Amyotrophic lateral sclerosis causes: Difference between revisions
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{{Amyotrophic lateral sclerosis}} | {{Amyotrophic lateral sclerosis}} | ||
{{CMG}} | {{CMG}}{{AE}}{{MMJ}} | ||
==Overview== | ==Overview== | ||
Approximately 5-10% of cases of ALS are familial ALS. More than 25 different genes could be linked to the causation of familial ALS. However, the remaining majority 90-95% of ALS cases are Sporadic ALS. There is no known cause for Sporadic ALS. | |||
==Cause== | ==Cause== | ||
Approximately 5-10% of Familial ALS cases could be linked to different genes and their pathological pathways. More than 25 different genes mutations are attributed to Familial ALS. The most common ones include: | |||
* | *[[Chromosome 9 Open Reading Frame 72]](c9orf72) | ||
* | *[[TAR DNA-binding protein 43]] (TDP-43) | ||
*[[Fused in Sarcoma]] (FUS) | |||
*[[Superoxide Dismutase 1]] (SOD1) | |||
*[[TANK-binding kinase 1]] (TBK1) | |||
*[[Optineurin]] (OPTN) | |||
<ref name="pmidPMID: 33918092">{{cite journal| author=Källstig E, McCabe BD, Schneider BL| title=The Links between ALS and NF-κB. | journal=Int J Mol Sci | year= 2021 | volume= 22 | issue= 8 | pages= | pmid=PMID: 33918092 | doi=10.3390/ijms22083875 | pmc=8070122 | url=https://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=33918092 }} </ref> | |||
==References== | ==References== | ||
Latest revision as of 16:35, 21 July 2021
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Differentiating Amyotrophic lateral sclerosis from other Diseases |
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Editor-In-Chief: C. Michael Gibson, M.S., M.D. [1]Associate Editor(s)-in-Chief: Mohamadmostafa Jahansouz M.D.[2]
Overview
Approximately 5-10% of cases of ALS are familial ALS. More than 25 different genes could be linked to the causation of familial ALS. However, the remaining majority 90-95% of ALS cases are Sporadic ALS. There is no known cause for Sporadic ALS.
Cause
Approximately 5-10% of Familial ALS cases could be linked to different genes and their pathological pathways. More than 25 different genes mutations are attributed to Familial ALS. The most common ones include:
- Chromosome 9 Open Reading Frame 72(c9orf72)
- TAR DNA-binding protein 43 (TDP-43)
- Fused in Sarcoma (FUS)
- Superoxide Dismutase 1 (SOD1)
- TANK-binding kinase 1 (TBK1)
- Optineurin (OPTN)
References
- ↑ Källstig E, McCabe BD, Schneider BL (2021). "The Links between ALS and NF-κB". Int J Mol Sci. 22 (8). doi:10.3390/ijms22083875. PMC 8070122 Check
|pmc=value (help). PMID 33918092 PMID: 33918092 Check|pmid=value (help).