Congenital syphilis other diagnostic studies: Difference between revisions
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__NOTOC__ | __NOTOC__ | ||
{{Congenital syphilis}} | {{Congenital syphilis}} | ||
{{CMG}}; {{AE}} {{ADI}}{{AKI}} | |||
==Overview== | |||
Pathologic examination of the [[placenta]] or [[umbilical cord]] by using specific fluorescent antitreponemal antibody staining and CSF analysis can be done. | |||
==Other Diagnostic Findings== | |||
===CSF Analysis=== | |||
'''Indications : ''' [[Lumbar puncture]] is indicated in the following situations.<ref name="Phiske2014">{{cite journal|last1=Phiske|first1=MeghanaMadhukar|title=Current trends in congenital syphilis|journal=Indian Journal of Sexually Transmitted Diseases and AIDS|volume=35|issue=1|year=2014|pages=12|issn=0253-7184|doi=10.4103/0253-7184.132404}}</ref> | |||
*If the [[infant]] or [[child]] has [[signs]] and [[symptoms]] of [[congenital Syphilis]]. | |||
*If there is no documentation of treatment for [[maternal]] infection during the period of [[gestation]]. | |||
*If the mother was treated within 4 weeks of [[delivery]]. | |||
*If the mother was inadequately treated or documentation of the treatment is incomplete. | |||
*A four-fold decline in [[titer]] following therapy in the mother is not documented. | |||
'''CSF Findings:''' | |||
*Reactive [[CSF]] [[VDRL]]. <ref name="pmid26042815">{{cite journal| author=Workowski KA, Bolan GA, Centers for Disease Control and Prevention| title=Sexually transmitted diseases treatment guidelines, 2015. | journal=MMWR Recomm Rep | year= 2015 | volume= 64 | issue= RR-03 | pages= 1-137 | pmid=26042815 | doi= | pmc= | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=26042815 }} </ref> | |||
*[[CSF pleocytosis]](>25 white blood cells [WBC]/microL for infants <1 month) | |||
*Elevated [[CSF]] [[protein]] (>150 mg/dL in term infants <1 month of age and >170 mg/dL in preterm infants <1 month of age) | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
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[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Pediatrics]] | [[Category:Pediatrics]] | ||
[[Category:Neonatology]] | [[Category:Neonatology]] | ||
[[Category:Needs content]] | [[Category:Needs content]] | ||
[[Category:Emergency medicine]] | |||
[[Category:Up-To-Date]] | |||
[[Category:Infectious disease]] | |||
[[Category:Obstetrics]] | |||
Latest revision as of 21:04, 29 July 2020
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]; Associate Editor(s)-in-Chief: Aditya Govindavarjhulla, M.B.B.S. [2]Aravind Kuchkuntla, M.B.B.S[3]
Overview
Pathologic examination of the placenta or umbilical cord by using specific fluorescent antitreponemal antibody staining and CSF analysis can be done.
Other Diagnostic Findings
CSF Analysis
Indications : Lumbar puncture is indicated in the following situations.[1]
- If the infant or child has signs and symptoms of congenital Syphilis.
- If there is no documentation of treatment for maternal infection during the period of gestation.
- If the mother was treated within 4 weeks of delivery.
- If the mother was inadequately treated or documentation of the treatment is incomplete.
- A four-fold decline in titer following therapy in the mother is not documented.
CSF Findings:
- Reactive CSF VDRL. [2]
- CSF pleocytosis(>25 white blood cells [WBC]/microL for infants <1 month)
- Elevated CSF protein (>150 mg/dL in term infants <1 month of age and >170 mg/dL in preterm infants <1 month of age)
References
- ↑ Phiske, MeghanaMadhukar (2014). "Current trends in congenital syphilis". Indian Journal of Sexually Transmitted Diseases and AIDS. 35 (1): 12. doi:10.4103/0253-7184.132404. ISSN 0253-7184.
- ↑ Workowski KA, Bolan GA, Centers for Disease Control and Prevention (2015). "Sexually transmitted diseases treatment guidelines, 2015". MMWR Recomm Rep. 64 (RR-03): 1–137. PMID 26042815.