2] Sowminya Arikapudi, M.B,B.S. [3]
Overview
The causes of mantle cell lymphoma have not been clearly identified.
Causes
- Mantle cell lymphoma is thought to be caused when the somatic cells acquire non-inherited genetic mutations.
- The typical mutation occurring in mantle cell lymphoma due to the “reciprocal translocation” between chromosome 11 and chromosome 14 t(11;14) causes the over expression of cyclin D1 which results in uncontrolled growth of B cells leading to lymphoma development.
- However, the initiating factors of these genetic alterations are generally not identifiable. People with no particular risk factors for lymphoma development are commonly affected by these alterations.