Diffuse panbronchiolitis history and symptoms: Difference between revisions

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{{Diffuse panbronchiolitis}}
{{Diffuse panbronchiolitis}}


{{CMG}}
{{CMG}} {{AE}}


==Overview==
==Overview==
==History==


==Symptoms==
==Symptoms==
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DPB can be characterized by a number of symptoms and [[histopathology|histological]] features (those detected by analysis of tissues).  
DPB can be characterized by a number of symptoms and [[histopathology|histological]] features (those detected by analysis of tissues).  


These include: chronic [[bronchi]]al and bronchiolar inflammation, lung tissue lesions, proliferation of [[lymphocyte]]s ([[white blood cell]]s that fight infection), [[neutrophil]] [[granulocyte]]s (white blood cells involved with inflammation) and [[histiocyte|foamy histiocytes]] (tissue [[macrophage]]s) in the lung [[lumen]];<ref name=dpb06>{{cite journal |author=Poletti V, Casoni G, Chilosi M, Zompatori M |title=Diffuse panbronchiolitis |journal=Eur Respir J. |volume=28 |issue=4 |pages=862-871 |year=2006 |pmid=17012632 }}</ref> <ref name=path>{{cite journal |author=Yanagihara K, Kadoto J, Kohno S |title=Diffuse panbronchiolitis--pathophysiology and treatment mechanisms |journal=Int J Antimicrob Agents |volume=18 |issue=Suppl. 1 |pages=S83-87 |year=2001 |pmid=11574201 }}</ref> detectable ''[[haemophilus influenzae]]'' (an [[opportunistic infection|opportunistic]] [[bacterium]]),<ref name=dpb06>{{cite journal |author=Poletti V, Casoni G, Chilosi M, Zompatori M |title=Diffuse panbronchiolitis |journal=Eur Respir J. |volume=28 |issue=4 |pages=862-871 |year=2006 |pmid=17012632 }}</ref>  ''[[pseudomonas aeruginosa]]'' (another opportunistic bacterium) and [[pus]] in the [[sputum]] (coughed-up [[phlegm]]);<ref name=dpb/><ref name=path>{{cite journal |author=Yanagihara K, Kadoto J, Kohno S |title=Diffuse panbronchiolitis--pathophysiology and treatment mechanisms |journal=Int J Antimicrob Agents |volume=18 |issue=Suppl. 1 |pages=S83-87 |year=2001 |pmid=11574201 }}</ref> [[chronic sinusitis]] (inflamed [[paranasal sinus]]es),<ref name=lat>{{cite journal |author=Martinez JA, Guimaraes SM, Ferreira RG, Pereira CA |title=Diffuse panbronchiolitis in Latin America |journal=Am J Med Sci. |volume=319|issue=3 |pages=183-185 |year=2000 |pmid=10746829 }}</ref><ref name=usa>{{cite journal |author=Fitzgerald JE, King TE Jr., Lynch DA, Tuder RM, Schwarz MI |title=Diffuse panbronchiolitis in the United States |journal=Am J Respir Crit Care Med. |volume=154 |issue=2 pt. 1 |pages=497-503 |year=1996 |pmid=8756828 }}</ref> [[hypoxemia]] (low levels of [[oxygen]] in the [[blood]]),<ref name=rep>{{cite journal |author=Chu YC, Yeh SZ, Chen CL, Chen CY, Chang CY, Chiang CD |title=Diffuse panbronchiolitis: report of a case |journal=J Formos Med Assoc. |volume=91 |issue=9 |pages=912-915 |year=1992 |pmid=1363394 }}</ref> nodules within [[terminal bronchiole|terminal]] and [[respiratory bronchiole]]s in both lungs,<ref name=thai>{{cite journal |author=Chantarotorn S, Palwatwichai A, Vattanathum A, Tantamacharik D |title=Diffuse panbronchiolitis, the first case reports in Thailand |journal=J Med Assoc Thai. |volume=82 |issue=8 |pages=833-838 |year=1999 |pmid=10511794 }}</ref><ref name=can>{{cite journal |author=Sandrini A, Balter MS, Chapman KR |title=Diffuse panbronchiolitis in a Caucasian man in Canada |journal=Can Respir J. |volume=10 |issue=8 |pages=449-451 |year=2003 |pmid=14679410 }}</ref> [[dyspnea]] (shortness of breath),<ref name=chitwo>{{cite journal |author=Chen Y, Kang J, Li S |title=Diffuse panbronchiolitis in China |journal=Respirology |volume=10 |issue=1 |pages=70-75 |year=2005 |pmid=15691241 }}</ref><ref name=usa>{{cite journal |author=Fitzgerald JE, King TE Jr., Lynch DA, Tuder RM, Schwarz MI |title=Diffuse panbronchiolitis in the United States |journal=Am J Respir Crit Care Med. |volume=154 |issue=2 pt. 1 |pages=497-503 |year=1996 |pmid=8756828 }}</ref>
If left untreated, as DPB progresses, signs of bronchiectasis begin to present themselves. These symptoms include chronic [[shortness of breath]], severe [[cough]], pooling of [[sputum]], thickening of [[bronchiolar walls]], [[hypoxemia]], and dilation (enlargement) of the bronchiolar passages.<ref name=dpb>{{cite journal |author=Homma H, Yamanaka A, Tanimoto S, Tamura M, Chijimatsu Y, Kira S, Izumi T |title=Diffuse panbronchiolitis. A disease of the transitional zone of the lung |journal=Chest. |volume=83 |issue=1 |pages=63-69 |year=1983 |pmid=6848335 }}</ref><ref name=usa>{{cite journal |author=Fitzgerald JE, King TE Jr., Lynch DA, Tuder RM, Schwarz MI |title=Diffuse panbronchiolitis in the United States |journal=Am J Respir Crit Care Med. |volume=154 |issue=2 pt. 1 |pages=497-503 |year=1996 |pmid=8756828 }}</ref> This eventually becomes life-threatening, leading to [[respiratory failure]].<ref name=dpb>{{cite journal |author=Homma H, Yamanaka A, Tanimoto S, Tamura M, Chijimatsu Y, Kira S, Izumi T |title=Diffuse panbronchiolitis. A disease of the transitional zone of the lung |journal=Chest. |volume=83 |issue=1 |pages=63-69 |year=1983 |pmid=6848335 }}</ref>
elevated [[IgG]] and [[IgA]] (classes of [[immunoglobulin]]s),<ref name=chi>{{cite journal |author=Tsang KW, Ooi CG, Ip MS, Lam WK, Ngan H, Chan EY, Hawkins B, Ho CS, Amitani R, Tanaka E, Inoh H |title=Clinical profiles of Chinese patients with diffuse panbronchiolitis |journal=Thorax |volume=53 |issue=4 |pages=274-280 |year=1998 |pmid=9741370 }}</ref> occurrences of elevated [[rheumatoid factor]] (an indicator of [[autoimmunity]]),<ref name=chi>{{cite journal |author=Tsang KW, Ooi CG, Ip MS, Lam WK, Ngan H, Chan EY, Hawkins B, Ho CS, Amitani R, Tanaka E, Inoh H |title=Clinical profiles of Chinese patients with diffuse panbronchiolitis |journal=Thorax |volume=53 |issue=4 |pages=274-280 |year=1998 |pmid=9741370 }}</ref> and [[hemagglutination]] (clumping of [[antibodies]] in the blood).<ref name=chi>{{cite journal |author=Tsang KW, Ooi CG, Ip MS, Lam WK, Ngan H, Chan EY, Hawkins B, Ho CS, Amitani R, Tanaka E, Inoh H |title=Clinical profiles of Chinese patients with diffuse panbronchiolitis |journal=Thorax |volume=53 |issue=4 |pages=274-280 |year=1998 |pmid=9741370 }}</ref><ref name=cold>{{cite journal |author=Schulte W, Szrepka A, Bauer PC, Guzman J, Costabel U |title=Diffuse panbronchiolitis. A differential diagnosis of chronic obstructive lung disease |journal=Dtsch Med Wochenschr. |volume=124 |issue=19 |pages=584-588 |year=1999 |pmid=10365176 }}</ref>
 
If left untreated, as DPB progresses, signs of bronchiectasis begin to present themselves. These symptoms include chronic shortness of breath, severe cough, pooling of sputum, thickening of bronchiolar walls, hypoxemia, and dilation (enlargement) of the bronchiolar passages.<ref name=dpb/><ref name=usa>{{cite journal |author=Fitzgerald JE, King TE Jr., Lynch DA, Tuder RM, Schwarz MI |title=Diffuse panbronchiolitis in the United States |journal=Am J Respir Crit Care Med. |volume=154 |issue=2 pt. 1 |pages=497-503 |year=1996 |pmid=8756828 }}</ref> This eventually becomes life-threatening, leading to respiratory failure.<ref name=dpb/>


==References==
==References==
{{Reflist|2}}
{{Reflist|2}}
[[Category:Pulmonology]]

Latest revision as of 14:20, 6 June 2016

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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1] Associate Editor(s)-in-Chief:

Overview

History

Symptoms

DPB can be characterized by a number of symptoms and histological features (those detected by analysis of tissues).

If left untreated, as DPB progresses, signs of bronchiectasis begin to present themselves. These symptoms include chronic shortness of breath, severe cough, pooling of sputum, thickening of bronchiolar walls, hypoxemia, and dilation (enlargement) of the bronchiolar passages.[1][2] This eventually becomes life-threatening, leading to respiratory failure.[1]

References

  1. ↑ 1.0 1.1 Homma H, Yamanaka A, Tanimoto S, Tamura M, Chijimatsu Y, Kira S, Izumi T (1983). "Diffuse panbronchiolitis. A disease of the transitional zone of the lung". Chest. 83 (1): 63–69. PMID 6848335.
  2. ↑ Fitzgerald JE, King TE Jr., Lynch DA, Tuder RM, Schwarz MI (1996). "Diffuse panbronchiolitis in the United States". Am J Respir Crit Care Med. 154 (2 pt. 1): 497–503. PMID 8756828.
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