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==Overview==
According to the American society of hematology, screening for paroxysmal nocturnal hemolglobinuria is recommended among patients with [[hemoglobinuria]], cytopenia, suspected myelodysplasia, negative direct coombs test intravascular hemolytic anemia, refractory anemia, and aplastic anemia with no apparent sign of intravascular hemolysis.
 
==Screening==
* According to the American society of hematology, screening for paroxysmal nocturnal hemolglobinuria is recommended among patients with:<ref name="pmid16051736">{{cite journal| author=Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R et al.| title=Diagnosis and management of paroxysmal nocturnal hemoglobinuria. | journal=Blood | year= 2005 | volume= 106 | issue= 12 | pages= 3699-709 | pmid=16051736 | doi=10.1182/blood-2005-04-1717 | pmc=1895106 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16051736  }}</ref>
** Hemoglobinuria 
** Cytopenia
** Suspected Myelodysplasia
** Negative direct coombs test intravascular hemolytic anemia
** Refractory anemia
** Aplastic anemia with no apparent sign of intravascular hemolysis 
** Unexplained thrombosis especially in unusual sites as:
*** Budd-Chiari syndrome
*** Other intra-abdominal sites (eg, mesenteric or portal veins)
*** Cerebral veins
*** Dermal veins


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==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
[[Category:Needs content]]
[[Category:Disease]]
[[Category:Hematology]]
[[Category:Rare diseases]]
[[Category:Genetic disorders]]
[[Category:Mature chapter]]


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Latest revision as of 23:27, 31 October 2018

Paroxysmal nocturnal hemoglobinuria Microchapters

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Ahmed Elsaiey, MBBCH [2]

Overview

According to the American society of hematology, screening for paroxysmal nocturnal hemolglobinuria is recommended among patients with hemoglobinuria, cytopenia, suspected myelodysplasia, negative direct coombs test intravascular hemolytic anemia, refractory anemia, and aplastic anemia with no apparent sign of intravascular hemolysis.

Screening

  • According to the American society of hematology, screening for paroxysmal nocturnal hemolglobinuria is recommended among patients with:[1]
    • Hemoglobinuria
    • Cytopenia
    • Suspected Myelodysplasia
    • Negative direct coombs test intravascular hemolytic anemia
    • Refractory anemia
    • Aplastic anemia with no apparent sign of intravascular hemolysis
    • Unexplained thrombosis especially in unusual sites as:
      • Budd-Chiari syndrome
      • Other intra-abdominal sites (eg, mesenteric or portal veins)
      • Cerebral veins
      • Dermal veins

References

  1. Parker C, Omine M, Richards S, Nishimura J, Bessler M, Ware R; et al. (2005). "Diagnosis and management of paroxysmal nocturnal hemoglobinuria". Blood. 106 (12): 3699–709. doi:10.1182/blood-2005-04-1717. PMC 1895106. PMID 16051736.

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