Beriberi medical therapy: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Beriberi}} | {{Beriberi}} | ||
{{CMG}} | {{CMG}}; {{AE}}{{AIA}} | ||
==Overview== | ==Overview== | ||
Beriberi is an easily treatable condition, using thiamine hydrochloride via oral or parentral routes. A rapid and dramatic recovery within hours can be made when this is administered to patients with beriberi. | |||
==Medical Therapy== | ==Medical Therapy== | ||
Treatment is with [[thiamine hydrochloride]], either in tablet form or injection. A rapid and dramatic recovery within hours can be made when this is administered to patients with beriberi. | |||
* Treatment is with [[thiamine hydrochloride]], either in tablet form or injection. | |||
* A rapid and dramatic recovery within hours can be made when this is administered to patients with beriberi. | |||
* The dose in chronic beriberi is 50 mg/day intravenously or intramuscularly for several days, followed by a maintainence dose of 2.5 to 5 mg/day orally.<ref name="pmid29489643">{{cite journal| author=Lei Y, Zheng MH, Huang W, Zhang J, Lu Y| title=Wet beriberi with multiple organ failure remarkably reversed by thiamine administration: A case report and literature review. | journal=Medicine (Baltimore) | year= 2018 | volume= 97 | issue= 9 | pages= e0010 | pmid=29489643 | doi=10.1097/MD.0000000000010010 | pmc=5851725 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=29489643 }}</ref> | |||
*In advanced dry or wet beriberi, the recommended dose is 200mg intravenous or orally thiamine three times/day till resolution of symptoms and then the maintainence dose should be 10 mg/day until expected recovery. | |||
*In Wernicke-Korsakoff syndrome, the recommended dose is: Three doses of intravenous 500 mg daily during the first two days of treatment, then shift to 250 mg/day for additional three days. | |||
*In Wernicke-Korsakoff syndrome, make sure to administer thiamine during the re-feeding period in alcoholic patients to avoid thiamine deficiency with lactic acidosis.<ref name="pmid30725889">{{cite journal| author=| title=StatPearls | journal= | year= 2019 | volume= | issue= | pages= | pmid=30725889 | doi= | pmc= | url= }}</ref> | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
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{{WikiDoc Sources}} | |||
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[[Category:Endocrinology]] | |||
[[Category:Gastroenterology]] | [[Category:Gastroenterology]] | ||
[[Category:Cardiology]] | [[Category:Cardiology]] | ||
Latest revision as of 20:48, 12 November 2019
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Abdelrahman Ibrahim Abushouk, MD[2]
Overview
Beriberi is an easily treatable condition, using thiamine hydrochloride via oral or parentral routes. A rapid and dramatic recovery within hours can be made when this is administered to patients with beriberi.
Medical Therapy
- Treatment is with thiamine hydrochloride, either in tablet form or injection.
- A rapid and dramatic recovery within hours can be made when this is administered to patients with beriberi.
- The dose in chronic beriberi is 50 mg/day intravenously or intramuscularly for several days, followed by a maintainence dose of 2.5 to 5 mg/day orally.[1]
- In advanced dry or wet beriberi, the recommended dose is 200mg intravenous or orally thiamine three times/day till resolution of symptoms and then the maintainence dose should be 10 mg/day until expected recovery.
- In Wernicke-Korsakoff syndrome, the recommended dose is: Three doses of intravenous 500 mg daily during the first two days of treatment, then shift to 250 mg/day for additional three days.
- In Wernicke-Korsakoff syndrome, make sure to administer thiamine during the re-feeding period in alcoholic patients to avoid thiamine deficiency with lactic acidosis.[2]
References
- ↑ Lei Y, Zheng MH, Huang W, Zhang J, Lu Y (2018). "Wet beriberi with multiple organ failure remarkably reversed by thiamine administration: A case report and literature review". Medicine (Baltimore). 97 (9): e0010. doi:10.1097/MD.0000000000010010. PMC 5851725. PMID 29489643.
- ↑ "StatPearls". 2019. PMID 30725889.