Creutzfeldt-Jakob disease MRI: Difference between revisions
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Created page with "__NOTOC__ {{Creutzfeldt-Jakob disease}} {{CMG}} ==Overview== == MRI== * Often shows high signal intensity in the caudate nucleus and putamen bilaterally on T2-weighted ..." |
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{{Creutzfeldt-Jakob disease}} | {{Creutzfeldt-Jakob disease}} | ||
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==Overview== | |||
MRI findings in CJD include high signal abnormalities in [[caudate nucleus]] and/or [[putamen]] on diffusion-weighted imaging (DWI) or fluid attenuated inversion recovery (FLAIR).<ref name="www.cdc.gov">{{Cite web | last = | first = | title = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | url = http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html | publisher = | date = | accessdate = 17 February 2014 }}</ref> Additional findings on diffusion weighted imaging include cortical, subcortical, and thalamic involvement. An abnormal signal in the poster thalami on T2 (pulvinar sign) and diffusion weighted images and fluid-attenuated inversion recovery sequences on brain MRI, in the appropriate clinical context, is highly specific for [[variant Creutzfeldt-Jakob disease]]. | |||
== MRI== | == MRI== | ||
* | * MRI often shows high signal intensity in the [[caudate nucleus]] and [[putamen]] bilaterally on T2-weighted images. | ||
* Diffusion Weighted Imaging (DWI) images | * [[Diffusion Weighted Imaging]] (DWI) images may be remarkable for the following findings:<ref>{{cite journal|last= Young|first= Geoffrey S.|coauthors= Michael D. Geschwind, Nancy J. Fischbein, Jennifer L. Martindale, Roland G. Henry, Songling Liu, Ying Lu, Stephen Wong, Hong Liu, Bruce L. Miller and William P. Dillon|title=Diffusion-Weighted and Fluid-Attenuated Inversion Recovery Imaging in Creutzfeldt-Jakob Disease: High Sensitivity and Specificity for Diagnosis|journal=American Journal of Neuroradiology|volume= 26|pages=1551-1562|date=June-July 2005|publisher=American Society of Neuroradiology|url=http://www.ajnr.org/cgi/content/full/26/6/1551|accessdate = 2007-10-30}}</ref> | ||
* | :*Cortical hyperintensity (25%-70% of cases) | ||
*An abnormal signal in the | :*Subcortical abnormalities (5% of cases) | ||
:*Thalamic involvement, usually in posterior thalamus (more strongly associated with [[variant Creutzfeldt-Jakob disease]] than with classic Creutzfeldt-Jakob disease)<ref>{{cite journal | last =Tschampa | first =Henriette J. |authorlink = | coauthors =Petra Mürtz, Sebastian Flacke, Sebastian Paus, Hans H. Schild and Horst Urbach | title =Thalamic Involvement in Sporadic Creutzfeldt-Jakob Disease: A Diffusion-Weighted MR Imaging Study | journal =American Journal of Neuroradiology | volume =24 | pages =908-915 | publisher =American Society of Neuroradiology |date=May 2003 | url =http://www.ajnr.org/cgi/content/full/24/5/908 | accessdate = 2007-10-30}}</ref> | |||
*An abnormal signal in the poster thalami on T2 (pulvinar sign) and diffusion weighted images and fluid-attenuated inversion recovery sequences on brain [[Magnetic resonance imaging|MRI]], in the appropriate clinical context, is highly specific for variant Creutzfeldt-Jakob disease. | |||
==References== | ==References== | ||
{{Reflist|2}} | {{Reflist|2}} | ||
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{{WikiDoc Sources}} | {{WikiDoc Sources}} | ||
[[Category:Neurology]] | [[Category:Neurology]] | ||
[[Category:Disease]] | [[Category:Disease]] | ||
[[Category:Transmissible spongiform encephalopathies]] | [[Category:Transmissible spongiform encephalopathies]] | ||
Latest revision as of 05:01, 30 October 2018
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]
Overview
MRI findings in CJD include high signal abnormalities in caudate nucleus and/or putamen on diffusion-weighted imaging (DWI) or fluid attenuated inversion recovery (FLAIR).[1] Additional findings on diffusion weighted imaging include cortical, subcortical, and thalamic involvement. An abnormal signal in the poster thalami on T2 (pulvinar sign) and diffusion weighted images and fluid-attenuated inversion recovery sequences on brain MRI, in the appropriate clinical context, is highly specific for variant Creutzfeldt-Jakob disease.
MRI
- MRI often shows high signal intensity in the caudate nucleus and putamen bilaterally on T2-weighted images.
- Diffusion Weighted Imaging (DWI) images may be remarkable for the following findings:[2]
- Cortical hyperintensity (25%-70% of cases)
- Subcortical abnormalities (5% of cases)
- Thalamic involvement, usually in posterior thalamus (more strongly associated with variant Creutzfeldt-Jakob disease than with classic Creutzfeldt-Jakob disease)[3]
- An abnormal signal in the poster thalami on T2 (pulvinar sign) and diffusion weighted images and fluid-attenuated inversion recovery sequences on brain MRI, in the appropriate clinical context, is highly specific for variant Creutzfeldt-Jakob disease.
References
- ↑ "http://www.cdc.gov/ncidod/dvrd/cjd/diagnostic_criteria.html". Retrieved 17 February 2014. External link in
|title=(help) - ↑ Young, Geoffrey S. (June–July 2005). "Diffusion-Weighted and Fluid-Attenuated Inversion Recovery Imaging in Creutzfeldt-Jakob Disease: High Sensitivity and Specificity for Diagnosis". American Journal of Neuroradiology. American Society of Neuroradiology. 26: 1551–1562. Retrieved 2007-10-30. Unknown parameter
|coauthors=ignored (help) - ↑ Tschampa, Henriette J. (May 2003). "Thalamic Involvement in Sporadic Creutzfeldt-Jakob Disease: A Diffusion-Weighted MR Imaging Study". American Journal of Neuroradiology. American Society of Neuroradiology. 24: 908–915. Retrieved 2007-10-30. Unknown parameter
|coauthors=ignored (help)