Polycythemia overview: Difference between revisions
Created page with "__NOTOC__ {{Polycythemia}} {{CMG}} Please help WikiDoc by adding more content here. It's easy! Click here to learn about editing. ==Overview=..." |
Homa Najafi (talk | contribs) |
||
| (6 intermediate revisions by 3 users not shown) | |||
| Line 1: | Line 1: | ||
__NOTOC__ | __NOTOC__ | ||
{{Polycythemia}} | {{Polycythemia}} | ||
{{CMG}} | {{CMG}}{{AE}}{{Debduti}} | ||
==Overview== | ==Overview== | ||
'''Polycythemia''' is a condition in which there is a net increase in the total number of [[red blood cell]]s in the body. The overproduction of red blood cells may be due to a primary process in the [[bone marrow]] (a so-called [[myeloproliferative syndrome]]), or it may be a reaction to chronically [[hypoxia|low oxygen levels]] or, rarely, a [[malignancy]]. | '''Polycythemia''' is a condition in which there is a net increase in the total number of [[red blood cell]]s in the body. The overproduction of red blood cells may be due to a primary process in the [[bone marrow]] (a so-called [[myeloproliferative syndrome]]), or it may be a reaction to chronically [[hypoxia|low oxygen levels]] or, rarely, a [[malignancy]]. | ||
==Historical Perspective== | |||
In 2005, a mutation in the ''[[JAK2]]'' kinase (V617F) was found in multiple patients with myeloprolifrative neoplasm (including polycythemia vera) by different researchers.<sup>[[Polycythemia vera historical perspective|[1]]]</sup> | |||
==Classification== | |||
Based on the reasons, polycythemia is classified into two types; primary and secondary. | |||
==Pathophysiology== | |||
Polycythemia is a number of symptoms that are caused by the increase of the total number of [[red blood cell]]s in the body. This makes blood thicker in our blood vessels which may cause some problems. People with polycythemia will have an increase in their [[hemoglobin]] and [[hematocrit]] levels. | |||
==Causes== | |||
Polycythemia is caused by the increase of the total number of [[red blood cells]] in the body. | |||
==Differentiating Polycythemia from Other Diseases== | |||
Polycythemia vera must be differentiated from [[chronic myelogenous leukemia]], [[essential thrombocythemia]], and [[primary myelofibrosis]]. | |||
==Epidemiology and Demographics== | |||
The incidence of polycythemia is approximately 0.7 to 2.6 per 100,000 individuals in the US. | |||
==Risk Factors== | |||
==Screening== | |||
==Natural History, Complications, and Prognosis== | |||
===Natural History=== | |||
===Complications=== | |||
===Prognosis=== | |||
==Diagnosis== | |||
===Diagnostic Study of Choice=== | |||
===History and Symptoms=== | |||
===Physical Examination=== | |||
===Laboratory Findings=== | |||
===Electrocardiogram=== | |||
===X-ray=== | |||
===Echocardiography and Ultrasound=== | |||
===CT scan=== | |||
===MRI=== | |||
===Other Imaging Findings=== | |||
===Other Diagnostic Studies=== | |||
==Treatment== | |||
===Medical Therapy=== | |||
===Interventions=== | |||
===Surgery=== | |||
===Primary Prevention=== | |||
===Secondary Prevention=== | |||
==References== | ==References== | ||
{{reflist|2}} | |||
[[Category:Hematology]] | |||
[[Category: | [[Category:Emergency medicine]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Blood disorders]] | [[Category:Blood disorders]] | ||
[[Category: | [[Category:Up-To-Date]] | ||
{{WS}} | |||
{{WH}} | |||
Latest revision as of 21:14, 24 September 2020
|
Polycythemia Microchapters |
|
Diagnosis |
|---|
|
Treatment |
|
Case Studies |
|
Polycythemia overview On the Web |
|
American Roentgen Ray Society Images of Polycythemia overview |
Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Debduti Mukhopadhyay, M.B.B.S[2]
Overview
Polycythemia is a condition in which there is a net increase in the total number of red blood cells in the body. The overproduction of red blood cells may be due to a primary process in the bone marrow (a so-called myeloproliferative syndrome), or it may be a reaction to chronically low oxygen levels or, rarely, a malignancy.
Historical Perspective
In 2005, a mutation in the JAK2 kinase (V617F) was found in multiple patients with myeloprolifrative neoplasm (including polycythemia vera) by different researchers.[1]
Classification
Based on the reasons, polycythemia is classified into two types; primary and secondary.
Pathophysiology
Polycythemia is a number of symptoms that are caused by the increase of the total number of red blood cells in the body. This makes blood thicker in our blood vessels which may cause some problems. People with polycythemia will have an increase in their hemoglobin and hematocrit levels.
Causes
Polycythemia is caused by the increase of the total number of red blood cells in the body.
Differentiating Polycythemia from Other Diseases
Polycythemia vera must be differentiated from chronic myelogenous leukemia, essential thrombocythemia, and primary myelofibrosis.
Epidemiology and Demographics
The incidence of polycythemia is approximately 0.7 to 2.6 per 100,000 individuals in the US.